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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGS1
Full Name:
Trimethylguanosine synthase
Alias:
CLL-associated antigen KW-2; HCA137; Hepatocellular carcinoma-associated antigen 137; NC6IP; NCOA6IP; Nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP-interacting protein with methyltransferase motif
Type:
EC 2.1.1.-; RNA processing; Nuclear receptor co-regulator; Methyltransferase
Mass (Da):
96608
Number AA:
853
UniProt ID:
Q96RS0
International Prot ID:
IPI00784316
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008168
PhosphoSite+
KinaseNET
Biological Process:
GO:0009452
GO:0001510
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y39
F
V
E
D
R
K
L
Y
N
L
G
L
K
G
Y
Site 2
Y46
Y
N
L
G
L
K
G
Y
Y
I
R
D
S
G
N
Site 3
Y47
N
L
G
L
K
G
Y
Y
I
R
D
S
G
N
N
Site 4
S51
K
G
Y
Y
I
R
D
S
G
N
N
S
G
D
Q
Site 5
S55
I
R
D
S
G
N
N
S
G
D
Q
A
T
E
E
Site 6
T60
N
N
S
G
D
Q
A
T
E
E
E
E
G
G
Y
Site 7
Y67
T
E
E
E
E
G
G
Y
S
C
G
T
A
E
S
Site 8
S68
E
E
E
E
G
G
Y
S
C
G
T
A
E
S
H
Site 9
T71
E
G
G
Y
S
C
G
T
A
E
S
H
D
S
K
Site 10
S74
Y
S
C
G
T
A
E
S
H
D
S
K
G
I
G
Site 11
S77
G
T
A
E
S
H
D
S
K
G
I
G
L
D
E
Site 12
S85
K
G
I
G
L
D
E
S
E
L
D
S
E
A
E
Site 13
S89
L
D
E
S
E
L
D
S
E
A
E
L
M
R
S
Site 14
S96
S
E
A
E
L
M
R
S
M
G
L
P
L
Q
F
Site 15
T107
P
L
Q
F
G
R
I
T
A
H
K
D
F
E
V
Site 16
Y133
K
K
K
H
Q
K
K
Y
L
D
E
I
V
Q
E
Site 17
S141
L
D
E
I
V
Q
E
S
W
R
K
E
Y
E
E
Site 18
Y146
Q
E
S
W
R
K
E
Y
E
E
D
D
I
L
A
Site 19
S154
E
E
D
D
I
L
A
S
D
D
P
S
S
I
E
Site 20
S158
I
L
A
S
D
D
P
S
S
I
E
Q
Y
E
N
Site 21
S159
L
A
S
D
D
P
S
S
I
E
Q
Y
E
N
T
Site 22
Y163
D
P
S
S
I
E
Q
Y
E
N
T
R
T
Y
E
Site 23
T168
E
Q
Y
E
N
T
R
T
Y
E
L
Q
S
K
K
Site 24
Y169
Q
Y
E
N
T
R
T
Y
E
L
Q
S
K
K
D
Site 25
T177
E
L
Q
S
K
K
D
T
E
T
E
N
P
P
V
Site 26
T179
Q
S
K
K
D
T
E
T
E
N
P
P
V
E
N
Site 27
T187
E
N
P
P
V
E
N
T
L
S
P
K
L
E
I
Site 28
S189
P
P
V
E
N
T
L
S
P
K
L
E
I
T
E
Site 29
Y201
I
T
E
K
W
E
K
Y
W
N
E
Y
G
G
G
Site 30
S213
G
G
G
L
L
W
Q
S
W
Q
E
K
H
P
G
Site 31
S224
K
H
P
G
Q
A
L
S
S
E
P
W
N
F
P
Site 32
S225
H
P
G
Q
A
L
S
S
E
P
W
N
F
P
D
Site 33
Y245
E
Q
H
Y
S
Q
L
Y
W
Y
Y
L
E
Q
F
Site 34
T270
D
A
S
Q
S
C
D
T
D
T
Y
T
S
K
T
Site 35
T272
S
Q
S
C
D
T
D
T
Y
T
S
K
T
E
A
Site 36
Y273
Q
S
C
D
T
D
T
Y
T
S
K
T
E
A
D
Site 37
T274
S
C
D
T
D
T
Y
T
S
K
T
E
A
D
D
Site 38
S294
C
M
K
V
D
L
V
S
F
P
S
S
P
I
M
Site 39
S298
D
L
V
S
F
P
S
S
P
I
M
V
D
N
D
Site 40
S306
P
I
M
V
D
N
D
S
S
G
T
S
D
K
D
Site 41
S310
D
N
D
S
S
G
T
S
D
K
D
H
S
E
I
Site 42
S315
G
T
S
D
K
D
H
S
E
I
L
D
G
I
S
Site 43
S322
S
E
I
L
D
G
I
S
N
I
K
L
N
S
E
Site 44
T332
K
L
N
S
E
E
V
T
Q
S
Q
L
D
S
C
Site 45
S334
N
S
E
E
V
T
Q
S
Q
L
D
S
C
T
S
Site 46
S338
V
T
Q
S
Q
L
D
S
C
T
S
H
D
G
H
Site 47
S341
S
Q
L
D
S
C
T
S
H
D
G
H
Q
Q
L
Site 48
S349
H
D
G
H
Q
Q
L
S
E
V
S
S
K
R
E
Site 49
S353
Q
Q
L
S
E
V
S
S
K
R
E
C
P
A
S
Site 50
S360
S
K
R
E
C
P
A
S
G
Q
S
E
P
R
N
Site 51
S363
E
C
P
A
S
G
Q
S
E
P
R
N
G
G
T
Site 52
T370
S
E
P
R
N
G
G
T
N
E
E
S
N
S
S
Site 53
S374
N
G
G
T
N
E
E
S
N
S
S
G
N
T
N
Site 54
S376
G
T
N
E
E
S
N
S
S
G
N
T
N
T
D
Site 55
T380
E
S
N
S
S
G
N
T
N
T
D
P
P
A
E
Site 56
T382
N
S
S
G
N
T
N
T
D
P
P
A
E
D
S
Site 57
S389
T
D
P
P
A
E
D
S
Q
K
S
S
G
A
N
Site 58
S393
A
E
D
S
Q
K
S
S
G
A
N
T
S
K
D
Site 59
T397
Q
K
S
S
G
A
N
T
S
K
D
R
P
H
A
Site 60
S398
K
S
S
G
A
N
T
S
K
D
R
P
H
A
S
Site 61
S405
S
K
D
R
P
H
A
S
G
T
D
G
D
E
S
Site 62
T407
D
R
P
H
A
S
G
T
D
G
D
E
S
E
E
Site 63
S412
S
G
T
D
G
D
E
S
E
E
D
P
P
E
H
Site 64
S422
D
P
P
E
H
K
P
S
K
L
K
R
S
H
E
Site 65
S438
D
I
D
E
N
P
A
S
D
F
D
D
S
G
S
Site 66
S443
P
A
S
D
F
D
D
S
G
S
L
L
G
F
K
Site 67
S445
S
D
F
D
D
S
G
S
L
L
G
F
K
Y
G
Site 68
Y451
G
S
L
L
G
F
K
Y
G
S
G
Q
K
Y
G
Site 69
S453
L
L
G
F
K
Y
G
S
G
Q
K
Y
G
G
I
Site 70
Y457
K
Y
G
S
G
Q
K
Y
G
G
I
P
N
F
S
Site 71
S479
E
K
N
V
K
L
K
S
K
Y
L
D
M
R
R
Site 72
Y481
N
V
K
L
K
S
K
Y
L
D
M
R
R
Q
I
Site 73
S509
E
K
P
F
F
K
K
S
K
I
L
S
K
V
E
Site 74
S513
F
K
K
S
K
I
L
S
K
V
E
K
F
L
T
Site 75
T520
S
K
V
E
K
F
L
T
W
V
N
K
P
M
D
Site 76
S531
K
P
M
D
E
E
A
S
Q
E
S
S
S
H
D
Site 77
S535
E
E
A
S
Q
E
S
S
S
H
D
N
V
H
D
Site 78
S536
E
A
S
Q
E
S
S
S
H
D
N
V
H
D
A
Site 79
S544
H
D
N
V
H
D
A
S
T
S
S
D
S
E
E
Site 80
T545
D
N
V
H
D
A
S
T
S
S
D
S
E
E
Q
Site 81
S547
V
H
D
A
S
T
S
S
D
S
E
E
Q
D
M
Site 82
S549
D
A
S
T
S
S
D
S
E
E
Q
D
M
S
V
Site 83
S555
D
S
E
E
Q
D
M
S
V
K
K
G
D
D
L
Site 84
T565
K
G
D
D
L
L
E
T
N
N
P
E
P
E
K
Site 85
S575
P
E
P
E
K
C
Q
S
V
S
S
A
G
E
L
Site 86
S577
P
E
K
C
Q
S
V
S
S
A
G
E
L
E
T
Site 87
S578
E
K
C
Q
S
V
S
S
A
G
E
L
E
T
E
Site 88
Y587
G
E
L
E
T
E
N
Y
E
R
D
S
L
L
A
Site 89
S591
T
E
N
Y
E
R
D
S
L
L
A
T
V
P
D
Site 90
T595
E
R
D
S
L
L
A
T
V
P
D
E
Q
D
C
Site 91
T604
P
D
E
Q
D
C
V
T
Q
E
V
P
D
S
R
Site 92
S610
V
T
Q
E
V
P
D
S
R
Q
A
E
T
E
A
Site 93
T615
P
D
S
R
Q
A
E
T
E
A
E
V
K
K
K
Site 94
Y647
A
V
P
E
L
A
K
Y
W
A
Q
R
Y
R
L
Site 95
Y652
A
K
Y
W
A
Q
R
Y
R
L
F
S
R
F
D
Site 96
S656
A
Q
R
Y
R
L
F
S
R
F
D
D
G
I
K
Site 97
S671
L
D
R
E
G
W
F
S
V
T
P
E
K
I
A
Site 98
T673
R
E
G
W
F
S
V
T
P
E
K
I
A
E
H
Site 99
S686
E
H
I
A
G
R
V
S
Q
S
F
K
C
D
V
Site 100
S753
G
D
F
L
L
L
A
S
F
L
K
A
D
V
V
Site 101
S763
K
A
D
V
V
F
L
S
P
P
W
G
G
P
D
Site 102
Y771
P
P
W
G
G
P
D
Y
A
T
A
E
T
F
D
Site 103
T773
W
G
G
P
D
Y
A
T
A
E
T
F
D
I
R
Site 104
T781
A
E
T
F
D
I
R
T
M
M
S
P
D
G
F
Site 105
S794
G
F
E
I
F
R
L
S
K
K
I
T
N
N
I
Site 106
Y803
K
I
T
N
N
I
V
Y
F
L
P
R
N
A
D
Site 107
S816
A
D
I
D
Q
V
A
S
L
A
G
P
G
G
Q
Site 108
Y841
K
L
K
T
I
T
A
Y
F
G
D
L
I
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation