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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PEO1
Full Name:
Twinkle protein, mitochondrial
Alias:
Progressive external ophthalmoplegia 1 protein;T7 gp4-like protein with intramitochondrial nucleoid localization;T7-like mitochondrial DNA helicase
Type:
Mass (Da):
77154
Number AA:
684
UniProt ID:
Q96RR1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
P
G
P
P
R
R
R
Y
R
K
E
T
L
Q
A
Site 2
T44
R
R
R
Y
R
K
E
T
L
Q
A
L
D
M
P
Site 3
T58
P
V
L
P
V
T
A
T
E
I
R
Q
Y
L
R
Site 4
Y63
T
A
T
E
I
R
Q
Y
L
R
G
H
G
I
P
Site 5
S76
I
P
F
Q
D
G
H
S
C
L
R
A
L
S
P
Site 6
S82
H
S
C
L
R
A
L
S
P
F
A
E
S
S
Q
Site 7
S88
L
S
P
F
A
E
S
S
Q
L
K
G
Q
T
G
Site 8
S121
M
T
S
L
A
E
G
S
W
E
D
F
Q
A
S
Site 9
S128
S
W
E
D
F
Q
A
S
V
E
G
R
G
D
G
Site 10
S143
A
R
E
G
F
L
L
S
K
A
P
E
F
E
D
Site 11
S151
K
A
P
E
F
E
D
S
E
E
V
R
R
I
W
Site 12
T178
E
E
V
Q
L
A
D
T
M
F
G
L
T
K
V
Site 13
T189
L
T
K
V
T
D
D
T
L
K
R
F
S
V
R
Site 14
S194
D
D
T
L
K
R
F
S
V
R
Y
L
R
P
A
Site 15
Y197
L
K
R
F
S
V
R
Y
L
R
P
A
R
S
L
Site 16
S203
R
Y
L
R
P
A
R
S
L
V
F
P
W
F
S
Site 17
S214
P
W
F
S
P
G
G
S
G
L
R
G
L
K
L
Site 18
S232
K
C
Q
G
D
G
V
S
Y
E
E
T
T
I
P
Site 19
T236
D
G
V
S
Y
E
E
T
T
I
P
R
P
S
A
Site 20
T237
G
V
S
Y
E
E
T
T
I
P
R
P
S
A
Y
Site 21
S242
E
T
T
I
P
R
P
S
A
Y
H
N
L
F
G
Site 22
Y244
T
I
P
R
P
S
A
Y
H
N
L
F
G
L
P
Site 23
T263
R
D
A
E
V
V
L
T
S
R
E
L
D
S
L
Site 24
S269
L
T
S
R
E
L
D
S
L
A
L
N
Q
S
T
Site 25
S275
D
S
L
A
L
N
Q
S
T
G
L
P
T
L
T
Site 26
T282
S
T
G
L
P
T
L
T
L
P
R
G
T
T
C
Site 27
S314
W
L
G
D
D
L
R
S
W
E
A
A
K
L
F
Site 28
T358
N
L
S
R
I
L
R
T
A
L
P
A
W
H
K
Site 29
S369
A
W
H
K
S
I
V
S
F
R
Q
L
R
E
E
Site 30
S382
E
E
V
L
G
E
L
S
N
V
E
Q
A
A
G
Site 31
S393
Q
A
A
G
L
R
W
S
R
F
P
D
L
N
R
Site 32
T411
G
H
R
K
G
E
L
T
V
F
T
G
P
T
G
Site 33
T414
K
G
E
L
T
V
F
T
G
P
T
G
S
G
K
Site 34
T423
P
T
G
S
G
K
T
T
F
I
S
E
Y
A
L
Site 35
Y428
K
T
T
F
I
S
E
Y
A
L
D
L
C
S
Q
Site 36
S443
G
V
N
T
L
W
G
S
F
E
I
S
N
V
R
Site 37
Y471
L
E
D
Q
L
D
K
Y
D
H
W
A
D
R
F
Site 38
Y484
R
F
E
D
L
P
L
Y
F
M
T
F
H
G
Q
Site 39
T496
H
G
Q
Q
S
I
R
T
V
I
D
T
M
Q
H
Site 40
T529
M
G
H
E
Q
L
S
T
D
R
I
A
A
Q
D
Site 41
Y537
D
R
I
A
A
Q
D
Y
I
I
G
V
F
R
K
Site 42
T570
D
D
D
K
E
L
Q
T
A
S
I
F
G
S
A
Site 43
S572
D
K
E
L
Q
T
A
S
I
F
G
S
A
K
A
Site 44
S576
Q
T
A
S
I
F
G
S
A
K
A
S
Q
E
A
Site 45
S580
I
F
G
S
A
K
A
S
Q
E
A
D
N
V
L
Site 46
Y602
V
T
G
P
G
K
R
Y
L
Q
V
S
K
N
R
Site 47
S606
G
K
R
Y
L
Q
V
S
K
N
R
F
D
G
D
Site 48
S625
P
L
E
F
N
K
N
S
L
T
F
S
I
P
P
Site 49
T627
E
F
N
K
N
S
L
T
F
S
I
P
P
K
N
Site 50
S629
N
K
N
S
L
T
F
S
I
P
P
K
N
K
A
Site 51
T645
L
K
K
I
K
D
D
T
G
P
V
A
K
K
P
Site 52
S654
P
V
A
K
K
P
S
S
G
K
K
G
A
T
T
Site 53
T660
S
S
G
K
K
G
A
T
T
Q
N
S
E
I
C
Site 54
T661
S
G
K
K
G
A
T
T
Q
N
S
E
I
C
S
Site 55
S664
K
G
A
T
T
Q
N
S
E
I
C
S
G
Q
A
Site 56
S668
T
Q
N
S
E
I
C
S
G
Q
A
P
T
P
D
Site 57
T673
I
C
S
G
Q
A
P
T
P
D
Q
P
D
T
S
Site 58
T679
P
T
P
D
Q
P
D
T
S
K
R
S
K
_
_
Site 59
S680
T
P
D
Q
P
D
T
S
K
R
S
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation