KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIAA0586
Full Name:
Uncharacterized protein KIAA0586
Alias:
K0586; Talpid3
Type:
Unknown function
Mass (Da):
169264
Number AA:
1533
UniProt ID:
Q9BVV6
International Prot ID:
IPI00006096
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
R
L
R
E
V
V
S
Q
N
H
G
D
H
L
Site 2
T42
N
K
R
L
P
V
G
T
G
T
S
L
N
G
T
Site 3
S45
L
P
V
G
T
G
T
S
L
N
G
T
S
R
G
Site 4
T49
T
G
T
S
L
N
G
T
S
R
G
S
S
D
L
Site 5
S50
G
T
S
L
N
G
T
S
R
G
S
S
D
L
T
Site 6
S53
L
N
G
T
S
R
G
S
S
D
L
T
S
A
R
Site 7
S54
N
G
T
S
R
G
S
S
D
L
T
S
A
R
N
Site 8
T57
S
R
G
S
S
D
L
T
S
A
R
N
C
Y
Q
Site 9
S58
R
G
S
S
D
L
T
S
A
R
N
C
Y
Q
P
Site 10
Y63
L
T
S
A
R
N
C
Y
Q
P
L
L
E
N
P
Site 11
S73
L
L
E
N
P
M
V
S
E
S
D
F
S
K
D
Site 12
S75
E
N
P
M
V
S
E
S
D
F
S
K
D
V
A
Site 13
T148
G
I
E
K
D
A
V
T
Q
E
T
R
I
S
P
Site 14
S154
V
T
Q
E
T
R
I
S
P
S
G
I
D
S
A
Site 15
S156
Q
E
T
R
I
S
P
S
G
I
D
S
A
T
T
Site 16
S183
A
P
L
I
K
V
Q
S
D
L
E
A
K
V
N
Site 17
S191
D
L
E
A
K
V
N
S
V
T
E
L
L
S
K
Site 18
T210
D
K
H
L
Q
R
V
T
E
Q
Q
T
S
I
Q
Site 19
S215
R
V
T
E
Q
Q
T
S
I
Q
R
K
Q
E
K
Site 20
S266
S
A
A
L
K
T
S
S
F
Q
P
V
S
M
P
Site 21
S271
T
S
S
F
Q
P
V
S
M
P
S
S
R
A
V
Site 22
S274
F
Q
P
V
S
M
P
S
S
R
A
V
E
K
Y
Site 23
S275
Q
P
V
S
M
P
S
S
R
A
V
E
K
Y
S
Site 24
Y281
S
S
R
A
V
E
K
Y
S
V
K
P
E
H
P
Site 25
S282
S
R
A
V
E
K
Y
S
V
K
P
E
H
P
N
Site 26
S292
P
E
H
P
N
L
G
S
C
N
P
S
L
Y
N
Site 27
S296
N
L
G
S
C
N
P
S
L
Y
N
T
F
A
S
Site 28
Y298
G
S
C
N
P
S
L
Y
N
T
F
A
S
K
Q
Site 29
T300
C
N
P
S
L
Y
N
T
F
A
S
K
Q
A
P
Site 30
T314
P
L
K
E
V
E
D
T
S
F
D
K
Q
K
S
Site 31
S315
L
K
E
V
E
D
T
S
F
D
K
Q
K
S
P
Site 32
S321
T
S
F
D
K
Q
K
S
P
L
E
T
P
A
P
Site 33
T325
K
Q
K
S
P
L
E
T
P
A
P
R
R
F
A
Site 34
S337
R
F
A
P
V
P
V
S
R
D
D
E
L
S
K
Site 35
S343
V
S
R
D
D
E
L
S
K
R
E
N
L
L
E
Site 36
S358
E
K
E
N
M
E
V
S
C
H
R
G
N
V
R
Site 37
S376
Q
I
L
N
N
N
D
S
L
T
R
K
S
E
S
Site 38
T378
L
N
N
N
D
S
L
T
R
K
S
E
S
S
N
Site 39
S381
N
D
S
L
T
R
K
S
E
S
S
N
T
T
S
Site 40
S383
S
L
T
R
K
S
E
S
S
N
T
T
S
L
T
Site 41
S384
L
T
R
K
S
E
S
S
N
T
T
S
L
T
R
Site 42
T386
R
K
S
E
S
S
N
T
T
S
L
T
R
S
K
Site 43
S388
S
E
S
S
N
T
T
S
L
T
R
S
K
I
G
Site 44
T390
S
S
N
T
T
S
L
T
R
S
K
I
G
W
T
Site 45
S392
N
T
T
S
L
T
R
S
K
I
G
W
T
P
E
Site 46
T397
T
R
S
K
I
G
W
T
P
E
K
T
N
R
F
Site 47
T401
I
G
W
T
P
E
K
T
N
R
F
P
S
C
E
Site 48
S406
E
K
T
N
R
F
P
S
C
E
E
L
E
T
T
Site 49
T412
P
S
C
E
E
L
E
T
T
K
V
T
M
Q
K
Site 50
T413
S
C
E
E
L
E
T
T
K
V
T
M
Q
K
S
Site 51
S420
T
K
V
T
M
Q
K
S
D
D
V
L
H
D
L
Site 52
S436
Q
K
E
K
E
T
N
S
M
V
Q
P
K
E
S
Site 53
S443
S
M
V
Q
P
K
E
S
L
S
M
L
K
L
P
Site 54
S445
V
Q
P
K
E
S
L
S
M
L
K
L
P
D
L
Site 55
S456
L
P
D
L
P
Q
N
S
V
K
L
Q
T
T
N
Site 56
T464
V
K
L
Q
T
T
N
T
T
R
S
V
L
K
D
Site 57
S510
Y
S
L
I
N
A
L
S
T
N
R
E
M
S
E
Site 58
T511
S
L
I
N
A
L
S
T
N
R
E
M
S
E
K
Site 59
S516
L
S
T
N
R
E
M
S
E
K
I
R
I
R
K
Site 60
T524
E
K
I
R
I
R
K
T
V
D
E
W
I
K
T
Site 61
T531
T
V
D
E
W
I
K
T
I
S
A
E
I
Q
D
Site 62
S541
A
E
I
Q
D
E
L
S
R
T
D
Y
E
Q
K
Site 63
T543
I
Q
D
E
L
S
R
T
D
Y
E
Q
K
R
F
Site 64
Y545
D
E
L
S
R
T
D
Y
E
Q
K
R
F
D
Q
Site 65
T571
T
K
D
I
R
T
N
T
Q
D
K
T
V
N
K
Site 66
T575
R
T
N
T
Q
D
K
T
V
N
K
S
V
I
P
Site 67
S579
Q
D
K
T
V
N
K
S
V
I
P
R
K
H
S
Site 68
S586
S
V
I
P
R
K
H
S
Q
K
Q
I
E
E
H
Site 69
S605
P
M
R
G
M
P
A
S
S
L
Q
K
E
R
K
Site 70
S606
M
R
G
M
P
A
S
S
L
Q
K
E
R
K
E
Site 71
T620
E
G
L
L
K
A
T
T
V
I
Q
D
E
D
Y
Site 72
Y627
T
V
I
Q
D
E
D
Y
M
L
Q
V
Y
G
K
Site 73
Y632
E
D
Y
M
L
Q
V
Y
G
K
P
V
Y
Q
G
Site 74
Y637
Q
V
Y
G
K
P
V
Y
Q
G
H
R
S
T
L
Site 75
S642
P
V
Y
Q
G
H
R
S
T
L
K
K
G
P
Y
Site 76
T643
V
Y
Q
G
H
R
S
T
L
K
K
G
P
Y
L
Site 77
Y649
S
T
L
K
K
G
P
Y
L
R
F
N
S
P
S
Site 78
S654
G
P
Y
L
R
F
N
S
P
S
P
K
S
R
P
Site 79
S656
Y
L
R
F
N
S
P
S
P
K
S
R
P
Q
R
Site 80
S659
F
N
S
P
S
P
K
S
R
P
Q
R
P
K
V
Site 81
S677
V
K
G
T
K
V
K
S
I
R
T
Q
T
D
F
Site 82
T682
V
K
S
I
R
T
Q
T
D
F
Y
A
T
K
P
Site 83
Y685
I
R
T
Q
T
D
F
Y
A
T
K
P
K
K
M
Site 84
S694
T
K
P
K
K
M
D
S
K
M
K
H
S
V
P
Site 85
S699
M
D
S
K
M
K
H
S
V
P
V
L
P
H
G
Site 86
Y710
L
P
H
G
D
Q
Q
Y
L
F
S
P
S
R
E
Site 87
S713
G
D
Q
Q
Y
L
F
S
P
S
R
E
M
P
T
Site 88
S715
Q
Q
Y
L
F
S
P
S
R
E
M
P
T
F
S
Site 89
T720
S
P
S
R
E
M
P
T
F
S
G
T
L
E
G
Site 90
S722
S
R
E
M
P
T
F
S
G
T
L
E
G
H
L
Site 91
T724
E
M
P
T
F
S
G
T
L
E
G
H
L
I
P
Site 92
S741
I
L
L
G
Q
T
Q
S
N
S
D
T
M
P
P
Site 93
S743
L
G
Q
T
Q
S
N
S
D
T
M
P
P
A
G
Site 94
T745
Q
T
Q
S
N
S
D
T
M
P
P
A
G
V
I
Site 95
T760
V
S
K
P
H
P
V
T
V
T
T
S
I
P
P
Site 96
T762
K
P
H
P
V
T
V
T
T
S
I
P
P
S
S
Site 97
T763
P
H
P
V
T
V
T
T
S
I
P
P
S
S
R
Site 98
S764
H
P
V
T
V
T
T
S
I
P
P
S
S
R
K
Site 99
S768
V
T
T
S
I
P
P
S
S
R
K
V
E
T
G
Site 100
S769
T
T
S
I
P
P
S
S
R
K
V
E
T
G
V
Site 101
T774
P
S
S
R
K
V
E
T
G
V
K
K
P
N
I
Site 102
T797
K
K
D
P
P
Q
L
T
V
Q
V
L
P
S
V
Site 103
S808
L
P
S
V
D
I
D
S
I
S
N
S
S
A
D
Site 104
S812
D
I
D
S
I
S
N
S
S
A
D
V
L
S
P
Site 105
S818
N
S
S
A
D
V
L
S
P
L
S
S
P
K
E
Site 106
S821
A
D
V
L
S
P
L
S
S
P
K
E
A
S
P
Site 107
S822
D
V
L
S
P
L
S
S
P
K
E
A
S
P
P
Site 108
S827
L
S
S
P
K
E
A
S
P
P
P
V
Q
T
W
Site 109
T833
A
S
P
P
P
V
Q
T
W
I
K
T
P
E
I
Site 110
T837
P
V
Q
T
W
I
K
T
P
E
I
M
K
V
D
Site 111
S874
K
C
D
E
I
P
D
S
E
P
I
L
E
F
N
Site 112
S883
P
I
L
E
F
N
R
S
V
K
A
D
S
T
K
Site 113
T889
R
S
V
K
A
D
S
T
K
Y
N
G
P
P
F
Site 114
Y891
V
K
A
D
S
T
K
Y
N
G
P
P
F
P
P
Site 115
S901
P
P
F
P
P
V
A
S
T
F
Q
P
T
A
D
Site 116
T919
K
V
I
E
R
K
E
T
L
E
N
S
L
I
Q
Site 117
S952
Q
Q
I
A
P
S
I
S
V
S
V
S
E
T
S
Site 118
S954
I
A
P
S
I
S
V
S
V
S
E
T
S
E
P
Site 119
S956
P
S
I
S
V
S
V
S
E
T
S
E
P
L
T
Site 120
T958
I
S
V
S
V
S
E
T
S
E
P
L
T
S
D
Site 121
S959
S
V
S
V
S
E
T
S
E
P
L
T
S
D
I
Site 122
T963
S
E
T
S
E
P
L
T
S
D
I
V
E
G
T
Site 123
S964
E
T
S
E
P
L
T
S
D
I
V
E
G
T
S
Site 124
S1022
G
P
V
A
T
G
V
S
G
D
A
S
T
N
E
Site 125
S1026
T
G
V
S
G
D
A
S
T
N
E
T
Y
L
P
Site 126
T1030
G
D
A
S
T
N
E
T
Y
L
P
A
R
V
C
Site 127
T1042
R
V
C
T
P
L
A
T
P
Q
P
T
P
P
C
Site 128
T1046
P
L
A
T
P
Q
P
T
P
P
C
S
P
S
S
Site 129
S1050
P
Q
P
T
P
P
C
S
P
S
S
P
A
K
E
Site 130
S1052
P
T
P
P
C
S
P
S
S
P
A
K
E
C
V
Site 131
S1053
T
P
P
C
S
P
S
S
P
A
K
E
C
V
L
Site 132
T1063
K
E
C
V
L
V
K
T
P
D
S
S
P
C
D
Site 133
S1066
V
L
V
K
T
P
D
S
S
P
C
D
S
D
H
Site 134
S1067
L
V
K
T
P
D
S
S
P
C
D
S
D
H
D
Site 135
S1071
P
D
S
S
P
C
D
S
D
H
D
M
A
F
P
Site 136
T1102
L
V
N
T
P
T
V
T
P
T
T
T
P
P
P
Site 137
T1104
N
T
P
T
V
T
P
T
T
T
P
P
P
A
A
Site 138
T1105
T
P
T
V
T
P
T
T
T
P
P
P
A
A
A
Site 139
S1129
S
I
D
K
L
K
V
S
S
P
E
L
P
K
P
Site 140
S1130
I
D
K
L
K
V
S
S
P
E
L
P
K
P
W
Site 141
S1151
L
E
E
E
N
P
N
S
P
Q
E
E
L
H
P
Site 142
S1164
H
P
R
A
I
V
M
S
V
A
K
D
E
E
P
Site 143
S1173
A
K
D
E
E
P
E
S
M
D
F
P
A
Q
P
Site 144
T1195
F
M
P
F
P
A
G
T
K
A
P
S
P
S
Q
Site 145
S1199
P
A
G
T
K
A
P
S
P
S
Q
M
P
G
S
Site 146
S1201
G
T
K
A
P
S
P
S
Q
M
P
G
S
D
S
Site 147
S1206
S
P
S
Q
M
P
G
S
D
S
S
T
L
E
S
Site 148
S1208
S
Q
M
P
G
S
D
S
S
T
L
E
S
T
L
Site 149
S1209
Q
M
P
G
S
D
S
S
T
L
E
S
T
L
S
Site 150
T1210
M
P
G
S
D
S
S
T
L
E
S
T
L
S
V
Site 151
S1213
S
D
S
S
T
L
E
S
T
L
S
V
T
V
T
Site 152
S1216
S
T
L
E
S
T
L
S
V
T
V
T
E
T
E
Site 153
T1220
S
T
L
S
V
T
V
T
E
T
E
T
L
D
K
Site 154
S1230
E
T
L
D
K
P
I
S
E
G
E
I
L
F
S
Site 155
S1237
S
E
G
E
I
L
F
S
C
G
Q
K
L
A
P
Site 156
T1255
E
D
I
G
L
Y
L
T
N
L
N
D
S
L
S
Site 157
S1260
Y
L
T
N
L
N
D
S
L
S
S
T
L
H
D
Site 158
S1262
T
N
L
N
D
S
L
S
S
T
L
H
D
A
V
Site 159
T1264
L
N
D
S
L
S
S
T
L
H
D
A
V
E
M
Site 160
S1277
E
M
E
D
D
P
P
S
E
G
Q
V
I
R
M
Site 161
S1296
F
H
A
D
A
I
L
S
F
A
K
Q
N
Q
E
Site 162
S1307
Q
N
Q
E
S
A
V
S
Q
Q
A
V
Y
H
S
Site 163
S1320
H
S
E
D
L
E
N
S
V
G
E
L
S
E
G
Site 164
S1325
E
N
S
V
G
E
L
S
E
G
Q
R
P
Q
L
Site 165
T1333
E
G
Q
R
P
Q
L
T
A
A
A
E
N
I
L
Site 166
T1352
L
Y
M
Q
P
P
V
T
N
T
Q
S
L
D
Q
Site 167
S1367
Q
C
D
P
K
P
L
S
R
Q
F
D
T
V
S
Site 168
T1372
P
L
S
R
Q
F
D
T
V
S
G
S
I
Y
E
Site 169
S1374
S
R
Q
F
D
T
V
S
G
S
I
Y
E
D
S
Site 170
S1376
Q
F
D
T
V
S
G
S
I
Y
E
D
S
C
A
Site 171
Y1378
D
T
V
S
G
S
I
Y
E
D
S
C
A
S
H
Site 172
S1381
S
G
S
I
Y
E
D
S
C
A
S
H
G
P
M
Site 173
S1384
I
Y
E
D
S
C
A
S
H
G
P
M
S
L
G
Site 174
S1389
C
A
S
H
G
P
M
S
L
G
E
L
E
L
E
Site 175
S1399
E
L
E
L
E
P
N
S
K
L
V
L
P
T
T
Site 176
S1425
P
V
A
A
E
D
F
S
Q
Y
Q
L
K
Q
N
Site 177
S1443
K
Q
V
E
H
K
P
S
Q
S
Y
L
R
V
R
Site 178
S1445
V
E
H
K
P
S
Q
S
Y
L
R
V
R
N
K
Site 179
Y1446
E
H
K
P
S
Q
S
Y
L
R
V
R
N
K
S
Site 180
S1453
Y
L
R
V
R
N
K
S
D
I
A
P
S
Q
Q
Site 181
S1458
N
K
S
D
I
A
P
S
Q
Q
Q
V
S
P
G
Site 182
S1463
A
P
S
Q
Q
Q
V
S
P
G
D
M
D
R
T
Site 183
T1470
S
P
G
D
M
D
R
T
Q
I
E
L
N
P
Y
Site 184
S1491
G
G
K
A
V
P
L
S
A
S
Q
M
P
P
A
Site 185
S1493
K
A
V
P
L
S
A
S
Q
M
P
P
A
K
M
Site 186
S1513
S
V
N
L
E
D
C
S
Q
S
L
S
L
S
T
Site 187
S1515
N
L
E
D
C
S
Q
S
L
S
L
S
T
M
Q
Site 188
S1517
E
D
C
S
Q
S
L
S
L
S
T
M
Q
E
D
Site 189
S1519
C
S
Q
S
L
S
L
S
T
M
Q
E
D
M
E
Site 190
S1527
T
M
Q
E
D
M
E
S
S
G
A
D
T
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation