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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP7
Full Name:
Sentrin-specific protease 7
Alias:
EC 3.4.22.-; KIAA1707, SSP2, SUSP2; SSP2; SUMO-1-specific protease 2
Type:
Intracellular, Nucleus protein
Mass (Da):
112159
Number AA:
984
UniProt ID:
Q9BQF6
International Prot ID:
IPI00296449
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008234
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0016925
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
K
L
G
R
R
P
S
S
S
E
I
I
T
E
Site 2
S12
K
L
G
R
R
P
S
S
S
E
I
I
T
E
G
Site 3
S13
L
G
R
R
P
S
S
S
E
I
I
T
E
G
K
Site 4
T17
P
S
S
S
E
I
I
T
E
G
K
R
K
K
S
Site 5
S24
T
E
G
K
R
K
K
S
S
S
D
L
S
E
I
Site 6
S25
E
G
K
R
K
K
S
S
S
D
L
S
E
I
R
Site 7
S26
G
K
R
K
K
S
S
S
D
L
S
E
I
R
K
Site 8
S29
K
K
S
S
S
D
L
S
E
I
R
K
M
L
N
Site 9
S46
P
E
D
V
H
V
Q
S
P
L
S
K
F
R
S
Site 10
S49
V
H
V
Q
S
P
L
S
K
F
R
S
S
E
R
Site 11
S53
S
P
L
S
K
F
R
S
S
E
R
W
T
L
P
Site 12
S54
P
L
S
K
F
R
S
S
E
R
W
T
L
P
L
Site 13
T58
F
R
S
S
E
R
W
T
L
P
L
Q
W
E
R
Site 14
S66
L
P
L
Q
W
E
R
S
L
R
N
K
V
I
S
Site 15
S73
S
L
R
N
K
V
I
S
L
D
H
K
N
K
K
Site 16
T88
H
I
R
G
C
P
V
T
S
K
S
S
P
E
R
Site 17
S89
I
R
G
C
P
V
T
S
K
S
S
P
E
R
I
Site 18
S91
G
C
P
V
T
S
K
S
S
P
E
R
I
P
R
Site 19
S92
C
P
V
T
S
K
S
S
P
E
R
I
P
R
V
Site 20
Y113
G
T
E
L
G
R
K
Y
I
R
T
P
P
V
T
Site 21
T116
L
G
R
K
Y
I
R
T
P
P
V
T
E
G
S
Site 22
T120
Y
I
R
T
P
P
V
T
E
G
S
L
S
D
T
Site 23
S123
T
P
P
V
T
E
G
S
L
S
D
T
D
N
L
Site 24
S125
P
V
T
E
G
S
L
S
D
T
D
N
L
Q
S
Site 25
T127
T
E
G
S
L
S
D
T
D
N
L
Q
S
E
Q
Site 26
S132
S
D
T
D
N
L
Q
S
E
Q
L
S
S
S
S
Site 27
S136
N
L
Q
S
E
Q
L
S
S
S
S
D
G
S
L
Site 28
S137
L
Q
S
E
Q
L
S
S
S
S
D
G
S
L
E
Site 29
S138
Q
S
E
Q
L
S
S
S
S
D
G
S
L
E
S
Site 30
S139
S
E
Q
L
S
S
S
S
D
G
S
L
E
S
Y
Site 31
S142
L
S
S
S
S
D
G
S
L
E
S
Y
Q
N
L
Site 32
S145
S
S
D
G
S
L
E
S
Y
Q
N
L
N
P
H
Site 33
Y146
S
D
G
S
L
E
S
Y
Q
N
L
N
P
H
K
Site 34
S154
Q
N
L
N
P
H
K
S
C
Y
L
S
E
R
G
Site 35
Y156
L
N
P
H
K
S
C
Y
L
S
E
R
G
S
Q
Site 36
S158
P
H
K
S
C
Y
L
S
E
R
G
S
Q
R
S
Site 37
S162
C
Y
L
S
E
R
G
S
Q
R
S
K
T
V
D
Site 38
S165
S
E
R
G
S
Q
R
S
K
T
V
D
D
N
S
Site 39
T167
R
G
S
Q
R
S
K
T
V
D
D
N
S
A
K
Site 40
S172
S
K
T
V
D
D
N
S
A
K
Q
T
A
H
N
Site 41
S190
R
R
K
D
D
G
I
S
L
L
I
S
D
T
Q
Site 42
S194
D
G
I
S
L
L
I
S
D
T
Q
P
E
D
L
Site 43
T196
I
S
L
L
I
S
D
T
Q
P
E
D
L
N
S
Site 44
S203
T
Q
P
E
D
L
N
S
G
S
R
G
C
D
H
Site 45
Y222
S
R
N
K
D
V
K
Y
S
D
S
K
V
E
L
Site 46
S223
R
N
K
D
V
K
Y
S
D
S
K
V
E
L
T
Site 47
S225
K
D
V
K
Y
S
D
S
K
V
E
L
T
L
I
Site 48
T230
S
D
S
K
V
E
L
T
L
I
S
R
K
T
K
Site 49
T236
L
T
L
I
S
R
K
T
K
R
R
L
R
N
N
Site 50
S247
L
R
N
N
L
P
D
S
Q
Y
C
T
S
L
D
Site 51
Y249
N
N
L
P
D
S
Q
Y
C
T
S
L
D
K
S
Site 52
T251
L
P
D
S
Q
Y
C
T
S
L
D
K
S
T
E
Site 53
S252
P
D
S
Q
Y
C
T
S
L
D
K
S
T
E
Q
Site 54
S256
Y
C
T
S
L
D
K
S
T
E
Q
T
K
K
Q
Site 55
S267
T
K
K
Q
E
D
D
S
T
I
S
T
E
F
E
Site 56
T268
K
K
Q
E
D
D
S
T
I
S
T
E
F
E
K
Site 57
T271
E
D
D
S
T
I
S
T
E
F
E
K
P
S
E
Site 58
T291
P
K
L
P
E
E
I
T
T
K
P
T
K
S
D
Site 59
T292
K
L
P
E
E
I
T
T
K
P
T
K
S
D
F
Site 60
S297
I
T
T
K
P
T
K
S
D
F
T
K
L
S
S
Site 61
T300
K
P
T
K
S
D
F
T
K
L
S
S
L
N
S
Site 62
S303
K
S
D
F
T
K
L
S
S
L
N
S
Q
E
L
Site 63
S304
S
D
F
T
K
L
S
S
L
N
S
Q
E
L
T
Site 64
S307
T
K
L
S
S
L
N
S
Q
E
L
T
L
S
N
Site 65
T311
S
L
N
S
Q
E
L
T
L
S
N
A
T
K
S
Site 66
S313
N
S
Q
E
L
T
L
S
N
A
T
K
S
A
S
Site 67
S318
T
L
S
N
A
T
K
S
A
S
A
G
S
T
T
Site 68
S320
S
N
A
T
K
S
A
S
A
G
S
T
T
E
T
Site 69
T324
K
S
A
S
A
G
S
T
T
E
T
V
E
N
S
Site 70
T327
S
A
G
S
T
T
E
T
V
E
N
S
N
S
I
Site 71
S333
E
T
V
E
N
S
N
S
I
D
I
V
G
I
S
Site 72
S367
G
H
N
E
G
N
Q
S
L
I
S
A
E
P
I
Site 73
S377
S
A
E
P
I
V
V
S
S
D
E
E
G
P
V
Site 74
S378
A
E
P
I
V
V
S
S
D
E
E
G
P
V
E
Site 75
S388
E
G
P
V
E
H
K
S
S
E
I
L
K
L
Q
Site 76
S389
G
P
V
E
H
K
S
S
E
I
L
K
L
Q
S
Site 77
T402
Q
S
K
Q
D
R
E
T
T
N
E
N
E
S
T
Site 78
T403
S
K
Q
D
R
E
T
T
N
E
N
E
S
T
S
Site 79
S408
E
T
T
N
E
N
E
S
T
S
E
S
A
L
L
Site 80
T409
T
T
N
E
N
E
S
T
S
E
S
A
L
L
E
Site 81
S410
T
N
E
N
E
S
T
S
E
S
A
L
L
E
L
Site 82
S412
E
N
E
S
T
S
E
S
A
L
L
E
L
P
L
Site 83
S428
T
C
E
S
V
Q
M
S
S
E
L
C
P
Y
N
Site 84
Y434
M
S
S
E
L
C
P
Y
N
P
V
M
E
N
I
Site 85
S443
P
V
M
E
N
I
S
S
I
M
P
S
N
E
M
Site 86
S447
N
I
S
S
I
M
P
S
N
E
M
D
L
Q
L
Site 87
S509
K
R
F
G
L
W
K
S
K
D
D
N
H
S
K
Site 88
S515
K
S
K
D
D
N
H
S
K
R
S
H
A
I
L
Site 89
Y530
F
F
W
V
S
S
D
Y
L
Q
E
I
Q
T
Q
Site 90
S544
Q
L
E
H
S
V
L
S
Q
Q
S
K
S
S
E
Site 91
S547
H
S
V
L
S
Q
Q
S
K
S
S
E
F
I
F
Site 92
S550
L
S
Q
Q
S
K
S
S
E
F
I
F
L
E
L
Site 93
S562
L
E
L
H
N
P
V
S
Q
R
E
E
L
K
L
Site 94
Y587
S
G
E
L
E
L
S
Y
P
L
S
W
V
Q
A
Site 95
S602
F
P
L
F
Q
N
L
S
S
K
E
S
S
F
I
Site 96
S603
P
L
F
Q
N
L
S
S
K
E
S
S
F
I
H
Site 97
S607
N
L
S
S
K
E
S
S
F
I
H
Y
Y
C
V
Site 98
Y611
K
E
S
S
F
I
H
Y
Y
C
V
S
T
C
S
Site 99
S633
A
E
E
M
K
L
K
S
V
S
Q
P
S
N
T
Site 100
S635
E
M
K
L
K
S
V
S
Q
P
S
N
T
D
A
Site 101
T640
S
V
S
Q
P
S
N
T
D
A
A
K
P
T
Y
Site 102
T648
D
A
A
K
P
T
Y
T
F
L
Q
K
Q
S
S
Site 103
S655
T
F
L
Q
K
Q
S
S
G
C
Y
S
L
S
I
Site 104
Y658
Q
K
Q
S
S
G
C
Y
S
L
S
I
T
S
N
Site 105
S659
K
Q
S
S
G
C
Y
S
L
S
I
T
S
N
P
Site 106
S661
S
S
G
C
Y
S
L
S
I
T
S
N
P
D
E
Site 107
T663
G
C
Y
S
L
S
I
T
S
N
P
D
E
E
W
Site 108
T676
E
W
R
E
V
R
H
T
G
L
V
Q
K
L
I
Site 109
Y685
L
V
Q
K
L
I
V
Y
P
P
P
P
T
K
G
Site 110
Y721
I
I
D
F
Y
L
K
Y
L
I
L
E
K
A
S
Site 111
S735
S
D
E
L
V
E
R
S
H
I
F
S
S
F
F
Site 112
Y743
H
I
F
S
S
F
F
Y
K
C
L
T
R
K
E
Site 113
T754
T
R
K
E
N
N
L
T
E
D
N
P
N
L
S
Site 114
S761
T
E
D
N
P
N
L
S
M
A
Q
R
R
H
K
Site 115
T772
R
R
H
K
R
V
R
T
W
T
R
H
I
N
I
Site 116
Y810
P
W
L
E
E
A
V
Y
E
D
F
P
Q
T
V
Site 117
T816
V
Y
E
D
F
P
Q
T
V
S
Q
Q
S
Q
A
Site 118
S818
E
D
F
P
Q
T
V
S
Q
Q
S
Q
A
Q
Q
Site 119
S821
P
Q
T
V
S
Q
Q
S
Q
A
Q
Q
S
Q
N
Site 120
S826
Q
Q
S
Q
A
Q
Q
S
Q
N
D
N
K
T
I
Site 121
T832
Q
S
Q
N
D
N
K
T
I
D
N
D
L
R
T
Site 122
T839
T
I
D
N
D
L
R
T
T
S
T
L
S
L
S
Site 123
T840
I
D
N
D
L
R
T
T
S
T
L
S
L
S
A
Site 124
S841
D
N
D
L
R
T
T
S
T
L
S
L
S
A
E
Site 125
T842
N
D
L
R
T
T
S
T
L
S
L
S
A
E
D
Site 126
S844
L
R
T
T
S
T
L
S
L
S
A
E
D
S
Q
Site 127
S846
T
T
S
T
L
S
L
S
A
E
D
S
Q
S
T
Site 128
S850
L
S
L
S
A
E
D
S
Q
S
T
E
S
N
M
Site 129
S852
L
S
A
E
D
S
Q
S
T
E
S
N
M
S
V
Site 130
S855
E
D
S
Q
S
T
E
S
N
M
S
V
P
K
K
Site 131
S858
Q
S
T
E
S
N
M
S
V
P
K
K
M
C
K
Site 132
T883
K
A
A
S
V
Q
N
T
V
Q
N
L
R
E
Y
Site 133
Y890
T
V
Q
N
L
R
E
Y
L
E
V
E
W
E
V
Site 134
T901
E
W
E
V
K
L
K
T
H
R
Q
F
S
K
T
Site 135
S906
L
K
T
H
R
Q
F
S
K
T
N
M
V
D
L
Site 136
T908
T
H
R
Q
F
S
K
T
N
M
V
D
L
C
P
Site 137
S923
K
V
P
K
Q
D
N
S
S
D
C
G
V
Y
L
Site 138
S924
V
P
K
Q
D
N
S
S
D
C
G
V
Y
L
L
Site 139
T962
F
P
R
H
V
I
K
T
K
R
E
D
I
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation