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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HHIP
Full Name:
Hedgehog-interacting protein
Alias:
FLJ20992; hedgehog interacting protein; hedgehog-interacting protein; HIP
Type:
Mass (Da):
78850
Number AA:
UniProt ID:
Q96QV1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005576
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
F
G
E
R
N
E
G
S
G
A
R
R
R
R
C
Site 2
S57
R
R
D
R
R
M
M
S
Q
L
E
L
L
S
G
Site 3
S77
G
G
F
Y
P
R
L
S
C
C
L
R
S
D
S
Site 4
S82
R
L
S
C
C
L
R
S
D
S
P
G
L
G
R
Site 5
S84
S
C
C
L
R
S
D
S
P
G
L
G
R
L
E
Site 6
S96
R
L
E
N
K
I
F
S
V
T
N
N
T
E
C
Site 7
S119
C
A
L
C
S
P
H
S
Q
S
L
F
H
S
P
Site 8
S121
L
C
S
P
H
S
Q
S
L
F
H
S
P
E
R
Site 9
S125
H
S
Q
S
L
F
H
S
P
E
R
E
V
L
E
Site 10
Y170
T
A
D
E
F
C
F
Y
Y
A
R
K
D
G
G
Site 11
Y171
A
D
E
F
C
F
Y
Y
A
R
K
D
G
G
L
Site 12
S193
K
Q
V
R
G
P
A
S
N
Y
L
D
Q
M
E
Site 13
Y195
V
R
G
P
A
S
N
Y
L
D
Q
M
E
E
Y
Site 14
Y202
Y
L
D
Q
M
E
E
Y
D
K
V
E
E
I
S
Site 15
S235
Q
P
V
G
A
L
H
S
G
D
G
S
Q
R
L
Site 16
S239
A
L
H
S
G
D
G
S
Q
R
L
F
I
L
E
Site 17
T255
E
G
Y
V
K
I
L
T
P
E
G
E
I
F
K
Site 18
Y265
G
E
I
F
K
E
P
Y
L
D
I
H
K
L
V
Site 19
S274
D
I
H
K
L
V
Q
S
G
I
K
G
G
D
E
Site 20
S286
G
D
E
R
G
L
L
S
L
A
F
H
P
N
Y
Site 21
Y293
S
L
A
F
H
P
N
Y
K
K
N
G
K
L
Y
Site 22
Y300
Y
K
K
N
G
K
L
Y
V
S
Y
T
T
N
Q
Site 23
S302
K
N
G
K
L
Y
V
S
Y
T
T
N
Q
E
R
Site 24
Y303
N
G
K
L
Y
V
S
Y
T
T
N
Q
E
R
W
Site 25
T304
G
K
L
Y
V
S
Y
T
T
N
Q
E
R
W
A
Site 26
Y324
H
I
L
R
V
V
E
Y
T
V
S
R
K
N
P
Site 27
T325
I
L
R
V
V
E
Y
T
V
S
R
K
N
P
H
Site 28
T338
P
H
Q
V
D
L
R
T
A
R
V
F
L
E
V
Site 29
S386
M
E
E
M
D
G
L
S
D
F
T
G
S
V
L
Site 30
Y406
T
D
M
C
N
V
P
Y
S
I
P
R
S
N
P
Site 31
S411
V
P
Y
S
I
P
R
S
N
P
H
F
N
S
T
Site 32
S417
R
S
N
P
H
F
N
S
T
N
Q
P
P
E
V
Site 33
T418
S
N
P
H
F
N
S
T
N
Q
P
P
E
V
F
Site 34
T442
C
A
V
D
R
H
P
T
D
I
N
I
N
L
T
Site 35
S453
I
N
L
T
I
L
C
S
D
S
N
G
K
N
R
Site 36
S455
L
T
I
L
C
S
D
S
N
G
K
N
R
S
S
Site 37
S461
D
S
N
G
K
N
R
S
S
A
R
I
L
Q
I
Site 38
S462
S
N
G
K
N
R
S
S
A
R
I
L
Q
I
I
Site 39
Y474
Q
I
I
K
G
K
D
Y
E
S
E
P
S
L
L
Site 40
S476
I
K
G
K
D
Y
E
S
E
P
S
L
L
E
F
Site 41
S479
K
D
Y
E
S
E
P
S
L
L
E
F
K
P
F
Site 42
Y497
P
L
V
G
G
F
V
Y
R
G
C
Q
S
E
R
Site 43
Y506
G
C
Q
S
E
R
L
Y
G
S
Y
V
F
G
D
Site 44
Y509
S
E
R
L
Y
G
S
Y
V
F
G
D
R
N
G
Site 45
T520
D
R
N
G
N
F
L
T
L
Q
Q
S
P
V
T
Site 46
S524
N
F
L
T
L
Q
Q
S
P
V
T
K
Q
W
Q
Site 47
S540
K
P
L
C
L
G
T
S
G
S
C
R
G
Y
F
Site 48
Y546
T
S
G
S
C
R
G
Y
F
S
G
H
I
L
G
Site 49
Y563
E
D
E
L
G
E
V
Y
I
L
S
S
S
K
S
Site 50
S566
L
G
E
V
Y
I
L
S
S
S
K
S
M
T
Q
Site 51
S568
E
V
Y
I
L
S
S
S
K
S
M
T
Q
T
H
Site 52
S570
Y
I
L
S
S
S
K
S
M
T
Q
T
H
N
G
Site 53
T572
L
S
S
S
K
S
M
T
Q
T
H
N
G
K
L
Site 54
T574
S
S
K
S
M
T
Q
T
H
N
G
K
L
Y
K
Site 55
Y580
Q
T
H
N
G
K
L
Y
K
I
V
D
P
K
R
Site 56
T597
M
P
E
E
C
R
A
T
V
Q
P
A
Q
T
L
Site 57
T603
A
T
V
Q
P
A
Q
T
L
T
S
E
C
S
R
Site 58
T605
V
Q
P
A
Q
T
L
T
S
E
C
S
R
L
C
Site 59
S606
Q
P
A
Q
T
L
T
S
E
C
S
R
L
C
R
Site 60
Y616
S
R
L
C
R
N
G
Y
C
T
P
T
G
K
C
Site 61
T618
L
C
R
N
G
Y
C
T
P
T
G
K
C
C
C
Site 62
T620
R
N
G
Y
C
T
P
T
G
K
C
C
C
S
P
Site 63
S626
P
T
G
K
C
C
C
S
P
G
W
E
G
D
F
Site 64
Y661
K
C
L
C
K
K
G
Y
L
G
P
Q
C
E
Q
Site 65
T677
D
R
N
I
R
R
V
T
R
A
G
I
L
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation