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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCD4
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
Alias:
EC 3.1.4.11; MGC12837; Phospholipase C, delta 4
Type:
EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase
Mass (Da):
87585
Number AA:
762
UniProt ID:
Q9BRC7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
S
L
L
Q
D
Q
L
T
T
D
Q
D
L
L
L
Site 2
S31
M
R
K
V
R
S
K
S
W
K
K
L
R
Y
F
Site 3
Y37
K
S
W
K
K
L
R
Y
F
R
L
Q
N
D
G
Site 4
S56
H
A
R
Q
A
R
G
S
A
K
P
S
F
S
I
Site 5
S60
A
R
G
S
A
K
P
S
F
S
I
S
D
V
E
Site 6
S62
G
S
A
K
P
S
F
S
I
S
D
V
E
T
I
Site 7
S64
A
K
P
S
F
S
I
S
D
V
E
T
I
R
N
Site 8
T68
F
S
I
S
D
V
E
T
I
R
N
G
H
D
S
Site 9
S75
T
I
R
N
G
H
D
S
E
L
L
R
S
L
A
Site 10
S80
H
D
S
E
L
L
R
S
L
A
E
E
L
P
L
Site 11
T92
L
P
L
E
Q
G
F
T
I
V
F
H
G
R
R
Site 12
S100
I
V
F
H
G
R
R
S
N
L
D
L
M
A
N
Site 13
S108
N
L
D
L
M
A
N
S
V
E
E
A
Q
I
W
Site 14
T127
Q
L
L
V
D
L
V
T
S
M
D
H
Q
E
R
Site 15
S155
K
N
Q
D
G
K
M
S
F
Q
E
V
Q
R
L
Site 16
Y174
N
V
E
M
D
Q
E
Y
A
F
S
L
F
Q
A
Site 17
S185
L
F
Q
A
A
D
T
S
Q
S
G
T
L
E
G
Site 18
T189
A
D
T
S
Q
S
G
T
L
E
G
E
E
F
V
Site 19
S214
E
V
Q
E
L
F
E
S
F
S
A
D
G
Q
K
Site 20
S216
Q
E
L
F
E
S
F
S
A
D
G
Q
K
L
T
Site 21
T241
E
Q
K
E
R
D
C
T
S
E
L
A
L
E
L
Site 22
Y252
A
L
E
L
I
D
R
Y
E
P
S
D
S
G
K
Site 23
S255
L
I
D
R
Y
E
P
S
D
S
G
K
L
R
H
Site 24
S257
D
R
Y
E
P
S
D
S
G
K
L
R
H
V
L
Site 25
S265
G
K
L
R
H
V
L
S
M
D
G
F
L
S
Y
Site 26
Y272
S
M
D
G
F
L
S
Y
L
C
S
K
D
G
D
Site 27
S275
G
F
L
S
Y
L
C
S
K
D
G
D
I
F
N
Site 28
Y289
N
P
A
C
L
P
I
Y
Q
D
M
T
Q
P
L
Site 29
S319
D
Q
L
C
G
Q
S
S
V
E
G
Y
I
R
A
Site 30
Y323
G
Q
S
S
V
E
G
Y
I
R
A
L
K
R
G
Site 31
S343
V
D
V
W
D
G
P
S
G
E
P
V
V
Y
H
Site 32
Y349
P
S
G
E
P
V
V
Y
H
G
H
T
L
T
S
Site 33
T355
V
Y
H
G
H
T
L
T
S
R
I
L
F
K
D
Site 34
S382
S
D
Y
P
V
I
L
S
L
E
T
H
C
S
W
Site 35
T400
Q
T
M
A
R
H
L
T
E
I
L
G
E
Q
L
Site 36
T418
T
L
D
G
V
L
P
T
Q
L
P
S
P
E
E
Site 37
S422
V
L
P
T
Q
L
P
S
P
E
E
L
R
R
K
Site 38
T438
L
V
K
G
K
K
L
T
L
E
E
D
L
E
Y
Site 39
Y445
T
L
E
E
D
L
E
Y
E
E
E
E
A
E
P
Site 40
S457
A
E
P
E
L
E
E
S
E
L
A
L
E
S
Q
Site 41
T467
A
L
E
S
Q
F
E
T
E
P
E
P
Q
E
Q
Site 42
S485
N
K
D
K
K
K
K
S
K
P
I
L
C
P
A
Site 43
S507
L
K
S
V
S
F
R
S
F
T
H
S
K
E
H
Site 44
T509
S
V
S
F
R
S
F
T
H
S
K
E
H
Y
H
Site 45
Y515
F
T
H
S
K
E
H
Y
H
F
Y
E
I
S
S
Site 46
Y518
S
K
E
H
Y
H
F
Y
E
I
S
S
F
S
E
Site 47
S522
Y
H
F
Y
E
I
S
S
F
S
E
T
K
A
K
Site 48
T526
E
I
S
S
F
S
E
T
K
A
K
R
L
I
K
Site 49
S548
Q
H
N
T
W
Q
L
S
R
V
Y
P
S
G
L
Site 50
Y551
T
W
Q
L
S
R
V
Y
P
S
G
L
R
T
D
Site 51
S553
Q
L
S
R
V
Y
P
S
G
L
R
T
D
S
S
Site 52
T557
V
Y
P
S
G
L
R
T
D
S
S
N
Y
N
P
Site 53
S559
P
S
G
L
R
T
D
S
S
N
Y
N
P
Q
E
Site 54
S560
S
G
L
R
T
D
S
S
N
Y
N
P
Q
E
L
Site 55
Y601
R
Q
N
G
G
C
G
Y
V
L
K
P
D
F
L
Site 56
S613
D
F
L
R
D
I
Q
S
S
F
H
P
E
K
P
Site 57
S614
F
L
R
D
I
Q
S
S
F
H
P
E
K
P
I
Site 58
S622
F
H
P
E
K
P
I
S
P
F
K
A
Q
T
L
Site 59
S635
T
L
L
I
Q
V
I
S
G
Q
Q
L
P
K
V
Site 60
T645
Q
L
P
K
V
D
K
T
K
E
G
S
I
V
D
Site 61
T666
I
F
G
V
R
L
D
T
A
R
Q
E
T
N
Y
Site 62
T671
L
D
T
A
R
Q
E
T
N
Y
V
E
N
N
G
Site 63
Y673
T
A
R
Q
E
T
N
Y
V
E
N
N
G
F
N
Site 64
Y706
L
R
F
V
V
M
D
Y
D
W
K
S
R
N
D
Site 65
S736
Y
R
H
I
H
L
L
S
K
D
G
I
S
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation