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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Sin3A
Full Name:
Paired amphipathic helix protein Sin3a
Alias:
DKFZP434K2235; KIAA0700; SIN3 A, transcription regulator; SN3A; Transcriptional corepressor Sin3a
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
145175
Number AA:
1273
UniProt ID:
Q96ST3
International Prot ID:
IPI00170596
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016580
GO:0005730
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
R
L
D
D
Q
E
S
P
V
Y
A
A
Q
Q
Site 2
Y13
D
D
Q
E
S
P
V
Y
A
A
Q
Q
R
R
I
Site 3
S23
Q
Q
R
R
I
P
G
S
T
E
A
F
P
H
Q
Site 4
T24
Q
R
R
I
P
G
S
T
E
A
F
P
H
Q
H
Site 5
Y41
L
A
P
A
P
P
V
Y
E
A
V
S
E
T
M
Site 6
S45
P
P
V
Y
E
A
V
S
E
T
M
Q
S
A
T
Site 7
S50
A
V
S
E
T
M
Q
S
A
T
G
I
Q
Y
S
Site 8
S57
S
A
T
G
I
Q
Y
S
V
T
P
S
Y
Q
V
Site 9
T59
T
G
I
Q
Y
S
V
T
P
S
Y
Q
V
S
A
Site 10
S61
I
Q
Y
S
V
T
P
S
Y
Q
V
S
A
M
P
Site 11
Y62
Q
Y
S
V
T
P
S
Y
Q
V
S
A
M
P
Q
Site 12
S65
V
T
P
S
Y
Q
V
S
A
M
P
Q
S
S
G
Site 13
S70
Q
V
S
A
M
P
Q
S
S
G
S
H
G
P
A
Site 14
S71
V
S
A
M
P
Q
S
S
G
S
H
G
P
A
I
Site 15
S73
A
M
P
Q
S
S
G
S
H
G
P
A
I
A
A
Site 16
S101
H
G
G
Q
V
V
Q
S
H
A
H
P
A
P
P
Site 17
S139
Q
V
K
L
Q
F
G
S
Q
P
Q
V
Y
N
D
Site 18
Y144
F
G
S
Q
P
Q
V
Y
N
D
F
L
D
I
M
Site 19
S156
D
I
M
K
E
F
K
S
Q
S
I
D
T
P
G
Site 20
T161
F
K
S
Q
S
I
D
T
P
G
V
I
S
R
V
Site 21
S166
I
D
T
P
G
V
I
S
R
V
S
Q
L
F
K
Site 22
S169
P
G
V
I
S
R
V
S
Q
L
F
K
G
H
P
Site 23
T204
N
D
M
V
N
V
T
T
P
G
Q
V
H
Q
I
Site 24
S228
Q
P
P
P
Q
H
P
S
Q
P
S
A
Q
S
A
Site 25
S231
P
Q
H
P
S
Q
P
S
A
Q
S
A
P
A
P
Site 26
S251
Q
P
P
P
A
K
V
S
K
P
S
Q
L
Q
A
Site 27
T260
P
S
Q
L
Q
A
H
T
P
A
S
Q
Q
T
P
Site 28
S263
L
Q
A
H
T
P
A
S
Q
Q
T
P
P
L
P
Site 29
T266
H
T
P
A
S
Q
Q
T
P
P
L
P
P
Y
A
Site 30
Y272
Q
T
P
P
L
P
P
Y
A
S
P
R
S
P
P
Site 31
S274
P
P
L
P
P
Y
A
S
P
R
S
P
P
V
Q
Site 32
S277
P
P
Y
A
S
P
R
S
P
P
V
Q
P
H
T
Site 33
T284
S
P
P
V
Q
P
H
T
P
V
T
I
S
L
G
Site 34
S289
P
H
T
P
V
T
I
S
L
G
T
A
P
S
L
Site 35
S295
I
S
L
G
T
A
P
S
L
Q
N
N
Q
P
V
Site 36
Y310
E
F
N
H
A
I
N
Y
V
N
K
I
K
N
R
Site 37
T334
A
F
L
E
I
L
H
T
Y
Q
K
E
Q
R
N
Site 38
T350
K
E
A
G
G
N
Y
T
P
A
L
T
E
Q
E
Site 39
S374
K
N
Q
E
D
L
L
S
E
F
G
Q
F
L
P
Site 40
S385
Q
F
L
P
D
A
N
S
S
V
L
L
S
K
T
Site 41
S390
A
N
S
S
V
L
L
S
K
T
T
A
E
K
V
Site 42
T392
S
S
V
L
L
S
K
T
T
A
E
K
V
D
S
Site 43
S399
T
T
A
E
K
V
D
S
V
R
N
D
H
G
G
Site 44
S421
N
N
K
P
Q
R
P
S
Q
N
G
C
Q
I
R
Site 45
T432
C
Q
I
R
R
H
P
T
G
T
T
P
P
V
K
Site 46
T434
I
R
R
H
P
T
G
T
T
P
P
V
K
K
K
Site 47
T435
R
R
H
P
T
G
T
T
P
P
V
K
K
K
P
Site 48
S450
K
L
L
N
L
K
D
S
S
M
A
D
A
S
K
Site 49
S451
L
L
N
L
K
D
S
S
M
A
D
A
S
K
H
Site 50
S456
D
S
S
M
A
D
A
S
K
H
G
G
G
T
E
Site 51
S464
K
H
G
G
G
T
E
S
L
F
F
D
K
V
R
Site 52
S476
K
V
R
K
A
L
R
S
A
E
A
Y
E
N
F
Site 53
Y480
A
L
R
S
A
E
A
Y
E
N
F
L
R
C
L
Site 54
Y524
W
F
K
N
F
L
G
Y
K
E
S
V
H
L
E
Site 55
S527
N
F
L
G
Y
K
E
S
V
H
L
E
T
Y
P
Site 56
Y533
E
S
V
H
L
E
T
Y
P
K
E
R
A
T
E
Site 57
T539
T
Y
P
K
E
R
A
T
E
G
I
A
M
E
I
Site 58
S550
A
M
E
I
D
Y
A
S
C
K
R
L
G
S
S
Site 59
S556
A
S
C
K
R
L
G
S
S
Y
R
A
L
P
K
Site 60
S557
S
C
K
R
L
G
S
S
Y
R
A
L
P
K
S
Site 61
Y558
C
K
R
L
G
S
S
Y
R
A
L
P
K
S
Y
Site 62
S564
S
Y
R
A
L
P
K
S
Y
Q
Q
P
K
C
T
Site 63
Y565
Y
R
A
L
P
K
S
Y
Q
Q
P
K
C
T
G
Site 64
T571
S
Y
Q
Q
P
K
C
T
G
R
T
P
L
C
K
Site 65
T574
Q
P
K
C
T
G
R
T
P
L
C
K
E
V
L
Site 66
S587
V
L
N
D
T
W
V
S
F
P
S
W
S
E
D
Site 67
S590
D
T
W
V
S
F
P
S
W
S
E
D
S
T
F
Site 68
S592
W
V
S
F
P
S
W
S
E
D
S
T
F
V
S
Site 69
S595
F
P
S
W
S
E
D
S
T
F
V
S
S
K
K
Site 70
T596
P
S
W
S
E
D
S
T
F
V
S
S
K
K
T
Site 71
S599
S
E
D
S
T
F
V
S
S
K
K
T
Q
Y
E
Site 72
T603
T
F
V
S
S
K
K
T
Q
Y
E
E
H
I
Y
Site 73
Y605
V
S
S
K
K
T
Q
Y
E
E
H
I
Y
R
C
Site 74
Y610
T
Q
Y
E
E
H
I
Y
R
C
E
D
E
R
F
Site 75
S641
E
A
I
Q
K
K
L
S
R
L
S
A
E
E
Q
Site 76
S644
Q
K
K
L
S
R
L
S
A
E
E
Q
A
K
F
Site 77
T656
A
K
F
R
L
D
N
T
L
G
G
T
S
E
V
Site 78
Y673
R
K
A
L
Q
R
I
Y
A
D
K
A
A
D
I
Site 79
Y724
W
R
E
Q
N
E
K
Y
Y
L
K
S
L
D
H
Site 80
Y725
R
E
Q
N
E
K
Y
Y
L
K
S
L
D
H
Q
Site 81
S746
N
D
T
K
V
L
R
S
K
S
L
L
N
E
I
Site 82
S748
T
K
V
L
R
S
K
S
L
L
N
E
I
E
S
Site 83
S755
S
L
L
N
E
I
E
S
I
Y
D
E
R
Q
E
Site 84
Y757
L
N
E
I
E
S
I
Y
D
E
R
Q
E
Q
A
Site 85
T765
D
E
R
Q
E
Q
A
T
E
E
N
A
G
V
P
Site 86
S778
V
P
V
G
P
H
L
S
L
A
Y
E
D
K
Q
Site 87
T802
I
H
H
V
K
R
Q
T
G
I
Q
K
E
D
K
Site 88
Y810
G
I
Q
K
E
D
K
Y
K
I
K
Q
I
M
H
Site 89
S832
F
A
Q
R
G
D
L
S
D
V
E
E
E
E
E
Site 90
T848
E
M
D
V
D
E
A
T
G
A
V
K
K
H
N
Site 91
S860
K
H
N
G
V
G
G
S
P
P
K
S
K
L
L
Site 92
S864
V
G
G
S
P
P
K
S
K
L
L
F
S
N
T
Site 93
S869
P
K
S
K
L
L
F
S
N
T
A
A
Q
K
L
Site 94
T871
S
K
L
L
F
S
N
T
A
A
Q
K
L
R
G
Site 95
Y883
L
R
G
M
D
E
V
Y
N
L
F
Y
V
N
N
Site 96
S911
L
R
L
L
R
I
C
S
Q
A
E
R
Q
I
E
Site 97
S938
L
G
I
K
R
D
K
S
D
S
P
A
I
Q
L
Site 98
S940
I
K
R
D
K
S
D
S
P
A
I
Q
L
R
L
Site 99
Y958
M
D
V
D
V
E
D
Y
Y
P
A
F
L
D
M
Site 100
S976
L
L
D
G
N
I
D
S
S
Q
Y
E
D
S
L
Site 101
S977
L
D
G
N
I
D
S
S
Q
Y
E
D
S
L
R
Site 102
S982
D
S
S
Q
Y
E
D
S
L
R
E
M
F
T
I
Site 103
S1003
T
M
D
K
L
I
Q
S
I
V
R
Q
L
Q
H
Site 104
Y1024
C
V
Q
V
T
D
L
Y
L
A
E
N
N
N
G
Site 105
T1039
A
T
G
G
Q
L
N
T
Q
N
S
R
S
L
L
Site 106
S1042
G
Q
L
N
T
Q
N
S
R
S
L
L
E
S
T
Site 107
S1044
L
N
T
Q
N
S
R
S
L
L
E
S
T
Y
Q
Site 108
S1048
N
S
R
S
L
L
E
S
T
Y
Q
R
K
A
E
Site 109
Y1050
R
S
L
L
E
S
T
Y
Q
R
K
A
E
Q
L
Site 110
S1059
R
K
A
E
Q
L
M
S
D
E
N
C
F
K
L
Site 111
T1084
L
T
I
E
L
L
D
T
E
E
E
N
S
D
D
Site 112
S1089
L
D
T
E
E
E
N
S
D
D
P
V
E
A
E
Site 113
Y1101
E
A
E
R
W
S
D
Y
V
E
R
Y
M
N
S
Site 114
S1108
Y
V
E
R
Y
M
N
S
D
T
T
S
P
E
L
Site 115
T1110
E
R
Y
M
N
S
D
T
T
S
P
E
L
R
E
Site 116
T1111
R
Y
M
N
S
D
T
T
S
P
E
L
R
E
H
Site 117
S1112
Y
M
N
S
D
T
T
S
P
E
L
R
E
H
L
Site 118
S1161
K
T
M
E
N
V
D
S
L
D
K
L
E
C
R
Site 119
Y1174
C
R
F
K
L
N
S
Y
K
M
V
Y
V
I
K
Site 120
Y1178
L
N
S
Y
K
M
V
Y
V
I
K
S
E
D
Y
Site 121
Y1185
Y
V
I
K
S
E
D
Y
M
Y
R
R
T
A
L
Site 122
Y1187
I
K
S
E
D
Y
M
Y
R
R
T
A
L
L
R
Site 123
T1190
E
D
Y
M
Y
R
R
T
A
L
L
R
A
H
Q
Site 124
S1198
A
L
L
R
A
H
Q
S
H
E
R
V
S
K
R
Site 125
S1203
H
Q
S
H
E
R
V
S
K
R
L
H
Q
R
F
Site 126
S1231
R
E
M
A
A
E
T
S
K
W
L
M
G
E
G
Site 127
T1253
T
T
T
C
D
T
E
T
L
H
F
V
S
I
N
Site 128
Y1262
H
F
V
S
I
N
K
Y
R
V
K
Y
G
T
V
Site 129
Y1266
I
N
K
Y
R
V
K
Y
G
T
V
F
K
A
P
Site 130
T1268
K
Y
R
V
K
Y
G
T
V
F
K
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation