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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKP4
Full Name:
Plakophilin-4
Alias:
P0071; Plakophilin 4
Type:
Intercellular junction protein
Mass (Da):
134269
Number AA:
1211
UniProt ID:
Q99569
International Prot ID:
IPI00021076
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030057
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
Q
T
R
Q
E
A
A
S
T
G
P
G
M
E
P
Site 2
T24
T
R
Q
E
A
A
S
T
G
P
G
M
E
P
E
Site 3
T33
P
G
M
E
P
E
T
T
A
T
T
I
L
A
S
Site 4
S40
T
A
T
T
I
L
A
S
V
K
E
Q
E
L
Q
Site 5
T52
E
L
Q
F
Q
R
L
T
R
E
L
E
V
E
R
Site 6
S64
V
E
R
Q
I
V
A
S
Q
L
E
R
C
R
L
Site 7
S75
R
C
R
L
G
A
E
S
P
S
I
A
S
T
S
Site 8
S77
R
L
G
A
E
S
P
S
I
A
S
T
S
S
T
Site 9
S80
A
E
S
P
S
I
A
S
T
S
S
T
E
K
S
Site 10
T81
E
S
P
S
I
A
S
T
S
S
T
E
K
S
F
Site 11
S82
S
P
S
I
A
S
T
S
S
T
E
K
S
F
P
Site 12
S83
P
S
I
A
S
T
S
S
T
E
K
S
F
P
W
Site 13
T84
S
I
A
S
T
S
S
T
E
K
S
F
P
W
R
Site 14
S87
S
T
S
S
T
E
K
S
F
P
W
R
S
T
D
Site 15
S92
E
K
S
F
P
W
R
S
T
D
V
P
N
T
G
Site 16
T93
K
S
F
P
W
R
S
T
D
V
P
N
T
G
V
Site 17
T98
R
S
T
D
V
P
N
T
G
V
S
K
P
R
V
Site 18
S101
D
V
P
N
T
G
V
S
K
P
R
V
S
D
A
Site 19
S106
G
V
S
K
P
R
V
S
D
A
V
Q
P
N
N
Site 20
Y114
D
A
V
Q
P
N
N
Y
L
I
R
T
E
P
E
Site 21
Y126
E
P
E
Q
G
T
L
Y
S
P
E
Q
T
S
L
Site 22
S127
P
E
Q
G
T
L
Y
S
P
E
Q
T
S
L
H
Site 23
T131
T
L
Y
S
P
E
Q
T
S
L
H
E
S
E
G
Site 24
S132
L
Y
S
P
E
Q
T
S
L
H
E
S
E
G
S
Site 25
S136
E
Q
T
S
L
H
E
S
E
G
S
L
G
N
S
Site 26
S139
S
L
H
E
S
E
G
S
L
G
N
S
R
S
S
Site 27
S143
S
E
G
S
L
G
N
S
R
S
S
T
Q
M
N
Site 28
S145
G
S
L
G
N
S
R
S
S
T
Q
M
N
S
Y
Site 29
S146
S
L
G
N
S
R
S
S
T
Q
M
N
S
Y
S
Site 30
T147
L
G
N
S
R
S
S
T
Q
M
N
S
Y
S
D
Site 31
S151
R
S
S
T
Q
M
N
S
Y
S
D
S
G
Y
Q
Site 32
Y152
S
S
T
Q
M
N
S
Y
S
D
S
G
Y
Q
E
Site 33
S153
S
T
Q
M
N
S
Y
S
D
S
G
Y
Q
E
A
Site 34
S155
Q
M
N
S
Y
S
D
S
G
Y
Q
E
A
G
S
Site 35
Y157
N
S
Y
S
D
S
G
Y
Q
E
A
G
S
F
H
Site 36
S162
S
G
Y
Q
E
A
G
S
F
H
N
S
Q
N
V
Site 37
S166
E
A
G
S
F
H
N
S
Q
N
V
S
K
A
D
Site 38
S170
F
H
N
S
Q
N
V
S
K
A
D
N
R
Q
Q
Site 39
S179
A
D
N
R
Q
Q
H
S
F
I
G
S
T
N
N
Site 40
S192
N
N
H
V
V
R
N
S
R
A
E
G
Q
T
L
Site 41
T198
N
S
R
A
E
G
Q
T
L
V
Q
P
S
V
A
Site 42
S203
G
Q
T
L
V
Q
P
S
V
A
N
R
A
M
R
Site 43
S213
N
R
A
M
R
R
V
S
S
V
P
S
R
A
Q
Site 44
S214
R
A
M
R
R
V
S
S
V
P
S
R
A
Q
S
Site 45
S217
R
R
V
S
S
V
P
S
R
A
Q
S
P
S
Y
Site 46
S221
S
V
P
S
R
A
Q
S
P
S
Y
V
I
S
T
Site 47
S223
P
S
R
A
Q
S
P
S
Y
V
I
S
T
G
V
Site 48
Y224
S
R
A
Q
S
P
S
Y
V
I
S
T
G
V
S
Site 49
S227
Q
S
P
S
Y
V
I
S
T
G
V
S
P
S
R
Site 50
T228
S
P
S
Y
V
I
S
T
G
V
S
P
S
R
G
Site 51
S231
Y
V
I
S
T
G
V
S
P
S
R
G
S
L
R
Site 52
S233
I
S
T
G
V
S
P
S
R
G
S
L
R
T
S
Site 53
S236
G
V
S
P
S
R
G
S
L
R
T
S
L
G
S
Site 54
T239
P
S
R
G
S
L
R
T
S
L
G
S
G
F
G
Site 55
S240
S
R
G
S
L
R
T
S
L
G
S
G
F
G
S
Site 56
S243
S
L
R
T
S
L
G
S
G
F
G
S
P
S
V
Site 57
S247
S
L
G
S
G
F
G
S
P
S
V
T
D
P
R
Site 58
S249
G
S
G
F
G
S
P
S
V
T
D
P
R
P
L
Site 59
T251
G
F
G
S
P
S
V
T
D
P
R
P
L
N
P
Site 60
S259
D
P
R
P
L
N
P
S
A
Y
S
S
T
T
L
Site 61
Y261
R
P
L
N
P
S
A
Y
S
S
T
T
L
P
A
Site 62
S263
L
N
P
S
A
Y
S
S
T
T
L
P
A
A
R
Site 63
S273
L
P
A
A
R
A
A
S
P
Y
S
Q
R
P
A
Site 64
Y275
A
A
R
A
A
S
P
Y
S
Q
R
P
A
S
P
Site 65
S276
A
R
A
A
S
P
Y
S
Q
R
P
A
S
P
T
Site 66
S281
P
Y
S
Q
R
P
A
S
P
T
A
I
R
R
I
Site 67
T283
S
Q
R
P
A
S
P
T
A
I
R
R
I
G
S
Site 68
S290
T
A
I
R
R
I
G
S
V
T
S
R
Q
T
S
Site 69
T292
I
R
R
I
G
S
V
T
S
R
Q
T
S
N
P
Site 70
S293
R
R
I
G
S
V
T
S
R
Q
T
S
N
P
N
Site 71
T296
G
S
V
T
S
R
Q
T
S
N
P
N
G
P
T
Site 72
S297
S
V
T
S
R
Q
T
S
N
P
N
G
P
T
P
Site 73
T303
T
S
N
P
N
G
P
T
P
Q
Y
Q
T
T
A
Site 74
Y306
P
N
G
P
T
P
Q
Y
Q
T
T
A
R
V
G
Site 75
T308
G
P
T
P
Q
Y
Q
T
T
A
R
V
G
S
P
Site 76
T309
P
T
P
Q
Y
Q
T
T
A
R
V
G
S
P
L
Site 77
S314
Q
T
T
A
R
V
G
S
P
L
T
L
T
D
A
Site 78
T317
A
R
V
G
S
P
L
T
L
T
D
A
Q
T
R
Site 79
T323
L
T
L
T
D
A
Q
T
R
V
A
S
P
S
Q
Site 80
S327
D
A
Q
T
R
V
A
S
P
S
Q
G
Q
V
G
Site 81
S329
Q
T
R
V
A
S
P
S
Q
G
Q
V
G
S
S
Site 82
S335
P
S
Q
G
Q
V
G
S
S
S
P
K
R
S
G
Site 83
S336
S
Q
G
Q
V
G
S
S
S
P
K
R
S
G
M
Site 84
S337
Q
G
Q
V
G
S
S
S
P
K
R
S
G
M
T
Site 85
S341
G
S
S
S
P
K
R
S
G
M
T
A
V
P
Q
Site 86
T344
S
P
K
R
S
G
M
T
A
V
P
Q
H
L
G
Site 87
S353
V
P
Q
H
L
G
P
S
L
Q
R
T
V
H
D
Site 88
T357
L
G
P
S
L
Q
R
T
V
H
D
M
E
Q
F
Site 89
Y369
E
Q
F
G
Q
Q
Q
Y
D
I
Y
E
R
M
V
Site 90
Y372
G
Q
Q
Q
Y
D
I
Y
E
R
M
V
P
P
R
Site 91
S382
M
V
P
P
R
P
D
S
L
T
G
L
R
S
S
Site 92
T384
P
P
R
P
D
S
L
T
G
L
R
S
S
Y
A
Site 93
S388
D
S
L
T
G
L
R
S
S
Y
A
S
Q
H
S
Site 94
S389
S
L
T
G
L
R
S
S
Y
A
S
Q
H
S
Q
Site 95
Y390
L
T
G
L
R
S
S
Y
A
S
Q
H
S
Q
L
Site 96
S392
G
L
R
S
S
Y
A
S
Q
H
S
Q
L
G
Q
Site 97
S395
S
S
Y
A
S
Q
H
S
Q
L
G
Q
D
L
R
Site 98
S403
Q
L
G
Q
D
L
R
S
A
V
S
P
D
L
H
Site 99
S406
Q
D
L
R
S
A
V
S
P
D
L
H
I
T
P
Site 100
T412
V
S
P
D
L
H
I
T
P
I
Y
E
G
R
T
Site 101
Y415
D
L
H
I
T
P
I
Y
E
G
R
T
Y
Y
S
Site 102
T419
T
P
I
Y
E
G
R
T
Y
Y
S
P
V
Y
R
Site 103
Y420
P
I
Y
E
G
R
T
Y
Y
S
P
V
Y
R
S
Site 104
Y421
I
Y
E
G
R
T
Y
Y
S
P
V
Y
R
S
P
Site 105
S422
Y
E
G
R
T
Y
Y
S
P
V
Y
R
S
P
N
Site 106
Y425
R
T
Y
Y
S
P
V
Y
R
S
P
N
H
G
T
Site 107
S427
Y
Y
S
P
V
Y
R
S
P
N
H
G
T
V
E
Site 108
T432
Y
R
S
P
N
H
G
T
V
E
L
Q
G
S
Q
Site 109
S438
G
T
V
E
L
Q
G
S
Q
T
A
L
Y
R
T
Site 110
T440
V
E
L
Q
G
S
Q
T
A
L
Y
R
T
G
V
Site 111
Y443
Q
G
S
Q
T
A
L
Y
R
T
G
V
S
G
I
Site 112
T445
S
Q
T
A
L
Y
R
T
G
V
S
G
I
G
N
Site 113
T456
G
I
G
N
L
Q
R
T
S
S
Q
R
S
T
L
Site 114
S457
I
G
N
L
Q
R
T
S
S
Q
R
S
T
L
T
Site 115
S458
G
N
L
Q
R
T
S
S
Q
R
S
T
L
T
Y
Site 116
S461
Q
R
T
S
S
Q
R
S
T
L
T
Y
Q
R
N
Site 117
T462
R
T
S
S
Q
R
S
T
L
T
Y
Q
R
N
N
Site 118
T464
S
S
Q
R
S
T
L
T
Y
Q
R
N
N
Y
A
Site 119
Y465
S
Q
R
S
T
L
T
Y
Q
R
N
N
Y
A
L
Site 120
Y470
L
T
Y
Q
R
N
N
Y
A
L
N
T
T
A
T
Site 121
T474
R
N
N
Y
A
L
N
T
T
A
T
Y
A
E
P
Site 122
T475
N
N
Y
A
L
N
T
T
A
T
Y
A
E
P
Y
Site 123
T477
Y
A
L
N
T
T
A
T
Y
A
E
P
Y
R
P
Site 124
Y478
A
L
N
T
T
A
T
Y
A
E
P
Y
R
P
I
Site 125
Y482
T
A
T
Y
A
E
P
Y
R
P
I
Q
Y
R
V
Site 126
Y487
E
P
Y
R
P
I
Q
Y
R
V
Q
E
C
N
Y
Site 127
Y494
Y
R
V
Q
E
C
N
Y
N
R
L
Q
H
A
V
Site 128
T507
A
V
P
A
D
D
G
T
T
R
S
P
S
I
D
Site 129
T508
V
P
A
D
D
G
T
T
R
S
P
S
I
D
S
Site 130
S510
A
D
D
G
T
T
R
S
P
S
I
D
S
I
Q
Site 131
S512
D
G
T
T
R
S
P
S
I
D
S
I
Q
K
D
Site 132
S515
T
R
S
P
S
I
D
S
I
Q
K
D
P
R
E
Site 133
S602
R
N
L
V
F
G
K
S
T
D
E
N
K
I
A
Site 134
S626
L
L
R
L
L
R
K
S
I
D
A
E
V
R
E
Site 135
S674
P
H
S
G
W
N
N
S
S
F
D
D
D
H
K
Site 136
S687
H
K
I
K
F
Q
T
S
L
V
L
R
N
T
T
Site 137
T701
T
G
C
L
R
N
L
T
S
A
G
E
E
A
R
Site 138
S702
G
C
L
R
N
L
T
S
A
G
E
E
A
R
K
Site 139
S713
E
A
R
K
Q
M
R
S
C
E
G
L
V
D
S
Site 140
Y734
T
C
V
N
T
S
D
Y
D
S
K
T
V
E
N
Site 141
S736
V
N
T
S
D
Y
D
S
K
T
V
E
N
C
V
Site 142
T738
T
S
D
Y
D
S
K
T
V
E
N
C
V
C
T
Site 143
T745
T
V
E
N
C
V
C
T
L
R
N
L
S
Y
R
Site 144
S776
D
D
L
L
G
K
E
S
P
S
K
D
S
E
P
Site 145
S778
L
L
G
K
E
S
P
S
K
D
S
E
P
S
C
Site 146
S781
K
E
S
P
S
K
D
S
E
P
S
C
W
G
K
Site 147
T796
K
K
K
K
K
K
R
T
P
Q
E
D
Q
W
D
Site 148
S812
V
G
P
I
P
G
L
S
K
S
P
K
G
V
E
Site 149
S814
P
I
P
G
L
S
K
S
P
K
G
V
E
M
L
Site 150
T842
A
E
S
S
N
P
A
T
L
E
G
S
A
G
S
Site 151
S849
T
L
E
G
S
A
G
S
L
Q
N
L
S
A
S
Site 152
S854
A
G
S
L
Q
N
L
S
A
S
N
W
K
F
A
Site 153
S856
S
L
Q
N
L
S
A
S
N
W
K
F
A
A
Y
Site 154
Y863
S
N
W
K
F
A
A
Y
I
R
G
G
R
P
K
Site 155
S890
M
D
N
D
R
V
V
S
S
G
A
T
A
L
R
Site 156
Y912
N
K
E
L
I
G
K
Y
A
M
R
D
L
V
N
Site 157
S977
K
G
R
G
D
R
S
S
L
K
V
V
K
A
A
Site 158
Y994
V
L
N
T
L
W
Q
Y
R
D
L
R
S
I
Y
Site 159
Y1001
Y
R
D
L
R
S
I
Y
K
K
D
G
W
N
Q
Site 160
T1013
W
N
Q
N
H
F
I
T
P
V
S
T
L
E
R
Site 161
S1016
N
H
F
I
T
P
V
S
T
L
E
R
D
R
F
Site 162
T1017
H
F
I
T
P
V
S
T
L
E
R
D
R
F
K
Site 163
S1025
L
E
R
D
R
F
K
S
H
P
S
L
S
T
T
Site 164
S1028
D
R
F
K
S
H
P
S
L
S
T
T
N
Q
Q
Site 165
S1030
F
K
S
H
P
S
L
S
T
T
N
Q
Q
M
S
Site 166
T1032
S
H
P
S
L
S
T
T
N
Q
Q
M
S
P
I
Site 167
S1037
S
T
T
N
Q
Q
M
S
P
I
I
Q
S
V
G
Site 168
S1042
Q
M
S
P
I
I
Q
S
V
G
S
T
S
S
S
Site 169
S1045
P
I
I
Q
S
V
G
S
T
S
S
S
P
A
L
Site 170
T1046
I
I
Q
S
V
G
S
T
S
S
S
P
A
L
L
Site 171
S1047
I
Q
S
V
G
S
T
S
S
S
P
A
L
L
G
Site 172
S1048
Q
S
V
G
S
T
S
S
S
P
A
L
L
G
I
Site 173
S1049
S
V
G
S
T
S
S
S
P
A
L
L
G
I
R
Site 174
S1060
L
G
I
R
D
P
R
S
E
Y
D
R
T
Q
P
Site 175
Y1062
I
R
D
P
R
S
E
Y
D
R
T
Q
P
P
M
Site 176
T1065
P
R
S
E
Y
D
R
T
Q
P
P
M
Q
Y
Y
Site 177
Y1071
R
T
Q
P
P
M
Q
Y
Y
N
S
Q
G
D
A
Site 178
Y1072
T
Q
P
P
M
Q
Y
Y
N
S
Q
G
D
A
T
Site 179
S1074
P
P
M
Q
Y
Y
N
S
Q
G
D
A
T
H
K
Site 180
Y1084
D
A
T
H
K
G
L
Y
P
G
S
S
K
P
S
Site 181
S1087
H
K
G
L
Y
P
G
S
S
K
P
S
P
I
Y
Site 182
S1088
K
G
L
Y
P
G
S
S
K
P
S
P
I
Y
I
Site 183
S1091
Y
P
G
S
S
K
P
S
P
I
Y
I
S
S
Y
Site 184
Y1094
S
S
K
P
S
P
I
Y
I
S
S
Y
S
S
P
Site 185
S1096
K
P
S
P
I
Y
I
S
S
Y
S
S
P
A
R
Site 186
S1097
P
S
P
I
Y
I
S
S
Y
S
S
P
A
R
E
Site 187
Y1098
S
P
I
Y
I
S
S
Y
S
S
P
A
R
E
Q
Site 188
S1099
P
I
Y
I
S
S
Y
S
S
P
A
R
E
Q
N
Site 189
S1100
I
Y
I
S
S
Y
S
S
P
A
R
E
Q
N
R
Site 190
Y1115
R
L
Q
H
Q
Q
L
Y
Y
S
Q
D
D
S
N
Site 191
Y1116
L
Q
H
Q
Q
L
Y
Y
S
Q
D
D
S
N
R
Site 192
S1117
Q
H
Q
Q
L
Y
Y
S
Q
D
D
S
N
R
K
Site 193
S1121
L
Y
Y
S
Q
D
D
S
N
R
K
N
F
D
A
Site 194
Y1129
N
R
K
N
F
D
A
Y
R
L
Y
L
Q
S
P
Site 195
Y1132
N
F
D
A
Y
R
L
Y
L
Q
S
P
H
S
Y
Site 196
S1135
A
Y
R
L
Y
L
Q
S
P
H
S
Y
E
D
P
Site 197
S1138
L
Y
L
Q
S
P
H
S
Y
E
D
P
Y
F
D
Site 198
Y1139
Y
L
Q
S
P
H
S
Y
E
D
P
Y
F
D
D
Site 199
Y1143
P
H
S
Y
E
D
P
Y
F
D
D
R
V
H
F
Site 200
S1153
D
R
V
H
F
P
A
S
T
D
Y
S
T
Q
Y
Site 201
T1154
R
V
H
F
P
A
S
T
D
Y
S
T
Q
Y
G
Site 202
Y1156
H
F
P
A
S
T
D
Y
S
T
Q
Y
G
L
K
Site 203
S1157
F
P
A
S
T
D
Y
S
T
Q
Y
G
L
K
S
Site 204
T1158
P
A
S
T
D
Y
S
T
Q
Y
G
L
K
S
T
Site 205
Y1160
S
T
D
Y
S
T
Q
Y
G
L
K
S
T
T
N
Site 206
S1164
S
T
Q
Y
G
L
K
S
T
T
N
Y
V
D
F
Site 207
T1166
Q
Y
G
L
K
S
T
T
N
Y
V
D
F
Y
S
Site 208
Y1168
G
L
K
S
T
T
N
Y
V
D
F
Y
S
T
K
Site 209
Y1172
T
T
N
Y
V
D
F
Y
S
T
K
R
P
S
Y
Site 210
S1173
T
N
Y
V
D
F
Y
S
T
K
R
P
S
Y
R
Site 211
T1174
N
Y
V
D
F
Y
S
T
K
R
P
S
Y
R
A
Site 212
S1178
F
Y
S
T
K
R
P
S
Y
R
A
E
Q
Y
P
Site 213
Y1179
Y
S
T
K
R
P
S
Y
R
A
E
Q
Y
P
G
Site 214
Y1184
P
S
Y
R
A
E
Q
Y
P
G
S
P
D
S
W
Site 215
S1187
R
A
E
Q
Y
P
G
S
P
D
S
W
V
Y
D
Site 216
S1190
Q
Y
P
G
S
P
D
S
W
V
Y
D
Q
D
A
Site 217
S1202
Q
D
A
Q
Q
R
N
S
F
F
L
T
L
F
R
Site 218
T1206
Q
R
N
S
F
F
L
T
L
F
R
L
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation