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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALS2
Full Name:
Alsin
Alias:
ALS2CR6; Alsin; Amyotrophic lateral sclerosis 2 (juvenile); Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein
Type:
Guanine nucleotide exchange factor, Rab
Mass (Da):
183666
Number AA:
1657
UniProt ID:
Q96Q42
International Prot ID:
IPI00295004
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005769
Uniprot
OncoNet
Molecular Function:
GO:0017137
GO:0017112
GO:0030676
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0007032
GO:0032855
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
S
K
K
R
S
S
T
E
A
E
G
S
Site 2
S8
M
D
S
K
K
R
S
S
T
E
A
E
G
S
K
Site 3
T9
D
S
K
K
R
S
S
T
E
A
E
G
S
K
E
Site 4
S14
S
S
T
E
A
E
G
S
K
E
R
G
L
V
H
Site 5
S27
V
H
I
W
Q
A
G
S
F
P
I
T
P
E
R
Site 6
T31
Q
A
G
S
F
P
I
T
P
E
R
L
P
G
W
Site 7
T57
V
K
H
G
V
L
L
T
E
D
G
E
V
Y
S
Site 8
S64
T
E
D
G
E
V
Y
S
F
G
T
L
P
W
R
Site 9
T67
G
E
V
Y
S
F
G
T
L
P
W
R
S
G
P
Site 10
T107
S
F
H
S
G
A
V
T
D
N
G
V
A
Y
M
Site 11
Y113
V
T
D
N
G
V
A
Y
M
W
G
E
N
S
A
Site 12
Y130
C
A
V
A
N
Q
Q
Y
V
P
E
P
N
P
V
Site 13
S138
V
P
E
P
N
P
V
S
I
A
D
S
E
A
S
Site 14
S166
E
E
H
T
L
A
L
S
I
S
R
E
I
W
A
Site 15
T264
C
P
L
G
V
T
L
T
E
S
Q
A
E
N
H
Site 16
S266
L
G
V
T
L
T
E
S
Q
A
E
N
H
A
S
Site 17
S273
S
Q
A
E
N
H
A
S
T
A
L
S
P
S
T
Site 18
S277
N
H
A
S
T
A
L
S
P
S
T
E
T
L
D
Site 19
S279
A
S
T
A
L
S
P
S
T
E
T
L
D
R
Q
Site 20
T313
N
A
V
S
A
Q
I
T
S
S
D
A
M
S
S
Site 21
S315
V
S
A
Q
I
T
S
S
D
A
M
S
S
Q
Q
Site 22
S319
I
T
S
S
D
A
M
S
S
Q
Q
N
V
M
G
Site 23
S320
T
S
S
D
A
M
S
S
Q
Q
N
V
M
G
T
Site 24
T327
S
Q
Q
N
V
M
G
T
T
E
I
S
S
A
R
Site 25
S332
M
G
T
T
E
I
S
S
A
R
N
I
P
S
Y
Site 26
S338
S
S
A
R
N
I
P
S
Y
P
D
T
Q
A
V
Site 27
Y339
S
A
R
N
I
P
S
Y
P
D
T
Q
A
V
N
Site 28
T342
N
I
P
S
Y
P
D
T
Q
A
V
N
E
Y
L
Site 29
Y348
D
T
Q
A
V
N
E
Y
L
R
K
L
S
D
H
Site 30
S353
N
E
Y
L
R
K
L
S
D
H
S
V
R
E
D
Site 31
S356
L
R
K
L
S
D
H
S
V
R
E
D
S
E
H
Site 32
S361
D
H
S
V
R
E
D
S
E
H
G
E
K
P
M
Site 33
S370
H
G
E
K
P
M
P
S
Q
P
L
L
E
E
A
Site 34
S383
E
A
I
P
N
L
H
S
P
P
T
T
S
T
S
Site 35
T386
P
N
L
H
S
P
P
T
T
S
T
S
A
L
N
Site 36
T387
N
L
H
S
P
P
T
T
S
T
S
A
L
N
S
Site 37
S388
L
H
S
P
P
T
T
S
T
S
A
L
N
S
L
Site 38
T428
V
M
N
F
Y
S
T
T
P
C
E
T
G
A
Q
Site 39
S438
E
T
G
A
Q
A
G
S
S
A
I
G
P
E
G
Site 40
S439
T
G
A
Q
A
G
S
S
A
I
G
P
E
G
L
Site 41
S449
G
P
E
G
L
K
D
S
R
E
E
Q
V
K
Q
Site 42
S464
E
S
M
Q
G
K
K
S
S
S
L
V
D
I
R
Site 43
S465
S
M
Q
G
K
K
S
S
S
L
V
D
I
R
E
Site 44
S466
M
Q
G
K
K
S
S
S
L
V
D
I
R
E
E
Site 45
S479
E
E
E
T
E
G
G
S
R
R
L
S
L
P
G
Site 46
S483
E
G
G
S
R
R
L
S
L
P
G
L
L
S
Q
Site 47
S489
L
S
L
P
G
L
L
S
Q
V
S
P
R
L
L
Site 48
S492
P
G
L
L
S
Q
V
S
P
R
L
L
R
K
A
Site 49
T504
R
K
A
A
R
V
K
T
R
T
V
V
L
T
P
Site 50
T510
K
T
R
T
V
V
L
T
P
T
Y
S
G
E
A
Site 51
S523
E
A
D
A
L
L
P
S
L
R
T
E
V
W
T
Site 52
T526
A
L
L
P
S
L
R
T
E
V
W
T
W
G
K
Site 53
T530
S
L
R
T
E
V
W
T
W
G
K
G
K
E
G
Site 54
S571
L
E
A
G
G
Y
H
S
L
A
L
T
A
K
S
Site 55
T575
G
Y
H
S
L
A
L
T
A
K
S
Q
V
Y
S
Site 56
S578
S
L
A
L
T
A
K
S
Q
V
Y
S
W
G
S
Site 57
S582
T
A
K
S
Q
V
Y
S
W
G
S
N
T
F
G
Site 58
S585
S
Q
V
Y
S
W
G
S
N
T
F
G
Q
L
G
Site 59
T587
V
Y
S
W
G
S
N
T
F
G
Q
L
G
H
S
Site 60
S594
T
F
G
Q
L
G
H
S
D
F
P
T
T
V
P
Site 61
T598
L
G
H
S
D
F
P
T
T
V
P
R
L
A
K
Site 62
T599
G
H
S
D
F
P
T
T
V
P
R
L
A
K
I
Site 63
S607
V
P
R
L
A
K
I
S
S
E
N
G
V
W
S
Site 64
S608
P
R
L
A
K
I
S
S
E
N
G
V
W
S
I
Site 65
Y636
E
D
F
Q
P
G
L
Y
Y
S
G
R
Q
D
P
Site 66
S638
F
Q
P
G
L
Y
Y
S
G
R
Q
D
P
T
E
Site 67
T644
Y
S
G
R
Q
D
P
T
E
G
D
N
L
P
E
Site 68
S654
D
N
L
P
E
N
H
S
G
S
K
T
P
V
L
Site 69
S656
L
P
E
N
H
S
G
S
K
T
P
V
L
L
S
Site 70
T658
E
N
H
S
G
S
K
T
P
V
L
L
S
C
S
Site 71
T674
L
G
Y
I
S
R
V
T
A
G
K
D
S
Y
L
Site 72
Y680
V
T
A
G
K
D
S
Y
L
A
L
V
D
K
N
Site 73
T700
A
S
L
H
E
L
A
T
T
E
R
R
F
Y
S
Site 74
T701
S
L
H
E
L
A
T
T
E
R
R
F
Y
S
K
Site 75
Y706
A
T
T
E
R
R
F
Y
S
K
L
S
D
I
K
Site 76
S707
T
T
E
R
R
F
Y
S
K
L
S
D
I
K
S
Site 77
S710
R
R
F
Y
S
K
L
S
D
I
K
S
Q
I
L
Site 78
S714
S
K
L
S
D
I
K
S
Q
I
L
R
P
L
L
Site 79
T731
E
N
L
G
T
T
T
T
V
Q
L
L
Q
E
V
Site 80
S740
Q
L
L
Q
E
V
A
S
R
F
S
K
L
C
Y
Site 81
Y747
S
R
F
S
K
L
C
Y
L
I
G
Q
H
G
A
Site 82
S757
G
Q
H
G
A
S
L
S
S
F
L
H
G
V
K
Site 83
S758
Q
H
G
A
S
L
S
S
F
L
H
G
V
K
E
Site 84
S768
H
G
V
K
E
A
R
S
L
V
I
L
K
H
S
Site 85
S781
H
S
S
L
F
L
D
S
Y
T
E
Y
C
T
S
Site 86
Y782
S
S
L
F
L
D
S
Y
T
E
Y
C
T
S
I
Site 87
Y785
F
L
D
S
Y
T
E
Y
C
T
S
I
T
N
F
Site 88
S820
Q
E
L
L
Q
D
L
S
E
V
N
D
E
N
T
Site 89
T827
S
E
V
N
D
E
N
T
Q
L
M
E
I
L
N
Site 90
Y847
P
I
R
R
L
H
N
Y
A
K
V
L
L
K
L
Site 91
S862
A
T
C
F
E
V
A
S
P
E
Y
Q
K
L
Q
Site 92
S871
E
Y
Q
K
L
Q
D
S
S
S
C
Y
E
C
L
Site 93
S873
Q
K
L
Q
D
S
S
S
C
Y
E
C
L
A
L
Site 94
Y891
R
K
R
K
E
A
E
Y
T
L
G
F
W
K
T
Site 95
T892
K
R
K
E
A
E
Y
T
L
G
F
W
K
T
F
Site 96
S906
F
P
G
K
M
T
D
S
L
R
K
P
E
R
R
Site 97
S918
E
R
R
L
L
C
E
S
S
N
R
A
L
S
L
Site 98
S919
R
R
L
L
C
E
S
S
N
R
A
L
S
L
Q
Site 99
S924
E
S
S
N
R
A
L
S
L
Q
H
A
G
R
F
Site 100
S965
T
L
W
A
E
P
L
S
E
E
A
G
G
V
N
Site 101
T978
V
N
G
L
K
I
T
T
P
E
E
Q
F
T
L
Site 102
T984
T
T
P
E
E
Q
F
T
L
I
S
S
T
P
Q
Site 103
T989
Q
F
T
L
I
S
S
T
P
Q
E
K
T
K
W
Site 104
S1001
T
K
W
L
R
A
I
S
Q
A
V
D
Q
A
L
Site 105
S1012
D
Q
A
L
R
G
M
S
D
L
P
P
Y
G
S
Site 106
Y1017
G
M
S
D
L
P
P
Y
G
S
G
S
S
V
Q
Site 107
S1019
S
D
L
P
P
Y
G
S
G
S
S
V
Q
R
Q
Site 108
S1022
P
P
Y
G
S
G
S
S
V
Q
R
Q
E
P
P
Site 109
S1031
Q
R
Q
E
P
P
I
S
R
S
A
K
Y
T
F
Site 110
Y1036
P
I
S
R
S
A
K
Y
T
F
Y
K
D
P
R
Site 111
T1037
I
S
R
S
A
K
Y
T
F
Y
K
D
P
R
L
Site 112
Y1039
R
S
A
K
Y
T
F
Y
K
D
P
R
L
K
D
Site 113
T1048
D
P
R
L
K
D
A
T
Y
D
G
R
W
L
S
Site 114
Y1049
P
R
L
K
D
A
T
Y
D
G
R
W
L
S
G
Site 115
S1055
T
Y
D
G
R
W
L
S
G
K
P
H
G
R
G
Site 116
Y1084
R
N
G
L
E
D
G
Y
G
E
Y
R
I
P
N
Site 117
Y1087
L
E
D
G
Y
G
E
Y
R
I
P
N
K
A
M
Site 118
Y1100
A
M
N
K
E
D
H
Y
V
G
H
W
K
E
G
Site 119
Y1115
K
M
C
G
Q
G
V
Y
S
Y
A
S
G
E
V
Site 120
Y1117
C
G
Q
G
V
Y
S
Y
A
S
G
E
V
F
E
Site 121
S1119
Q
G
V
Y
S
Y
A
S
G
E
V
F
E
G
C
Site 122
S1140
H
G
H
G
L
L
R
S
G
K
L
T
S
S
S
Site 123
T1144
L
L
R
S
G
K
L
T
S
S
S
P
S
M
F
Site 124
S1145
L
R
S
G
K
L
T
S
S
S
P
S
M
F
I
Site 125
S1146
R
S
G
K
L
T
S
S
S
P
S
M
F
I
G
Site 126
S1147
S
G
K
L
T
S
S
S
P
S
M
F
I
G
Q
Site 127
S1149
K
L
T
S
S
S
P
S
M
F
I
G
Q
W
V
Site 128
T1170
Y
G
V
F
D
D
I
T
R
G
E
K
Y
M
G
Site 129
Y1175
D
I
T
R
G
E
K
Y
M
G
M
W
Q
D
D
Site 130
Y1198
V
T
Q
F
G
L
Y
Y
E
G
N
F
H
L
N
Site 131
S1215
M
G
N
G
V
L
L
S
E
D
D
T
I
Y
E
Site 132
T1219
V
L
L
S
E
D
D
T
I
Y
E
G
E
F
S
Site 133
Y1221
L
S
E
D
D
T
I
Y
E
G
E
F
S
D
D
Site 134
S1226
T
I
Y
E
G
E
F
S
D
D
W
T
L
S
G
Site 135
T1230
G
E
F
S
D
D
W
T
L
S
G
K
G
T
L
Site 136
S1232
F
S
D
D
W
T
L
S
G
K
G
T
L
T
M
Site 137
T1236
W
T
L
S
G
K
G
T
L
T
M
P
N
G
D
Site 138
T1238
L
S
G
K
G
T
L
T
M
P
N
G
D
Y
I
Site 139
Y1244
L
T
M
P
N
G
D
Y
I
E
G
Y
F
S
G
Site 140
Y1248
N
G
D
Y
I
E
G
Y
F
S
G
E
W
G
S
Site 141
T1262
S
G
I
K
I
T
G
T
Y
F
K
P
S
L
Y
Site 142
Y1263
G
I
K
I
T
G
T
Y
F
K
P
S
L
Y
E
Site 143
S1267
T
G
T
Y
F
K
P
S
L
Y
E
S
D
K
D
Site 144
Y1269
T
Y
F
K
P
S
L
Y
E
S
D
K
D
R
P
Site 145
S1271
F
K
P
S
L
Y
E
S
D
K
D
R
P
K
V
Site 146
T1326
D
N
I
A
V
A
L
T
T
S
R
R
Q
H
R
Site 147
T1327
N
I
A
V
A
L
T
T
S
R
R
Q
H
R
D
Site 148
S1328
I
A
V
A
L
T
T
S
R
R
Q
H
R
D
S
Site 149
S1335
S
R
R
Q
H
R
D
S
P
E
I
L
S
R
S
Site 150
S1340
R
D
S
P
E
I
L
S
R
S
Q
T
Q
T
L
Site 151
S1342
S
P
E
I
L
S
R
S
Q
T
Q
T
L
E
S
Site 152
T1344
E
I
L
S
R
S
Q
T
Q
T
L
E
S
L
E
Site 153
T1346
L
S
R
S
Q
T
Q
T
L
E
S
L
E
F
I
Site 154
S1349
S
Q
T
Q
T
L
E
S
L
E
F
I
P
Q
H
Site 155
Y1365
G
A
F
S
V
E
K
Y
D
D
I
R
K
Y
L
Site 156
Y1371
K
Y
D
D
I
R
K
Y
L
I
K
A
C
D
T
Site 157
T1378
Y
L
I
K
A
C
D
T
P
L
H
P
L
G
R
Site 158
Y1394
V
E
T
L
V
A
V
Y
R
M
T
Y
V
G
V
Site 159
Y1398
V
A
V
Y
R
M
T
Y
V
G
V
G
A
N
R
Site 160
S1417
E
A
V
K
E
I
K
S
Y
L
K
R
I
F
Q
Site 161
Y1418
A
V
K
E
I
K
S
Y
L
K
R
I
F
Q
L
Site 162
S1438
P
E
L
P
E
E
G
S
T
I
P
L
S
A
P
Site 163
T1439
E
L
P
E
E
G
S
T
I
P
L
S
A
P
L
Site 164
S1443
E
G
S
T
I
P
L
S
A
P
L
P
T
E
R
Site 165
T1448
P
L
S
A
P
L
P
T
E
R
K
S
F
C
T
Site 166
S1452
P
L
P
T
E
R
K
S
F
C
T
G
K
S
D
Site 167
T1455
T
E
R
K
S
F
C
T
G
K
S
D
S
R
S
Site 168
S1458
K
S
F
C
T
G
K
S
D
S
R
S
E
S
P
Site 169
S1460
F
C
T
G
K
S
D
S
R
S
E
S
P
E
P
Site 170
S1462
T
G
K
S
D
S
R
S
E
S
P
E
P
G
Y
Site 171
S1464
K
S
D
S
R
S
E
S
P
E
P
G
Y
V
V
Site 172
Y1469
S
E
S
P
E
P
G
Y
V
V
T
S
S
G
L
Site 173
Y1504
N
D
R
E
E
D
I
Y
W
E
C
V
L
R
L
Site 174
T1533
Q
R
K
F
W
P
A
T
L
S
I
L
G
E
S
Site 175
S1535
K
F
W
P
A
T
L
S
I
L
G
E
S
K
K
Site 176
T1547
S
K
K
V
L
P
T
T
K
D
A
C
F
A
S
Site 177
S1563
V
E
C
L
Q
Q
I
S
T
T
F
T
P
S
D
Site 178
T1565
C
L
Q
Q
I
S
T
T
F
T
P
S
D
K
L
Site 179
T1567
Q
Q
I
S
T
T
F
T
P
S
D
K
L
K
V
Site 180
T1578
K
L
K
V
I
Q
Q
T
F
E
E
I
S
Q
S
Site 181
S1583
Q
Q
T
F
E
E
I
S
Q
S
V
L
A
S
L
Site 182
S1585
T
F
E
E
I
S
Q
S
V
L
A
S
L
H
E
Site 183
S1619
A
R
I
R
N
L
G
S
E
V
H
L
I
E
D
Site 184
Y1631
I
E
D
L
M
D
P
Y
L
Q
H
G
E
Q
G
Site 185
Y1649
T
T
L
K
A
C
Y
Y
Q
I
Q
R
E
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation