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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAGI1
Full Name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alias:
AIP3; Atrophin-1-interacting 3; Atrophin-1-interacting protein 3; BAI1-associated 1; BAI1-associated protein 1; BAIAP1; BAP1; BAP-1; MAGI-1; Membrane associated guanylate kinase, WW and PDZ domain containing 1; Membrane-associated guanylate kinase inverted 1; Membrane-associated guanylate kinase, WW and PDZ domain-containing 1; TNRC19; Trinucleotide repeat-containing gene 19; Trinucleotide repeat-containing gene 19 protein; WW domain-containing protein 3; WWP3
Type:
Adhesion protein
Mass (Da):
164581
Number AA:
1491
UniProt ID:
Q96QZ7
International Prot ID:
IPI00165946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007166
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
T
S
R
V
H
E
C
T
V
K
R
G
P
Q
G
Site 2
T31
P
Q
G
E
L
G
V
T
V
L
G
G
A
E
H
Site 3
S79
E
V
Q
G
V
R
V
S
G
L
P
R
Y
D
V
Site 4
T132
P
D
H
E
L
Q
Q
T
I
R
D
N
L
Y
R
Site 5
Y138
Q
T
I
R
D
N
L
Y
R
H
A
V
P
C
T
Site 6
T145
Y
R
H
A
V
P
C
T
T
R
S
P
R
E
G
Site 7
S148
A
V
P
C
T
T
R
S
P
R
E
G
E
V
P
Site 8
Y159
G
E
V
P
G
V
D
Y
N
F
L
T
V
K
E
Site 9
T175
L
D
L
E
Q
S
G
T
L
L
E
V
G
T
Y
Site 10
Y182
T
L
L
E
V
G
T
Y
E
G
N
Y
Y
G
T
Site 11
Y186
V
G
T
Y
E
G
N
Y
Y
G
T
P
K
P
P
Site 12
Y187
G
T
Y
E
G
N
Y
Y
G
T
P
K
P
P
S
Site 13
T189
Y
E
G
N
Y
Y
G
T
P
K
P
P
S
Q
P
Site 14
S194
Y
G
T
P
K
P
P
S
Q
P
V
S
G
K
V
Site 15
S198
K
P
P
S
Q
P
V
S
G
K
V
I
T
T
D
Site 16
S209
I
T
T
D
A
L
H
S
L
Q
S
G
S
K
Q
Site 17
S212
D
A
L
H
S
L
Q
S
G
S
K
Q
S
T
P
Site 18
T218
Q
S
G
S
K
Q
S
T
P
K
R
T
K
S
Y
Site 19
T222
K
Q
S
T
P
K
R
T
K
S
Y
N
D
M
Q
Site 20
S224
S
T
P
K
R
T
K
S
Y
N
D
M
Q
N
A
Site 21
S250
D
V
P
E
M
N
S
S
F
T
A
D
S
G
E
Site 22
S255
N
S
S
F
T
A
D
S
G
E
Q
E
E
H
T
Site 23
T262
S
G
E
Q
E
E
H
T
L
Q
E
T
A
L
P
Site 24
T281
S
I
I
A
A
P
I
T
D
P
S
Q
K
F
P
Site 25
S284
A
A
P
I
T
D
P
S
Q
K
F
P
Q
Y
L
Site 26
Y290
P
S
Q
K
F
P
Q
Y
L
P
L
S
A
E
D
Site 27
S294
F
P
Q
Y
L
P
L
S
A
E
D
N
L
G
P
Site 28
Y310
P
E
N
W
E
M
A
Y
T
E
N
G
E
V
Y
Site 29
Y317
Y
T
E
N
G
E
V
Y
F
I
D
H
N
T
K
Site 30
T325
F
I
D
H
N
T
K
T
T
S
W
L
D
P
R
Site 31
T352
E
D
D
E
G
V
H
T
E
E
L
D
S
E
L
Site 32
S357
V
H
T
E
E
L
D
S
E
L
E
L
P
A
G
Site 33
Y373
E
K
I
E
D
P
V
Y
G
I
Y
Y
V
D
H
Site 34
Y376
E
D
P
V
Y
G
I
Y
Y
V
D
H
I
N
R
Site 35
Y377
D
P
V
Y
G
I
Y
Y
V
D
H
I
N
R
K
Site 36
T385
V
D
H
I
N
R
K
T
Q
Y
E
N
P
V
L
Site 37
Y387
H
I
N
R
K
T
Q
Y
E
N
P
V
L
E
A
Site 38
S430
E
E
W
T
E
D
H
S
A
L
V
P
P
V
I
Site 39
S443
V
I
P
N
H
P
P
S
N
P
E
P
A
R
E
Site 40
T460
L
Q
G
K
P
F
F
T
R
N
P
S
E
L
K
Site 41
S464
P
F
F
T
R
N
P
S
E
L
K
G
K
F
I
Site 42
T473
L
K
G
K
F
I
H
T
K
L
R
K
S
S
R
Site 43
S478
I
H
T
K
L
R
K
S
S
R
G
F
G
F
T
Site 44
S479
H
T
K
L
R
K
S
S
R
G
F
G
F
T
V
Site 45
T485
S
S
R
G
F
G
F
T
V
V
G
G
D
E
P
Site 46
S500
D
E
F
L
Q
I
K
S
L
V
L
D
G
P
A
Site 47
Y556
D
L
E
L
C
R
G
Y
P
L
P
F
D
P
D
Site 48
T567
F
D
P
D
D
P
N
T
S
L
V
T
S
V
A
Site 49
S568
D
P
D
D
P
N
T
S
L
V
T
S
V
A
I
Site 50
Y589
I
V
N
G
Q
E
T
Y
D
S
P
A
S
H
S
Site 51
S591
N
G
Q
E
T
Y
D
S
P
A
S
H
S
S
K
Site 52
S594
E
T
Y
D
S
P
A
S
H
S
S
K
T
G
K
Site 53
S597
D
S
P
A
S
H
S
S
K
T
G
K
V
N
G
Site 54
S611
G
M
K
D
A
R
P
S
S
P
A
D
V
A
S
Site 55
S612
M
K
D
A
R
P
S
S
P
A
D
V
A
S
N
Site 56
S618
S
S
P
A
D
V
A
S
N
S
S
H
G
Y
P
Site 57
S620
P
A
D
V
A
S
N
S
S
H
G
Y
P
N
D
Site 58
Y624
A
S
N
S
S
H
G
Y
P
N
D
T
V
S
L
Site 59
T628
S
H
G
Y
P
N
D
T
V
S
L
A
S
S
I
Site 60
S630
G
Y
P
N
D
T
V
S
L
A
S
S
I
A
T
Site 61
S660
F
G
F
T
I
A
D
S
P
G
G
G
G
Q
R
Site 62
S674
R
V
K
Q
I
V
D
S
P
R
C
R
G
L
K
Site 63
S730
G
L
P
V
P
K
K
S
P
K
S
Q
P
L
E
Site 64
S733
V
P
K
K
S
P
K
S
Q
P
L
E
R
K
D
Site 65
S741
Q
P
L
E
R
K
D
S
Q
N
S
S
Q
H
S
Site 66
S744
E
R
K
D
S
Q
N
S
S
Q
H
S
V
S
S
Site 67
S745
R
K
D
S
Q
N
S
S
Q
H
S
V
S
S
H
Site 68
S748
S
Q
N
S
S
Q
H
S
V
S
S
H
R
S
L
Site 69
S750
N
S
S
Q
H
S
V
S
S
H
R
S
L
H
T
Site 70
S751
S
S
Q
H
S
V
S
S
H
R
S
L
H
T
A
Site 71
S754
H
S
V
S
S
H
R
S
L
H
T
A
S
P
S
Site 72
T757
S
S
H
R
S
L
H
T
A
S
P
S
H
S
T
Site 73
S759
H
R
S
L
H
T
A
S
P
S
H
S
T
Q
V
Site 74
S761
S
L
H
T
A
S
P
S
H
S
T
Q
V
L
P
Site 75
S763
H
T
A
S
P
S
H
S
T
Q
V
L
P
E
F
Site 76
T781
E
A
Q
A
P
D
Q
T
D
S
S
G
Q
K
K
Site 77
S784
A
P
D
Q
T
D
S
S
G
Q
K
K
P
D
P
Site 78
S800
K
I
W
A
Q
S
R
S
M
Y
E
N
R
P
M
Site 79
Y802
W
A
Q
S
R
S
M
Y
E
N
R
P
M
S
P
Site 80
S808
M
Y
E
N
R
P
M
S
P
S
P
A
S
G
L
Site 81
S810
E
N
R
P
M
S
P
S
P
A
S
G
L
S
K
Site 82
S813
P
M
S
P
S
P
A
S
G
L
S
K
G
E
R
Site 83
T827
R
E
R
E
I
N
S
T
N
F
G
E
C
P
I
Site 84
Y837
G
E
C
P
I
P
D
Y
Q
E
Q
D
I
F
L
Site 85
Y866
N
E
P
G
E
P
I
Y
I
G
H
I
V
P
L
Site 86
T878
V
P
L
G
A
A
D
T
D
G
R
L
R
S
G
Site 87
S884
D
T
D
G
R
L
R
S
G
D
E
L
I
C
V
Site 88
T920
K
Q
G
H
V
N
L
T
V
R
R
K
V
V
F
Site 89
T932
V
V
F
A
V
P
K
T
E
N
E
V
P
S
P
Site 90
S938
K
T
E
N
E
V
P
S
P
A
S
S
H
H
S
Site 91
S941
N
E
V
P
S
P
A
S
S
H
H
S
S
N
Q
Site 92
S942
E
V
P
S
P
A
S
S
H
H
S
S
N
Q
P
Site 93
S945
S
P
A
S
S
H
H
S
S
N
Q
P
A
S
L
Site 94
S946
P
A
S
S
H
H
S
S
N
Q
P
A
S
L
T
Site 95
S951
H
S
S
N
Q
P
A
S
L
T
E
E
K
R
T
Site 96
T953
S
N
Q
P
A
S
L
T
E
E
K
R
T
P
Q
Site 97
T958
S
L
T
E
E
K
R
T
P
Q
G
S
Q
N
S
Site 98
S962
E
K
R
T
P
Q
G
S
Q
N
S
L
N
T
V
Site 99
S965
T
P
Q
G
S
Q
N
S
L
N
T
V
S
S
G
Site 100
T968
G
S
Q
N
S
L
N
T
V
S
S
G
S
G
S
Site 101
S971
N
S
L
N
T
V
S
S
G
S
G
S
T
S
G
Site 102
S973
L
N
T
V
S
S
G
S
G
S
T
S
G
I
G
Site 103
S975
T
V
S
S
G
S
G
S
T
S
G
I
G
S
G
Site 104
S977
S
S
G
S
G
S
T
S
G
I
G
S
G
G
G
Site 105
S981
G
S
T
S
G
I
G
S
G
G
G
G
G
S
G
Site 106
T1024
V
S
R
P
E
A
G
T
T
F
A
G
N
A
C
Site 107
T1025
S
R
P
E
A
G
T
T
F
A
G
N
A
C
V
Site 108
S1045
I
G
R
I
I
E
G
S
P
A
D
R
C
G
K
Site 109
S1071
G
C
S
I
T
N
K
S
H
S
D
I
V
N
L
Site 110
S1073
S
I
T
N
K
S
H
S
D
I
V
N
L
I
K
Site 111
T1087
K
E
A
G
N
T
V
T
L
R
I
I
P
G
D
Site 112
S1096
R
I
I
P
G
D
E
S
S
N
A
T
L
L
T
Site 113
S1097
I
I
P
G
D
E
S
S
N
A
T
L
L
T
N
Site 114
T1100
G
D
E
S
S
N
A
T
L
L
T
N
A
E
K
Site 115
T1110
T
N
A
E
K
I
A
T
I
T
T
T
H
T
P
Site 116
T1114
K
I
A
T
I
T
T
T
H
T
P
S
Q
Q
G
Site 117
T1116
A
T
I
T
T
T
H
T
P
S
Q
Q
G
T
Q
Site 118
S1118
I
T
T
T
H
T
P
S
Q
Q
G
T
Q
E
T
Site 119
T1122
H
T
P
S
Q
Q
G
T
Q
E
T
R
N
T
T
Site 120
T1128
G
T
Q
E
T
R
N
T
T
K
P
K
Q
E
S
Site 121
T1129
T
Q
E
T
R
N
T
T
K
P
K
Q
E
S
Q
Site 122
S1135
T
T
K
P
K
Q
E
S
Q
F
E
F
K
A
P
Site 123
Y1151
A
T
Q
E
Q
D
F
Y
T
V
E
L
E
R
G
Site 124
T1152
T
Q
E
Q
D
F
Y
T
V
E
L
E
R
G
A
Site 125
S1165
G
A
K
G
F
G
F
S
L
R
G
G
R
E
Y
Site 126
Y1172
S
L
R
G
G
R
E
Y
N
M
D
L
Y
V
L
Site 127
Y1177
R
E
Y
N
M
D
L
Y
V
L
R
L
A
E
D
Site 128
S1236
F
L
K
R
G
D
G
S
V
P
E
Y
D
P
S
Site 129
Y1240
G
D
G
S
V
P
E
Y
D
P
S
S
D
R
H
Site 130
S1243
S
V
P
E
Y
D
P
S
S
D
R
H
G
P
A
Site 131
S1244
V
P
E
Y
D
P
S
S
D
R
H
G
P
A
T
Site 132
T1251
S
D
R
H
G
P
A
T
G
P
Q
G
V
P
E
Site 133
S1270
P
D
R
R
Q
H
P
S
L
E
S
S
Y
P
P
Site 134
S1274
Q
H
P
S
L
E
S
S
Y
P
P
D
L
H
K
Site 135
Y1275
H
P
S
L
E
S
S
Y
P
P
D
L
H
K
S
Site 136
S1282
Y
P
P
D
L
H
K
S
S
P
H
G
E
K
R
Site 137
S1283
P
P
D
L
H
K
S
S
P
H
G
E
K
R
A
Site 138
S1298
H
A
R
D
P
K
G
S
R
E
Y
S
R
Q
P
Site 139
Y1301
D
P
K
G
S
R
E
Y
S
R
Q
P
N
E
H
Site 140
S1302
P
K
G
S
R
E
Y
S
R
Q
P
N
E
H
H
Site 141
T1310
R
Q
P
N
E
H
H
T
W
N
G
T
S
R
K
Site 142
S1320
G
T
S
R
K
P
D
S
G
A
C
R
P
K
D
Site 143
S1351
A
N
G
P
K
R
R
S
P
E
K
R
R
E
G
Site 144
T1359
P
E
K
R
R
E
G
T
R
S
A
D
N
T
L
Site 145
S1361
K
R
R
E
G
T
R
S
A
D
N
T
L
E
R
Site 146
T1365
G
T
R
S
A
D
N
T
L
E
R
R
E
K
H
Site 147
S1379
H
E
K
R
R
D
V
S
P
E
R
R
R
E
R
Site 148
S1387
P
E
R
R
R
E
R
S
P
T
R
R
R
D
G
Site 149
T1389
R
R
R
E
R
S
P
T
R
R
R
D
G
S
P
Site 150
S1395
P
T
R
R
R
D
G
S
P
S
R
R
R
R
S
Site 151
S1397
R
R
R
D
G
S
P
S
R
R
R
R
S
L
E
Site 152
S1402
S
P
S
R
R
R
R
S
L
E
R
L
L
E
Q
Site 153
S1412
R
L
L
E
Q
R
R
S
P
E
R
R
R
G
G
Site 154
S1420
P
E
R
R
R
G
G
S
P
E
R
R
A
K
S
Site 155
S1427
S
P
E
R
R
A
K
S
T
D
R
R
R
A
R
Site 156
T1428
P
E
R
R
A
K
S
T
D
R
R
R
A
R
S
Site 157
S1435
T
D
R
R
R
A
R
S
P
E
R
R
R
E
R
Site 158
S1443
P
E
R
R
R
E
R
S
L
D
K
R
N
R
E
Site 159
S1454
R
N
R
E
D
R
A
S
H
R
E
R
E
E
A
Site 160
S1470
L
K
Q
D
A
G
R
S
S
R
H
P
P
E
Q
Site 161
S1471
K
Q
D
A
G
R
S
S
R
H
P
P
E
Q
R
Site 162
Y1482
P
E
Q
R
R
R
P
Y
K
E
C
S
T
D
L
Site 163
S1486
R
R
P
Y
K
E
C
S
T
D
L
S
I
_
_
Site 164
T1487
R
P
Y
K
E
C
S
T
D
L
S
I
_
_
_
Site 165
S1490
K
E
C
S
T
D
L
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation