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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POP1
Full Name:
Ribonucleases P/MRP protein subunit POP1
Alias:
HPOP1; KIAA0061; Processing of precursor 1, ribonuclease P/MRP subunit; Processing of precursors 1; Ribonucleases P/MRP protein subunit POP1
Type:
Ribonuclease; EC 3.1.26.5; RNA processing
Mass (Da):
114709
Number AA:
1024
UniProt ID:
Q99575
International Prot ID:
IPI00293331
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000172
GO:0005634
GO:0005655
Uniprot
OncoNet
Molecular Function:
GO:0000171
GO:0003824
GO:0004518
PhosphoSite+
KinaseNET
Biological Process:
GO:0001682
GO:0006139
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
K
K
M
R
N
Q
P
T
N
V
T
L
S
S
G
Site 2
T21
R
N
Q
P
T
N
V
T
L
S
S
G
F
V
A
Site 3
S36
D
R
G
V
K
H
H
S
G
G
E
K
P
F
Q
Site 4
T53
K
Q
E
P
H
P
G
T
S
R
Q
R
Q
T
R
Site 5
S54
Q
E
P
H
P
G
T
S
R
Q
R
Q
T
R
V
Site 6
T59
G
T
S
R
Q
R
Q
T
R
V
N
P
H
S
L
Site 7
S65
Q
T
R
V
N
P
H
S
L
P
D
P
E
V
N
Site 8
S77
E
V
N
E
Q
S
S
S
K
G
M
F
R
K
K
Site 9
S95
K
A
G
P
E
G
T
S
Q
E
I
P
K
Y
I
Site 10
Y101
T
S
Q
E
I
P
K
Y
I
T
A
S
T
F
A
Site 11
T106
P
K
Y
I
T
A
S
T
F
A
Q
A
R
A
A
Site 12
T123
S
A
M
L
K
A
V
T
Q
K
S
S
N
S
L
Site 13
S126
L
K
A
V
T
Q
K
S
S
N
S
L
V
F
Q
Site 14
S129
V
T
Q
K
S
S
N
S
L
V
F
Q
T
L
P
Site 15
T134
S
N
S
L
V
F
Q
T
L
P
R
H
M
R
R
Site 16
S145
H
M
R
R
R
A
M
S
H
N
V
K
R
L
P
Site 17
T204
K
K
N
I
W
L
E
T
H
I
W
H
A
K
R
Site 18
T227
Y
C
L
G
E
R
P
T
V
K
S
H
R
A
C
Site 19
S230
G
E
R
P
T
V
K
S
H
R
A
C
Y
R
A
Site 20
Y235
V
K
S
H
R
A
C
Y
R
A
M
T
N
R
C
Site 21
S291
L
S
G
K
R
Q
G
S
L
V
L
Y
R
V
N
Site 22
Y295
R
Q
G
S
L
V
L
Y
R
V
N
K
Y
P
R
Site 23
Y300
V
L
Y
R
V
N
K
Y
P
R
E
M
L
G
P
Site 24
T309
R
E
M
L
G
P
V
T
F
I
W
K
S
Q
R
Site 25
S314
P
V
T
F
I
W
K
S
Q
R
T
P
G
D
P
Site 26
T317
F
I
W
K
S
Q
R
T
P
G
D
P
S
E
S
Site 27
S322
Q
R
T
P
G
D
P
S
E
S
R
Q
L
W
I
Site 28
S355
Q
C
V
E
P
I
K
S
A
V
C
I
A
D
P
Site 29
T365
C
I
A
D
P
L
P
T
P
S
Q
E
K
S
Q
Site 30
S367
A
D
P
L
P
T
P
S
Q
E
K
S
Q
T
E
Site 31
S371
P
T
P
S
Q
E
K
S
Q
T
E
L
P
D
E
Site 32
T373
P
S
Q
E
K
S
Q
T
E
L
P
D
E
K
I
Site 33
T404
K
K
I
I
G
D
G
T
R
D
P
C
L
P
Y
Site 34
Y411
T
R
D
P
C
L
P
Y
S
W
I
S
P
T
T
Site 35
S412
R
D
P
C
L
P
Y
S
W
I
S
P
T
T
G
Site 36
S476
E
T
C
K
K
P
D
S
V
S
L
H
C
R
Q
Site 37
S478
C
K
K
P
D
S
V
S
L
H
C
R
Q
E
A
Site 38
S521
I
N
L
P
Q
K
K
S
K
A
L
P
N
P
E
Site 39
S568
S
V
T
E
N
K
I
S
D
Q
D
L
N
R
M
Site 40
S577
Q
D
L
N
R
M
R
S
E
L
L
V
P
G
S
Site 41
S584
S
E
L
L
V
P
G
S
Q
L
I
L
G
P
H
Site 42
S616
E
D
R
L
G
W
G
S
G
W
D
V
L
L
P
Site 43
S647
R
V
G
G
L
K
E
S
A
V
H
S
Q
Y
K
Site 44
S651
L
K
E
S
A
V
H
S
Q
Y
K
R
S
P
N
Site 45
Y653
E
S
A
V
H
S
Q
Y
K
R
S
P
N
V
P
Site 46
S656
V
H
S
Q
Y
K
R
S
P
N
V
P
G
D
F
Site 47
Y684
A
K
N
L
L
E
K
Y
K
R
R
P
P
A
K
Site 48
Y695
P
P
A
K
R
P
N
Y
V
K
L
G
T
L
A
Site 49
Y722
W
E
S
R
V
Q
A
Y
E
E
P
S
V
A
S
Site 50
S726
V
Q
A
Y
E
E
P
S
V
A
S
S
P
N
G
Site 51
S729
Y
E
E
P
S
V
A
S
S
P
N
G
K
E
S
Site 52
S730
E
E
P
S
V
A
S
S
P
N
G
K
E
S
D
Site 53
S736
S
S
P
N
G
K
E
S
D
L
R
R
S
E
V
Site 54
S741
K
E
S
D
L
R
R
S
E
V
P
C
A
P
M
Site 55
T752
C
A
P
M
P
K
K
T
H
Q
P
S
D
E
V
Site 56
S756
P
K
K
T
H
Q
P
S
D
E
V
G
T
S
I
Site 57
S762
P
S
D
E
V
G
T
S
I
E
H
P
R
E
A
Site 58
S780
M
D
A
G
C
Q
E
S
A
G
P
E
R
I
T
Site 59
T787
S
A
G
P
E
R
I
T
D
Q
E
A
S
E
N
Site 60
S808
S
H
L
C
V
L
R
S
R
K
L
L
K
Q
L
Site 61
S816
R
K
L
L
K
Q
L
S
A
W
C
G
P
S
S
Site 62
S822
L
S
A
W
C
G
P
S
S
E
D
S
R
G
G
Site 63
S823
S
A
W
C
G
P
S
S
E
D
S
R
G
G
R
Site 64
S826
C
G
P
S
S
E
D
S
R
G
G
R
R
A
P
Site 65
T841
G
R
G
Q
Q
G
L
T
R
E
A
C
L
S
I
Site 66
S868
L
S
L
L
S
K
G
S
P
E
P
H
T
M
I
Site 67
T873
K
G
S
P
E
P
H
T
M
I
C
V
P
A
K
Site 68
Y892
Q
L
H
E
D
W
H
Y
C
G
P
Q
E
S
K
Site 69
S901
G
P
Q
E
S
K
H
S
D
P
F
R
S
K
I
Site 70
S927
R
Q
K
P
G
R
A
S
S
D
G
P
A
G
E
Site 71
S928
Q
K
P
G
R
A
S
S
D
G
P
A
G
E
E
Site 72
T956
S
G
P
L
P
R
V
T
L
H
C
S
R
T
L
Site 73
S995
T
G
L
L
D
M
L
S
S
Q
P
A
A
Q
R
Site 74
S996
G
L
L
D
M
L
S
S
Q
P
A
A
Q
R
G
Site 75
S1012
V
L
L
R
P
P
A
S
L
Q
Y
R
F
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation