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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SEMA3C
Full Name:
Semaphorin-3C
Alias:
Sema domain, immunoglobulin domain (Ig) short basic domain, secreted (semaphorin) 3C; Sema domain, immunoglobulin domain(Ig), short basic domain, secreted, 3C; SEMAE; Semaphorin3C; Semaphorin-E; SemE
Type:
Secreted protein
Mass (Da):
85189
Number AA:
751
UniProt ID:
Q99985
International Prot ID:
IPI00019209
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0042493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
S
I
C
V
K
G
S
S
Q
P
Q
A
R
V
Y
Site 2
Y30
S
Q
P
Q
A
R
V
Y
L
T
F
D
E
L
R
Site 3
T32
P
Q
A
R
V
Y
L
T
F
D
E
L
R
E
T
Site 4
T39
T
F
D
E
L
R
E
T
K
T
S
E
Y
F
S
Site 5
T41
D
E
L
R
E
T
K
T
S
E
Y
F
S
L
S
Site 6
S42
E
L
R
E
T
K
T
S
E
Y
F
S
L
S
H
Site 7
Y44
R
E
T
K
T
S
E
Y
F
S
L
S
H
H
P
Site 8
S46
T
K
T
S
E
Y
F
S
L
S
H
H
P
L
D
Site 9
S48
T
S
E
Y
F
S
L
S
H
H
P
L
D
Y
R
Site 10
Y54
L
S
H
H
P
L
D
Y
R
I
L
L
M
D
E
Site 11
Y67
D
E
D
Q
D
R
I
Y
V
G
S
K
D
H
I
Site 12
S70
Q
D
R
I
Y
V
G
S
K
D
H
I
L
S
L
Site 13
S76
G
S
K
D
H
I
L
S
L
N
I
N
N
I
S
Site 14
S88
N
I
S
Q
E
A
L
S
V
F
W
P
A
S
T
Site 15
T140
G
A
F
S
P
V
C
T
Y
L
N
R
G
R
R
Site 16
Y141
A
F
S
P
V
C
T
Y
L
N
R
G
R
R
S
Site 17
S148
Y
L
N
R
G
R
R
S
E
D
Q
V
F
M
I
Site 18
S157
D
Q
V
F
M
I
D
S
K
C
E
S
G
K
G
Site 19
S161
M
I
D
S
K
C
E
S
G
K
G
R
C
S
F
Site 20
S167
E
S
G
K
G
R
C
S
F
N
P
N
V
N
T
Site 21
T174
S
F
N
P
N
V
N
T
V
S
V
M
I
N
E
Site 22
Y188
E
E
L
F
S
G
M
Y
I
D
F
M
G
T
D
Site 23
S201
T
D
A
A
I
F
R
S
L
T
K
R
N
A
V
Site 24
T203
A
A
I
F
R
S
L
T
K
R
N
A
V
R
T
Site 25
T210
T
K
R
N
A
V
R
T
D
Q
H
N
S
K
W
Site 26
Y241
D
P
N
D
A
K
V
Y
F
F
F
K
E
K
L
Site 27
T249
F
F
F
K
E
K
L
T
D
N
N
R
S
T
K
Site 28
T255
L
T
D
N
N
R
S
T
K
Q
I
H
S
M
I
Site 29
T270
A
R
I
C
P
N
D
T
G
G
L
R
S
L
V
Site 30
S275
N
D
T
G
G
L
R
S
L
V
N
K
W
T
T
Site 31
S291
L
K
A
R
L
V
C
S
V
T
D
E
D
G
P
Site 32
T293
A
R
L
V
C
S
V
T
D
E
D
G
P
E
T
Site 33
T313
E
D
V
F
L
L
E
T
D
N
P
R
T
T
L
Site 34
T318
L
E
T
D
N
P
R
T
T
L
V
Y
G
I
F
Site 35
T319
E
T
D
N
P
R
T
T
L
V
Y
G
I
F
T
Site 36
Y322
N
P
R
T
T
L
V
Y
G
I
F
T
T
S
S
Site 37
T327
L
V
Y
G
I
F
T
T
S
S
S
V
F
K
G
Site 38
Y366
P
N
H
Q
L
I
S
Y
Q
G
R
I
P
Y
P
Site 39
Y372
S
Y
Q
G
R
I
P
Y
P
R
P
G
T
C
P
Site 40
T377
I
P
Y
P
R
P
G
T
C
P
G
G
A
F
T
Site 41
T384
T
C
P
G
G
A
F
T
P
N
M
R
T
T
K
Site 42
T390
F
T
P
N
M
R
T
T
K
E
F
P
D
D
V
Site 43
T399
E
F
P
D
D
V
V
T
F
I
R
N
H
P
L
Site 44
Y408
I
R
N
H
P
L
M
Y
N
S
I
Y
P
I
H
Site 45
Y412
P
L
M
Y
N
S
I
Y
P
I
H
K
R
P
L
Site 46
T425
P
L
I
V
R
I
G
T
D
Y
K
Y
T
K
I
Site 47
Y429
R
I
G
T
D
Y
K
Y
T
K
I
A
V
D
R
Site 48
T487
F
K
N
H
A
P
I
T
T
M
K
I
S
S
K
Site 49
S492
P
I
T
T
M
K
I
S
S
K
K
Q
Q
L
Y
Site 50
Y499
S
S
K
K
Q
Q
L
Y
V
S
S
N
E
G
V
Site 51
S507
V
S
S
N
E
G
V
S
Q
V
S
L
H
R
C
Site 52
Y543
G
H
S
C
S
R
F
Y
P
T
G
K
R
R
S
Site 53
T545
S
C
S
R
F
Y
P
T
G
K
R
R
S
R
R
Site 54
S550
Y
P
T
G
K
R
R
S
R
R
Q
D
V
R
H
Site 55
T562
V
R
H
G
N
P
L
T
Q
C
R
G
F
N
L
Site 56
Y572
R
G
F
N
L
K
A
Y
R
N
A
A
E
I
V
Site 57
Y581
N
A
A
E
I
V
Q
Y
G
V
K
N
N
T
T
Site 58
T588
Y
G
V
K
N
N
T
T
F
L
E
C
A
P
K
Site 59
S596
F
L
E
C
A
P
K
S
P
Q
A
S
I
K
W
Site 60
S600
A
P
K
S
P
Q
A
S
I
K
W
L
L
Q
K
Site 61
S625
N
E
R
I
I
A
T
S
Q
G
L
L
I
R
S
Site 62
S632
S
Q
G
L
L
I
R
S
V
Q
G
S
D
Q
G
Site 63
S636
L
I
R
S
V
Q
G
S
D
Q
G
L
Y
H
C
Site 64
Y641
Q
G
S
D
Q
G
L
Y
H
C
I
A
T
E
N
Site 65
T653
T
E
N
S
F
K
Q
T
I
A
K
I
N
F
K
Site 66
T671
S
E
M
V
A
V
V
T
D
K
W
S
P
W
T
Site 67
T678
T
D
K
W
S
P
W
T
W
A
S
S
V
R
A
Site 68
S682
S
P
W
T
W
A
S
S
V
R
A
L
P
F
H
Site 69
Y729
S
Q
K
M
R
G
D
Y
G
K
L
K
A
L
I
Site 70
S741
A
L
I
N
S
R
K
S
R
N
R
R
N
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation