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Updated November 2019
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Protein Info
Short Name:
TEP1
Full Name:
Telomerase protein component 1
Alias:
P240; Telomerase 1; Telomerase-associated 1; Telomerase-associated protein 1; TLP1; TP1; TROVE domain family, member 1; TROVE1; VAULT2
Type:
DNA repair
Mass (Da):
290410
Number AA:
UniProt ID:
Q99973
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000781
GO:0005737
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0000722
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
K
L
H
G
H
V
S
A
H
P
D
I
L
S
Site 2
S16
S
A
H
P
D
I
L
S
L
E
N
R
C
L
A
Site 3
S39
E
K
L
H
Q
H
V
S
T
H
S
D
I
L
S
Site 4
T40
K
L
H
Q
H
V
S
T
H
S
D
I
L
S
L
Site 5
S42
H
Q
H
V
S
T
H
S
D
I
L
S
L
K
N
Site 6
S46
S
T
H
S
D
I
L
S
L
K
N
Q
C
L
A
Site 7
T60
A
T
L
P
D
L
K
T
M
E
K
P
H
G
Y
Site 8
Y67
T
M
E
K
P
H
G
Y
V
S
A
H
P
D
I
Site 9
S69
E
K
P
H
G
Y
V
S
A
H
P
D
I
L
S
Site 10
S76
S
A
H
P
D
I
L
S
L
E
N
Q
C
L
A
Site 11
S86
N
Q
C
L
A
T
L
S
D
L
K
T
M
E
K
Site 12
T90
A
T
L
S
D
L
K
T
M
E
K
P
H
G
H
Site 13
S99
E
K
P
H
G
H
V
S
A
H
P
D
I
L
S
Site 14
T114
L
E
N
R
C
L
A
T
L
S
S
L
K
S
T
Site 15
S116
N
R
C
L
A
T
L
S
S
L
K
S
T
V
S
Site 16
S123
S
S
L
K
S
T
V
S
A
S
P
L
F
Q
S
Site 17
S130
S
A
S
P
L
F
Q
S
L
Q
I
S
H
M
T
Site 18
Y142
H
M
T
Q
A
D
L
Y
R
V
N
N
S
N
C
Site 19
S147
D
L
Y
R
V
N
N
S
N
C
L
L
S
E
P
Site 20
S152
N
N
S
N
C
L
L
S
E
P
P
S
W
R
A
Site 21
S156
C
L
L
S
E
P
P
S
W
R
A
Q
H
F
S
Site 22
S163
S
W
R
A
Q
H
F
S
K
G
L
D
L
S
T
Site 23
S179
P
I
A
L
K
S
I
S
A
T
E
T
A
Q
E
Site 24
T181
A
L
K
S
I
S
A
T
E
T
A
Q
E
A
T
Site 25
T183
K
S
I
S
A
T
E
T
A
Q
E
A
T
L
G
Site 26
S195
T
L
G
R
W
F
D
S
E
E
K
K
G
A
E
Site 27
T203
E
E
K
K
G
A
E
T
Q
M
P
S
Y
S
L
Site 28
S207
G
A
E
T
Q
M
P
S
Y
S
L
S
L
G
E
Site 29
S209
E
T
Q
M
P
S
Y
S
L
S
L
G
E
E
E
Site 30
S211
Q
M
P
S
Y
S
L
S
L
G
E
E
E
E
V
Site 31
T226
E
D
L
A
V
K
L
T
S
G
D
S
E
S
H
Site 32
S227
D
L
A
V
K
L
T
S
G
D
S
E
S
H
P
Site 33
S230
V
K
L
T
S
G
D
S
E
S
H
P
E
P
T
Site 34
S232
L
T
S
G
D
S
E
S
H
P
E
P
T
D
H
Site 35
Y343
W
I
Q
V
A
E
L
Y
Q
S
L
A
E
G
D
Site 36
S345
Q
V
A
E
L
Y
Q
S
L
A
E
G
D
K
N
Site 37
Y375
K
F
A
Q
F
D
E
Y
Q
L
A
K
Y
N
P
Site 38
Y380
D
E
Y
Q
L
A
K
Y
N
P
R
K
H
R
A
Site 39
S397
H
P
R
R
P
P
R
S
P
G
M
E
P
P
F
Site 40
Y412
S
H
R
C
F
P
R
Y
I
G
F
L
R
E
E
Site 41
T429
K
F
E
K
A
G
D
T
V
S
E
K
K
N
P
Site 42
S431
E
K
A
G
D
T
V
S
E
K
K
N
P
P
R
Site 43
T440
K
K
N
P
P
R
F
T
L
K
K
L
V
Q
R
Site 44
Y463
H
V
Q
A
L
L
G
Y
R
Y
P
S
N
L
Q
Site 45
Y465
Q
A
L
L
G
Y
R
Y
P
S
N
L
Q
L
F
Site 46
S467
L
L
G
Y
R
Y
P
S
N
L
Q
L
F
S
R
Site 47
S473
P
S
N
L
Q
L
F
S
R
S
R
L
P
G
P
Site 48
S475
N
L
Q
L
F
S
R
S
R
L
P
G
P
W
D
Site 49
S483
R
L
P
G
P
W
D
S
S
R
A
G
K
R
M
Site 50
S484
L
P
G
P
W
D
S
S
R
A
G
K
R
M
K
Site 51
T497
M
K
L
S
R
P
E
T
W
E
R
E
L
S
L
Site 52
S503
E
T
W
E
R
E
L
S
L
R
G
N
K
A
S
Site 53
S510
S
L
R
G
N
K
A
S
V
W
E
E
L
I
E
Site 54
S539
N
L
L
R
V
G
I
S
S
R
H
H
E
L
I
Site 55
S555
Q
R
L
Q
H
A
K
S
V
I
H
S
R
Q
F
Site 56
S559
H
A
K
S
V
I
H
S
R
Q
F
P
F
R
F
Site 57
T599
T
L
M
R
R
I
L
T
R
N
E
K
N
R
P
Site 58
S615
R
R
F
L
C
H
L
S
R
Q
Q
L
R
M
A
Site 59
Y629
A
M
R
I
P
V
L
Y
E
Q
L
K
R
E
K
Site 60
Y647
H
K
A
R
Q
W
K
Y
D
G
E
M
L
N
R
Site 61
Y655
D
G
E
M
L
N
R
Y
R
Q
A
L
E
T
A
Site 62
T661
R
Y
R
Q
A
L
E
T
A
V
N
L
S
V
K
Site 63
Y682
P
G
R
T
V
L
V
Y
L
T
D
A
N
A
D
Site 64
S695
A
D
R
L
C
P
K
S
N
P
Q
G
P
P
L
Site 65
T714
L
L
I
G
M
M
I
T
R
A
E
Q
V
D
V
Site 66
T764
N
D
G
W
S
L
N
T
F
G
K
Y
L
L
S
Site 67
Y801
I
N
V
A
K
Q
L
Y
W
Q
R
V
N
S
K
Site 68
Y821
I
L
L
R
R
V
Q
Y
L
S
T
D
L
N
P
Site 69
S823
L
R
R
V
Q
Y
L
S
T
D
L
N
P
N
D
Site 70
T832
D
L
N
P
N
D
V
T
L
S
G
C
T
D
A
Site 71
T872
I
P
P
P
P
G
K
T
G
V
Q
S
L
R
P
Site 72
S876
P
G
K
T
G
V
Q
S
L
R
P
L
E
E
D
Site 73
T884
L
R
P
L
E
E
D
T
P
S
P
L
A
P
V
Site 74
S886
P
L
E
E
D
T
P
S
P
L
A
P
V
S
Q
Site 75
S892
P
S
P
L
A
P
V
S
Q
Q
G
W
R
S
I
Site 76
S898
V
S
Q
Q
G
W
R
S
I
R
L
F
I
S
S
Site 77
S905
S
I
R
L
F
I
S
S
T
F
R
D
M
H
G
Site 78
T906
I
R
L
F
I
S
S
T
F
R
D
M
H
G
E
Site 79
S935
R
A
A
P
H
R
I
S
L
H
G
I
D
L
R
Site 80
Y979
I
L
G
S
R
Y
G
Y
I
P
P
S
Y
N
L
Site 81
S983
R
Y
G
Y
I
P
P
S
Y
N
L
P
D
H
P
Site 82
Y984
Y
G
Y
I
P
P
S
Y
N
L
P
D
H
P
H
Site 83
T1005
Y
P
S
G
R
S
V
T
E
M
E
V
M
Q
F
Site 84
S1022
R
N
Q
R
L
Q
P
S
A
Q
A
L
I
Y
F
Site 85
S1036
F
R
D
S
S
F
L
S
S
V
P
D
A
W
K
Site 86
S1037
R
D
S
S
F
L
S
S
V
P
D
A
W
K
S
Site 87
S1044
S
V
P
D
A
W
K
S
D
F
V
S
E
S
E
Site 88
S1048
A
W
K
S
D
F
V
S
E
S
E
E
A
A
R
Site 89
S1050
K
S
D
F
V
S
E
S
E
E
A
A
R
R
I
Site 90
S1058
E
E
A
A
R
R
I
S
E
L
K
S
Y
L
S
Site 91
S1062
R
R
I
S
E
L
K
S
Y
L
S
R
Q
K
G
Site 92
Y1063
R
I
S
E
L
K
S
Y
L
S
R
Q
K
G
I
Site 93
S1065
S
E
L
K
S
Y
L
S
R
Q
K
G
I
T
C
Site 94
T1071
L
S
R
Q
K
G
I
T
C
R
R
Y
P
C
E
Site 95
Y1075
K
G
I
T
C
R
R
Y
P
C
E
W
G
G
V
Site 96
S1142
Q
Q
L
Q
K
P
P
S
P
A
R
P
R
L
L
Site 97
T1152
R
P
R
L
L
Q
D
T
V
Q
R
L
M
L
P
Site 98
S1164
M
L
P
H
G
R
L
S
L
V
T
G
Q
S
G
Site 99
T1167
H
G
R
L
S
L
V
T
G
Q
S
G
Q
G
K
Site 100
S1170
L
S
L
V
T
G
Q
S
G
Q
G
K
T
A
F
Site 101
S1202
S
L
V
F
F
H
F
S
G
A
R
P
D
Q
G
Site 102
T1220
T
L
L
R
R
L
C
T
Y
L
R
G
Q
L
K
Site 103
Y1221
L
L
R
R
L
C
T
Y
L
R
G
Q
L
K
E
Site 104
S1234
K
E
P
G
A
L
P
S
T
Y
R
S
L
V
W
Site 105
T1235
E
P
G
A
L
P
S
T
Y
R
S
L
V
W
E
Site 106
Y1236
P
G
A
L
P
S
T
Y
R
S
L
V
W
E
L
Site 107
S1238
A
L
P
S
T
Y
R
S
L
V
W
E
L
Q
Q
Site 108
S1251
Q
Q
R
L
L
P
K
S
A
E
S
L
H
P
G
Site 109
S1254
L
L
P
K
S
A
E
S
L
H
P
G
Q
T
Q
Site 110
T1306
S
D
A
G
L
G
E
T
L
E
Q
S
Q
G
A
Site 111
S1310
L
G
E
T
L
E
Q
S
Q
G
A
H
V
L
A
Site 112
Y1337
V
R
E
E
L
A
L
Y
G
K
R
L
E
E
S
Site 113
S1344
Y
G
K
R
L
E
E
S
P
F
N
N
Q
M
R
Site 114
S1359
L
L
L
V
K
R
E
S
G
R
P
L
Y
L
R
Site 115
Y1364
R
E
S
G
R
P
L
Y
L
R
L
V
T
D
H
Site 116
T1376
T
D
H
L
R
L
F
T
L
Y
E
Q
V
S
E
Site 117
Y1378
H
L
R
L
F
T
L
Y
E
Q
V
S
E
R
L
Site 118
S1382
F
T
L
Y
E
Q
V
S
E
R
L
R
T
L
P
Site 119
T1387
Q
V
S
E
R
L
R
T
L
P
A
T
V
P
L
Site 120
S1401
L
L
L
Q
H
I
L
S
T
L
E
K
E
H
G
Site 121
T1402
L
L
Q
H
I
L
S
T
L
E
K
E
H
G
P
Site 122
T1427
E
V
T
R
S
G
L
T
V
D
Q
L
H
G
V
Site 123
S1436
D
Q
L
H
G
V
L
S
V
W
R
T
L
P
K
Site 124
T1440
G
V
L
S
V
W
R
T
L
P
K
G
T
K
S
Site 125
S1447
T
L
P
K
G
T
K
S
W
E
E
A
V
A
A
Site 126
S1457
E
A
V
A
A
G
N
S
G
D
P
Y
P
M
G
Site 127
Y1461
A
G
N
S
G
D
P
Y
P
M
G
P
F
A
C
Site 128
Y1504
R
T
A
A
K
R
C
Y
G
K
R
P
G
L
E
Site 129
S1531
K
T
C
D
A
D
A
S
G
T
F
R
S
C
P
Site 130
T1533
C
D
A
D
A
S
G
T
F
R
S
C
P
P
E
Site 131
S1536
D
A
S
G
T
F
R
S
C
P
P
E
A
L
G
Site 132
Y1547
E
A
L
G
D
L
P
Y
H
L
L
Q
S
G
N
Site 133
S1552
L
P
Y
H
L
L
Q
S
G
N
R
G
L
L
S
Site 134
S1559
S
G
N
R
G
L
L
S
K
F
L
T
N
L
H
Site 135
S1589
E
A
H
A
L
Y
A
S
S
V
P
K
E
E
Q
Site 136
S1615
T
F
L
R
Q
Q
A
S
I
L
S
Q
Y
P
R
Site 137
S1618
R
Q
Q
A
S
I
L
S
Q
Y
P
R
L
L
P
Site 138
Y1620
Q
A
S
I
L
S
Q
Y
P
R
L
L
P
Q
Q
Site 139
S1635
A
A
N
Q
P
L
D
S
P
L
C
H
Q
A
S
Site 140
S1642
S
P
L
C
H
Q
A
S
L
L
S
R
R
W
H
Site 141
T1653
R
R
W
H
L
Q
H
T
L
R
W
L
N
K
P
Site 142
T1662
R
W
L
N
K
P
R
T
M
K
N
Q
Q
S
S
Site 143
S1668
R
T
M
K
N
Q
Q
S
S
S
L
S
L
A
V
Site 144
S1670
M
K
N
Q
Q
S
S
S
L
S
L
A
V
S
S
Site 145
S1672
N
Q
Q
S
S
S
L
S
L
A
V
S
S
S
P
Site 146
T1707
V
Y
L
L
D
L
R
T
W
Q
E
E
K
S
V
Site 147
S1713
R
T
W
Q
E
E
K
S
V
V
S
G
C
D
G
Site 148
Y1760
L
Q
T
K
A
H
Q
Y
Q
I
T
G
C
C
L
Site 149
T1763
K
A
H
Q
Y
Q
I
T
G
C
C
L
S
P
D
Site 150
T1798
G
Q
L
A
F
Q
H
T
Y
P
K
S
L
N
C
Site 151
Y1799
Q
L
A
F
Q
H
T
Y
P
K
S
L
N
C
V
Site 152
T1847
A
P
G
A
S
I
R
T
L
A
F
N
V
P
G
Site 153
S1912
D
G
K
V
Q
V
W
S
G
S
L
G
R
P
R
Site 154
S1914
K
V
Q
V
W
S
G
S
L
G
R
P
R
G
H
Site 155
S1924
R
P
R
G
H
L
G
S
L
S
L
S
P
A
L
Site 156
Y1946
G
D
R
V
A
V
G
Y
R
A
D
G
I
R
I
Site 157
Y1954
R
A
D
G
I
R
I
Y
K
I
S
S
G
S
Q
Site 158
S1957
G
I
R
I
Y
K
I
S
S
G
S
Q
G
A
Q
Site 159
S1960
I
Y
K
I
S
S
G
S
Q
G
A
Q
G
Q
A
Site 160
S1991
V
S
G
A
E
D
G
S
L
Q
G
W
A
L
K
Site 161
S2027
T
S
Q
E
L
L
A
S
A
S
E
D
F
T
V
Site 162
T2033
A
S
A
S
E
D
F
T
V
Q
L
W
P
R
Q
Site 163
S2065
R
G
H
E
G
P
V
S
C
C
S
F
S
T
D
Site 164
S2068
E
G
P
V
S
C
C
S
F
S
T
D
G
G
S
Site 165
S2075
S
F
S
T
D
G
G
S
L
A
T
G
G
R
D
Site 166
S2084
A
T
G
G
R
D
R
S
L
L
C
W
D
V
R
Site 167
T2095
W
D
V
R
T
P
K
T
P
V
L
I
H
S
F
Site 168
S2101
K
T
P
V
L
I
H
S
F
P
A
C
H
R
D
Site 169
S2123
T
K
D
N
L
L
I
S
C
S
S
D
G
S
V
Site 170
S2129
I
S
C
S
S
D
G
S
V
G
L
W
D
P
E
Site 171
S2137
V
G
L
W
D
P
E
S
G
Q
R
L
G
Q
F
Site 172
S2163
A
V
E
E
H
V
V
S
V
S
R
D
G
T
L
Site 173
T2169
V
S
V
S
R
D
G
T
L
K
V
W
D
H
Q
Site 174
T2181
D
H
Q
G
V
E
L
T
S
I
P
A
H
S
G
Site 175
S2191
P
A
H
S
G
P
I
S
H
C
A
A
A
M
E
Site 176
T2255
E
T
S
G
L
M
L
T
A
S
E
D
G
S
V
Site 177
S2261
L
T
A
S
E
D
G
S
V
R
L
W
Q
V
P
Site 178
T2274
V
P
K
E
A
D
D
T
C
I
P
R
S
S
A
Site 179
S2293
V
A
W
A
P
D
G
S
M
A
V
S
G
N
Q
Site 180
S2297
P
D
G
S
M
A
V
S
G
N
Q
A
G
E
L
Site 181
S2337
A
H
T
F
F
V
L
S
A
D
E
K
I
S
E
Site 182
S2353
Q
V
K
L
R
K
G
S
A
P
G
N
L
S
L
Site 183
S2375
E
D
L
G
V
L
T
S
L
D
W
A
P
D
G
Site 184
S2404
M
K
P
G
D
A
P
S
E
I
W
S
S
Y
T
Site 185
S2408
D
A
P
S
E
I
W
S
S
Y
T
E
N
P
M
Site 186
S2409
A
P
S
E
I
W
S
S
Y
T
E
N
P
M
I
Site 187
T2411
S
E
I
W
S
S
Y
T
E
N
P
M
I
L
S
Site 188
S2437
P
K
D
P
G
V
L
S
F
L
R
Q
K
E
S
Site 189
S2444
S
F
L
R
Q
K
E
S
G
E
F
E
E
R
L
Site 190
S2474
I
T
Q
A
K
P
E
S
E
S
S
F
L
C
A
Site 191
S2477
A
K
P
E
S
E
S
S
F
L
C
A
S
S
D
Site 192
S2494
L
W
N
L
A
K
C
S
P
E
G
E
W
T
T
Site 193
T2511
M
W
Q
K
K
A
N
T
P
E
T
Q
T
P
G
Site 194
T2514
K
K
A
N
T
P
E
T
Q
T
P
G
T
D
P
Site 195
T2516
A
N
T
P
E
T
Q
T
P
G
T
D
P
S
T
Site 196
T2519
P
E
T
Q
T
P
G
T
D
P
S
T
C
R
E
Site 197
S2522
Q
T
P
G
T
D
P
S
T
C
R
E
S
D
A
Site 198
T2523
T
P
G
T
D
P
S
T
C
R
E
S
D
A
S
Site 199
S2527
D
P
S
T
C
R
E
S
D
A
S
M
D
S
D
Site 200
S2530
T
C
R
E
S
D
A
S
M
D
S
D
A
S
M
Site 201
S2533
E
S
D
A
S
M
D
S
D
A
S
M
D
S
E
Site 202
S2536
A
S
M
D
S
D
A
S
M
D
S
E
P
T
P
Site 203
S2539
D
S
D
A
S
M
D
S
E
P
T
P
H
L
K
Site 204
T2542
A
S
M
D
S
E
P
T
P
H
L
K
T
R
Q
Site 205
T2547
E
P
T
P
H
L
K
T
R
Q
R
R
K
I
H
Site 206
S2555
R
Q
R
R
K
I
H
S
G
S
V
T
A
L
H
Site 207
S2557
R
R
K
I
H
S
G
S
V
T
A
L
H
V
L
Site 208
S2572
P
E
L
L
V
T
A
S
K
D
R
D
V
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation