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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THUMPD3
Full Name:
THUMP domain-containing protein 3
Alias:
DKFZP434F091; Gene trap ROSA 26 antisense; THUM3; THUMP domain containing 3
Type:
Unknown function
Mass (Da):
57003
Number AA:
507
UniProt ID:
Q9BV44
International Prot ID:
IPI00306127
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0008168
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
N
L
H
E
N
Q
K
S
V
Q
V
T
E
S
D
Site 2
T26
N
Q
K
S
V
Q
V
T
E
S
D
L
G
S
E
Site 3
S28
K
S
V
Q
V
T
E
S
D
L
G
S
E
S
E
Site 4
S32
V
T
E
S
D
L
G
S
E
S
E
L
L
V
T
Site 5
S34
E
S
D
L
G
S
E
S
E
L
L
V
T
I
G
Site 6
S62
E
V
R
E
K
L
G
S
S
C
K
I
S
R
D
Site 7
S63
V
R
E
K
L
G
S
S
C
K
I
S
R
D
R
Site 8
S67
L
G
S
S
C
K
I
S
R
D
R
G
K
I
Y
Site 9
Y74
S
R
D
R
G
K
I
Y
F
V
I
S
V
E
S
Site 10
Y104
V
V
Q
E
F
Q
D
Y
Q
F
K
Q
T
K
E
Site 11
S127
L
A
G
K
L
P
W
S
N
P
L
K
V
W
K
Site 12
S138
K
V
W
K
I
N
A
S
F
K
K
K
K
A
K
Site 13
S154
K
K
I
N
Q
N
S
S
K
E
K
I
N
N
G
Site 14
S177
N
V
K
K
E
F
T
S
H
A
L
D
S
H
I
Site 15
Y187
L
D
S
H
I
L
D
Y
Y
E
N
P
A
I
K
Site 16
Y188
D
S
H
I
L
D
Y
Y
E
N
P
A
I
K
E
Site 17
S198
P
A
I
K
E
D
V
S
T
L
I
G
D
D
L
Site 18
T212
L
A
S
C
K
D
E
T
D
E
S
S
K
E
E
Site 19
S215
C
K
D
E
T
D
E
S
S
K
E
E
T
E
P
Site 20
S216
K
D
E
T
D
E
S
S
K
E
E
T
E
P
Q
Site 21
T220
D
E
S
S
K
E
E
T
E
P
Q
V
L
K
F
Site 22
T230
Q
V
L
K
F
R
V
T
C
N
R
A
G
E
K
Site 23
Y256
F
G
G
A
V
Q
D
Y
F
K
W
K
A
D
M
Site 24
S289
G
I
A
L
T
E
E
S
L
H
R
R
N
I
T
Site 25
T296
S
L
H
R
R
N
I
T
H
F
G
P
T
T
L
Site 26
T306
G
P
T
T
L
R
S
T
L
A
Y
G
M
L
R
Site 27
Y309
T
L
R
S
T
L
A
Y
G
M
L
R
L
C
D
Site 28
S365
R
A
A
N
N
I
A
S
L
L
T
K
S
Q
I
Site 29
S370
I
A
S
L
L
T
K
S
Q
I
K
E
G
K
P
Site 30
S378
Q
I
K
E
G
K
P
S
W
G
L
P
I
D
A
Site 31
S415
P
F
G
K
R
M
G
S
K
K
R
N
W
N
L
Site 32
Y423
K
K
R
N
W
N
L
Y
P
A
C
L
R
E
M
Site 33
S431
P
A
C
L
R
E
M
S
R
V
C
T
P
T
T
Site 34
T435
R
E
M
S
R
V
C
T
P
T
T
G
R
A
V
Site 35
T445
T
G
R
A
V
L
L
T
Q
D
T
K
C
F
T
Site 36
T452
T
Q
D
T
K
C
F
T
K
A
L
S
G
M
R
Site 37
S493
P
Q
A
F
V
H
P
S
E
Q
D
G
E
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation