PhosphoNET

           
Protein Info 
   
Short Name:  MED15
Full Name:  Mediator of RNA polymerase II transcription subunit 15
Alias:  Activator-recruited cofactor 105 kDa component; ARC105; CAG7A; CTG repeat protein 7a; CTG7A; Mediator complex subunit 15; Mediator of RNA polymerase II transcription subunit 15: Mediator complex subunit 15: Positive cofactor 2 glutamine/Q-rich-associated protein: TPA-inducible gene 1 protein: Activator-recruited cofactor 105 kDa component: CTG repeat protein 7a: Trinucleotide repeat-containing gene 7 protein: Mediator of RNA polymerase II transcription subunit 15: Mediator complex subunit 15: Positive cofactor 2 glutamine/Q-rich-associated protein: TPA-inducible gene 1 protein: Activator-recruited cofactor 105 kDa component: CTG repeat protein 7a: Trinucleotide repeat-containing gene 7 protein: Mediator of RNA polymerase II transcription subunit 15: Mediator complex subunit 15: Positive cofactor 2 glutamine/Q-rich-associated protein: TPA-inducible gene 1 protein: Activator-recruited cofactor 105 kDa component: CTG repeat protein 7a: Trinucleotide repeat-containing gene 7 protein; PCQAP; Positive cofactor 2 glutamine/Q-rich-associated protein; TIG-1; TNRC7; TPA-inducible gene 1 protein; Trinucleotide repeat-containing gene 7 protein
Type:  Transcription, coactivator/corepressor, Nuclear receptor co-regulator
Mass (Da):  86753
Number AA:  788
UniProt ID:  Q96RN5
International Prot ID:  IPI00107693
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0016592   Uniprot OncoNet
Molecular Function:  GO:0016455  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0006357  GO:0006350   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T8MDVSGQETDWRSTAF
Site 2T13QETDWRSTAFRQKLV
Site 3S21AFRQKLVSQIEDAMR
Site 4S35RKAGVAHSKSSKDME
Site 5S37AGVAHSKSSKDMESH
Site 6S38GVAHSKSSKDMESHV
Site 7S43KSSKDMESHVFLKAK
Site 8Y55KAKTRDEYLSLVARL
Site 9S74RDIHNKKSQASVSDP
Site 10S77HNKKSQASVSDPMNA
Site 11S79KKSQASVSDPMNALQ
Site 12S87DPMNALQSLTGGPAA
Site 13S109PPRGPGQSLGGMGSL
Site 14S115QSLGGMGSLGAMGQP
Site 15S124GAMGQPMSLSGQPPP
Site 16S126MGQPMSLSGQPPPGT
Site 17T133SGQPPPGTSGMAPHS
Site 18S134GQPPPGTSGMAPHSM
Site 19S283QQPQPPPSQALPQQL
Site 20S316PVAQNQPSQLPPQSQ
Site 21S322PSQLPPQSQTQPLVS
Site 22S329SQTQPLVSQAQALPG
Site 23Y340ALPGQMLYTQPPLKF
Site 24T405RARFPPTTAVSAIPS
Site 25S414VSAIPSSSIPLGRQP
Site 26S426RQPMAQVSQSSLPML
Site 27S428PMAQVSQSSLPMLSS
Site 28S429MAQVSQSSLPMLSSP
Site 29S434QSSLPMLSSPSPGQQ
Site 30S435SSLPMLSSPSPGQQV
Site 31S437LPMLSSPSPGQQVQT
Site 32T444SPGQQVQTPQSMPPP
Site 33S447QQVQTPQSMPPPPQP
Site 34S455MPPPPQPSPQPGQPS
Site 35S462SPQPGQPSSQPNSNV
Site 36S463PQPGQPSSQPNSNVS
Site 37S467QPSSQPNSNVSSGPA
Site 38S470SQPNSNVSSGPAPSP
Site 39S471QPNSNVSSGPAPSPS
Site 40S476VSSGPAPSPSSFLPS
Site 41S478SGPAPSPSSFLPSPS
Site 42S479GPAPSPSSFLPSPSP
Site 43S483SPSSFLPSPSPQPSQ
Site 44S485SSFLPSPSPQPSQSP
Site 45S489PSPSPQPSQSPVTAR
Site 46S491PSPQPSQSPVTARTP
Site 47T494QPSQSPVTARTPQNF
Site 48T497QSPVTARTPQNFSVP
Site 49S502ARTPQNFSVPSPGPL
Site 50S505PQNFSVPSPGPLNTP
Site 51T511PSPGPLNTPVNPSSV
Site 52S516LNTPVNPSSVMSPAG
Site 53S517NTPVNPSSVMSPAGS
Site 54S520VNPSSVMSPAGSSQA
Site 55S524SVMSPAGSSQAEEQQ
Site 56S525VMSPAGSSQAEEQQY
Site 57Y532SQAEEQQYLDKLKQL
Site 58S540LDKLKQLSKYIEPLR
Site 59Y542KLKQLSKYIEPLRRM
Site 60S564EDRKKDLSKMKSLLD
Site 61S568KDLSKMKSLLDILTD
Site 62T574KSLLDILTDPSKRCP
Site 63S577LDILTDPSKRCPLKT
Site 64T584SKRCPLKTLQKCEIA
Site 65T603KNDMAVPTPPPPPVP
Site 66T612PPPPVPPTKQQYLCQ
Site 67Y616VPPTKQQYLCQPLLD
Site 68S631AVLANIRSPVFNHSL
Site 69S637RSPVFNHSLYRTFVP
Site 70S673LEDDERQSIPSVLQG
Site 71S676DERQSIPSVLQGEVA
Site 72S696FLVNLDPSHCSNNGT
Site 73S717LDDKDLPSVPPLELS
Site 74Y729ELSVPADYPAQSPLW
Site 75S733PADYPAQSPLWIDRQ
Site 76T757QSVHRCMTSRLLQLP
Site 77S768LQLPDKHSVTALLNT
Site 78T775SVTALLNTWAQSVHQ
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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