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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT12
Full Name:
Keratin, type I cytoskeletal 12
Alias:
Cytokeratin-12;Keratin-12
Type:
Mass (Da):
53511
Number AA:
494
UniProt ID:
Q99456
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
L
S
N
N
T
M
S
L
S
V
R
T
P
G
Site 2
S11
S
N
N
T
M
S
L
S
V
R
T
P
G
L
S
Site 3
T14
T
M
S
L
S
V
R
T
P
G
L
S
R
R
L
Site 4
S18
S
V
R
T
P
G
L
S
R
R
L
S
S
Q
S
Site 5
S22
P
G
L
S
R
R
L
S
S
Q
S
V
I
G
R
Site 6
S23
G
L
S
R
R
L
S
S
Q
S
V
I
G
R
P
Site 7
S25
S
R
R
L
S
S
Q
S
V
I
G
R
P
R
G
Site 8
S34
I
G
R
P
R
G
M
S
A
S
S
V
G
S
G
Site 9
S36
R
P
R
G
M
S
A
S
S
V
G
S
G
Y
G
Site 10
S37
P
R
G
M
S
A
S
S
V
G
S
G
Y
G
G
Site 11
S67
A
S
M
F
G
S
S
S
G
F
G
G
G
S
G
Site 12
S73
S
S
G
F
G
G
G
S
G
S
S
M
A
G
G
Site 13
S109
G
G
S
P
G
G
G
S
L
G
I
L
S
G
N
Site 14
S122
G
N
D
G
G
L
L
S
G
S
E
K
E
T
M
Site 15
S124
D
G
G
L
L
S
G
S
E
K
E
T
M
Q
N
Site 16
T128
L
S
G
S
E
K
E
T
M
Q
N
L
N
D
R
Site 17
S138
N
L
N
D
R
L
A
S
Y
L
D
K
V
R
A
Site 18
Y139
L
N
D
R
L
A
S
Y
L
D
K
V
R
A
L
Site 19
T151
R
A
L
E
E
A
N
T
E
L
E
N
K
I
R
Site 20
Y161
E
N
K
I
R
E
W
Y
E
T
R
G
T
G
T
Site 21
T163
K
I
R
E
W
Y
E
T
R
G
T
G
T
A
D
Site 22
T166
E
W
Y
E
T
R
G
T
G
T
A
D
A
S
Q
Site 23
S172
G
T
G
T
A
D
A
S
Q
S
D
Y
S
K
Y
Site 24
S174
G
T
A
D
A
S
Q
S
D
Y
S
K
Y
Y
P
Site 25
Y176
A
D
A
S
Q
S
D
Y
S
K
Y
Y
P
L
I
Site 26
Y179
S
Q
S
D
Y
S
K
Y
Y
P
L
I
E
D
L
Site 27
Y180
Q
S
D
Y
S
K
Y
Y
P
L
I
E
D
L
R
Site 28
S192
D
L
R
N
K
I
I
S
A
S
I
G
N
A
Q
Site 29
Y218
A
E
D
F
R
M
K
Y
E
N
E
L
A
L
R
Site 30
T243
R
R
V
L
D
E
L
T
L
T
R
T
D
L
E
Site 31
T245
V
L
D
E
L
T
L
T
R
T
D
L
E
M
Q
Site 32
S255
D
L
E
M
Q
I
E
S
L
N
E
E
L
A
Y
Site 33
Y262
S
L
N
E
E
L
A
Y
M
K
K
N
H
E
D
Site 34
S273
N
H
E
D
E
L
Q
S
F
R
V
G
G
P
G
Site 35
T295
A
A
P
G
V
D
L
T
R
L
L
N
D
M
R
Site 36
Y305
L
N
D
M
R
A
Q
Y
E
T
I
A
E
Q
N
Site 37
T307
D
M
R
A
Q
Y
E
T
I
A
E
Q
N
R
K
Site 38
S324
E
A
W
F
I
E
K
S
G
E
L
R
K
E
I
Site 39
S332
G
E
L
R
K
E
I
S
T
N
T
E
Q
L
Q
Site 40
T333
E
L
R
K
E
I
S
T
N
T
E
Q
L
Q
S
Site 41
S343
E
Q
L
Q
S
S
K
S
E
V
T
D
L
R
R
Site 42
S368
S
Q
L
A
M
K
K
S
L
E
D
S
L
A
E
Site 43
S372
M
K
K
S
L
E
D
S
L
A
E
A
E
G
D
Site 44
Y380
L
A
E
A
E
G
D
Y
C
A
Q
L
S
Q
V
Site 45
S385
G
D
Y
C
A
Q
L
S
Q
V
Q
Q
L
I
S
Site 46
T428
R
L
E
L
E
I
E
T
Y
R
R
L
L
D
G
Site 47
Y429
L
E
L
E
I
E
T
Y
R
R
L
L
D
G
E
Site 48
S445
Q
G
D
G
L
E
E
S
L
F
V
T
D
S
K
Site 49
T449
L
E
E
S
L
F
V
T
D
S
K
S
Q
A
Q
Site 50
S451
E
S
L
F
V
T
D
S
K
S
Q
A
Q
S
T
Site 51
S453
L
F
V
T
D
S
K
S
Q
A
Q
S
T
D
S
Site 52
S457
D
S
K
S
Q
A
Q
S
T
D
S
S
K
D
P
Site 53
T458
S
K
S
Q
A
Q
S
T
D
S
S
K
D
P
T
Site 54
S460
S
Q
A
Q
S
T
D
S
S
K
D
P
T
K
T
Site 55
S461
Q
A
Q
S
T
D
S
S
K
D
P
T
K
T
R
Site 56
T465
T
D
S
S
K
D
P
T
K
T
R
K
I
K
T
Site 57
T467
S
S
K
D
P
T
K
T
R
K
I
K
T
V
V
Site 58
T472
T
K
T
R
K
I
K
T
V
V
Q
E
M
V
N
Site 59
S485
V
N
G
E
V
V
S
S
Q
V
Q
E
I
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation