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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BDP1
Full Name:
Tyrosine-protein phosphatase non-receptor type 18
Alias:
Brain-derived phosphatase; EC 3.1.3.48; Fetal liver phosphatase 1; FLP1; HSCF; Protein tyrosine phosphatase 20; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Protein-tyrosine phosphatase 18; Protein-tyrosine phosphatase, non-receptor type 18; PTN18; PTNI; PTP 49; PTP HSCF; PTP20; PTPK1; PTP-K1; PTPN18
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
50482
Number AA:
460
UniProt ID:
Q99952
International Prot ID:
IPI00219132
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004726
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
R
S
L
D
S
A
R
S
F
L
E
R
Site 2
S10
R
S
L
D
S
A
R
S
F
L
E
R
L
E
A
Site 3
S47
W
K
A
D
G
V
C
S
T
V
A
G
S
R
P
Site 4
T48
K
A
D
G
V
C
S
T
V
A
G
S
R
P
E
Site 5
Y62
E
N
V
R
K
N
R
Y
K
D
V
L
P
Y
D
Site 6
S76
D
Q
T
R
V
I
L
S
L
L
Q
E
E
G
H
Site 7
S84
L
L
Q
E
E
G
H
S
D
Y
I
N
G
N
F
Site 8
Y86
Q
E
E
G
H
S
D
Y
I
N
G
N
F
I
R
Site 9
T111
T
Q
G
P
L
P
H
T
L
L
D
F
W
R
L
Site 10
T179
M
L
R
T
L
K
V
T
F
Q
K
E
S
R
S
Site 11
S186
T
F
Q
K
E
S
R
S
V
Y
Q
L
Q
Y
M
Site 12
Y188
Q
K
E
S
R
S
V
Y
Q
L
Q
Y
M
S
W
Site 13
Y192
R
S
V
Y
Q
L
Q
Y
M
S
W
P
D
R
G
Site 14
S202
W
P
D
R
G
V
P
S
S
P
D
H
M
L
A
Site 15
S203
P
D
R
G
V
P
S
S
P
D
H
M
L
A
M
Site 16
S220
E
A
R
R
L
Q
G
S
G
P
E
P
L
C
V
Site 17
Y281
A
V
Q
T
E
E
Q
Y
R
F
L
Y
H
T
V
Site 18
Y285
E
E
Q
Y
R
F
L
Y
H
T
V
A
Q
M
F
Site 19
S300
C
S
T
L
Q
N
A
S
P
H
Y
Q
N
I
K
Site 20
Y303
L
Q
N
A
S
P
H
Y
Q
N
I
K
E
N
C
Site 21
Y314
K
E
N
C
A
P
L
Y
D
D
A
L
F
L
R
Site 22
T322
D
D
A
L
F
L
R
T
P
Q
A
L
L
A
I
Site 23
S339
P
P
G
G
V
L
R
S
I
S
V
P
G
S
P
Site 24
S341
G
G
V
L
R
S
I
S
V
P
G
S
P
G
H
Site 25
S345
R
S
I
S
V
P
G
S
P
G
H
A
M
A
D
Site 26
T353
P
G
H
A
M
A
D
T
Y
A
V
V
Q
K
R
Site 27
Y354
G
H
A
M
A
D
T
Y
A
V
V
Q
K
R
G
Site 28
S368
G
A
P
A
G
A
G
S
G
T
Q
T
G
T
G
Site 29
T370
P
A
G
A
G
S
G
T
Q
T
G
T
G
T
G
Site 30
T372
G
A
G
S
G
T
Q
T
G
T
G
T
G
T
G
Site 31
T374
G
S
G
T
Q
T
G
T
G
T
G
T
G
A
R
Site 32
T376
G
T
Q
T
G
T
G
T
G
T
G
A
R
S
A
Site 33
T378
Q
T
G
T
G
T
G
T
G
A
R
S
A
E
E
Site 34
S382
G
T
G
T
G
A
R
S
A
E
E
A
P
L
Y
Site 35
Y389
S
A
E
E
A
P
L
Y
S
K
V
T
P
R
A
Site 36
T393
A
P
L
Y
S
K
V
T
P
R
A
Q
R
P
G
Site 37
T409
H
A
E
D
A
R
G
T
L
P
G
R
V
P
A
Site 38
S419
G
R
V
P
A
D
Q
S
P
A
G
S
G
A
Y
Site 39
S423
A
D
Q
S
P
A
G
S
G
A
Y
E
D
V
A
Site 40
Y426
S
P
A
G
S
G
A
Y
E
D
V
A
G
G
A
Site 41
T435
D
V
A
G
G
A
Q
T
G
G
L
G
F
N
L
Site 42
T458
R
D
P
P
A
E
W
T
R
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation