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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAPKAP1
Full Name:
Target of rapamycin complex 2 subunit MAPKAP1
Alias:
MGC2745; MIP1; Mitogen-activated protein kinase associated protein 1; Ras inhibitor JC310; SAPK-interacting protein 1; SIN1; Stress-activated map kinase-interacting protein 1; Stress-activated protein kinase-interacting 1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1
Type:
Adaptor/scaffold protein
Mass (Da):
59123
Number AA:
522
UniProt ID:
Q9BPZ7
International Prot ID:
IPI00028195
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0005829
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0017016
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
I
L
A
H
I
R
Q
S
H
V
T
S
D
D
T
Site 2
T20
H
I
R
Q
S
H
V
T
S
D
D
T
G
M
C
Site 3
S21
I
R
Q
S
H
V
T
S
D
D
T
G
M
C
E
Site 4
T24
S
H
V
T
S
D
D
T
G
M
C
E
M
V
L
Site 5
S45
L
E
K
I
H
P
P
S
M
P
G
D
S
G
S
Site 6
S50
P
P
S
M
P
G
D
S
G
S
E
I
Q
G
S
Site 7
S52
S
M
P
G
D
S
G
S
E
I
Q
G
S
N
G
Site 8
S57
S
G
S
E
I
Q
G
S
N
G
E
T
Q
G
Y
Site 9
Y64
S
N
G
E
T
Q
G
Y
V
Y
A
Q
S
V
D
Site 10
T73
Y
A
Q
S
V
D
I
T
S
S
W
D
F
G
I
Site 11
S74
A
Q
S
V
D
I
T
S
S
W
D
F
G
I
R
Site 12
S84
D
F
G
I
R
R
R
S
N
T
A
Q
R
L
E
Site 13
T86
G
I
R
R
R
S
N
T
A
Q
R
L
E
R
L
Site 14
S113
I
Q
W
K
E
R
N
S
K
Q
S
A
Q
E
L
Site 15
S116
K
E
R
N
S
K
Q
S
A
Q
E
L
K
S
L
Site 16
S122
Q
S
A
Q
E
L
K
S
L
F
E
K
K
S
L
Site 17
S128
K
S
L
F
E
K
K
S
L
K
E
K
P
P
I
Site 18
S136
L
K
E
K
P
P
I
S
G
K
Q
S
I
L
S
Site 19
S140
P
P
I
S
G
K
Q
S
I
L
S
V
R
L
E
Site 20
S143
S
G
K
Q
S
I
L
S
V
R
L
E
Q
C
P
Site 21
Y180
A
T
K
K
I
D
V
Y
L
P
L
H
S
S
Q
Site 22
S185
D
V
Y
L
P
L
H
S
S
Q
D
R
L
L
P
Site 23
S186
V
Y
L
P
L
H
S
S
Q
D
R
L
L
P
M
Site 24
Y214
I
G
L
I
C
W
Q
Y
T
S
E
G
R
E
P
Site 25
S216
L
I
C
W
Q
Y
T
S
E
G
R
E
P
K
L
Site 26
T243
E
D
D
G
E
V
D
T
D
F
P
P
L
D
S
Site 27
S250
T
D
F
P
P
L
D
S
N
E
P
I
H
K
F
Site 28
Y268
T
L
A
L
V
E
K
Y
S
S
P
G
L
T
S
Site 29
S269
L
A
L
V
E
K
Y
S
S
P
G
L
T
S
K
Site 30
S270
A
L
V
E
K
Y
S
S
P
G
L
T
S
K
E
Site 31
T274
K
Y
S
S
P
G
L
T
S
K
E
S
L
F
V
Site 32
S275
Y
S
S
P
G
L
T
S
K
E
S
L
F
V
R
Site 33
S278
P
G
L
T
S
K
E
S
L
F
V
R
I
N
A
Site 34
T297
S
L
I
Q
V
D
N
T
K
V
T
M
K
E
I
Site 35
S315
A
V
K
R
R
K
G
S
Q
K
V
S
G
P
Q
Site 36
S319
R
K
G
S
Q
K
V
S
G
P
Q
Y
R
L
E
Site 37
Y323
Q
K
V
S
G
P
Q
Y
R
L
E
K
Q
S
E
Site 38
S329
Q
Y
R
L
E
K
Q
S
E
P
N
V
A
V
D
Site 39
S339
N
V
A
V
D
L
D
S
T
L
E
S
Q
S
A
Site 40
T340
V
A
V
D
L
D
S
T
L
E
S
Q
S
A
W
Site 41
S343
D
L
D
S
T
L
E
S
Q
S
A
W
E
F
C
Site 42
S345
D
S
T
L
E
S
Q
S
A
W
E
F
C
L
V
Site 43
S356
F
C
L
V
R
E
N
S
S
R
A
D
G
V
F
Site 44
S367
D
G
V
F
E
E
D
S
Q
I
D
I
A
T
V
Site 45
T373
D
S
Q
I
D
I
A
T
V
Q
D
M
L
S
S
Site 46
S379
A
T
V
Q
D
M
L
S
S
H
H
Y
K
S
F
Site 47
Y383
D
M
L
S
S
H
H
Y
K
S
F
K
V
S
M
Site 48
T415
K
V
E
I
D
P
V
T
N
Q
K
A
S
T
K
Site 49
S431
W
I
K
Q
K
P
I
S
I
D
S
D
L
L
C
Site 50
S447
C
D
L
A
E
E
K
S
P
S
H
A
I
F
K
Site 51
S449
L
A
E
E
K
S
P
S
H
A
I
F
K
L
T
Site 52
T456
S
H
A
I
F
K
L
T
Y
L
S
N
H
D
Y
Site 53
Y457
H
A
I
F
K
L
T
Y
L
S
N
H
D
Y
K
Site 54
Y463
T
Y
L
S
N
H
D
Y
K
H
L
Y
F
E
S
Site 55
Y467
N
H
D
Y
K
H
L
Y
F
E
S
D
A
A
T
Site 56
S491
Y
I
L
E
S
R
A
S
T
A
R
A
D
Y
F
Site 57
T492
I
L
E
S
R
A
S
T
A
R
A
D
Y
F
A
Site 58
Y497
A
S
T
A
R
A
D
Y
F
A
Q
K
Q
R
K
Site 59
T509
Q
R
K
L
N
R
R
T
S
F
S
F
Q
K
E
Site 60
S510
R
K
L
N
R
R
T
S
F
S
F
Q
K
E
K
Site 61
S512
L
N
R
R
T
S
F
S
F
Q
K
E
K
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation