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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD1
Full Name:
26S proteasome non-ATPase regulatory subunit 1
Alias:
26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; P112; Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; PSD1; Rpn2; S1
Type:
Proteasome complex; Protease
Mass (Da):
105836
Number AA:
953
UniProt ID:
Q99460
International Prot ID:
IPI00299608
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000502
GO:0005829
GO:0005838
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0030234
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
S
A
A
G
I
I
S
L
L
D
E
D
E
P
Site 2
Y49
V
D
K
I
E
V
L
Y
E
D
E
G
F
R
S
Site 3
Y96
N
V
N
D
N
S
E
Y
V
E
T
I
I
A
K
Site 4
T99
D
N
S
E
Y
V
E
T
I
I
A
K
C
I
D
Site 5
Y108
I
A
K
C
I
D
H
Y
T
K
Q
C
V
E
N
Site 6
Y147
R
C
L
D
D
H
K
Y
K
Q
A
I
G
I
A
Site 7
T157
A
I
G
I
A
L
E
T
R
R
L
D
V
F
E
Site 8
T166
R
L
D
V
F
E
K
T
I
L
E
S
N
D
V
Site 9
S180
V
P
G
M
L
A
Y
S
L
K
L
C
M
S
L
Site 10
Y253
Y
Q
I
C
F
D
L
Y
E
S
A
S
Q
Q
F
Site 11
S257
F
D
L
Y
E
S
A
S
Q
Q
F
L
S
S
V
Site 12
S262
S
A
S
Q
Q
F
L
S
S
V
I
Q
N
L
R
Site 13
S263
A
S
Q
Q
F
L
S
S
V
I
Q
N
L
R
T
Site 14
T270
S
V
I
Q
N
L
R
T
V
G
T
P
I
A
S
Site 15
T273
Q
N
L
R
T
V
G
T
P
I
A
S
V
P
G
Site 16
S281
P
I
A
S
V
P
G
S
T
N
T
G
T
V
P
Site 17
T284
S
V
P
G
S
T
N
T
G
T
V
P
G
S
E
Site 18
T286
P
G
S
T
N
T
G
T
V
P
G
S
E
K
D
Site 19
S290
N
T
G
T
V
P
G
S
E
K
D
S
D
S
M
Site 20
S294
V
P
G
S
E
K
D
S
D
S
M
E
T
E
E
Site 21
S296
G
S
E
K
D
S
D
S
M
E
T
E
E
K
T
Site 22
T299
K
D
S
D
S
M
E
T
E
E
K
T
S
S
A
Site 23
T303
S
M
E
T
E
E
K
T
S
S
A
F
V
G
K
Site 24
S305
E
T
E
E
K
T
S
S
A
F
V
G
K
T
P
Site 25
T311
S
S
A
F
V
G
K
T
P
E
A
S
P
E
P
Site 26
S315
V
G
K
T
P
E
A
S
P
E
P
K
D
Q
T
Site 27
T322
S
P
E
P
K
D
Q
T
L
K
M
I
K
I
L
Site 28
S363
T
K
D
A
V
R
N
S
V
C
H
T
A
T
V
Site 29
T425
E
A
L
Q
L
M
A
T
Y
L
P
K
D
T
S
Site 30
T431
A
T
Y
L
P
K
D
T
S
P
G
S
A
Y
Q
Site 31
S432
T
Y
L
P
K
D
T
S
P
G
S
A
Y
Q
E
Site 32
S435
P
K
D
T
S
P
G
S
A
Y
Q
E
G
G
G
Site 33
Y437
D
T
S
P
G
S
A
Y
Q
E
G
G
G
L
Y
Site 34
Y460
H
G
G
D
I
I
D
Y
L
L
N
Q
L
K
N
Site 35
T488
L
G
L
A
A
M
G
T
A
R
Q
D
V
Y
D
Site 36
Y494
G
T
A
R
Q
D
V
Y
D
L
L
K
T
N
L
Site 37
Y502
D
L
L
K
T
N
L
Y
Q
D
D
A
V
T
G
Site 38
S581
K
D
P
I
L
R
R
S
G
M
Y
T
V
A
M
Site 39
S608
R
L
L
H
V
A
V
S
D
V
N
D
D
V
R
Site 40
S635
R
T
P
E
Q
C
P
S
V
V
S
L
L
S
E
Site 41
S638
E
Q
C
P
S
V
V
S
L
L
S
E
S
Y
N
Site 42
S641
P
S
V
V
S
L
L
S
E
S
Y
N
P
H
V
Site 43
S643
V
V
S
L
L
S
E
S
Y
N
P
H
V
R
Y
Site 44
T676
I
N
L
L
E
P
M
T
N
D
P
V
N
Y
V
Site 45
Y682
M
T
N
D
P
V
N
Y
V
R
Q
G
A
L
I
Site 46
Y713
V
N
Q
F
R
Q
L
Y
S
K
V
I
N
D
K
Site 47
S747
G
G
H
N
V
T
I
S
L
Q
S
R
T
G
H
Site 48
S750
N
V
T
I
S
L
Q
S
R
T
G
H
T
H
M
Site 49
T755
L
Q
S
R
T
G
H
T
H
M
P
S
V
V
G
Site 50
S809
Y
K
S
N
C
K
P
S
T
F
A
Y
P
A
P
Site 51
T810
K
S
N
C
K
P
S
T
F
A
Y
P
A
P
L
Site 52
Y813
C
K
P
S
T
F
A
Y
P
A
P
L
E
V
P
Site 53
S829
E
K
E
K
E
K
V
S
T
A
V
L
S
I
T
Site 54
T830
K
E
K
E
K
V
S
T
A
V
L
S
I
T
A
Site 55
T893
P
A
Q
L
K
V
L
T
M
P
E
T
C
R
Y
Site 56
T897
K
V
L
T
M
P
E
T
C
R
Y
Q
P
F
K
Site 57
Y900
T
M
P
E
T
C
R
Y
Q
P
F
K
P
L
S
Site 58
Y950
E
P
P
E
P
F
E
Y
I
D
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation