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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS35
Full Name:
Vacuolar protein sorting-associated protein 35
Alias:
FLJ10752; HVPS35; Maternal-embryonic 3; MEM3; TCCCTA00141; Vacuolar protein sorting 35; Vacuolar protein sorting 35 (yeast homolog); Vacuolar protein sorting 35 (yeast); Vesicle protein sorting 35
Type:
Vesicle protein
Mass (Da):
91707
Number AA:
796
UniProt ID:
Q96QK1
International Prot ID:
IPI00018931
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005768
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0015031
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
T
T
Q
Q
S
P
Q
D
E
Q
E
K
Site 2
T55
N
M
L
G
E
L
R
T
S
M
L
S
P
K
S
Site 3
S56
M
L
G
E
L
R
T
S
M
L
S
P
K
S
Y
Site 4
S59
E
L
R
T
S
M
L
S
P
K
S
Y
Y
E
L
Site 5
S62
T
S
M
L
S
P
K
S
Y
Y
E
L
Y
M
A
Site 6
Y63
S
M
L
S
P
K
S
Y
Y
E
L
Y
M
A
I
Site 7
Y67
P
K
S
Y
Y
E
L
Y
M
A
I
S
D
E
L
Site 8
S71
Y
E
L
Y
M
A
I
S
D
E
L
H
Y
L
E
Site 9
Y76
A
I
S
D
E
L
H
Y
L
E
V
Y
L
T
D
Site 10
Y80
E
L
H
Y
L
E
V
Y
L
T
D
E
F
A
K
Site 11
T82
H
Y
L
E
V
Y
L
T
D
E
F
A
K
G
R
Site 12
Y95
G
R
K
V
A
D
L
Y
E
L
V
Q
Y
A
G
Site 13
Y100
D
L
Y
E
L
V
Q
Y
A
G
N
I
I
P
R
Site 14
S121
V
G
V
V
Y
V
K
S
F
P
Q
S
R
K
D
Site 15
S125
Y
V
K
S
F
P
Q
S
R
K
D
I
L
K
D
Site 16
Y152
R
G
L
F
L
R
N
Y
L
L
Q
C
T
R
N
Site 17
T168
L
P
D
E
G
E
P
T
D
E
E
T
T
G
D
Site 18
S177
E
E
T
T
G
D
I
S
D
S
M
D
F
V
L
Site 19
S203
R
M
Q
H
Q
G
H
S
R
D
R
E
K
R
E
Site 20
Y238
E
G
V
N
V
E
R
Y
K
Q
I
V
L
T
G
Site 21
T278
P
D
E
F
H
L
Q
T
L
N
P
F
L
R
A
Site 22
S344
Q
S
R
Q
D
M
P
S
E
D
V
V
S
L
Q
Site 23
Y362
I
N
L
A
M
K
C
Y
P
D
R
V
D
Y
V
Site 24
Y368
C
Y
P
D
R
V
D
Y
V
D
K
V
L
E
T
Site 25
T390
L
N
L
E
H
I
A
T
S
S
A
V
S
K
E
Site 26
S391
N
L
E
H
I
A
T
S
S
A
V
S
K
E
L
Site 27
S392
L
E
H
I
A
T
S
S
A
V
S
K
E
L
T
Site 28
T399
S
A
V
S
K
E
L
T
R
L
L
K
I
P
V
Site 29
T414
D
T
Y
N
N
I
L
T
V
L
K
L
K
H
F
Site 30
Y427
H
F
H
P
L
F
E
Y
F
D
Y
E
S
R
K
Site 31
Y430
P
L
F
E
Y
F
D
Y
E
S
R
K
S
M
S
Site 32
S432
F
E
Y
F
D
Y
E
S
R
K
S
M
S
C
Y
Site 33
S435
F
D
Y
E
S
R
K
S
M
S
C
Y
V
L
S
Site 34
S437
Y
E
S
R
K
S
M
S
C
Y
V
L
S
N
V
Site 35
Y439
S
R
K
S
M
S
C
Y
V
L
S
N
V
L
D
Site 36
T449
S
N
V
L
D
Y
N
T
E
I
V
S
Q
D
Q
Site 37
S453
D
Y
N
T
E
I
V
S
Q
D
Q
V
D
S
I
Site 38
S459
V
S
Q
D
Q
V
D
S
I
M
N
L
V
S
T
Site 39
S489
E
D
F
A
D
E
Q
S
L
V
G
R
F
I
H
Site 40
S500
R
F
I
H
L
L
R
S
E
D
P
D
Q
Q
Y
Site 41
Y507
S
E
D
P
D
Q
Q
Y
L
I
L
N
T
A
R
Site 42
Y543
A
Y
Q
L
A
F
R
Y
K
E
N
S
K
V
D
Site 43
S547
A
F
R
Y
K
E
N
S
K
V
D
D
K
W
E
Site 44
Y604
E
N
H
E
T
V
A
Y
E
F
M
S
Q
A
F
Site 45
S612
E
F
M
S
Q
A
F
S
L
Y
E
D
E
I
S
Site 46
S619
S
L
Y
E
D
E
I
S
D
S
K
A
Q
L
A
Site 47
S621
Y
E
D
E
I
S
D
S
K
A
Q
L
A
A
I
Site 48
S642
F
E
R
M
K
C
F
S
E
E
N
H
E
P
L
Site 49
T651
E
N
H
E
P
L
R
T
Q
C
A
L
A
A
S
Site 50
T683
L
F
W
S
G
R
N
T
D
K
N
G
E
E
L
Site 51
S714
A
N
Q
C
M
D
P
S
L
Q
V
Q
L
F
I
Site 52
Y727
F
I
E
I
L
N
R
Y
I
Y
F
Y
E
K
E
Site 53
Y729
E
I
L
N
R
Y
I
Y
F
Y
E
K
E
N
D
Site 54
Y731
L
N
R
Y
I
Y
F
Y
E
K
E
N
D
A
V
Site 55
T739
E
K
E
N
D
A
V
T
I
Q
V
L
N
Q
L
Site 56
S759
E
D
L
P
N
L
E
S
S
E
E
T
E
Q
I
Site 57
S760
D
L
P
N
L
E
S
S
E
E
T
E
Q
I
N
Site 58
S783
H
L
R
L
R
R
E
S
P
E
S
E
G
P
I
Site 59
S786
L
R
R
E
S
P
E
S
E
G
P
I
Y
E
G
Site 60
Y791
P
E
S
E
G
P
I
Y
E
G
L
I
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation