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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF251
Full Name:
Zinc finger protein 251
Alias:
Z251
Type:
Transcription regulation, DNA binding protein
Mass (Da):
70885
Number AA:
628
UniProt ID:
Q9BRH9
International Prot ID:
IPI00556189
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
N
Y
G
N
V
A
S
L
G
F
P
V
P
K
Site 2
S46
E
E
P
D
I
L
K
S
C
Q
K
D
S
E
V
Site 3
T55
Q
K
D
S
E
V
G
T
K
K
E
L
S
I
L
Site 4
S67
S
I
L
N
Q
K
F
S
E
E
V
K
T
P
E
Site 5
T72
K
F
S
E
E
V
K
T
P
E
F
V
S
R
R
Site 6
S77
V
K
T
P
E
F
V
S
R
R
L
L
R
D
N
Site 7
S107
L
K
E
R
V
G
N
S
A
G
Q
S
L
N
K
Site 8
S111
V
G
N
S
A
G
Q
S
L
N
K
P
N
I
H
Site 9
T123
N
I
H
K
R
V
L
T
E
A
T
V
G
R
E
Site 10
T126
K
R
V
L
T
E
A
T
V
G
R
E
R
S
L
Site 11
S132
A
T
V
G
R
E
R
S
L
G
E
R
T
Q
E
Site 12
T137
E
R
S
L
G
E
R
T
Q
E
C
S
A
F
D
Site 13
S141
G
E
R
T
Q
E
C
S
A
F
D
R
N
L
N
Site 14
T161
V
R
L
Q
R
N
K
T
G
E
R
V
F
K
C
Site 15
Y177
I
C
S
K
T
F
K
Y
N
S
D
L
S
R
H
Site 16
S179
S
K
T
F
K
Y
N
S
D
L
S
R
H
Q
R
Site 17
S182
F
K
Y
N
S
D
L
S
R
H
Q
R
S
H
T
Site 18
S187
D
L
S
R
H
Q
R
S
H
T
G
E
K
P
Y
Site 19
T189
S
R
H
Q
R
S
H
T
G
E
K
P
Y
E
C
Site 20
Y194
S
H
T
G
E
K
P
Y
E
C
G
R
C
G
R
Site 21
T204
G
R
C
G
R
A
F
T
H
S
S
N
L
V
L
Site 22
S206
C
G
R
A
F
T
H
S
S
N
L
V
L
H
H
Site 23
S207
G
R
A
F
T
H
S
S
N
L
V
L
H
H
H
Site 24
T230
K
C
D
E
C
G
K
T
F
G
L
N
S
H
L
Site 25
S235
G
K
T
F
G
L
N
S
H
L
R
L
H
R
R
Site 26
T245
R
L
H
R
R
I
H
T
G
E
K
P
F
G
C
Site 27
S260
G
E
C
G
K
A
F
S
R
S
S
T
L
I
Q
Site 28
S262
C
G
K
A
F
S
R
S
S
T
L
I
Q
H
R
Site 29
S263
G
K
A
F
S
R
S
S
T
L
I
Q
H
R
I
Site 30
T264
K
A
F
S
R
S
S
T
L
I
Q
H
R
I
I
Site 31
Y278
I
H
T
G
E
K
P
Y
K
C
N
E
C
G
R
Site 32
S288
N
E
C
G
R
G
F
S
Q
S
P
Q
L
T
Q
Site 33
S290
C
G
R
G
F
S
Q
S
P
Q
L
T
Q
H
Q
Site 34
T294
F
S
Q
S
P
Q
L
T
Q
H
Q
R
I
H
T
Site 35
T301
T
Q
H
Q
R
I
H
T
G
E
K
P
H
E
C
Site 36
S309
G
E
K
P
H
E
C
S
H
C
G
K
A
F
S
Site 37
S316
S
H
C
G
K
A
F
S
R
S
S
S
L
I
Q
Site 38
S318
C
G
K
A
F
S
R
S
S
S
L
I
Q
H
E
Site 39
S319
G
K
A
F
S
R
S
S
S
L
I
Q
H
E
R
Site 40
S320
K
A
F
S
R
S
S
S
L
I
Q
H
E
R
I
Site 41
T329
I
Q
H
E
R
I
H
T
G
E
K
P
H
K
C
Site 42
S344
N
Q
C
G
K
A
F
S
Q
S
S
S
L
F
L
Site 43
S346
C
G
K
A
F
S
Q
S
S
S
L
F
L
H
H
Site 44
S347
G
K
A
F
S
Q
S
S
S
L
F
L
H
H
R
Site 45
S348
K
A
F
S
Q
S
S
S
L
F
L
H
H
R
V
Site 46
T357
F
L
H
H
R
V
H
T
G
E
K
P
Y
V
C
Site 47
Y362
V
H
T
G
E
K
P
Y
V
C
N
E
C
G
R
Site 48
T385
T
E
H
V
R
I
H
T
G
E
K
P
Y
V
C
Site 49
Y390
I
H
T
G
E
K
P
Y
V
C
N
E
C
G
K
Site 50
S402
C
G
K
A
F
R
R
S
S
T
L
V
Q
H
R
Site 51
S403
G
K
A
F
R
R
S
S
T
L
V
Q
H
R
R
Site 52
T404
K
A
F
R
R
S
S
T
L
V
Q
H
R
R
V
Site 53
T413
V
Q
H
R
R
V
H
T
G
E
K
P
Y
Q
C
Site 54
Y418
V
H
T
G
E
K
P
Y
Q
C
V
E
C
G
K
Site 55
S428
V
E
C
G
K
A
F
S
Q
S
S
Q
L
T
L
Site 56
S430
C
G
K
A
F
S
Q
S
S
Q
L
T
L
H
Q
Site 57
S431
G
K
A
F
S
Q
S
S
Q
L
T
L
H
Q
R
Site 58
T434
F
S
Q
S
S
Q
L
T
L
H
Q
R
V
H
T
Site 59
T441
T
L
H
Q
R
V
H
T
G
E
K
P
Y
D
C
Site 60
Y446
V
H
T
G
E
K
P
Y
D
C
G
D
C
G
K
Site 61
S456
G
D
C
G
K
A
F
S
R
R
S
T
L
I
Q
Site 62
S459
G
K
A
F
S
R
R
S
T
L
I
Q
H
Q
K
Site 63
T460
K
A
F
S
R
R
S
T
L
I
Q
H
Q
K
V
Site 64
T515
A
N
L
I
L
R
W
T
V
H
T
G
E
K
S
Site 65
T518
I
L
R
W
T
V
H
T
G
E
K
S
F
G
C
Site 66
S522
T
V
H
T
G
E
K
S
F
G
C
N
E
Y
G
Site 67
Y528
K
S
F
G
C
N
E
Y
G
K
A
F
S
P
T
Site 68
S533
N
E
Y
G
K
A
F
S
P
T
S
R
P
T
E
Site 69
T535
Y
G
K
A
F
S
P
T
S
R
P
T
E
D
Q
Site 70
S536
G
K
A
F
S
P
T
S
R
P
T
E
D
Q
I
Site 71
T539
F
S
P
T
S
R
P
T
E
D
Q
I
M
H
A
Site 72
S561
Q
E
C
G
N
A
F
S
G
K
S
T
L
I
Q
Site 73
S564
G
N
A
F
S
G
K
S
T
L
I
Q
H
Q
V
Site 74
T565
N
A
F
S
G
K
S
T
L
I
Q
H
Q
V
T
Site 75
Y584
K
P
C
H
C
S
V
Y
G
K
A
F
S
Q
S
Site 76
S589
S
V
Y
G
K
A
F
S
Q
S
S
Q
L
T
P
Site 77
S591
Y
G
K
A
F
S
Q
S
S
Q
L
T
P
P
Q
Site 78
S592
G
K
A
F
S
Q
S
S
Q
L
T
P
P
Q
Q
Site 79
T595
F
S
Q
S
S
Q
L
T
P
P
Q
Q
T
R
V
Site 80
S612
K
P
A
L
N
D
G
S
K
R
Y
F
I
H
I
Site 81
Y615
L
N
D
G
S
K
R
Y
F
I
H
I
K
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation