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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RUSC1
Full Name:
RUN and SH3 domain-containing protein 1
Alias:
dkfzp761a1822; nesca; run and sh3 domain containing 1; run and sh3 domain containing 1 isoform a; run and sh3 domain containing 1 isoform c; run and sh3 domain containing 1 isoform d; rusc1; rusc1 protein
Type:
Mass (Da):
96444
Number AA:
902
UniProt ID:
Q9BVN2
International Prot ID:
IPI00425688
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
L
S
P
Q
R
A
L
L
C
Site 2
S21
H
I
H
L
Q
H
V
S
L
G
L
H
L
S
R
Site 3
S27
V
S
L
G
L
H
L
S
R
R
P
E
L
Q
E
Site 4
S38
E
L
Q
E
G
P
L
S
T
P
P
P
P
G
D
Site 5
T39
L
Q
E
G
P
L
S
T
P
P
P
P
G
D
T
Site 6
T46
T
P
P
P
P
G
D
T
G
G
K
E
S
R
G
Site 7
S51
G
D
T
G
G
K
E
S
R
G
P
C
S
G
T
Site 8
S56
K
E
S
R
G
P
C
S
G
T
L
V
D
A
N
Site 9
T58
S
R
G
P
C
S
G
T
L
V
D
A
N
S
N
Site 10
S64
G
T
L
V
D
A
N
S
N
S
P
A
V
P
C
Site 11
S66
L
V
D
A
N
S
N
S
P
A
V
P
C
R
C
Site 12
S88
L
E
N
R
Q
D
P
S
Q
E
E
E
G
A
A
Site 13
S96
Q
E
E
E
G
A
A
S
P
S
D
P
G
C
S
Site 14
S98
E
E
G
A
A
S
P
S
D
P
G
C
S
S
S
Site 15
S103
S
P
S
D
P
G
C
S
S
S
L
S
S
C
S
Site 16
S104
P
S
D
P
G
C
S
S
S
L
S
S
C
S
D
Site 17
S105
S
D
P
G
C
S
S
S
L
S
S
C
S
D
L
Site 18
S107
P
G
C
S
S
S
L
S
S
C
S
D
L
S
P
Site 19
S108
G
C
S
S
S
L
S
S
C
S
D
L
S
P
D
Site 20
S110
S
S
S
L
S
S
C
S
D
L
S
P
D
E
S
Site 21
S113
L
S
S
C
S
D
L
S
P
D
E
S
P
V
S
Site 22
S117
S
D
L
S
P
D
E
S
P
V
S
V
Y
L
R
Site 23
S120
S
P
D
E
S
P
V
S
V
Y
L
R
D
L
P
Site 24
Y122
D
E
S
P
V
S
V
Y
L
R
D
L
P
G
D
Site 25
S149
E
Q
G
S
P
L
A
S
A
G
P
G
T
C
S
Site 26
S156
S
A
G
P
G
T
C
S
P
D
S
F
C
C
S
Site 27
S159
P
G
T
C
S
P
D
S
F
C
C
S
P
D
S
Site 28
S163
S
P
D
S
F
C
C
S
P
D
S
C
S
G
A
Site 29
S166
S
F
C
C
S
P
D
S
C
S
G
A
S
S
S
Site 30
S168
C
C
S
P
D
S
C
S
G
A
S
S
S
P
D
Site 31
S171
P
D
S
C
S
G
A
S
S
S
P
D
P
G
L
Site 32
S172
D
S
C
S
G
A
S
S
S
P
D
P
G
L
D
Site 33
S173
S
C
S
G
A
S
S
S
P
D
P
G
L
D
S
Site 34
S180
S
P
D
P
G
L
D
S
N
C
N
A
L
T
T
Site 35
T187
S
N
C
N
A
L
T
T
C
Q
D
V
P
S
P
Site 36
S193
T
T
C
Q
D
V
P
S
P
G
L
E
E
E
D
Site 37
T225
G
K
I
D
A
G
K
T
E
P
S
W
K
I
N
Site 38
S264
K
N
N
G
N
V
N
S
S
W
K
S
E
P
E
Site 39
S265
N
N
G
N
V
N
S
S
W
K
S
E
P
E
K
Site 40
S268
N
V
N
S
S
W
K
S
E
P
E
K
F
D
S
Site 41
S275
S
E
P
E
K
F
D
S
G
W
K
T
N
T
R
Site 42
T279
K
F
D
S
G
W
K
T
N
T
R
I
T
D
S
Site 43
T284
W
K
T
N
T
R
I
T
D
S
G
S
K
T
D
Site 44
S286
T
N
T
R
I
T
D
S
G
S
K
T
D
A
G
Site 45
S288
T
R
I
T
D
S
G
S
K
T
D
A
G
K
I
Site 46
T290
I
T
D
S
G
S
K
T
D
A
G
K
I
D
G
Site 47
S301
K
I
D
G
G
W
R
S
D
V
S
E
E
P
V
Site 48
S304
G
G
W
R
S
D
V
S
E
E
P
V
P
H
R
Site 49
T314
P
V
P
H
R
T
I
T
S
F
H
E
L
A
Q
Site 50
S315
V
P
H
R
T
I
T
S
F
H
E
L
A
Q
K
Site 51
S340
P
Q
A
K
K
D
R
S
D
W
L
I
V
F
S
Site 52
S347
S
D
W
L
I
V
F
S
P
D
T
E
L
P
P
Site 53
T350
L
I
V
F
S
P
D
T
E
L
P
P
S
G
S
Site 54
S355
P
D
T
E
L
P
P
S
G
S
P
G
G
S
S
Site 55
S357
T
E
L
P
P
S
G
S
P
G
G
S
S
A
P
Site 56
S361
P
S
G
S
P
G
G
S
S
A
P
P
R
E
V
Site 57
S362
S
G
S
P
G
G
S
S
A
P
P
R
E
V
T
Site 58
T369
S
A
P
P
R
E
V
T
T
F
K
E
L
R
S
Site 59
T370
A
P
P
R
E
V
T
T
F
K
E
L
R
S
R
Site 60
S376
T
T
F
K
E
L
R
S
R
S
R
A
P
A
P
Site 61
S378
F
K
E
L
R
S
R
S
R
A
P
A
P
P
V
Site 62
S432
S
E
E
G
R
A
V
S
P
A
A
G
E
E
A
Site 63
S492
K
G
L
L
I
A
V
S
V
S
V
D
K
I
I
Site 64
S494
L
L
I
A
V
S
V
S
V
D
K
I
I
S
H
Site 65
S520
Q
L
G
D
S
R
L
S
P
D
V
G
H
L
V
Site 66
T552
P
F
R
K
D
L
I
T
G
Q
R
R
S
S
P
Site 67
S557
L
I
T
G
Q
R
R
S
S
P
W
S
V
V
E
Site 68
S558
I
T
G
Q
R
R
S
S
P
W
S
V
V
E
A
Site 69
S561
Q
R
R
S
S
P
W
S
V
V
E
A
S
V
K
Site 70
S566
P
W
S
V
V
E
A
S
V
K
P
G
S
S
T
Site 71
S571
E
A
S
V
K
P
G
S
S
T
R
S
L
G
T
Site 72
S572
A
S
V
K
P
G
S
S
T
R
S
L
G
T
L
Site 73
T573
S
V
K
P
G
S
S
T
R
S
L
G
T
L
Y
Site 74
S575
K
P
G
S
S
T
R
S
L
G
T
L
Y
S
Q
Site 75
T578
S
S
T
R
S
L
G
T
L
Y
S
Q
V
S
R
Site 76
Y580
T
R
S
L
G
T
L
Y
S
Q
V
S
R
L
A
Site 77
S581
R
S
L
G
T
L
Y
S
Q
V
S
R
L
A
P
Site 78
S584
G
T
L
Y
S
Q
V
S
R
L
A
P
L
S
S
Site 79
S590
V
S
R
L
A
P
L
S
S
S
R
S
R
F
H
Site 80
S591
S
R
L
A
P
L
S
S
S
R
S
R
F
H
A
Site 81
S592
R
L
A
P
L
S
S
S
R
S
R
F
H
A
F
Site 82
S614
K
Q
L
E
L
W
F
S
S
L
Q
E
D
A
G
Site 83
S615
Q
L
E
L
W
F
S
S
L
Q
E
D
A
G
L
Site 84
T691
P
P
P
A
L
Q
Q
T
M
Q
A
M
L
H
F
Site 85
S705
F
G
G
R
L
A
Q
S
L
R
G
T
S
K
E
Site 86
T709
L
A
Q
S
L
R
G
T
S
K
E
A
A
S
D
Site 87
S710
A
Q
S
L
R
G
T
S
K
E
A
A
S
D
P
Site 88
S715
G
T
S
K
E
A
A
S
D
P
S
D
S
P
N
Site 89
S718
K
E
A
A
S
D
P
S
D
S
P
N
L
P
T
Site 90
S720
A
A
S
D
P
S
D
S
P
N
L
P
T
P
G
Site 91
T725
S
D
S
P
N
L
P
T
P
G
S
W
W
E
Q
Site 92
S728
P
N
L
P
T
P
G
S
W
W
E
Q
L
T
Q
Site 93
T734
G
S
W
W
E
Q
L
T
Q
A
S
R
V
Y
A
Site 94
Y740
L
T
Q
A
S
R
V
Y
A
S
G
G
T
E
G
Site 95
S751
G
T
E
G
F
P
L
S
R
W
A
P
G
R
H
Site 96
T760
W
A
P
G
R
H
G
T
A
A
E
E
G
A
Q
Site 97
S804
N
E
N
G
A
L
K
S
R
R
P
S
S
W
L
Site 98
S808
A
L
K
S
R
R
P
S
S
W
L
P
P
T
V
Site 99
S809
L
K
S
R
R
P
S
S
W
L
P
P
T
V
S
Site 100
S831
G
A
P
P
E
M
P
S
P
Q
E
L
E
A
S
Site 101
S838
S
P
Q
E
L
E
A
S
A
P
R
M
V
Q
T
Site 102
T845
S
A
P
R
M
V
Q
T
H
R
A
V
R
A
L
Site 103
T856
V
R
A
L
C
D
H
T
A
A
R
P
D
Q
L
Site 104
S864
A
A
R
P
D
Q
L
S
F
R
R
G
E
V
L
Site 105
T876
E
V
L
R
V
I
T
T
V
D
E
D
W
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation