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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAF4
Full Name:
TNF receptor-associated factor 4
Alias:
CART1; CART1, MLN62, RNF83, TNF receptor associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Malignant 62; MLN62; RING finger protein 83; RNF83; TNF receptor-associated factor 4; TRA4
Type:
Adaptor/scaffold
Mass (Da):
53543
Number AA:
470
UniProt ID:
Q9BUZ4
International Prot ID:
IPI00162088
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0042981
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y63
E
D
Q
L
P
L
D
Y
A
K
I
Y
P
D
P
Site 2
Y67
P
L
D
Y
A
K
I
Y
P
D
P
E
L
E
V
Site 3
S93
S
E
E
G
C
R
W
S
G
P
L
R
H
L
Q
Site 4
S122
N
R
C
P
M
K
L
S
R
R
D
L
P
A
H
Site 5
Y153
C
D
F
S
G
E
A
Y
E
S
H
E
G
M
C
Site 6
S155
F
S
G
E
A
Y
E
S
H
E
G
M
C
P
Q
Site 7
Y166
M
C
P
Q
E
S
V
Y
C
E
N
K
C
G
A
Site 8
T206
T
K
E
F
V
F
D
T
I
Q
S
H
Q
Y
Q
Site 9
S209
F
V
F
D
T
I
Q
S
H
Q
Y
Q
C
P
R
Site 10
Y212
D
T
I
Q
S
H
Q
Y
Q
C
P
R
L
P
V
Site 11
T229
P
N
Q
C
G
V
G
T
V
A
R
E
D
L
P
Site 12
S273
M
A
R
H
V
E
E
S
V
K
P
H
L
A
M
Site 13
S303
R
R
E
L
E
E
L
S
V
G
S
D
G
V
L
Site 14
S316
V
L
I
W
K
I
G
S
Y
G
R
R
L
Q
E
Site 15
Y317
L
I
W
K
I
G
S
Y
G
R
R
L
Q
E
A
Site 16
S334
K
P
N
L
E
C
F
S
P
A
F
Y
T
H
K
Site 17
Y338
E
C
F
S
P
A
F
Y
T
H
K
Y
G
Y
K
Site 18
Y342
P
A
F
Y
T
H
K
Y
G
Y
K
L
Q
V
S
Site 19
Y344
F
Y
T
H
K
Y
G
Y
K
L
Q
V
S
A
F
Site 20
S349
Y
G
Y
K
L
Q
V
S
A
F
L
N
G
N
G
Site 21
S357
A
F
L
N
G
N
G
S
G
E
G
T
H
L
S
Site 22
T361
G
N
G
S
G
E
G
T
H
L
S
L
Y
I
R
Site 23
T387
W
P
F
A
R
R
V
T
F
S
L
L
D
Q
S
Site 24
S389
F
A
R
R
V
T
F
S
L
L
D
Q
S
D
P
Site 25
S394
T
F
S
L
L
D
Q
S
D
P
G
L
A
K
P
Site 26
T422
K
N
F
Q
K
P
G
T
W
R
G
S
L
D
E
Site 27
S426
K
P
G
T
W
R
G
S
L
D
E
S
S
L
G
Site 28
S430
W
R
G
S
L
D
E
S
S
L
G
F
G
Y
P
Site 29
S431
R
G
S
L
D
E
S
S
L
G
F
G
Y
P
K
Site 30
Y436
E
S
S
L
G
F
G
Y
P
K
F
I
S
H
Q
Site 31
Y450
Q
D
I
R
K
R
N
Y
V
R
D
D
A
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation