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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKP2
Full Name:
Plakophilin-2
Alias:
Plakophilin 2
Type:
Membrane protein, integral; Adhesion
Mass (Da):
97399
Number AA:
881
UniProt ID:
Q99959
International Prot ID:
IPI00219688
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0030057
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016337
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
A
P
G
A
P
A
E
Y
G
Y
I
R
T
V
L
Site 2
Y12
G
A
P
A
E
Y
G
Y
I
R
T
V
L
G
Q
Site 3
S29
L
G
Q
L
D
S
S
S
L
A
L
P
S
E
A
Site 4
S43
A
K
L
K
L
A
G
S
S
G
R
G
G
Q
T
Site 5
S44
K
L
K
L
A
G
S
S
G
R
G
G
Q
T
V
Site 6
T50
S
S
G
R
G
G
Q
T
V
K
S
L
R
I
Q
Site 7
S53
R
G
G
Q
T
V
K
S
L
R
I
Q
E
Q
V
Site 8
T63
I
Q
E
Q
V
Q
Q
T
L
A
R
K
G
R
S
Site 9
S71
L
A
R
K
G
R
S
S
V
G
N
G
N
L
H
Site 10
T80
G
N
G
N
L
H
R
T
S
S
V
P
E
Y
V
Site 11
S81
N
G
N
L
H
R
T
S
S
V
P
E
Y
V
Y
Site 12
S82
G
N
L
H
R
T
S
S
V
P
E
Y
V
Y
N
Site 13
Y86
R
T
S
S
V
P
E
Y
V
Y
N
L
H
L
V
Site 14
Y88
S
S
V
P
E
Y
V
Y
N
L
H
L
V
E
N
Site 15
S102
N
D
F
V
G
G
R
S
P
V
P
K
T
Y
D
Site 16
T107
G
R
S
P
V
P
K
T
Y
D
M
L
K
A
G
Site 17
Y108
R
S
P
V
P
K
T
Y
D
M
L
K
A
G
T
Site 18
T118
L
K
A
G
T
T
A
T
Y
E
G
R
W
G
R
Site 19
Y119
K
A
G
T
T
A
T
Y
E
G
R
W
G
R
G
Site 20
T127
E
G
R
W
G
R
G
T
A
Q
Y
S
S
Q
K
Site 21
Y130
W
G
R
G
T
A
Q
Y
S
S
Q
K
S
V
E
Site 22
S131
G
R
G
T
A
Q
Y
S
S
Q
K
S
V
E
E
Site 23
S132
R
G
T
A
Q
Y
S
S
Q
K
S
V
E
E
R
Site 24
S135
A
Q
Y
S
S
Q
K
S
V
E
E
R
S
L
R
Site 25
S140
Q
K
S
V
E
E
R
S
L
R
H
P
L
R
R
Site 26
S151
P
L
R
R
L
E
I
S
P
D
S
S
P
E
R
Site 27
S154
R
L
E
I
S
P
D
S
S
P
E
R
A
H
Y
Site 28
S155
L
E
I
S
P
D
S
S
P
E
R
A
H
Y
T
Site 29
Y161
S
S
P
E
R
A
H
Y
T
H
S
D
Y
Q
Y
Site 30
T162
S
P
E
R
A
H
Y
T
H
S
D
Y
Q
Y
S
Site 31
S164
E
R
A
H
Y
T
H
S
D
Y
Q
Y
S
Q
R
Site 32
Y166
A
H
Y
T
H
S
D
Y
Q
Y
S
Q
R
S
Q
Site 33
Y168
Y
T
H
S
D
Y
Q
Y
S
Q
R
S
Q
A
G
Site 34
S169
T
H
S
D
Y
Q
Y
S
Q
R
S
Q
A
G
H
Site 35
S172
D
Y
Q
Y
S
Q
R
S
Q
A
G
H
T
L
H
Site 36
S183
H
T
L
H
H
Q
E
S
R
R
A
A
L
L
V
Site 37
Y194
A
L
L
V
P
P
R
Y
A
R
S
E
I
V
G
Site 38
S197
V
P
P
R
Y
A
R
S
E
I
V
G
V
S
R
Site 39
S203
R
S
E
I
V
G
V
S
R
A
G
T
T
S
R
Site 40
T207
V
G
V
S
R
A
G
T
T
S
R
Q
R
H
F
Site 41
T208
G
V
S
R
A
G
T
T
S
R
Q
R
H
F
D
Site 42
S209
V
S
R
A
G
T
T
S
R
Q
R
H
F
D
T
Site 43
T216
S
R
Q
R
H
F
D
T
Y
H
R
Q
Y
Q
H
Site 44
Y217
R
Q
R
H
F
D
T
Y
H
R
Q
Y
Q
H
G
Site 45
Y221
F
D
T
Y
H
R
Q
Y
Q
H
G
S
V
S
D
Site 46
S225
H
R
Q
Y
Q
H
G
S
V
S
D
T
V
F
D
Site 47
S227
Q
Y
Q
H
G
S
V
S
D
T
V
F
D
S
I
Site 48
T229
Q
H
G
S
V
S
D
T
V
F
D
S
I
P
A
Site 49
T242
P
A
N
P
A
L
L
T
Y
P
R
P
G
T
S
Site 50
Y243
A
N
P
A
L
L
T
Y
P
R
P
G
T
S
R
Site 51
T248
L
T
Y
P
R
P
G
T
S
R
S
M
G
N
L
Site 52
S249
T
Y
P
R
P
G
T
S
R
S
M
G
N
L
L
Site 53
S251
P
R
P
G
T
S
R
S
M
G
N
L
L
E
K
Site 54
Y261
N
L
L
E
K
E
N
Y
L
T
A
G
L
T
V
Site 55
T263
L
E
K
E
N
Y
L
T
A
G
L
T
V
G
Q
Site 56
T267
N
Y
L
T
A
G
L
T
V
G
Q
V
R
P
L
Site 57
T281
L
V
P
L
Q
P
V
T
Q
N
R
A
S
R
S
Site 58
S286
P
V
T
Q
N
R
A
S
R
S
S
W
H
Q
S
Site 59
S288
T
Q
N
R
A
S
R
S
S
W
H
Q
S
S
F
Site 60
S289
Q
N
R
A
S
R
S
S
W
H
Q
S
S
F
H
Site 61
S293
S
R
S
S
W
H
Q
S
S
F
H
S
T
R
T
Site 62
S294
R
S
S
W
H
Q
S
S
F
H
S
T
R
T
L
Site 63
S297
W
H
Q
S
S
F
H
S
T
R
T
L
R
E
A
Site 64
T298
H
Q
S
S
F
H
S
T
R
T
L
R
E
A
G
Site 65
T300
S
S
F
H
S
T
R
T
L
R
E
A
G
P
S
Site 66
S307
T
L
R
E
A
G
P
S
V
A
V
D
S
S
G
Site 67
S312
G
P
S
V
A
V
D
S
S
G
R
R
A
H
L
Site 68
S313
P
S
V
A
V
D
S
S
G
R
R
A
H
L
T
Site 69
T320
S
G
R
R
A
H
L
T
V
G
Q
A
A
A
G
Site 70
S329
G
Q
A
A
A
G
G
S
G
N
L
L
T
E
R
Site 71
T334
G
G
S
G
N
L
L
T
E
R
S
T
F
T
D
Site 72
S337
G
N
L
L
T
E
R
S
T
F
T
D
S
Q
L
Site 73
T338
N
L
L
T
E
R
S
T
F
T
D
S
Q
L
G
Site 74
S342
E
R
S
T
F
T
D
S
Q
L
G
N
A
D
M
Site 75
S368
E
A
D
H
M
P
P
S
R
I
S
A
A
A
T
Site 76
T462
K
K
Q
I
T
D
H
T
V
N
L
R
S
R
N
Site 77
S467
D
H
T
V
N
L
R
S
R
N
G
W
P
G
A
Site 78
S482
V
A
H
A
C
N
P
S
T
L
G
G
Q
G
G
Site 79
T483
A
H
A
C
N
P
S
T
L
G
G
Q
G
G
R
Site 80
T492
G
G
Q
G
G
R
I
T
R
S
G
V
R
D
Q
Site 81
S494
Q
G
G
R
I
T
R
S
G
V
R
D
Q
P
D
Site 82
S510
H
G
L
L
W
N
L
S
S
N
D
K
L
K
N
Site 83
S511
G
L
L
W
N
L
S
S
N
D
K
L
K
N
L
Site 84
Y543
S
G
W
P
E
G
D
Y
P
K
A
N
G
L
L
Site 85
S566
T
G
C
L
R
N
M
S
S
A
G
A
D
G
R
Site 86
S567
G
C
L
R
N
M
S
S
A
G
A
D
G
R
K
Site 87
S585
R
C
D
G
L
I
D
S
L
V
H
Y
V
R
G
Site 88
T593
L
V
H
Y
V
R
G
T
I
A
D
Y
Q
P
D
Site 89
Y597
V
R
G
T
I
A
D
Y
Q
P
D
D
K
A
T
Site 90
Y616
C
I
L
H
N
L
S
Y
Q
L
E
A
E
L
P
Site 91
Y626
E
A
E
L
P
E
K
Y
S
Q
N
I
Y
I
Q
Site 92
S627
A
E
L
P
E
K
Y
S
Q
N
I
Y
I
Q
N
Site 93
Y631
E
K
Y
S
Q
N
I
Y
I
Q
N
R
N
I
Q
Site 94
S650
K
S
I
G
C
F
G
S
R
S
R
K
V
K
E
Site 95
S652
I
G
C
F
G
S
R
S
R
K
V
K
E
Q
Y
Site 96
Y659
S
R
K
V
K
E
Q
Y
Q
D
V
P
M
P
E
Site 97
S669
V
P
M
P
E
E
K
S
N
P
K
G
V
E
W
Site 98
Y686
H
S
I
V
I
R
M
Y
L
S
L
I
A
K
S
Site 99
S693
Y
L
S
L
I
A
K
S
V
R
N
Y
T
Q
E
Site 100
Y697
I
A
K
S
V
R
N
Y
T
Q
E
A
S
L
G
Site 101
T698
A
K
S
V
R
N
Y
T
Q
E
A
S
L
G
A
Site 102
S713
L
Q
N
L
T
A
G
S
G
P
M
P
T
S
V
Site 103
T723
M
P
T
S
V
A
Q
T
V
V
Q
K
E
S
G
Site 104
S744
M
L
H
V
G
D
P
S
V
K
K
T
A
I
S
Site 105
T748
G
D
P
S
V
K
K
T
A
I
S
L
L
R
N
Site 106
S751
S
V
K
K
T
A
I
S
L
L
R
N
L
S
R
Site 107
S757
I
S
L
L
R
N
L
S
R
N
L
S
L
Q
N
Site 108
S761
R
N
L
S
R
N
L
S
L
Q
N
E
I
A
K
Site 109
T798
T
T
A
S
A
C
Y
T
L
N
N
I
I
Q
N
Site 110
T816
N
A
R
D
L
L
N
T
G
G
I
Q
K
I
M
Site 111
Y831
A
I
S
A
G
D
A
Y
A
S
N
K
A
S
K
Site 112
S833
S
A
G
D
A
Y
A
S
N
K
A
S
K
A
A
Site 113
Y845
K
A
A
S
V
L
L
Y
S
L
W
A
H
T
E
Site 114
T865
K
K
A
Q
F
K
K
T
D
F
V
N
S
R
T
Site 115
S870
K
K
T
D
F
V
N
S
R
T
A
K
A
Y
H
Site 116
Y876
N
S
R
T
A
K
A
Y
H
S
L
K
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation