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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCA3
Full Name:
ATP-binding cassette sub-family A member 3
Alias:
ABC transporter 3; ABC3; ABC-C; ABC-C transporter; ATP-binding cassette 3; ATP-binding cassette, sub-family A (ABC1) member 3; EST111653; LBM180
Type:
Transporter
Mass (Da):
191362
Number AA:
1704
UniProt ID:
Q99758
International Prot ID:
IPI00017800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0042599
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
PhosphoSite+
KinaseNET
Biological Process:
GO:0042493
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
W
L
R
L
K
I
Q
S
E
N
V
P
N
A
T
Site 2
T55
S
E
N
V
P
N
A
T
I
Y
P
G
Q
S
I
Site 3
Y57
N
V
P
N
A
T
I
Y
P
G
Q
S
I
Q
E
Site 4
T70
Q
E
L
P
L
F
F
T
F
P
P
P
G
D
T
Site 5
S85
W
E
L
A
Y
I
P
S
H
S
D
A
A
K
T
Site 6
S87
L
A
Y
I
P
S
H
S
D
A
A
K
T
V
T
Site 7
T92
S
H
S
D
A
A
K
T
V
T
E
T
V
R
R
Site 8
S112
M
R
V
R
G
F
P
S
E
K
D
F
E
D
Y
Site 9
Y119
S
E
K
D
F
E
D
Y
I
R
Y
D
N
C
S
Site 10
Y122
D
F
E
D
Y
I
R
Y
D
N
C
S
S
S
V
Site 11
S142
F
E
H
P
F
N
H
S
K
E
P
L
P
L
A
Site 12
Y152
P
L
P
L
A
V
K
Y
H
L
R
F
S
Y
T
Site 13
Y163
F
S
Y
T
R
R
N
Y
M
W
T
Q
T
G
S
Site 14
T181
K
E
T
E
G
W
H
T
T
S
L
F
P
L
F
Site 15
S183
T
E
G
W
H
T
T
S
L
F
P
L
F
P
N
Site 16
T197
N
P
G
P
R
E
P
T
S
P
D
G
G
E
P
Site 17
S198
P
G
P
R
E
P
T
S
P
D
G
G
E
P
G
Site 18
Y206
P
D
G
G
E
P
G
Y
I
R
E
G
F
L
A
Site 19
Y225
V
D
R
A
I
M
E
Y
H
A
D
A
A
T
R
Site 20
T239
R
Q
L
F
Q
R
L
T
V
T
I
K
R
F
P
Site 21
T241
L
F
Q
R
L
T
V
T
I
K
R
F
P
Y
P
Site 22
Y247
V
T
I
K
R
F
P
Y
P
P
F
I
A
D
P
Site 23
Y293
K
E
R
R
L
K
E
Y
M
R
M
M
G
L
S
Site 24
S339
K
P
N
V
A
V
L
S
R
S
D
P
S
L
V
Site 25
T385
G
G
F
L
Y
F
F
T
Y
I
P
Y
F
F
V
Site 26
S439
I
Q
W
R
D
L
L
S
P
V
N
V
D
D
D
Site 27
S508
A
G
K
E
E
E
D
S
D
P
E
K
A
L
R
Site 28
Y518
E
K
A
L
R
N
E
Y
F
E
A
E
P
E
D
Site 29
S536
G
I
K
I
K
H
L
S
K
V
F
R
V
G
N
Site 30
Y557
R
D
L
N
L
N
L
Y
E
G
Q
I
T
V
L
Site 31
T562
N
L
Y
E
G
Q
I
T
V
L
L
G
H
N
G
Site 32
T573
G
H
N
G
A
G
K
T
T
T
L
S
M
L
T
Site 33
T575
N
G
A
G
K
T
T
T
L
S
M
L
T
G
L
Site 34
T586
L
T
G
L
F
P
P
T
S
G
R
A
Y
I
S
Site 35
S587
T
G
L
F
P
P
T
S
G
R
A
Y
I
S
G
Site 36
Y591
P
P
T
S
G
R
A
Y
I
S
G
Y
E
I
S
Site 37
Y595
G
R
A
Y
I
S
G
Y
E
I
S
Q
D
M
V
Site 38
S607
D
M
V
Q
I
R
K
S
L
G
L
C
P
Q
H
Site 39
S660
G
L
E
D
K
W
N
S
R
S
R
F
L
S
G
Site 40
S662
E
D
K
W
N
S
R
S
R
F
L
S
G
G
M
Site 41
S666
N
S
R
S
R
F
L
S
G
G
M
R
R
K
L
Site 42
S693
L
I
L
D
E
P
T
S
G
M
D
A
I
S
R
Site 43
S699
T
S
G
M
D
A
I
S
R
R
A
I
W
D
L
Site 44
S712
D
L
L
Q
R
Q
K
S
D
R
T
I
V
L
T
Site 45
T715
Q
R
Q
K
S
D
R
T
I
V
L
T
T
H
F
Site 46
T719
S
D
R
T
I
V
L
T
T
H
F
M
D
E
A
Site 47
S746
G
E
L
Q
C
C
G
S
S
L
F
L
K
Q
K
Site 48
S747
E
L
Q
C
C
G
S
S
L
F
L
K
Q
K
Y
Site 49
Y754
S
L
F
L
K
Q
K
Y
G
A
G
Y
H
M
T
Site 50
T761
Y
G
A
G
Y
H
M
T
L
V
K
E
P
H
C
Site 51
T785
H
H
H
V
P
N
A
T
L
E
S
S
A
G
A
Site 52
S789
P
N
A
T
L
E
S
S
A
G
A
E
L
S
F
Site 53
S795
S
S
A
G
A
E
L
S
F
I
L
P
R
E
S
Site 54
S802
S
F
I
L
P
R
E
S
T
H
R
F
E
G
L
Site 55
T803
F
I
L
P
R
E
S
T
H
R
F
E
G
L
F
Site 56
S866
Y
Q
H
E
R
R
A
S
D
W
A
V
D
S
N
Site 57
T893
A
L
I
E
E
E
R
T
A
V
K
L
N
T
G
Site 58
T959
D
D
P
M
L
R
L
T
L
G
E
Y
G
R
T
Site 59
T975
V
P
F
S
V
P
G
T
S
Q
L
G
Q
Q
L
Site 60
S976
P
F
S
V
P
G
T
S
Q
L
G
Q
Q
L
S
Site 61
S983
S
Q
L
G
Q
Q
L
S
E
H
L
K
D
A
L
Site 62
S1028
E
R
C
L
V
A
A
S
F
R
D
V
G
E
R
Site 63
T1036
F
R
D
V
G
E
R
T
V
V
N
A
L
F
N
Site 64
Y1047
A
L
F
N
N
Q
A
Y
H
S
P
A
T
A
L
Site 65
S1049
F
N
N
Q
A
Y
H
S
P
A
T
A
L
A
V
Site 66
S1075
P
H
A
S
I
V
V
S
N
F
P
Q
P
R
S
Site 67
S1082
S
N
F
P
Q
P
R
S
A
L
Q
A
A
K
D
Site 68
T1173
A
F
D
V
R
A
F
T
R
D
G
H
M
A
D
Site 69
Y1265
G
M
A
V
S
S
F
Y
E
N
Y
E
T
R
R
Site 70
Y1268
V
S
S
F
Y
E
N
Y
E
T
R
R
Y
C
T
Site 71
Y1273
E
N
Y
E
T
R
R
Y
C
T
S
S
E
V
A
Site 72
T1275
Y
E
T
R
R
Y
C
T
S
S
E
V
A
A
H
Site 73
S1276
E
T
R
R
Y
C
T
S
S
E
V
A
A
H
Y
Site 74
Y1283
S
S
E
V
A
A
H
Y
C
K
K
Y
N
I
Q
Site 75
Y1287
A
A
H
Y
C
K
K
Y
N
I
Q
Y
Q
E
N
Site 76
Y1296
I
Q
Y
Q
E
N
F
Y
A
W
S
A
P
G
V
Site 77
T1344
C
A
L
R
R
R
R
T
L
T
E
L
Y
T
R
Site 78
T1346
L
R
R
R
R
T
L
T
E
L
Y
T
R
M
P
Site 79
Y1349
R
R
T
L
T
E
L
Y
T
R
M
P
V
L
P
Site 80
T1350
R
T
L
T
E
L
Y
T
R
M
P
V
L
P
E
Site 81
S1372
R
T
R
I
L
A
P
S
P
D
S
L
L
H
T
Site 82
T1425
N
G
A
G
K
T
T
T
F
K
M
L
T
G
E
Site 83
T1430
T
T
T
F
K
M
L
T
G
E
E
S
L
T
S
Site 84
S1434
K
M
L
T
G
E
E
S
L
T
S
G
D
A
F
Site 85
T1436
L
T
G
E
E
S
L
T
S
G
D
A
F
V
G
Site 86
S1437
T
G
E
E
S
L
T
S
G
D
A
F
V
G
G
Site 87
S1448
F
V
G
G
H
R
I
S
S
D
V
G
K
V
R
Site 88
S1449
V
G
G
H
R
I
S
S
D
V
G
K
V
R
Q
Site 89
Y1460
K
V
R
Q
R
I
G
Y
C
P
Q
F
D
A
L
Site 90
Y1480
G
R
E
M
L
V
M
Y
A
R
L
R
G
I
P
Site 91
T1514
H
A
N
K
L
V
R
T
Y
S
G
G
N
K
R
Site 92
Y1515
A
N
K
L
V
R
T
Y
S
G
G
N
K
R
K
Site 93
S1516
N
K
L
V
R
T
Y
S
G
G
N
K
R
K
L
Site 94
S1524
G
G
N
K
R
K
L
S
T
G
I
A
L
I
G
Site 95
T1556
A
R
R
L
L
W
D
T
V
A
R
A
R
E
S
Site 96
S1571
G
K
A
I
I
I
T
S
H
S
M
E
E
C
E
Site 97
S1597
G
Q
F
K
C
L
G
S
P
Q
H
L
K
S
K
Site 98
S1603
G
S
P
Q
H
L
K
S
K
F
G
S
G
Y
S
Site 99
S1607
H
L
K
S
K
F
G
S
G
Y
S
L
R
A
K
Site 100
S1610
S
K
F
G
S
G
Y
S
L
R
A
K
V
Q
S
Site 101
S1617
S
L
R
A
K
V
Q
S
E
G
Q
Q
E
A
L
Site 102
S1638
V
D
L
T
F
P
G
S
V
L
E
D
E
H
Q
Site 103
Y1650
E
H
Q
G
M
V
H
Y
H
L
P
G
R
D
L
Site 104
Y1673
L
E
K
A
K
E
K
Y
G
V
D
D
Y
S
V
Site 105
Y1678
E
K
Y
G
V
D
D
Y
S
V
S
Q
I
S
L
Site 106
S1679
K
Y
G
V
D
D
Y
S
V
S
Q
I
S
L
E
Site 107
S1681
G
V
D
D
Y
S
V
S
Q
I
S
L
E
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation