KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
POLR3C
Full Name:
DNA-directed RNA polymerase III subunit RPC3
Alias:
DNA-directed RNA polymerase III 62 kDa polypeptide; EC 2.7.7.6; Polymerase (RNA) III (DNA directed) polypeptide C; RNA polymerase C subunit 3; RNA polymerase III C62 subunit; RPC3; RPC62
Type:
Transcription initiation complex, Transferase, Nucleotide Metabolism group, Purine metabolism family, Pyrimidine metabolism family
Mass (Da):
60612
Number AA:
534
UniProt ID:
Q9BUI4
International Prot ID:
IPI00007948
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005666
GO:0005634
GO:0005666
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0045089
GO:0032728
GO:0006359
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y65
V
Q
H
N
L
V
S
Y
Q
V
H
K
R
G
V
Site 2
Y75
H
K
R
G
V
V
E
Y
E
A
Q
C
S
R
V
Site 3
S80
V
E
Y
E
A
Q
C
S
R
V
L
R
M
L
R
Site 4
Y88
R
V
L
R
M
L
R
Y
P
R
Y
I
Y
T
T
Site 5
Y91
R
M
L
R
Y
P
R
Y
I
Y
T
T
K
T
L
Site 6
Y93
L
R
Y
P
R
Y
I
Y
T
T
K
T
L
Y
S
Site 7
T95
Y
P
R
Y
I
Y
T
T
K
T
L
Y
S
D
T
Site 8
T97
R
Y
I
Y
T
T
K
T
L
Y
S
D
T
G
E
Site 9
Y99
I
Y
T
T
K
T
L
Y
S
D
T
G
E
L
I
Site 10
S100
Y
T
T
K
T
L
Y
S
D
T
G
E
L
I
V
Site 11
T130
K
K
V
A
D
R
L
T
E
T
M
E
D
G
K
Site 12
T138
E
T
M
E
D
G
K
T
M
D
Y
A
E
V
S
Site 13
Y141
E
D
G
K
T
M
D
Y
A
E
V
S
N
T
F
Site 14
T147
D
Y
A
E
V
S
N
T
F
V
R
L
A
D
T
Site 15
T154
T
F
V
R
L
A
D
T
H
F
V
Q
R
C
P
Site 16
S162
H
F
V
Q
R
C
P
S
V
P
T
T
E
N
S
Site 17
T166
R
C
P
S
V
P
T
T
E
N
S
D
P
G
P
Site 18
S169
S
V
P
T
T
E
N
S
D
P
G
P
P
P
P
Site 19
S194
M
Y
L
V
P
K
L
S
L
I
G
K
G
K
R
Site 20
S204
G
K
G
K
R
R
R
S
S
D
E
D
A
A
G
Site 21
S205
K
G
K
R
R
R
S
S
D
E
D
A
A
G
E
Site 22
Y220
P
K
A
K
R
P
K
Y
T
T
D
N
K
E
P
Site 23
T222
A
K
R
P
K
Y
T
T
D
N
K
E
P
I
P
Site 24
Y234
P
I
P
D
D
G
I
Y
W
Q
A
N
L
D
R
Site 25
S263
A
N
R
M
D
Q
T
S
S
E
I
V
R
T
M
Site 26
S264
N
R
M
D
Q
T
S
S
E
I
V
R
T
M
L
Site 27
T269
T
S
S
E
I
V
R
T
M
L
R
M
S
E
I
Site 28
S274
V
R
T
M
L
R
M
S
E
I
T
T
S
S
S
Site 29
T277
M
L
R
M
S
E
I
T
T
S
S
S
A
P
F
Site 30
T278
L
R
M
S
E
I
T
T
S
S
S
A
P
F
T
Site 31
S279
R
M
S
E
I
T
T
S
S
S
A
P
F
T
Q
Site 32
S280
M
S
E
I
T
T
S
S
S
A
P
F
T
Q
P
Site 33
S281
S
E
I
T
T
S
S
S
A
P
F
T
Q
P
L
Site 34
T285
T
S
S
S
A
P
F
T
Q
P
L
S
S
N
E
Site 35
S289
A
P
F
T
Q
P
L
S
S
N
E
I
F
R
S
Site 36
S290
P
F
T
Q
P
L
S
S
N
E
I
F
R
S
L
Site 37
S296
S
S
N
E
I
F
R
S
L
P
V
G
Y
N
I
Site 38
S304
L
P
V
G
Y
N
I
S
K
Q
V
L
D
Q
Y
Site 39
Y311
S
K
Q
V
L
D
Q
Y
L
T
L
L
A
D
D
Site 40
S326
P
L
E
F
V
G
K
S
G
D
S
G
G
G
M
Site 41
Y334
G
D
S
G
G
G
M
Y
V
I
N
L
H
K
A
Site 42
S360
V
V
Q
E
R
F
G
S
R
C
A
R
I
F
R
Site 43
Y396
K
E
A
K
D
M
L
Y
K
M
L
S
E
N
F
Site 44
S405
M
L
S
E
N
F
M
S
L
Q
E
I
P
K
T
Site 45
T412
S
L
Q
E
I
P
K
T
P
D
H
A
P
S
R
Site 46
T420
P
D
H
A
P
S
R
T
F
Y
L
Y
T
V
N
Site 47
S442
L
L
H
R
C
Y
K
S
I
A
N
L
I
E
R
Site 48
T454
I
E
R
R
Q
F
E
T
K
E
N
K
R
L
L
Site 49
S464
N
K
R
L
L
E
K
S
Q
R
V
E
A
I
I
Site 50
T492
Q
E
I
E
E
M
I
T
A
P
E
R
Q
Q
L
Site 51
T501
P
E
R
Q
Q
L
E
T
L
K
R
N
V
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation