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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPOLG
Full Name:
Poly(A) polymerase gamma
Alias:
FLJ12972; PAP gamma; PAP2; PAPG; PAPOG; Poly (A) polymerase gamma; Polynucleotide adenylyltransferase gamma; SRP RNA 3' adenylating enzyme
Type:
Transferase; EC 2.7.7.19
Mass (Da):
82803
Number AA:
736
UniProt ID:
Q9BWT3
International Prot ID:
IPI00304442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003723
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
K
E
M
S
A
N
T
V
L
D
S
Q
R
Q
Site 2
S12
S
A
N
T
V
L
D
S
Q
R
Q
Q
K
H
Y
Site 3
Y19
S
Q
R
Q
Q
K
H
Y
G
I
T
S
P
I
S
Site 4
T22
Q
Q
K
H
Y
G
I
T
S
P
I
S
L
A
S
Site 5
S23
Q
K
H
Y
G
I
T
S
P
I
S
L
A
S
P
Site 6
S26
Y
G
I
T
S
P
I
S
L
A
S
P
K
E
I
Site 7
S29
T
S
P
I
S
L
A
S
P
K
E
I
D
H
I
Site 8
Y37
P
K
E
I
D
H
I
Y
T
Q
K
L
I
D
A
Site 9
S76
N
L
V
K
E
W
I
S
D
V
S
E
S
K
N
Site 10
S79
K
E
W
I
S
D
V
S
E
S
K
N
L
P
P
Site 11
S81
W
I
S
D
V
S
E
S
K
N
L
P
P
S
V
Site 12
S87
E
S
K
N
L
P
P
S
V
V
A
T
V
G
G
Site 13
S101
G
K
I
F
T
F
G
S
Y
R
L
G
V
H
T
Site 14
T108
S
Y
R
L
G
V
H
T
K
G
A
D
I
D
A
Site 15
S126
A
P
R
H
V
E
R
S
D
F
F
Q
S
F
F
Site 16
S131
E
R
S
D
F
F
Q
S
F
F
E
K
L
K
H
Site 17
S178
R
L
A
I
Q
T
I
S
D
N
L
D
L
R
D
Site 18
S187
N
L
D
L
R
D
D
S
R
L
R
S
L
D
I
Site 19
S191
R
D
D
S
R
L
R
S
L
D
I
R
C
I
R
Site 20
T218
H
L
V
P
N
K
E
T
F
R
L
T
L
R
A
Site 21
T222
N
K
E
T
F
R
L
T
L
R
A
V
K
L
W
Site 22
Y236
W
A
K
R
R
G
I
Y
S
N
M
L
G
F
L
Site 23
S237
A
K
R
R
G
I
Y
S
N
M
L
G
F
L
G
Site 24
Y259
V
A
R
T
C
Q
L
Y
P
N
A
A
A
S
T
Site 25
Y309
R
V
N
P
S
D
R
Y
H
L
M
P
I
I
T
Site 26
T316
Y
H
L
M
P
I
I
T
P
A
Y
P
Q
Q
N
Site 27
Y319
M
P
I
I
T
P
A
Y
P
Q
Q
N
S
T
Y
Site 28
S324
P
A
Y
P
Q
Q
N
S
T
Y
N
V
S
T
S
Site 29
T325
A
Y
P
Q
Q
N
S
T
Y
N
V
S
T
S
T
Site 30
Y326
Y
P
Q
Q
N
S
T
Y
N
V
S
T
S
T
R
Site 31
S331
S
T
Y
N
V
S
T
S
T
R
T
V
M
V
E
Site 32
T334
N
V
S
T
S
T
R
T
V
M
V
E
E
F
K
Site 33
S355
D
E
I
L
Q
G
K
S
D
W
S
K
L
L
E
Site 34
Y370
P
P
N
F
F
Q
K
Y
R
H
Y
I
V
L
T
Site 35
T377
Y
R
H
Y
I
V
L
T
A
S
A
S
T
E
E
Site 36
S381
I
V
L
T
A
S
A
S
T
E
E
N
H
L
E
Site 37
T411
L
E
R
N
E
F
I
T
L
A
H
V
N
P
Q
Site 38
S419
L
A
H
V
N
P
Q
S
F
P
G
N
K
E
H
Site 39
Y432
E
H
H
K
D
N
N
Y
V
S
M
W
F
L
G
Site 40
S450
R
R
V
E
N
A
E
S
V
N
I
D
L
T
Y
Site 41
T456
E
S
V
N
I
D
L
T
Y
D
I
Q
S
F
T
Site 42
Y457
S
V
N
I
D
L
T
Y
D
I
Q
S
F
T
D
Site 43
S461
D
L
T
Y
D
I
Q
S
F
T
D
T
V
Y
R
Site 44
T465
D
I
Q
S
F
T
D
T
V
Y
R
Q
A
N
N
Site 45
Y467
Q
S
F
T
D
T
V
Y
R
Q
A
N
N
I
N
Site 46
Y495
K
K
K
Q
L
H
H
Y
L
P
A
E
I
L
Q
Site 47
S508
L
Q
K
K
K
K
Q
S
L
S
D
V
N
R
S
Site 48
S510
K
K
K
K
Q
S
L
S
D
V
N
R
S
S
G
Site 49
S515
S
L
S
D
V
N
R
S
S
G
G
L
Q
S
K
Site 50
S516
L
S
D
V
N
R
S
S
G
G
L
Q
S
K
R
Site 51
S521
R
S
S
G
G
L
Q
S
K
R
L
S
L
D
S
Site 52
S525
G
L
Q
S
K
R
L
S
L
D
S
S
C
L
D
Site 53
S528
S
K
R
L
S
L
D
S
S
C
L
D
S
S
R
Site 54
S529
K
R
L
S
L
D
S
S
C
L
D
S
S
R
D
Site 55
S533
L
D
S
S
C
L
D
S
S
R
D
T
D
N
G
Site 56
T537
C
L
D
S
S
R
D
T
D
N
G
T
P
F
N
Site 57
T541
S
R
D
T
D
N
G
T
P
F
N
S
P
A
S
Site 58
S545
D
N
G
T
P
F
N
S
P
A
S
K
S
D
S
Site 59
S548
T
P
F
N
S
P
A
S
K
S
D
S
P
S
V
Site 60
S550
F
N
S
P
A
S
K
S
D
S
P
S
V
G
E
Site 61
S552
S
P
A
S
K
S
D
S
P
S
V
G
E
T
E
Site 62
S554
A
S
K
S
D
S
P
S
V
G
E
T
E
R
N
Site 63
T558
D
S
P
S
V
G
E
T
E
R
N
S
A
E
P
Site 64
S562
V
G
E
T
E
R
N
S
A
E
P
A
A
V
I
Site 65
T594
I
G
A
K
V
D
S
T
V
K
T
V
S
P
P
Site 66
T597
K
V
D
S
T
V
K
T
V
S
P
P
T
V
C
Site 67
S599
D
S
T
V
K
T
V
S
P
P
T
V
C
T
I
Site 68
T619
R
N
V
I
P
R
I
T
T
P
H
N
P
A
Q
Site 69
T620
N
V
I
P
R
I
T
T
P
H
N
P
A
Q
G
Site 70
T640
G
M
S
N
I
T
K
T
V
T
P
K
R
S
H
Site 71
T642
S
N
I
T
K
T
V
T
P
K
R
S
H
S
P
Site 72
S646
K
T
V
T
P
K
R
S
H
S
P
S
I
D
G
Site 73
S648
V
T
P
K
R
S
H
S
P
S
I
D
G
T
P
Site 74
S650
P
K
R
S
H
S
P
S
I
D
G
T
P
K
R
Site 75
T654
H
S
P
S
I
D
G
T
P
K
R
L
K
D
V
Site 76
S669
E
K
F
I
R
L
E
S
T
F
K
D
P
R
T
Site 77
T670
K
F
I
R
L
E
S
T
F
K
D
P
R
T
A
Site 78
T676
S
T
F
K
D
P
R
T
A
E
E
R
K
R
K
Site 79
S684
A
E
E
R
K
R
K
S
V
D
A
I
G
G
E
Site 80
T697
G
E
S
M
P
I
P
T
I
D
T
S
R
K
K
Site 81
T700
M
P
I
P
T
I
D
T
S
R
K
K
R
L
P
Site 82
S701
P
I
P
T
I
D
T
S
R
K
K
R
L
P
S
Site 83
S708
S
R
K
K
R
L
P
S
K
E
L
P
D
S
S
Site 84
S714
P
S
K
E
L
P
D
S
S
S
P
V
P
A
N
Site 85
S715
S
K
E
L
P
D
S
S
S
P
V
P
A
N
N
Site 86
S716
K
E
L
P
D
S
S
S
P
V
P
A
N
N
I
Site 87
S729
N
I
R
V
I
K
N
S
I
R
L
T
L
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation