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Updated November 2019
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Protein Info
Short Name:
Lmr3
Full Name:
Serine/threonine-protein kinase LMTK3
Alias:
EC 2.7.11.1; KIAA1883; LMTK3
Type:
Protein-tyrosine kinase, TK group, Lmr family
Mass (Da):
155952
Number AA:
1480
UniProt ID:
Q96Q04
International Prot ID:
IPI00140833
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
S
A
S
G
C
L
A
S
P
A
H
P
D
G
F
Site 2
S81
N
P
E
G
E
D
C
S
G
E
Y
T
P
P
A
Site 3
Y84
G
E
D
C
S
G
E
Y
T
P
P
A
E
E
T
Site 4
T85
E
D
C
S
G
E
Y
T
P
P
A
E
E
T
S
Site 5
S92
T
P
P
A
E
E
T
S
S
S
Q
S
L
P
D
Site 6
S93
P
P
A
E
E
T
S
S
S
Q
S
L
P
D
V
Site 7
S94
P
A
E
E
T
S
S
S
Q
S
L
P
D
V
Y
Site 8
S96
E
E
T
S
S
S
Q
S
L
P
D
V
Y
I
L
Site 9
S118
P
M
P
A
P
Q
P
S
H
S
D
M
T
T
P
Site 10
S120
P
A
P
Q
P
S
H
S
D
M
T
T
P
L
G
Site 11
T123
Q
P
S
H
S
D
M
T
T
P
L
G
L
S
R
Site 12
T124
P
S
H
S
D
M
T
T
P
L
G
L
S
R
Q
Site 13
S129
M
T
T
P
L
G
L
S
R
Q
H
L
S
Y
L
Site 14
S134
G
L
S
R
Q
H
L
S
Y
L
Q
E
I
G
S
Site 15
Y135
L
S
R
Q
H
L
S
Y
L
Q
E
I
G
S
G
Site 16
Y156
L
G
E
I
F
S
D
Y
T
P
A
Q
V
V
V
Site 17
S169
V
V
K
E
L
R
A
S
A
G
P
L
E
Q
R
Site 18
Y185
F
I
S
E
A
Q
P
Y
R
S
L
Q
H
P
N
Site 19
Y221
Q
L
G
D
L
K
R
Y
L
R
A
Q
R
P
P
Site 20
S232
Q
R
P
P
E
G
L
S
P
E
L
P
P
R
D
Site 21
T242
L
P
P
R
D
L
R
T
L
Q
R
M
G
L
E
Site 22
S259
R
G
L
A
H
L
H
S
H
N
Y
V
H
S
D
Site 23
Y262
A
H
L
H
S
H
N
Y
V
H
S
D
L
A
L
Site 24
Y285
L
T
V
R
I
G
D
Y
G
L
A
H
S
N
Y
Site 25
Y292
Y
G
L
A
H
S
N
Y
K
E
D
Y
Y
L
T
Site 26
Y296
H
S
N
Y
K
E
D
Y
Y
L
T
P
E
R
L
Site 27
Y297
S
N
Y
K
E
D
Y
Y
L
T
P
E
R
L
W
Site 28
T299
Y
K
E
D
Y
Y
L
T
P
E
R
L
W
I
P
Site 29
S331
V
V
D
Q
S
R
E
S
N
I
W
S
L
G
V
Site 30
S335
S
R
E
S
N
I
W
S
L
G
V
T
L
W
E
Site 31
S355
A
Q
P
Y
R
H
L
S
D
E
E
V
L
A
F
Site 32
Y380
R
P
R
L
K
L
P
Y
A
D
Y
W
Y
D
I
Site 33
Y383
L
K
L
P
Y
A
D
Y
W
Y
D
I
L
Q
S
Site 34
S400
R
P
P
A
Q
R
P
S
A
S
D
L
Q
L
Q
Site 35
S402
P
A
Q
R
P
S
A
S
D
L
Q
L
Q
L
T
Site 36
T409
S
D
L
Q
L
Q
L
T
Y
L
L
S
E
R
P
Site 37
S413
L
Q
L
T
Y
L
L
S
E
R
P
P
R
P
P
Site 38
S440
W
P
W
P
P
A
H
S
A
P
R
P
G
T
L
Site 39
T446
H
S
A
P
R
P
G
T
L
S
S
P
F
P
L
Site 40
S448
A
P
R
P
G
T
L
S
S
P
F
P
L
L
D
Site 41
S449
P
R
P
G
T
L
S
S
P
F
P
L
L
D
G
Site 42
T467
A
D
P
D
D
V
L
T
V
T
E
S
S
R
G
Site 43
T469
P
D
D
V
L
T
V
T
E
S
S
R
G
L
N
Site 44
S471
D
V
L
T
V
T
E
S
S
R
G
L
N
L
E
Site 45
S501
A
P
A
W
Q
P
A
S
A
P
P
A
P
H
A
Site 46
S511
P
A
P
H
A
N
P
S
N
P
F
Y
E
A
L
Site 47
Y515
A
N
P
S
N
P
F
Y
E
A
L
S
T
P
S
Site 48
S531
L
P
V
I
S
A
R
S
P
S
V
S
S
E
Y
Site 49
S533
V
I
S
A
R
S
P
S
V
S
S
E
Y
Y
I
Site 50
S535
S
A
R
S
P
S
V
S
S
E
Y
Y
I
R
L
Site 51
Y538
S
P
S
V
S
S
E
Y
Y
I
R
L
E
E
H
Site 52
Y539
P
S
V
S
S
E
Y
Y
I
R
L
E
E
H
G
Site 53
S547
I
R
L
E
E
H
G
S
P
P
E
P
L
F
P
Site 54
S574
P
Q
A
P
Q
A
P
S
E
V
P
Q
L
V
S
Site 55
S581
S
E
V
P
Q
L
V
S
E
T
W
A
S
P
L
Site 56
S599
P
R
P
F
P
A
Q
S
S
A
S
G
S
F
L
Site 57
S600
R
P
F
P
A
Q
S
S
A
S
G
S
F
L
L
Site 58
S604
A
Q
S
S
A
S
G
S
F
L
L
S
G
W
D
Site 59
S608
A
S
G
S
F
L
L
S
G
W
D
P
E
G
R
Site 60
T620
E
G
R
G
A
G
E
T
L
A
G
D
P
A
E
Site 61
T634
E
V
L
G
E
R
G
T
A
P
W
V
E
E
E
Site 62
S648
E
E
E
E
E
E
G
S
S
P
G
E
D
S
S
Site 63
S649
E
E
E
E
E
G
S
S
P
G
E
D
S
S
S
Site 64
S654
G
S
S
P
G
E
D
S
S
S
L
G
G
G
P
Site 65
S655
S
S
P
G
E
D
S
S
S
L
G
G
G
P
S
Site 66
S656
S
P
G
E
D
S
S
S
L
G
G
G
P
S
R
Site 67
S662
S
S
L
G
G
G
P
S
R
R
G
P
L
P
C
Site 68
S679
C
S
R
E
G
A
C
S
C
L
P
L
E
R
G
Site 69
S708
P
H
P
P
E
D
D
S
S
L
R
A
E
R
G
Site 70
S709
H
P
P
E
D
D
S
S
L
R
A
E
R
G
S
Site 71
S716
S
L
R
A
E
R
G
S
L
A
D
L
P
M
A
Site 72
Y744
M
G
A
A
A
P
Q
Y
P
G
R
G
P
P
P
Site 73
S769
A
P
A
D
P
A
A
S
P
D
P
P
S
A
V
Site 74
S774
A
A
S
P
D
P
P
S
A
V
A
S
P
G
S
Site 75
S778
D
P
P
S
A
V
A
S
P
G
S
G
L
S
S
Site 76
S781
S
A
V
A
S
P
G
S
G
L
S
S
P
G
P
Site 77
S784
A
S
P
G
S
G
L
S
S
P
G
P
K
P
G
Site 78
S785
S
P
G
S
G
L
S
S
P
G
P
K
P
G
D
Site 79
S793
P
G
P
K
P
G
D
S
G
Y
E
T
E
T
P
Site 80
Y795
P
K
P
G
D
S
G
Y
E
T
E
T
P
F
S
Site 81
T797
P
G
D
S
G
Y
E
T
E
T
P
F
S
P
E
Site 82
T799
D
S
G
Y
E
T
E
T
P
F
S
P
E
G
A
Site 83
S802
Y
E
T
E
T
P
F
S
P
E
G
A
F
P
G
Site 84
T852
P
G
P
R
E
K
P
T
F
V
V
Q
V
S
T
Site 85
S865
S
T
E
Q
L
L
M
S
L
R
E
D
V
T
R
Site 86
T871
M
S
L
R
E
D
V
T
R
N
L
L
G
E
K
Site 87
T881
L
L
G
E
K
G
A
T
A
R
E
T
G
P
R
Site 88
T885
K
G
A
T
A
R
E
T
G
P
R
K
A
G
R
Site 89
T908
P
G
L
N
R
D
P
T
V
L
G
N
G
K
Q
Site 90
S918
G
N
G
K
Q
A
P
S
L
S
L
P
V
N
G
Site 91
S920
G
K
Q
A
P
S
L
S
L
P
V
N
G
V
T
Site 92
T927
S
L
P
V
N
G
V
T
V
L
E
N
G
D
Q
Site 93
S951
A
E
N
G
A
L
G
S
P
E
R
E
E
K
V
Site 94
T965
V
L
E
N
G
E
L
T
P
P
R
R
E
E
K
Site 95
S981
L
E
N
G
E
L
R
S
P
E
A
G
E
K
V
Site 96
T995
V
L
V
N
G
G
L
T
P
P
K
S
E
D
K
Site 97
S999
G
G
L
T
P
P
K
S
E
D
K
V
S
E
N
Site 98
S1004
P
K
S
E
D
K
V
S
E
N
G
G
L
R
F
Site 99
T1015
G
L
R
F
P
R
N
T
E
R
P
P
E
T
G
Site 100
T1033
A
P
G
P
W
E
K
T
P
E
S
W
G
P
A
Site 101
S1036
P
W
E
K
T
P
E
S
W
G
P
A
P
T
I
Site 102
S1051
G
E
P
A
P
E
T
S
L
E
R
A
P
A
P
Site 103
S1059
L
E
R
A
P
A
P
S
A
V
V
S
S
R
N
Site 104
S1063
P
A
P
S
A
V
V
S
S
R
N
G
G
E
T
Site 105
T1070
S
S
R
N
G
G
E
T
A
P
G
P
L
G
P
Site 106
T1083
G
P
A
P
K
N
G
T
L
E
P
G
T
E
R
Site 107
T1088
N
G
T
L
E
P
G
T
E
R
R
A
P
E
T
Site 108
T1095
T
E
R
R
A
P
E
T
G
G
A
P
R
A
P
Site 109
S1111
A
G
R
L
D
L
G
S
G
G
R
A
P
V
G
Site 110
T1119
G
G
R
A
P
V
G
T
G
T
A
P
G
G
G
Site 111
T1121
R
A
P
V
G
T
G
T
A
P
G
G
G
P
G
Site 112
S1129
A
P
G
G
G
P
G
S
G
V
D
A
K
A
G
Site 113
T1141
K
A
G
W
V
D
N
T
R
P
Q
P
P
P
P
Site 114
S1183
G
E
P
G
A
P
D
S
R
A
G
G
D
T
A
Site 115
T1189
D
S
R
A
G
G
D
T
A
L
S
G
D
G
D
Site 116
S1192
A
G
G
D
T
A
L
S
G
D
G
D
P
P
K
Site 117
S1229
E
Q
I
K
A
R
L
S
R
L
S
L
A
L
P
Site 118
S1332
P
L
R
G
L
L
K
S
P
R
G
A
D
E
P
Site 119
S1342
G
A
D
E
P
E
D
S
E
L
E
R
K
R
K
Site 120
S1352
E
R
K
R
K
M
V
S
F
H
G
D
V
T
V
Site 121
Y1360
F
H
G
D
V
T
V
Y
L
F
D
Q
E
T
P
Site 122
T1366
V
Y
L
F
D
Q
E
T
P
T
N
E
L
S
V
Site 123
S1372
E
T
P
T
N
E
L
S
V
Q
A
P
P
E
G
Site 124
T1381
Q
A
P
P
E
G
D
T
D
P
S
T
P
P
A
Site 125
S1384
P
E
G
D
T
D
P
S
T
P
P
A
P
P
T
Site 126
T1385
E
G
D
T
D
P
S
T
P
P
A
P
P
T
P
Site 127
T1391
S
T
P
P
A
P
P
T
P
P
H
P
A
T
P
Site 128
T1397
P
T
P
P
H
P
A
T
P
G
D
G
F
P
S
Site 129
S1404
T
P
G
D
G
F
P
S
N
D
S
G
F
G
G
Site 130
S1407
D
G
F
P
S
N
D
S
G
F
G
G
S
F
E
Site 131
S1412
N
D
S
G
F
G
G
S
F
E
W
A
E
D
F
Site 132
T1442
S
V
S
P
A
L
E
T
P
G
P
P
A
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation