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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH2D3A
Full Name:
SH2 domain-containing protein 3A
Alias:
Novel SH2-containing protein 1; NSP1; SH2 domain containing 3A; SH23A
Type:
Adapter/scaffold protein
Mass (Da):
63093
Number AA:
576
UniProt ID:
Q9BRG2
International Prot ID:
IPI00305020
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005085
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0007264
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
D
L
A
G
Q
P
W
Y
H
G
L
L
S
R
Q
Site 2
S40
G
D
F
L
V
R
A
S
G
S
R
G
G
N
P
Site 3
S50
R
G
G
N
P
V
I
S
C
R
W
R
G
S
A
Site 4
S56
I
S
C
R
W
R
G
S
A
L
H
F
E
V
F
Site 5
T75
R
P
R
P
G
R
P
T
A
L
F
Q
L
E
D
Site 6
S87
L
E
D
E
Q
F
P
S
I
P
A
L
V
H
S
Site 7
Y95
I
P
A
L
V
H
S
Y
M
T
G
R
R
P
L
Site 8
T97
A
L
V
H
S
Y
M
T
G
R
R
P
L
S
Q
Site 9
S103
M
T
G
R
R
P
L
S
Q
A
T
G
A
V
V
Site 10
T115
A
V
V
S
R
P
V
T
W
Q
G
P
L
R
R
Site 11
S123
W
Q
G
P
L
R
R
S
F
S
E
D
T
L
M
Site 12
S125
G
P
L
R
R
S
F
S
E
D
T
L
M
D
G
Site 13
T128
R
R
S
F
S
E
D
T
L
M
D
G
P
A
R
Site 14
S145
P
L
R
A
R
K
W
S
N
S
Q
P
A
D
L
Site 15
S147
R
A
R
K
W
S
N
S
Q
P
A
D
L
A
H
Site 16
S173
E
A
S
T
M
P
I
S
A
L
P
R
T
S
S
Site 17
T178
P
I
S
A
L
P
R
T
S
S
D
P
V
L
L
Site 18
S179
I
S
A
L
P
R
T
S
S
D
P
V
L
L
K
Site 19
S180
S
A
L
P
R
T
S
S
D
P
V
L
L
K
A
Site 20
T193
K
A
P
A
P
L
G
T
V
A
D
S
L
R
A
Site 21
S197
P
L
G
T
V
A
D
S
L
R
A
S
D
G
Q
Site 22
S201
V
A
D
S
L
R
A
S
D
G
Q
L
Q
A
K
Site 23
T216
A
P
T
K
P
P
R
T
P
S
F
E
L
P
D
Site 24
S218
T
K
P
P
R
T
P
S
F
E
L
P
D
A
S
Site 25
S225
S
F
E
L
P
D
A
S
E
R
P
P
T
Y
C
Site 26
T230
D
A
S
E
R
P
P
T
Y
C
E
L
V
P
R
Site 27
Y231
A
S
E
R
P
P
T
Y
C
E
L
V
P
R
V
Site 28
S240
E
L
V
P
R
V
P
S
V
Q
G
T
S
P
S
Site 29
T244
R
V
P
S
V
Q
G
T
S
P
S
Q
S
C
P
Site 30
S245
V
P
S
V
Q
G
T
S
P
S
Q
S
C
P
E
Site 31
S247
S
V
Q
G
T
S
P
S
Q
S
C
P
E
P
E
Site 32
S249
Q
G
T
S
P
S
Q
S
C
P
E
P
E
A
P
Site 33
T272
E
E
E
N
R
C
F
T
R
P
Q
A
E
I
S
Site 34
S279
T
R
P
Q
A
E
I
S
F
C
P
H
D
A
P
Site 35
T352
S
S
G
L
E
L
L
T
L
P
H
G
H
H
L
Site 36
S438
T
W
R
Q
L
R
R
S
H
T
E
A
A
L
A
Site 37
T440
R
Q
L
R
R
S
H
T
E
A
A
L
A
F
E
Site 38
S493
V
A
G
P
L
D
E
S
C
E
R
L
L
R
T
Site 39
T500
S
C
E
R
L
L
R
T
L
H
G
A
R
H
M
Site 40
S547
V
R
R
L
L
W
G
S
R
G
A
G
A
P
R
Site 41
S569
Q
R
V
L
G
V
L
S
Q
R
L
E
P
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation