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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Pnk1
Full Name:
Bifunctional polynucleotide phosphatase/kinase
Alias:
DNA 5'-kinase/3'-phosphatase; EC 2.7.1.78; EC 3.1.3.32; PNKP; Polynucleotide kinase-3'-phosphatase
Type:
Nucleolus, Nucleus protein
Mass (Da):
57076
Number AA:
521
UniProt ID:
Q96T60
International Prot ID:
IPI00290684
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046404
GO:0003684
PhosphoSite+
KinaseNET
Biological Process:
GO:0042769
GO:0006261
GO:0016311
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
G
R
L
W
L
E
S
P
P
G
G
A
P
P
Site 2
T39
V
L
G
R
G
P
L
T
Q
V
T
D
R
K
C
Site 3
T42
R
G
P
L
T
Q
V
T
D
R
K
C
S
R
T
Site 4
S47
Q
V
T
D
R
K
C
S
R
T
Q
V
E
L
V
Site 5
T49
T
D
R
K
C
S
R
T
Q
V
E
L
V
A
D
Site 6
T59
E
L
V
A
D
P
E
T
R
T
V
A
V
K
Q
Site 7
T61
V
A
D
P
E
T
R
T
V
A
V
K
Q
L
G
Site 8
S72
K
Q
L
G
V
N
P
S
T
T
G
T
Q
E
L
Site 9
T76
V
N
P
S
T
T
G
T
Q
E
L
K
P
G
L
Site 10
T103
V
N
G
L
H
P
L
T
L
R
W
E
E
T
R
Site 11
T109
L
T
L
R
W
E
E
T
R
T
P
E
S
Q
P
Site 12
T111
L
R
W
E
E
T
R
T
P
E
S
Q
P
D
T
Site 13
S114
E
E
T
R
T
P
E
S
Q
P
D
T
P
P
G
Site 14
T118
T
P
E
S
Q
P
D
T
P
P
G
T
P
L
V
Site 15
T122
Q
P
D
T
P
P
G
T
P
L
V
S
Q
D
E
Site 16
S126
P
P
G
T
P
L
V
S
Q
D
E
K
R
D
A
Site 17
S143
P
K
K
R
M
R
K
S
N
P
G
W
E
N
L
Site 18
T175
A
G
F
D
L
D
G
T
L
I
T
T
R
S
G
Site 19
T178
D
L
D
G
T
L
I
T
T
R
S
G
K
V
F
Site 20
S181
G
T
L
I
T
T
R
S
G
K
V
F
P
T
G
Site 21
Y196
P
S
D
W
R
I
L
Y
P
E
I
P
R
K
L
Site 22
Y211
R
E
L
E
A
E
G
Y
K
L
V
I
F
T
N
Site 23
T277
Q
E
Q
A
N
D
G
T
P
I
S
I
G
D
S
Site 24
S307
G
R
K
K
K
D
F
S
C
A
D
R
L
F
A
Site 25
T345
L
P
A
F
D
P
R
T
V
S
R
S
G
P
L
Site 26
S347
A
F
D
P
R
T
V
S
R
S
G
P
L
C
L
Site 27
S349
D
P
R
T
V
S
R
S
G
P
L
C
L
P
E
Site 28
S364
S
R
A
L
L
S
A
S
P
E
V
V
V
A
V
Site 29
S379
G
F
P
G
A
G
K
S
T
F
L
K
K
H
L
Site 30
T380
F
P
G
A
G
K
S
T
F
L
K
K
H
L
V
Site 31
Y391
K
H
L
V
S
A
G
Y
V
H
V
N
R
D
T
Site 32
T398
Y
V
H
V
N
R
D
T
L
G
S
W
Q
R
C
Site 33
S401
V
N
R
D
T
L
G
S
W
Q
R
C
V
T
T
Site 34
T407
G
S
W
Q
R
C
V
T
T
C
E
T
A
L
K
Site 35
T424
K
R
V
A
I
D
N
T
N
P
D
A
A
S
R
Site 36
Y434
D
A
A
S
R
A
R
Y
V
Q
C
A
R
A
A
Site 37
T467
N
N
R
F
R
E
M
T
D
S
S
H
I
P
V
Site 38
S469
R
F
R
E
M
T
D
S
S
H
I
P
V
S
D
Site 39
S470
F
R
E
M
T
D
S
S
H
I
P
V
S
D
M
Site 40
Y480
P
V
S
D
M
V
M
Y
G
Y
R
K
Q
F
E
Site 41
Y482
S
D
M
V
M
Y
G
Y
R
K
Q
F
E
A
P
Site 42
Y515
E
P
R
L
G
R
L
Y
C
Q
F
S
E
G
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation