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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRAM1
Full Name:
PML-RARA-regulated adapter molecule 1
Alias:
Type:
Mass (Da):
79217
Number AA:
718
UniProt ID:
Q96QH2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
S
H
Q
D
F
R
S
I
K
A
K
F
Q
A
Site 2
S25
I
K
A
K
F
Q
A
S
Q
P
E
P
S
D
L
Site 3
S30
Q
A
S
Q
P
E
P
S
D
L
P
K
K
P
P
Site 4
S48
F
G
K
L
K
K
F
S
Q
P
E
L
S
E
H
Site 5
S53
K
F
S
Q
P
E
L
S
E
H
P
Q
K
A
P
Site 6
S68
L
P
E
F
G
A
V
S
L
K
P
P
Q
P
Q
Site 7
T77
K
P
P
Q
P
Q
F
T
D
L
P
K
K
P
P
Site 8
T89
K
P
P
P
P
E
V
T
D
L
P
K
K
P
P
Site 9
T161
K
P
P
P
P
E
V
T
D
L
P
K
K
P
S
Site 10
S168
T
D
L
P
K
K
P
S
K
L
E
L
S
D
L
Site 11
S173
K
P
S
K
L
E
L
S
D
L
S
K
K
F
P
Site 12
S176
K
L
E
L
S
D
L
S
K
K
F
P
Q
L
G
Site 13
T185
K
F
P
Q
L
G
A
T
P
F
P
R
K
P
L
Site 14
S204
G
E
A
P
L
K
A
S
L
P
E
P
G
A
P
Site 15
S222
P
L
Q
P
D
E
L
S
H
P
A
R
P
P
S
Site 16
S229
S
H
P
A
R
P
P
S
E
P
K
S
G
A
F
Site 17
S233
R
P
P
S
E
P
K
S
G
A
F
P
R
K
L
Site 18
T249
Q
P
E
A
G
E
A
T
P
R
S
P
Q
P
E
Site 19
S252
A
G
E
A
T
P
R
S
P
Q
P
E
L
S
T
Site 20
S258
R
S
P
Q
P
E
L
S
T
F
P
K
K
P
A
Site 21
T259
S
P
Q
P
E
L
S
T
F
P
K
K
P
A
Q
Site 22
Y272
A
Q
P
E
F
N
V
Y
P
K
K
P
P
Q
P
Site 23
S288
V
G
G
L
P
K
K
S
V
P
Q
P
E
F
S
Site 24
T300
E
F
S
E
A
A
Q
T
P
L
W
K
P
Q
S
Site 25
S307
T
P
L
W
K
P
Q
S
S
E
P
K
R
D
S
Site 26
S308
P
L
W
K
P
Q
S
S
E
P
K
R
D
S
S
Site 27
S314
S
S
E
P
K
R
D
S
S
A
F
P
K
K
A
Site 28
S315
S
E
P
K
R
D
S
S
A
F
P
K
K
A
S
Site 29
S322
S
A
F
P
K
K
A
S
Q
P
P
L
S
D
F
Site 30
S327
K
A
S
Q
P
P
L
S
D
F
P
K
K
P
P
Site 31
T342
Q
P
E
L
G
D
L
T
R
T
S
S
E
P
E
Site 32
S345
L
G
D
L
T
R
T
S
S
E
P
E
V
S
V
Site 33
S346
G
D
L
T
R
T
S
S
E
P
E
V
S
V
L
Site 34
S351
T
S
S
E
P
E
V
S
V
L
P
K
R
P
R
Site 35
S366
P
A
E
F
K
A
L
S
K
K
P
P
Q
P
E
Site 36
T380
E
L
G
G
L
P
R
T
S
S
E
P
E
F
N
Site 37
S381
L
G
G
L
P
R
T
S
S
E
P
E
F
N
S
Site 38
S382
G
G
L
P
R
T
S
S
E
P
E
F
N
S
L
Site 39
S388
S
S
E
P
E
F
N
S
L
P
R
K
L
L
Q
Site 40
S406
R
G
P
P
R
K
F
S
Q
P
E
P
S
A
V
Site 41
S411
K
F
S
Q
P
E
P
S
A
V
L
K
R
H
P
Site 42
S434
P
R
K
P
P
L
P
S
S
A
S
E
S
S
L
Site 43
S435
R
K
P
P
L
P
S
S
A
S
E
S
S
L
P
Site 44
S437
P
P
L
P
S
S
A
S
E
S
S
L
P
A
A
Site 45
S440
P
S
S
A
S
E
S
S
L
P
A
A
V
A
G
Site 46
S449
P
A
A
V
A
G
F
S
S
R
H
P
L
S
P
Site 47
S455
F
S
S
R
H
P
L
S
P
G
F
G
A
A
G
Site 48
T463
P
G
F
G
A
A
G
T
P
R
W
R
S
G
G
Site 49
S468
A
G
T
P
R
W
R
S
G
G
L
V
H
S
G
Site 50
S474
R
S
G
G
L
V
H
S
G
G
A
R
P
G
L
Site 51
S484
A
R
P
G
L
R
P
S
H
P
P
R
R
R
P
Site 52
S496
R
R
P
L
P
P
A
S
S
L
G
H
P
P
A
Site 53
S497
R
P
L
P
P
A
S
S
L
G
H
P
P
A
K
Site 54
S516
P
G
P
V
D
M
Q
S
F
R
R
P
S
A
A
Site 55
S521
M
Q
S
F
R
R
P
S
A
A
S
I
D
L
R
Site 56
S524
F
R
R
P
S
A
A
S
I
D
L
R
R
T
R
Site 57
T530
A
S
I
D
L
R
R
T
R
S
A
A
G
L
H
Site 58
S532
I
D
L
R
R
T
R
S
A
A
G
L
H
F
Q
Site 59
Y554
P
Q
V
P
D
E
I
Y
E
L
Y
D
D
V
E
Site 60
Y557
P
D
E
I
Y
E
L
Y
D
D
V
E
P
R
D
Site 61
S566
D
V
E
P
R
D
D
S
S
P
S
P
K
G
R
Site 62
S567
V
E
P
R
D
D
S
S
P
S
P
K
G
R
D
Site 63
S569
P
R
D
D
S
S
P
S
P
K
G
R
D
E
A
Site 64
S578
K
G
R
D
E
A
P
S
V
Q
Q
A
A
R
R
Site 65
T648
M
I
D
P
N
A
K
T
R
R
G
G
G
K
H
Site 66
S671
L
E
V
I
E
F
T
S
N
E
E
M
L
C
R
Site 67
Y686
D
P
K
G
K
Y
G
Y
V
P
R
T
A
L
L
Site 68
Y700
L
P
L
E
T
E
V
Y
D
D
V
D
F
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation