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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LENG8
Full Name:
Leukocyte receptor cluster member 8
Alias:
KIAA1932; Leukocyte receptor cluster (LRC) member 8; Leukocyte receptor cluster 8; MGC40108; Pp13842
Type:
Unknown function
Mass (Da):
86129
Number AA:
779
UniProt ID:
Q96PV6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005635
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
N
V
G
D
Q
R
S
T
D
W
S
S
Q
Y
Site 2
T11
N
V
G
D
Q
R
S
T
D
W
S
S
Q
Y
S
Site 3
S14
D
Q
R
S
T
D
W
S
S
Q
Y
S
M
V
A
Site 4
S15
Q
R
S
T
D
W
S
S
Q
Y
S
M
V
A
G
Site 5
Y17
S
T
D
W
S
S
Q
Y
S
M
V
A
G
A
G
Site 6
S18
T
D
W
S
S
Q
Y
S
M
V
A
G
A
G
R
Site 7
T31
G
R
E
N
G
M
E
T
P
M
H
E
N
P
E
Site 8
S48
K
A
R
Q
A
L
A
S
I
S
K
S
G
A
A
Site 9
S50
R
Q
A
L
A
S
I
S
K
S
G
A
A
G
G
Site 10
S58
K
S
G
A
A
G
G
S
A
K
S
S
S
N
G
Site 11
S61
A
A
G
G
S
A
K
S
S
S
N
G
P
V
A
Site 12
S62
A
G
G
S
A
K
S
S
S
N
G
P
V
A
S
Site 13
S63
G
G
S
A
K
S
S
S
N
G
P
V
A
S
A
Site 14
S69
S
S
N
G
P
V
A
S
A
Q
Y
V
S
Q
A
Site 15
Y72
G
P
V
A
S
A
Q
Y
V
S
Q
A
E
A
S
Site 16
Y86
S
A
L
Q
Q
Q
Q
Y
Y
Q
W
Y
Q
Q
Y
Site 17
Y97
Y
Q
Q
Y
N
Y
A
Y
P
Y
S
Y
Y
Y
P
Site 18
Y101
N
Y
A
Y
P
Y
S
Y
Y
Y
P
M
P
P
V
Site 19
Y102
Y
A
Y
P
Y
S
Y
Y
Y
P
M
P
P
V
P
Site 20
Y103
A
Y
P
Y
S
Y
Y
Y
P
M
P
P
V
P
G
Site 21
S114
P
V
P
G
M
D
E
S
M
S
Y
Q
A
P
P
Site 22
S116
P
G
M
D
E
S
M
S
Y
Q
A
P
P
Q
Q
Site 23
Y117
G
M
D
E
S
M
S
Y
Q
A
P
P
Q
Q
L
Site 24
S126
A
P
P
Q
Q
L
P
S
A
Q
P
P
Q
P
S
Site 25
S133
S
A
Q
P
P
Q
P
S
N
P
P
H
G
A
H
Site 26
T141
N
P
P
H
G
A
H
T
L
N
S
G
P
Q
P
Site 27
S144
H
G
A
H
T
L
N
S
G
P
Q
P
G
T
A
Site 28
T150
N
S
G
P
Q
P
G
T
A
P
A
T
Q
H
S
Site 29
S157
T
A
P
A
T
Q
H
S
Q
A
G
P
A
T
G
Site 30
Y172
Q
A
Y
G
P
H
T
Y
T
E
P
A
K
P
K
Site 31
T173
A
Y
G
P
H
T
Y
T
E
P
A
K
P
K
K
Site 32
T209
Q
K
R
P
F
A
V
T
T
Q
S
F
G
S
N
Site 33
T210
K
R
P
F
A
V
T
T
Q
S
F
G
S
N
A
Site 34
S212
P
F
A
V
T
T
Q
S
F
G
S
N
A
E
G
Site 35
S215
V
T
T
Q
S
F
G
S
N
A
E
G
Q
H
S
Site 36
S222
S
N
A
E
G
Q
H
S
G
F
G
P
Q
P
N
Site 37
S237
P
E
K
V
Q
N
H
S
G
S
S
A
R
G
N
Site 38
S239
K
V
Q
N
H
S
G
S
S
A
R
G
N
L
S
Site 39
S240
V
Q
N
H
S
G
S
S
A
R
G
N
L
S
G
Site 40
S246
S
S
A
R
G
N
L
S
G
K
P
D
D
W
P
Site 41
Y259
W
P
Q
D
M
K
E
Y
V
E
R
C
F
T
A
Site 42
T265
E
Y
V
E
R
C
F
T
A
C
E
S
E
E
D
Site 43
T276
S
E
E
D
K
D
R
T
E
K
L
L
K
E
V
Site 44
S292
Q
A
R
L
Q
D
G
S
A
Y
T
I
D
W
S
Site 45
S299
S
A
Y
T
I
D
W
S
R
E
P
L
P
G
L
Site 46
T307
R
E
P
L
P
G
L
T
R
E
P
V
A
E
S
Site 47
S314
T
R
E
P
V
A
E
S
P
K
K
K
R
W
E
Site 48
S324
K
K
R
W
E
A
A
S
S
L
H
P
P
R
G
Site 49
S325
K
R
W
E
A
A
S
S
L
H
P
P
R
G
A
Site 50
S334
H
P
P
R
G
A
G
S
A
T
R
G
G
G
A
Site 51
S343
T
R
G
G
G
A
P
S
Q
R
G
T
P
G
A
Site 52
T347
G
A
P
S
Q
R
G
T
P
G
A
G
G
A
G
Site 53
S360
A
G
R
A
R
G
N
S
F
T
K
F
G
N
R
Site 54
T362
R
A
R
G
N
S
F
T
K
F
G
N
R
N
V
Site 55
S375
N
V
F
M
K
D
N
S
S
S
S
S
T
D
S
Site 56
S376
V
F
M
K
D
N
S
S
S
S
S
T
D
S
R
Site 57
S377
F
M
K
D
N
S
S
S
S
S
T
D
S
R
S
Site 58
S378
M
K
D
N
S
S
S
S
S
T
D
S
R
S
R
Site 59
S379
K
D
N
S
S
S
S
S
T
D
S
R
S
R
S
Site 60
T380
D
N
S
S
S
S
S
T
D
S
R
S
R
S
S
Site 61
S382
S
S
S
S
S
T
D
S
R
S
R
S
S
S
R
Site 62
S384
S
S
S
T
D
S
R
S
R
S
S
S
R
S
P
Site 63
S386
S
T
D
S
R
S
R
S
S
S
R
S
P
T
R
Site 64
S387
T
D
S
R
S
R
S
S
S
R
S
P
T
R
H
Site 65
S388
D
S
R
S
R
S
S
S
R
S
P
T
R
H
F
Site 66
S390
R
S
R
S
S
S
R
S
P
T
R
H
F
R
R
Site 67
T392
R
S
S
S
R
S
P
T
R
H
F
R
R
S
D
Site 68
S398
P
T
R
H
F
R
R
S
D
S
H
S
D
S
D
Site 69
S400
R
H
F
R
R
S
D
S
H
S
D
S
D
S
S
Site 70
S402
F
R
R
S
D
S
H
S
D
S
D
S
S
Y
S
Site 71
S404
R
S
D
S
H
S
D
S
D
S
S
Y
S
G
N
Site 72
S406
D
S
H
S
D
S
D
S
S
Y
S
G
N
E
C
Site 73
S407
S
H
S
D
S
D
S
S
Y
S
G
N
E
C
H
Site 74
Y408
H
S
D
S
D
S
S
Y
S
G
N
E
C
H
P
Site 75
T451
K
R
H
D
L
A
P
T
K
R
S
R
K
K
M
Site 76
S484
A
R
F
Q
H
G
H
S
R
R
L
R
L
E
P
Site 77
S497
E
P
L
V
L
Q
M
S
S
L
E
S
S
G
A
Site 78
S498
P
L
V
L
Q
M
S
S
L
E
S
S
G
A
D
Site 79
S501
L
Q
M
S
S
L
E
S
S
G
A
D
P
D
W
Site 80
S502
Q
M
S
S
L
E
S
S
G
A
D
P
D
W
Q
Site 81
T521
V
G
T
C
P
D
I
T
K
H
Y
L
R
L
T
Site 82
Y524
C
P
D
I
T
K
H
Y
L
R
L
T
C
A
P
Site 83
T528
T
K
H
Y
L
R
L
T
C
A
P
D
P
S
T
Site 84
T535
T
C
A
P
D
P
S
T
V
R
P
V
A
V
L
Site 85
T574
K
S
I
R
Q
D
L
T
V
Q
G
I
R
T
E
Site 86
T583
Q
G
I
R
T
E
F
T
V
E
V
Y
E
T
H
Site 87
T608
E
E
F
N
Q
C
Q
T
Q
L
K
S
L
Y
A
Site 88
S612
Q
C
Q
T
Q
L
K
S
L
Y
A
E
N
L
P
Site 89
Y614
Q
T
Q
L
K
S
L
Y
A
E
N
L
P
G
N
Site 90
T626
P
G
N
V
G
E
F
T
A
Y
R
I
L
Y
Y
Site 91
Y633
T
A
Y
R
I
L
Y
Y
I
F
T
K
N
S
G
Site 92
T636
R
I
L
Y
Y
I
F
T
K
N
S
G
D
I
T
Site 93
T643
T
K
N
S
G
D
I
T
T
E
L
A
Y
L
T
Site 94
Y648
D
I
T
T
E
L
A
Y
L
T
R
E
L
K
A
Site 95
Y674
T
A
W
A
L
G
N
Y
H
R
F
F
R
L
Y
Site 96
Y690
H
A
P
C
M
S
G
Y
L
V
D
K
F
A
D
Site 97
T770
P
W
F
S
T
G
K
T
V
P
L
P
P
S
S
Site 98
S776
K
T
V
P
L
P
P
S
S
A
M
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation