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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BEGAIN
Full Name:
Brain-enriched guanylate kinase-associated protein
Alias:
BEGIN; Brain-enriched guanylate kinase-associated; KIAA1446
Type:
Unknown function
Mass (Da):
64803
Number AA:
593
UniProt ID:
Q9BUH8
International Prot ID:
IPI00010853
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
E
L
R
K
R
L
S
Y
T
T
H
K
L
E
Site 2
Y20
E
L
R
K
R
L
S
Y
T
T
H
K
L
E
K
Site 3
T30
H
K
L
E
K
L
E
T
E
F
D
S
T
R
H
Site 4
S34
K
L
E
T
E
F
D
S
T
R
H
Y
L
E
I
Site 5
T35
L
E
T
E
F
D
S
T
R
H
Y
L
E
I
E
Site 6
Y38
E
F
D
S
T
R
H
Y
L
E
I
E
L
R
R
Site 7
S62
E
K
L
R
R
I
Q
S
N
Y
M
A
L
Q
R
Site 8
Y64
L
R
R
I
Q
S
N
Y
M
A
L
Q
R
I
N
Site 9
Y79
Q
E
L
E
D
K
L
Y
R
M
G
Q
H
Y
E
Site 10
Y85
L
Y
R
M
G
Q
H
Y
E
E
E
K
R
A
L
Site 11
S93
E
E
E
K
R
A
L
S
H
E
I
V
A
L
N
Site 12
T109
H
L
L
E
A
K
V
T
I
D
K
L
S
E
D
Site 13
S114
K
V
T
I
D
K
L
S
E
D
N
E
L
Y
R
Site 14
Y120
L
S
E
D
N
E
L
Y
R
K
D
C
N
L
A
Site 15
S134
A
A
Q
L
L
Q
C
S
Q
T
Y
G
R
V
H
Site 16
T136
Q
L
L
Q
C
S
Q
T
Y
G
R
V
H
K
V
Site 17
Y137
L
L
Q
C
S
Q
T
Y
G
R
V
H
K
V
S
Site 18
S144
Y
G
R
V
H
K
V
S
E
L
P
S
D
F
Q
Site 19
S148
H
K
V
S
E
L
P
S
D
F
Q
E
R
V
S
Site 20
S155
S
D
F
Q
E
R
V
S
L
H
M
E
K
H
G
Site 21
S167
K
H
G
C
S
L
P
S
P
L
C
H
P
A
Y
Site 22
Y174
S
P
L
C
H
P
A
Y
A
D
S
V
P
T
C
Site 23
S194
L
E
K
P
D
P
A
S
L
S
S
R
L
S
D
Site 24
S196
K
P
D
P
A
S
L
S
S
R
L
S
D
A
S
Site 25
S197
P
D
P
A
S
L
S
S
R
L
S
D
A
S
A
Site 26
S200
A
S
L
S
S
R
L
S
D
A
S
A
R
D
L
Site 27
S203
S
S
R
L
S
D
A
S
A
R
D
L
A
F
C
Site 28
Y222
K
P
G
P
R
P
P
Y
K
G
D
I
Y
C
S
Site 29
Y227
P
P
Y
K
G
D
I
Y
C
S
D
T
A
L
Y
Site 30
S229
Y
K
G
D
I
Y
C
S
D
T
A
L
Y
C
P
Site 31
Y234
Y
C
S
D
T
A
L
Y
C
P
E
E
R
R
R
Site 32
S246
R
R
R
D
R
R
P
S
V
D
A
P
V
T
D
Site 33
S262
G
F
L
R
A
Q
N
S
T
D
S
A
A
E
E
Site 34
T263
F
L
R
A
Q
N
S
T
D
S
A
A
E
E
E
Site 35
S265
R
A
Q
N
S
T
D
S
A
A
E
E
E
E
E
Site 36
S289
F
Q
H
E
A
F
P
S
Y
A
G
S
L
P
T
Site 37
Y290
Q
H
E
A
F
P
S
Y
A
G
S
L
P
T
S
Site 38
S293
A
F
P
S
Y
A
G
S
L
P
T
S
S
S
Y
Site 39
T296
S
Y
A
G
S
L
P
T
S
S
S
Y
S
S
F
Site 40
S297
Y
A
G
S
L
P
T
S
S
S
Y
S
S
F
S
Site 41
S298
A
G
S
L
P
T
S
S
S
Y
S
S
F
S
A
Site 42
S299
G
S
L
P
T
S
S
S
Y
S
S
F
S
A
T
Site 43
Y300
S
L
P
T
S
S
S
Y
S
S
F
S
A
T
S
Site 44
S301
L
P
T
S
S
S
Y
S
S
F
S
A
T
S
E
Site 45
S302
P
T
S
S
S
Y
S
S
F
S
A
T
S
E
E
Site 46
S304
S
S
S
Y
S
S
F
S
A
T
S
E
E
K
E
Site 47
T306
S
Y
S
S
F
S
A
T
S
E
E
K
E
H
A
Site 48
S316
E
K
E
H
A
Q
A
S
T
L
T
A
S
Q
Q
Site 49
S321
Q
A
S
T
L
T
A
S
Q
Q
A
I
Y
L
N
Site 50
T341
F
D
R
K
P
P
A
T
T
Y
E
G
S
P
R
Site 51
T342
D
R
K
P
P
A
T
T
Y
E
G
S
P
R
F
Site 52
Y343
R
K
P
P
A
T
T
Y
E
G
S
P
R
F
A
Site 53
S346
P
A
T
T
Y
E
G
S
P
R
F
A
K
A
T
Site 54
T371
V
A
P
G
F
G
R
T
M
S
P
Y
P
A
E
Site 55
S373
P
G
F
G
R
T
M
S
P
Y
P
A
E
T
F
Site 56
Y375
F
G
R
T
M
S
P
Y
P
A
E
T
F
R
F
Site 57
T379
M
S
P
Y
P
A
E
T
F
R
F
P
A
S
P
Site 58
S385
E
T
F
R
F
P
A
S
P
G
P
Q
Q
A
L
Site 59
S399
L
M
P
P
N
L
W
S
L
R
A
K
P
G
T
Site 60
T406
S
L
R
A
K
P
G
T
A
R
L
P
G
E
D
Site 61
S422
R
G
Q
W
R
P
L
S
V
E
D
I
G
A
Y
Site 62
Y429
S
V
E
D
I
G
A
Y
S
Y
P
V
S
A
A
Site 63
Y431
E
D
I
G
A
Y
S
Y
P
V
S
A
A
G
R
Site 64
S434
G
A
Y
S
Y
P
V
S
A
A
G
R
A
S
P
Site 65
S440
V
S
A
A
G
R
A
S
P
C
S
F
S
E
R
Site 66
S443
A
G
R
A
S
P
C
S
F
S
E
R
Y
Y
G
Site 67
S445
R
A
S
P
C
S
F
S
E
R
Y
Y
G
G
A
Site 68
Y448
P
C
S
F
S
E
R
Y
Y
G
G
A
G
G
S
Site 69
Y449
C
S
F
S
E
R
Y
Y
G
G
A
G
G
S
P
Site 70
S455
Y
Y
G
G
A
G
G
S
P
G
K
K
A
D
G
Site 71
S465
K
K
A
D
G
R
A
S
P
L
Y
A
S
Y
K
Site 72
Y468
D
G
R
A
S
P
L
Y
A
S
Y
K
A
D
S
Site 73
S470
R
A
S
P
L
Y
A
S
Y
K
A
D
S
F
S
Site 74
Y471
A
S
P
L
Y
A
S
Y
K
A
D
S
F
S
E
Site 75
S475
Y
A
S
Y
K
A
D
S
F
S
E
G
D
D
L
Site 76
S477
S
Y
K
A
D
S
F
S
E
G
D
D
L
S
Q
Site 77
S483
F
S
E
G
D
D
L
S
Q
G
H
L
A
E
P
Site 78
S500
L
R
A
G
G
D
L
S
L
S
P
G
R
S
A
Site 79
S502
A
G
G
D
L
S
L
S
P
G
R
S
A
D
P
Site 80
S506
L
S
L
S
P
G
R
S
A
D
P
L
P
G
Y
Site 81
Y513
S
A
D
P
L
P
G
Y
A
P
S
E
G
G
D
Site 82
S516
P
L
P
G
Y
A
P
S
E
G
G
D
G
D
R
Site 83
S533
V
Q
L
C
G
T
A
S
S
P
E
P
E
Q
G
Site 84
S534
Q
L
C
G
T
A
S
S
P
E
P
E
Q
G
S
Site 85
S541
S
P
E
P
E
Q
G
S
R
D
S
L
E
P
S
Site 86
S544
P
E
Q
G
S
R
D
S
L
E
P
S
S
M
E
Site 87
S548
S
R
D
S
L
E
P
S
S
M
E
A
S
P
E
Site 88
S549
R
D
S
L
E
P
S
S
M
E
A
S
P
E
M
Site 89
S553
E
P
S
S
M
E
A
S
P
E
M
H
P
A
A
Site 90
S563
M
H
P
A
A
R
L
S
P
Q
Q
A
F
P
R
Site 91
T571
P
Q
Q
A
F
P
R
T
G
G
S
G
L
S
R
Site 92
S577
R
T
G
G
S
G
L
S
R
K
D
S
L
T
K
Site 93
S581
S
G
L
S
R
K
D
S
L
T
K
A
Q
L
Y
Site 94
T583
L
S
R
K
D
S
L
T
K
A
Q
L
Y
G
T
Site 95
Y588
S
L
T
K
A
Q
L
Y
G
T
L
L
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation