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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EYA3
Full Name:
Eyes absent homolog 3
Alias:
DKFZp686C132; EC 3.1.3.48; Eyes absent 3
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
62558
Number AA:
573
UniProt ID:
Q99504
International Prot ID:
IPI00015990
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0006302
GO:0016576
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
K
K
A
K
M
Q
E
S
G
E
Q
T
I
S
Q
Site 2
T24
M
Q
E
S
G
E
Q
T
I
S
Q
V
S
N
P
Site 3
S26
E
S
G
E
Q
T
I
S
Q
V
S
N
P
D
V
Site 4
S34
Q
V
S
N
P
D
V
S
D
Q
K
P
E
T
S
Site 5
T40
V
S
D
Q
K
P
E
T
S
S
L
A
S
N
L
Site 6
S41
S
D
Q
K
P
E
T
S
S
L
A
S
N
L
P
Site 7
S42
D
Q
K
P
E
T
S
S
L
A
S
N
L
P
M
Site 8
S45
P
E
T
S
S
L
A
S
N
L
P
M
S
E
E
Site 9
T55
P
M
S
E
E
I
M
T
C
T
D
Y
I
P
R
Site 10
Y59
E
I
M
T
C
T
D
Y
I
P
R
S
S
N
D
Site 11
S63
C
T
D
Y
I
P
R
S
S
N
D
Y
T
S
Q
Site 12
S64
T
D
Y
I
P
R
S
S
N
D
Y
T
S
Q
M
Site 13
Y67
I
P
R
S
S
N
D
Y
T
S
Q
M
Y
S
A
Site 14
T68
P
R
S
S
N
D
Y
T
S
Q
M
Y
S
A
K
Site 15
S69
R
S
S
N
D
Y
T
S
Q
M
Y
S
A
K
P
Site 16
Y77
Q
M
Y
S
A
K
P
Y
A
H
I
L
S
V
P
Site 17
S86
H
I
L
S
V
P
V
S
E
T
A
Y
P
G
Q
Site 18
Y90
V
P
V
S
E
T
A
Y
P
G
Q
T
Q
Y
Q
Site 19
T98
P
G
Q
T
Q
Y
Q
T
L
Q
Q
T
Q
P
Y
Site 20
Y108
Q
T
Q
P
Y
A
V
Y
P
Q
A
T
Q
T
Y
Site 21
Y115
Y
P
Q
A
T
Q
T
Y
G
L
P
P
F
G
A
Site 22
S131
W
P
G
M
K
P
E
S
G
L
I
Q
T
P
S
Site 23
T136
P
E
S
G
L
I
Q
T
P
S
P
S
Q
H
S
Site 24
S138
S
G
L
I
Q
T
P
S
P
S
Q
H
S
V
L
Site 25
S140
L
I
Q
T
P
S
P
S
Q
H
S
V
L
T
C
Site 26
S143
T
P
S
P
S
Q
H
S
V
L
T
C
T
T
G
Site 27
T153
T
C
T
T
G
L
T
T
S
Q
P
S
P
A
H
Site 28
S154
C
T
T
G
L
T
T
S
Q
P
S
P
A
H
Y
Site 29
S157
G
L
T
T
S
Q
P
S
P
A
H
Y
S
Y
P
Site 30
Y161
S
Q
P
S
P
A
H
Y
S
Y
P
I
Q
A
S
Site 31
S162
Q
P
S
P
A
H
Y
S
Y
P
I
Q
A
S
S
Site 32
Y163
P
S
P
A
H
Y
S
Y
P
I
Q
A
S
S
T
Site 33
S169
S
Y
P
I
Q
A
S
S
T
N
A
S
L
I
S
Site 34
S173
Q
A
S
S
T
N
A
S
L
I
S
T
S
S
T
Site 35
S176
S
T
N
A
S
L
I
S
T
S
S
T
I
A
N
Site 36
Y197
A
S
I
S
N
Q
D
Y
P
T
Y
T
I
L
G
Site 37
T199
I
S
N
Q
D
Y
P
T
Y
T
I
L
G
Q
N
Site 38
Y200
S
N
Q
D
Y
P
T
Y
T
I
L
G
Q
N
Q
Site 39
Y208
T
I
L
G
Q
N
Q
Y
Q
A
C
Y
P
S
S
Site 40
Y212
Q
N
Q
Y
Q
A
C
Y
P
S
S
S
F
G
V
Site 41
S214
Q
Y
Q
A
C
Y
P
S
S
S
F
G
V
T
G
Site 42
S215
Y
Q
A
C
Y
P
S
S
S
F
G
V
T
G
Q
Site 43
S216
Q
A
C
Y
P
S
S
S
F
G
V
T
G
Q
T
Site 44
T220
P
S
S
S
F
G
V
T
G
Q
T
N
S
D
A
Site 45
S225
G
V
T
G
Q
T
N
S
D
A
E
S
T
T
L
Site 46
S229
Q
T
N
S
D
A
E
S
T
T
L
A
A
T
T
Site 47
Y237
T
T
L
A
A
T
T
Y
Q
S
E
K
P
S
V
Site 48
S239
L
A
A
T
T
Y
Q
S
E
K
P
S
V
M
A
Site 49
S243
T
Y
Q
S
E
K
P
S
V
M
A
P
A
P
A
Site 50
S255
A
P
A
A
Q
R
L
S
S
G
D
P
S
T
S
Site 51
S256
P
A
A
Q
R
L
S
S
G
D
P
S
T
S
P
Site 52
S260
R
L
S
S
G
D
P
S
T
S
P
S
L
S
Q
Site 53
T261
L
S
S
G
D
P
S
T
S
P
S
L
S
Q
T
Site 54
S262
S
S
G
D
P
S
T
S
P
S
L
S
Q
T
T
Site 55
S264
G
D
P
S
T
S
P
S
L
S
Q
T
T
P
S
Site 56
S266
P
S
T
S
P
S
L
S
Q
T
T
P
S
K
D
Site 57
T268
T
S
P
S
L
S
Q
T
T
P
S
K
D
T
D
Site 58
T269
S
P
S
L
S
Q
T
T
P
S
K
D
T
D
D
Site 59
S271
S
L
S
Q
T
T
P
S
K
D
T
D
D
Q
S
Site 60
S278
S
K
D
T
D
D
Q
S
R
K
N
M
T
S
K
Site 61
S284
Q
S
R
K
N
M
T
S
K
N
R
G
K
R
K
Site 62
T295
G
K
R
K
A
D
A
T
S
S
Q
D
S
E
L
Site 63
S296
K
R
K
A
D
A
T
S
S
Q
D
S
E
L
E
Site 64
S297
R
K
A
D
A
T
S
S
Q
D
S
E
L
E
R
Site 65
S300
D
A
T
S
S
Q
D
S
E
L
E
R
V
F
L
Site 66
Y329
T
G
S
Y
A
Q
K
Y
G
K
D
P
T
V
V
Site 67
T334
Q
K
Y
G
K
D
P
T
V
V
I
G
S
G
L
Site 68
S373
V
H
V
E
D
V
A
S
D
D
N
G
Q
D
L
Site 69
S381
D
D
N
G
Q
D
L
S
N
Y
S
F
S
T
D
Site 70
Y383
N
G
Q
D
L
S
N
Y
S
F
S
T
D
G
F
Site 71
S384
G
Q
D
L
S
N
Y
S
F
S
T
D
G
F
S
Site 72
S386
D
L
S
N
Y
S
F
S
T
D
G
F
S
G
S
Site 73
T387
L
S
N
Y
S
F
S
T
D
G
F
S
G
S
G
Site 74
S391
S
F
S
T
D
G
F
S
G
S
G
G
S
G
S
Site 75
S393
S
T
D
G
F
S
G
S
G
G
S
G
S
H
G
Site 76
S396
G
F
S
G
S
G
G
S
G
S
H
G
S
S
V
Site 77
S398
S
G
S
G
G
S
G
S
H
G
S
S
V
G
V
Site 78
S401
G
G
S
G
S
H
G
S
S
V
G
V
Q
G
G
Site 79
S402
G
S
G
S
H
G
S
S
V
G
V
Q
G
G
V
Site 80
Y426
Y
R
K
V
R
E
I
Y
D
K
H
K
S
N
V
Site 81
S431
E
I
Y
D
K
H
K
S
N
V
G
G
L
L
S
Site 82
S438
S
N
V
G
G
L
L
S
P
Q
R
K
E
A
L
Site 83
S472
K
S
L
L
L
I
Q
S
R
K
N
C
V
N
V
Site 84
S509
F
P
I
E
N
I
Y
S
A
T
K
I
G
K
E
Site 85
S524
S
C
F
E
R
I
V
S
R
F
G
K
K
V
T
Site 86
T531
S
R
F
G
K
K
V
T
Y
V
V
I
G
D
G
Site 87
Y532
R
F
G
K
K
V
T
Y
V
V
I
G
D
G
R
Site 88
S563
T
N
H
G
D
L
V
S
L
H
Q
A
L
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation