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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL5
Full Name:
Kelch-like protein 5
Alias:
Type:
Mass (Da):
84457
Number AA:
755
UniProt ID:
Q96PQ7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
C
L
D
D
H
L
V
S
L
R
M
S
G
S
R
Site 2
S48
H
L
V
S
L
R
M
S
G
S
R
K
E
F
D
Site 3
S50
V
S
L
R
M
S
G
S
R
K
E
F
D
V
K
Site 4
S72
R
W
F
G
H
Q
A
S
S
P
N
S
T
V
D
Site 5
S73
W
F
G
H
Q
A
S
S
P
N
S
T
V
D
S
Site 6
S76
H
Q
A
S
S
P
N
S
T
V
D
S
Q
Q
G
Site 7
T77
Q
A
S
S
P
N
S
T
V
D
S
Q
Q
G
E
Site 8
S80
S
P
N
S
T
V
D
S
Q
Q
G
E
F
W
N
Site 9
T91
E
F
W
N
R
G
Q
T
G
A
N
G
G
R
K
Site 10
S104
R
K
F
L
D
P
C
S
L
Q
L
P
L
A
S
Site 11
S111
S
L
Q
L
P
L
A
S
I
G
Y
R
R
S
S
Site 12
Y114
L
P
L
A
S
I
G
Y
R
R
S
S
Q
L
D
Site 13
S117
A
S
I
G
Y
R
R
S
S
Q
L
D
F
Q
N
Site 14
S118
S
I
G
Y
R
R
S
S
Q
L
D
F
Q
N
S
Site 15
S125
S
Q
L
D
F
Q
N
S
P
S
W
P
M
A
S
Site 16
S127
L
D
F
Q
N
S
P
S
W
P
M
A
S
T
S
Site 17
S132
S
P
S
W
P
M
A
S
T
S
E
V
P
A
F
Site 18
S134
S
W
P
M
A
S
T
S
E
V
P
A
F
E
F
Site 19
T161
R
P
E
V
D
D
G
T
S
E
E
E
N
E
S
Site 20
S162
P
E
V
D
D
G
T
S
E
E
E
N
E
S
D
Site 21
S168
T
S
E
E
E
N
E
S
D
S
S
S
C
R
T
Site 22
S170
E
E
E
N
E
S
D
S
S
S
C
R
T
S
N
Site 23
S171
E
E
N
E
S
D
S
S
S
C
R
T
S
N
S
Site 24
S172
E
N
E
S
D
S
S
S
C
R
T
S
N
S
S
Site 25
T175
S
D
S
S
S
C
R
T
S
N
S
S
Q
T
L
Site 26
S176
D
S
S
S
C
R
T
S
N
S
S
Q
T
L
S
Site 27
S178
S
S
C
R
T
S
N
S
S
Q
T
L
S
S
C
Site 28
S179
S
C
R
T
S
N
S
S
Q
T
L
S
S
C
H
Site 29
T181
R
T
S
N
S
S
Q
T
L
S
S
C
H
T
M
Site 30
S183
S
N
S
S
Q
T
L
S
S
C
H
T
M
E
P
Site 31
S184
N
S
S
Q
T
L
S
S
C
H
T
M
E
P
C
Site 32
T187
Q
T
L
S
S
C
H
T
M
E
P
C
T
S
D
Site 33
T206
A
L
N
H
A
E
Q
T
F
K
K
M
E
N
Y
Site 34
Y213
T
F
K
K
M
E
N
Y
L
R
H
K
Q
L
C
Site 35
S270
M
E
G
V
E
P
N
S
L
W
S
L
I
Q
Y
Site 36
Y277
S
L
W
S
L
I
Q
Y
A
Y
T
G
R
L
E
Site 37
Y279
W
S
L
I
Q
Y
A
Y
T
G
R
L
E
L
K
Site 38
T280
S
L
I
Q
Y
A
Y
T
G
R
L
E
L
K
E
Site 39
S320
L
M
K
Q
L
H
P
S
N
C
L
G
I
R
S
Site 40
S372
E
I
A
K
L
L
A
S
D
D
M
N
I
P
N
Site 41
S403
E
Q
R
R
K
D
L
S
K
L
L
A
Y
I
R
Site 42
Y444
L
I
M
E
A
M
K
Y
H
L
L
P
E
R
R
Site 43
S456
E
R
R
P
M
L
Q
S
P
R
T
K
P
R
K
Site 44
T459
P
M
L
Q
S
P
R
T
K
P
R
K
S
T
V
Site 45
S464
P
R
T
K
P
R
K
S
T
V
G
T
L
F
A
Site 46
T465
R
T
K
P
R
K
S
T
V
G
T
L
F
A
V
Site 47
T478
A
V
G
G
M
D
S
T
K
G
A
T
S
I
E
Site 48
Y487
G
A
T
S
I
E
K
Y
D
L
R
T
N
M
W
Site 49
T527
G
G
R
D
G
L
K
T
L
N
T
V
E
C
Y
Site 50
T530
D
G
L
K
T
L
N
T
V
E
C
Y
N
P
K
Site 51
S542
N
P
K
T
K
T
W
S
V
M
P
P
M
S
T
Site 52
T549
S
V
M
P
P
M
S
T
H
R
H
G
L
G
V
Site 53
Y574
G
G
H
D
G
W
S
Y
L
N
T
V
E
R
W
Site 54
S595
W
N
F
V
A
T
M
S
T
P
R
S
T
V
G
Site 55
S619
A
V
G
G
R
D
G
S
S
C
L
K
S
V
E
Site 56
S620
V
G
G
R
D
G
S
S
C
L
K
S
V
E
C
Site 57
S624
D
G
S
S
C
L
K
S
V
E
C
F
D
P
H
Site 58
S668
G
G
H
D
A
P
A
S
N
L
T
S
R
L
S
Site 59
T671
D
A
P
A
S
N
L
T
S
R
L
S
D
C
V
Site 60
S672
A
P
A
S
N
L
T
S
R
L
S
D
C
V
E
Site 61
S675
S
N
L
T
S
R
L
S
D
C
V
E
R
Y
D
Site 62
Y681
L
S
D
C
V
E
R
Y
D
P
K
T
D
M
W
Site 63
T685
V
E
R
Y
D
P
K
T
D
M
W
T
A
V
A
Site 64
T689
D
P
K
T
D
M
W
T
A
V
A
S
M
S
I
Site 65
S693
D
M
W
T
A
V
A
S
M
S
I
S
R
D
A
Site 66
Y721
G
G
Y
D
G
Q
A
Y
L
N
T
V
E
A
Y
Site 67
T724
D
G
Q
A
Y
L
N
T
V
E
A
Y
D
P
Q
Site 68
T732
V
E
A
Y
D
P
Q
T
N
E
W
T
Q
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation