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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FOXC2
Full Name:
Forkhead box protein C2
Alias:
Fkhl14; Forkhead box C2; Forkhead box protein C2: Forkhead-related protein FKHL14: Transcription factor FKH-14: Mesenchyme fork head protein 1; Forkhead-related protein FKHL14; Foxc2; Mesenchyme fork head protein 1; Mfh1; MFH-1; MFH-1 protein; MFH-1, mesenchyme forkhead 1; Transcription factor FKH-14
Type:
Apoptosis; Cell development/differentiation; Transcription factor
Mass (Da):
53719
Number AA:
501
UniProt ID:
Q99958
International Prot ID:
IPI00019155
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0031490
GO:0043565
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0008286
GO:0001946
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
Q
A
R
Y
S
V
S
D
P
N
A
L
Site 2
S8
M
Q
A
R
Y
S
V
S
D
P
N
A
L
G
V
Site 3
Y18
N
A
L
G
V
V
P
Y
L
S
E
Q
N
Y
Y
Site 4
Y24
P
Y
L
S
E
Q
N
Y
Y
R
A
A
G
S
Y
Site 5
Y25
Y
L
S
E
Q
N
Y
Y
R
A
A
G
S
Y
G
Site 6
S30
N
Y
Y
R
A
A
G
S
Y
G
G
M
A
S
P
Site 7
Y31
Y
Y
R
A
A
G
S
Y
G
G
M
A
S
P
M
Site 8
S36
G
S
Y
G
G
M
A
S
P
M
G
V
Y
S
G
Site 9
S42
A
S
P
M
G
V
Y
S
G
H
P
E
Q
Y
S
Site 10
S49
S
G
H
P
E
Q
Y
S
A
G
M
G
R
S
Y
Site 11
Y56
S
A
G
M
G
R
S
Y
A
P
Y
H
H
H
Q
Site 12
Y59
M
G
R
S
Y
A
P
Y
H
H
H
Q
P
A
A
Site 13
T94
N
A
P
E
K
K
I
T
L
N
G
I
Y
Q
F
Site 14
Y109
I
M
D
R
F
P
F
Y
R
E
N
K
Q
G
W
Site 15
S125
N
S
I
R
H
N
L
S
L
N
E
C
F
V
K
Site 16
T147
P
G
K
G
S
Y
W
T
L
D
P
D
S
Y
N
Site 17
Y153
W
T
L
D
P
D
S
Y
N
M
F
E
N
G
S
Site 18
S160
Y
N
M
F
E
N
G
S
F
L
R
R
R
R
R
Site 19
S174
R
F
K
K
K
D
V
S
K
E
K
E
E
R
A
Site 20
T197
A
S
K
G
A
P
A
T
P
H
L
A
D
A
P
Site 21
S215
E
K
K
V
V
I
K
S
E
A
A
S
P
A
L
Site 22
S219
V
I
K
S
E
A
A
S
P
A
L
P
V
I
T
Site 23
T226
S
P
A
L
P
V
I
T
K
V
E
T
L
S
P
Site 24
T230
P
V
I
T
K
V
E
T
L
S
P
E
S
A
L
Site 25
S232
I
T
K
V
E
T
L
S
P
E
S
A
L
Q
G
Site 26
S235
V
E
T
L
S
P
E
S
A
L
Q
G
S
P
R
Site 27
S240
P
E
S
A
L
Q
G
S
P
R
S
A
A
S
T
Site 28
S243
A
L
Q
G
S
P
R
S
A
A
S
T
P
A
G
Site 29
S246
G
S
P
R
S
A
A
S
T
P
A
G
S
P
D
Site 30
T247
S
P
R
S
A
A
S
T
P
A
G
S
P
D
G
Site 31
S251
A
A
S
T
P
A
G
S
P
D
G
S
L
P
E
Site 32
S255
P
A
G
S
P
D
G
S
L
P
E
H
H
A
A
Site 33
T277
F
S
V
E
N
I
M
T
L
R
T
S
P
P
G
Site 34
T280
E
N
I
M
T
L
R
T
S
P
P
G
G
E
L
Site 35
S281
N
I
M
T
L
R
T
S
P
P
G
G
E
L
S
Site 36
S288
S
P
P
G
G
E
L
S
P
G
A
G
R
A
G
Site 37
Y313
A
A
A
P
P
A
A
Y
G
Q
P
C
A
Q
G
Site 38
Y329
E
A
G
A
A
G
G
Y
Q
C
S
M
R
A
M
Site 39
S337
Q
C
S
M
R
A
M
S
L
Y
T
G
A
E
R
Site 40
Y339
S
M
R
A
M
S
L
Y
T
G
A
E
R
P
A
Site 41
S359
P
A
L
D
E
A
L
S
D
H
P
S
G
P
T
Site 42
S363
E
A
L
S
D
H
P
S
G
P
T
S
P
L
S
Site 43
S367
D
H
P
S
G
P
T
S
P
L
S
A
L
N
L
Site 44
T411
P
A
P
Q
P
Q
P
T
P
Q
P
G
A
A
A
Site 45
Y425
A
A
Q
A
A
S
W
Y
L
N
H
S
G
D
L
Site 46
T446
T
F
A
A
Q
Q
Q
T
F
P
N
V
R
E
M
Site 47
S464
H
R
L
G
I
E
N
S
T
L
G
E
S
Q
V
Site 48
T465
R
L
G
I
E
N
S
T
L
G
E
S
Q
V
S
Site 49
S469
E
N
S
T
L
G
E
S
Q
V
S
G
N
A
S
Site 50
S472
T
L
G
E
S
Q
V
S
G
N
A
S
C
Q
L
Site 51
S476
S
Q
V
S
G
N
A
S
C
Q
L
P
Y
R
S
Site 52
S483
S
C
Q
L
P
Y
R
S
T
P
P
L
Y
R
H
Site 53
T484
C
Q
L
P
Y
R
S
T
P
P
L
Y
R
H
A
Site 54
Y488
Y
R
S
T
P
P
L
Y
R
H
A
A
P
Y
S
Site 55
Y494
L
Y
R
H
A
A
P
Y
S
Y
D
C
T
K
Y
Site 56
Y496
R
H
A
A
P
Y
S
Y
D
C
T
K
Y
_
_
Site 57
T499
A
P
Y
S
Y
D
C
T
K
Y
_
_
_
_
_
Site 58
Y501
Y
S
Y
D
C
T
K
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation