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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOX2
Full Name:
Peroxisomal acyl-coenzyme A oxidase 2
Alias:
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Acyl-Coenzyme A oxidase 2, branched chain; Acyl-coenzyme A oxidase 2, peroxisomal; BRCACOX; BRCOX; THCA-CoA oxidase; THCCox; Trihydroxycoprostanoyl-CoA oxidase
Type:
EC 1.17.99.3; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase
Mass (Da):
76827
Number AA:
681
UniProt ID:
Q99424
International Prot ID:
IPI00783092
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0033791
GO:0050660
GO:0003995
PhosphoSite+
KinaseNET
Biological Process:
GO:0008206
GO:0006635
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
G
S
P
V
H
R
V
S
L
Site 2
S9
G
S
P
V
H
R
V
S
L
G
D
T
W
S
R
Site 3
T13
H
R
V
S
L
G
D
T
W
S
R
Q
M
H
P
Site 4
Y27
P
D
I
E
S
E
R
Y
M
Q
S
F
D
V
E
Site 5
S30
E
S
E
R
Y
M
Q
S
F
D
V
E
R
L
T
Site 6
T37
S
F
D
V
E
R
L
T
N
I
L
D
G
G
A
Site 7
S55
A
L
R
R
K
V
E
S
I
I
H
S
Y
P
E
Site 8
S59
K
V
E
S
I
I
H
S
Y
P
E
F
S
C
K
Site 9
Y60
V
E
S
I
I
H
S
Y
P
E
F
S
C
K
D
Site 10
Y69
E
F
S
C
K
D
N
Y
F
M
T
Q
N
E
R
Site 11
Y105
E
D
G
R
E
L
G
Y
A
Y
R
A
L
S
G
Site 12
Y107
G
R
E
L
G
Y
A
Y
R
A
L
S
G
D
V
Site 13
S131
R
A
L
R
S
L
G
S
E
E
Q
I
A
K
W
Site 14
T170
Q
G
L
E
T
E
A
T
Y
D
A
A
T
Q
E
Site 15
T175
E
A
T
Y
D
A
A
T
Q
E
F
V
I
H
S
Site 16
S182
T
Q
E
F
V
I
H
S
P
T
L
T
A
T
K
Site 17
T186
V
I
H
S
P
T
L
T
A
T
K
W
W
P
G
Site 18
T200
G
D
L
G
R
S
A
T
H
A
L
V
Q
A
Q
Site 19
S211
V
Q
A
Q
L
I
C
S
G
A
R
R
G
M
H
Site 20
T250
P
K
M
D
F
D
Q
T
D
N
G
F
L
Q
L
Site 21
S269
V
P
R
E
N
M
L
S
R
F
A
Q
V
L
P
Site 22
Y280
Q
V
L
P
D
G
T
Y
V
K
L
G
T
A
Q
Site 23
Y290
L
G
T
A
Q
S
N
Y
L
P
M
V
V
V
R
Site 24
S320
C
V
I
A
M
R
Y
S
V
I
R
R
Q
S
R
Site 25
S326
Y
S
V
I
R
R
Q
S
R
L
R
P
S
D
P
Site 26
S331
R
Q
S
R
L
R
P
S
D
P
E
A
K
V
L
Site 27
Y340
P
E
A
K
V
L
D
Y
Q
T
Q
Q
Q
K
L
Site 28
T342
A
K
V
L
D
Y
Q
T
Q
Q
Q
K
L
F
P
Site 29
T391
P
E
L
H
A
L
S
T
G
M
K
A
M
M
S
Site 30
Y417
R
A
C
G
G
H
G
Y
S
K
L
S
G
L
P
Site 31
S418
A
C
G
G
H
G
Y
S
K
L
S
G
L
P
S
Site 32
S421
G
H
G
Y
S
K
L
S
G
L
P
S
L
V
T
Site 33
S431
P
S
L
V
T
K
L
S
A
S
C
T
Y
E
G
Site 34
S433
L
V
T
K
L
S
A
S
C
T
Y
E
G
E
N
Site 35
T435
T
K
L
S
A
S
C
T
Y
E
G
E
N
T
V
Site 36
T458
L
V
K
S
Y
L
Q
T
Q
M
S
P
G
S
T
Site 37
S461
S
Y
L
Q
T
Q
M
S
P
G
S
T
P
Q
R
Site 38
S464
Q
T
Q
M
S
P
G
S
T
P
Q
R
S
L
S
Site 39
T465
T
Q
M
S
P
G
S
T
P
Q
R
S
L
S
P
Site 40
S469
P
G
S
T
P
Q
R
S
L
S
P
S
V
A
Y
Site 41
S471
S
T
P
Q
R
S
L
S
P
S
V
A
Y
L
T
Site 42
S473
P
Q
R
S
L
S
P
S
V
A
Y
L
T
A
P
Site 43
T520
D
S
V
Q
H
L
Q
T
L
T
Q
S
G
A
D
Site 44
T624
R
K
D
A
I
L
L
T
D
A
F
D
F
T
D
Site 45
T630
L
T
D
A
F
D
F
T
D
Q
C
L
N
S
A
Site 46
Y646
G
C
Y
D
G
N
V
Y
E
R
L
F
Q
W
A
Site 47
S656
L
F
Q
W
A
Q
K
S
P
T
N
T
Q
E
N
Site 48
T660
A
Q
K
S
P
T
N
T
Q
E
N
P
A
Y
E
Site 49
Y666
N
T
Q
E
N
P
A
Y
E
E
Y
I
R
P
L
Site 50
Y669
E
N
P
A
Y
E
E
Y
I
R
P
L
L
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation