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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBX5
Full Name:
T-box transcription factor TBX5
Alias:
HOS; T-box 5; T-box protein 5
Type:
Transcription factor
Mass (Da):
57711
Number AA:
518
UniProt ID:
Q99593
International Prot ID:
IPI00216449
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0035117
GO:0006917
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
E
G
F
G
L
A
H
T
P
L
E
P
D
A
K
Site 2
S26
A
K
D
L
P
C
D
S
K
P
E
S
A
L
G
Site 3
S30
P
C
D
S
K
P
E
S
A
L
G
A
P
S
K
Site 4
S36
E
S
A
L
G
A
P
S
K
S
P
S
S
P
Q
Site 5
S38
A
L
G
A
P
S
K
S
P
S
S
P
Q
A
A
Site 6
S40
G
A
P
S
K
S
P
S
S
P
Q
A
A
F
T
Site 7
S41
A
P
S
K
S
P
S
S
P
Q
A
A
F
T
Q
Site 8
S86
A
G
R
R
M
F
P
S
Y
K
V
K
V
T
G
Site 9
Y87
G
R
R
M
F
P
S
Y
K
V
K
V
T
G
L
Site 10
T92
P
S
Y
K
V
K
V
T
G
L
N
P
K
T
K
Site 11
Y100
G
L
N
P
K
T
K
Y
I
L
L
M
D
I
V
Site 12
Y114
V
P
A
D
D
H
R
Y
K
F
A
D
N
K
W
Site 13
S122
K
F
A
D
N
K
W
S
V
T
G
K
A
E
P
Site 14
Y136
P
A
M
P
G
R
L
Y
V
H
P
D
S
P
A
Site 15
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Site 16
T161
S
F
Q
K
L
K
L
T
N
N
H
L
D
P
F
Site 17
Y179
I
L
N
S
M
H
K
Y
Q
P
R
L
H
I
V
Site 18
Y217
A
F
I
A
V
T
S
Y
Q
N
H
K
I
T
Q
Site 19
S239
F
A
K
G
F
R
G
S
D
D
M
E
L
H
R
Site 20
S248
D
M
E
L
H
R
M
S
R
M
Q
S
K
E
Y
Site 21
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Site 22
Y255
S
R
M
Q
S
K
E
Y
P
V
V
P
R
S
T
Site 23
S261
E
Y
P
V
V
P
R
S
T
V
R
Q
K
V
A
Site 24
T262
Y
P
V
V
P
R
S
T
V
R
Q
K
V
A
S
Site 25
S269
T
V
R
Q
K
V
A
S
N
H
S
P
F
S
S
Site 26
S272
Q
K
V
A
S
N
H
S
P
F
S
S
E
S
R
Site 27
S275
A
S
N
H
S
P
F
S
S
E
S
R
A
L
S
Site 28
S276
S
N
H
S
P
F
S
S
E
S
R
A
L
S
T
Site 29
S278
H
S
P
F
S
S
E
S
R
A
L
S
T
S
S
Site 30
S282
S
S
E
S
R
A
L
S
T
S
S
N
L
G
S
Site 31
T283
S
E
S
R
A
L
S
T
S
S
N
L
G
S
Q
Site 32
S284
E
S
R
A
L
S
T
S
S
N
L
G
S
Q
Y
Site 33
S285
S
R
A
L
S
T
S
S
N
L
G
S
Q
Y
Q
Site 34
S289
S
T
S
S
N
L
G
S
Q
Y
Q
C
E
N
G
Site 35
Y291
S
S
N
L
G
S
Q
Y
Q
C
E
N
G
V
S
Site 36
S298
Y
Q
C
E
N
G
V
S
G
P
S
Q
D
L
L
Site 37
S301
E
N
G
V
S
G
P
S
Q
D
L
L
P
P
P
Site 38
Y311
L
L
P
P
P
N
P
Y
P
L
P
Q
E
H
S
Site 39
T324
H
S
Q
I
Y
H
C
T
K
R
K
E
E
E
C
Site 40
S332
K
R
K
E
E
E
C
S
T
T
D
H
P
Y
K
Site 41
T333
R
K
E
E
E
C
S
T
T
D
H
P
Y
K
K
Site 42
T334
K
E
E
E
C
S
T
T
D
H
P
Y
K
K
P
Site 43
Y338
C
S
T
T
D
H
P
Y
K
K
P
Y
M
E
T
Site 44
Y342
D
H
P
Y
K
K
P
Y
M
E
T
S
P
S
E
Site 45
S346
K
K
P
Y
M
E
T
S
P
S
E
E
D
S
F
Site 46
S348
P
Y
M
E
T
S
P
S
E
E
D
S
F
Y
R
Site 47
S352
T
S
P
S
E
E
D
S
F
Y
R
S
S
Y
P
Site 48
Y354
P
S
E
E
D
S
F
Y
R
S
S
Y
P
Q
Q
Site 49
S356
E
E
D
S
F
Y
R
S
S
Y
P
Q
Q
Q
G
Site 50
S357
E
D
S
F
Y
R
S
S
Y
P
Q
Q
Q
G
L
Site 51
Y358
D
S
F
Y
R
S
S
Y
P
Q
Q
Q
G
L
G
Site 52
S367
Q
Q
Q
G
L
G
A
S
Y
R
T
E
S
A
Q
Site 53
Y368
Q
Q
G
L
G
A
S
Y
R
T
E
S
A
Q
R
Site 54
S372
G
A
S
Y
R
T
E
S
A
Q
R
Q
A
C
M
Site 55
Y380
A
Q
R
Q
A
C
M
Y
A
S
S
A
P
P
S
Site 56
S383
Q
A
C
M
Y
A
S
S
A
P
P
S
E
P
V
Site 57
S387
Y
A
S
S
A
P
P
S
E
P
V
P
S
L
E
Site 58
S392
P
P
S
E
P
V
P
S
L
E
D
I
S
C
N
Site 59
T400
L
E
D
I
S
C
N
T
W
P
S
M
P
S
Y
Site 60
S406
N
T
W
P
S
M
P
S
Y
S
S
C
T
V
T
Site 61
Y407
T
W
P
S
M
P
S
Y
S
S
C
T
V
T
T
Site 62
S408
W
P
S
M
P
S
Y
S
S
C
T
V
T
T
V
Site 63
S409
P
S
M
P
S
Y
S
S
C
T
V
T
T
V
Q
Site 64
T413
S
Y
S
S
C
T
V
T
T
V
Q
P
M
D
R
Site 65
T414
Y
S
S
C
T
V
T
T
V
Q
P
M
D
R
L
Site 66
Y423
Q
P
M
D
R
L
P
Y
Q
H
F
S
A
H
F
Site 67
S427
R
L
P
Y
Q
H
F
S
A
H
F
T
S
G
P
Site 68
T431
Q
H
F
S
A
H
F
T
S
G
P
L
V
P
R
Site 69
S447
A
G
M
A
N
H
G
S
P
Q
L
G
E
G
M
Site 70
T474
V
R
Q
C
G
P
Q
T
G
L
Q
S
P
G
T
Site 71
S478
G
P
Q
T
G
L
Q
S
P
G
T
L
Q
P
P
Site 72
T481
T
G
L
Q
S
P
G
T
L
Q
P
P
E
F
L
Site 73
Y489
L
Q
P
P
E
F
L
Y
S
H
G
V
P
R
T
Site 74
S490
Q
P
P
E
F
L
Y
S
H
G
V
P
R
T
L
Site 75
T496
Y
S
H
G
V
P
R
T
L
S
P
H
Q
Y
H
Site 76
S498
H
G
V
P
R
T
L
S
P
H
Q
Y
H
S
V
Site 77
Y502
R
T
L
S
P
H
Q
Y
H
S
V
H
G
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation