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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMO
Full Name:
Smoothened homolog
Alias:
Gx; Gx protein; SMOH; Smoothened; Smoothened homolog (Drosophila)
Type:
Receptor, GPCR
Mass (Da):
86378
Number AA:
787
UniProt ID:
Q99835
International Prot ID:
IPI00018471
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0004926
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
D
P
G
R
G
A
A
S
S
G
N
A
T
G
P
Site 2
S33
P
G
R
G
A
A
S
S
G
N
A
T
G
P
G
Site 3
T37
A
A
S
S
G
N
A
T
G
P
G
P
R
S
A
Site 4
S43
A
T
G
P
G
P
R
S
A
G
G
S
A
R
R
Site 5
S47
G
P
R
S
A
G
G
S
A
R
R
S
A
A
V
Site 6
S51
A
G
G
S
A
R
R
S
A
A
V
T
G
P
P
Site 7
T55
A
R
R
S
A
A
V
T
G
P
P
P
P
L
S
Site 8
S62
T
G
P
P
P
P
L
S
H
C
G
R
A
A
P
Site 9
S96
S
T
L
L
A
G
D
S
D
S
Q
E
E
A
H
Site 10
S98
L
L
A
G
D
S
D
S
Q
E
E
A
H
G
K
Site 11
S110
H
G
K
L
V
L
W
S
G
L
R
N
A
P
R
Site 12
Y130
Q
P
L
L
C
A
V
Y
M
P
K
C
E
N
D
Site 13
S143
N
D
R
V
E
L
P
S
R
T
L
C
Q
A
T
Site 14
T145
R
V
E
L
P
S
R
T
L
C
Q
A
T
R
G
Site 15
T170
W
P
D
F
L
R
C
T
P
D
R
F
P
E
G
Site 16
T200
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
Site 17
S205
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
Site 18
Y207
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
Site 19
Y233
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
Site 20
Y262
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
Site 21
T300
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
Site 22
T307
T
M
R
L
G
E
P
T
S
N
E
T
L
S
C
Site 23
S308
M
R
L
G
E
P
T
S
N
E
T
L
S
C
V
Site 24
T349
S
F
K
A
L
G
T
T
Y
Q
P
L
S
G
K
Site 25
Y350
F
K
A
L
G
T
T
Y
Q
P
L
S
G
K
T
Site 26
S354
G
T
T
Y
Q
P
L
S
G
K
T
S
Y
F
H
Site 27
S358
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
Site 28
Y359
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
Site 29
Y394
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
Site 30
Y397
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
Site 31
Y399
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
Site 32
S428
R
G
V
M
T
L
F
S
I
K
S
N
H
P
G
Site 33
S438
S
N
H
P
G
L
L
S
E
K
A
A
S
K
I
Site 34
Y487
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
Site 35
S514
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
Site 36
T553
R
R
T
W
C
R
L
T
G
Q
S
D
D
E
P
Site 37
S556
W
C
R
L
T
G
Q
S
D
D
E
P
K
R
I
Site 38
S566
E
P
K
R
I
K
K
S
K
M
I
A
K
A
F
Site 39
S574
K
M
I
A
K
A
F
S
K
R
H
E
L
L
Q
Site 40
S588
Q
N
P
G
Q
E
L
S
F
S
M
H
T
V
S
Site 41
S590
P
G
Q
E
L
S
F
S
M
H
T
V
S
H
D
Site 42
T593
E
L
S
F
S
M
H
T
V
S
H
D
G
P
V
Site 43
S595
S
F
S
M
H
T
V
S
H
D
G
P
V
A
G
Site 44
S611
A
F
D
L
N
E
P
S
A
D
V
S
S
A
W
Site 45
S615
N
E
P
S
A
D
V
S
S
A
W
A
Q
H
V
Site 46
T644
I
S
V
T
P
V
A
T
P
V
P
P
E
E
Q
Site 47
S662
W
L
V
E
A
E
I
S
P
E
L
Q
K
R
L
Site 48
S699
H
P
P
A
P
A
P
S
T
I
P
R
L
P
Q
Site 49
T700
P
P
A
P
A
P
S
T
I
P
R
L
P
Q
L
Site 50
T731
S
C
R
Q
G
A
W
T
L
V
S
N
P
F
C
Site 51
S742
N
P
F
C
P
E
P
S
P
P
Q
D
P
F
L
Site 52
S751
P
Q
D
P
F
L
P
S
A
P
A
P
V
A
W
Site 53
S771
Q
G
L
G
P
I
H
S
R
T
N
L
M
D
T
Site 54
S785
T
E
L
M
D
A
D
S
D
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation