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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR1H4
Full Name:
Bile acid receptor
Alias:
Farnesoid X-activated receptor;Farnesol receptor HRR-1;Nuclear receptor subfamily 1 group H member 4;Retinoid X receptor-interacting protein 14
Type:
Mass (Da):
55914
Number AA:
486
UniProt ID:
Q96RI1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
E
N
P
I
Q
I
S
P
H
C
S
C
T
P
Site 2
Y56
Q
N
L
E
V
E
P
Y
S
Q
Y
S
N
V
Q
Site 3
S57
N
L
E
V
E
P
Y
S
Q
Y
S
N
V
Q
F
Site 4
S60
V
E
P
Y
S
Q
Y
S
N
V
Q
F
P
Q
V
Site 5
S72
P
Q
V
Q
P
Q
I
S
S
S
S
Y
Y
S
N
Site 6
S73
Q
V
Q
P
Q
I
S
S
S
S
Y
Y
S
N
L
Site 7
S74
V
Q
P
Q
I
S
S
S
S
Y
Y
S
N
L
G
Site 8
S75
Q
P
Q
I
S
S
S
S
Y
Y
S
N
L
G
F
Site 9
Y76
P
Q
I
S
S
S
S
Y
Y
S
N
L
G
F
Y
Site 10
Y77
Q
I
S
S
S
S
Y
Y
S
N
L
G
F
Y
P
Site 11
S78
I
S
S
S
S
Y
Y
S
N
L
G
F
Y
P
Q
Site 12
Y83
Y
Y
S
N
L
G
F
Y
P
Q
Q
P
E
E
W
Site 13
Y91
P
Q
Q
P
E
E
W
Y
S
P
G
I
Y
E
L
Site 14
S92
Q
Q
P
E
E
W
Y
S
P
G
I
Y
E
L
R
Site 15
Y96
E
W
Y
S
P
G
I
Y
E
L
R
R
M
P
A
Site 16
T105
L
R
R
M
P
A
E
T
L
Y
Q
G
E
T
E
Site 17
Y107
R
M
P
A
E
T
L
Y
Q
G
E
T
E
V
A
Site 18
T119
E
V
A
E
M
P
V
T
K
K
P
R
M
G
A
Site 19
S127
K
K
P
R
M
G
A
S
A
G
R
I
K
G
D
Site 20
Y147
C
G
D
R
A
S
G
Y
H
Y
N
A
L
T
C
Site 21
Y149
D
R
A
S
G
Y
H
Y
N
A
L
T
C
E
G
Site 22
T166
G
F
F
R
R
S
I
T
K
N
A
V
Y
K
C
Site 23
Y171
S
I
T
K
N
A
V
Y
K
C
K
N
G
G
N
Site 24
S219
L
T
E
I
Q
C
K
S
K
R
L
R
K
N
V
Site 25
T233
V
K
Q
H
A
D
Q
T
V
N
E
D
S
E
G
Site 26
S238
D
Q
T
V
N
E
D
S
E
G
R
D
L
R
Q
Site 27
T247
G
R
D
L
R
Q
V
T
S
T
T
K
S
C
R
Site 28
S248
R
D
L
R
Q
V
T
S
T
T
K
S
C
R
E
Site 29
T249
D
L
R
Q
V
T
S
T
T
K
S
C
R
E
K
Site 30
S252
Q
V
T
S
T
T
K
S
C
R
E
K
T
E
L
Site 31
T257
T
K
S
C
R
E
K
T
E
L
T
P
D
Q
Q
Site 32
T260
C
R
E
K
T
E
L
T
P
D
Q
Q
T
L
L
Site 33
T265
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
Site 34
Y274
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
Site 35
S293
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
Site 36
T324
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
Site 37
S356
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
Site 38
S369
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
Site 39
S372
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
Site 40
Y375
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Site 41
T377
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
Site 42
S381
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
Site 43
S385
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Site 44
T392
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
Site 45
Y411
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
Site 46
T456
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation