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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY10
Full Name:
Adenylate cyclase type 10
Alias:
AH-related protein;Adenylate cyclase homolog;Germ cell soluble adenylyl cyclase;Testicular soluble adenylyl cyclase
Type:
Mass (Da):
187135
Number AA:
1610
UniProt ID:
Q96PN6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
H
L
P
D
L
I
V
Y
G
H
F
S
P
E
R
Site 2
S30
L
I
V
Y
G
H
F
S
P
E
R
P
F
M
D
Site 3
Y38
P
E
R
P
F
M
D
Y
F
D
G
V
L
M
F
Site 4
S59
T
A
M
T
E
K
F
S
S
A
M
Y
M
D
R
Site 5
S60
A
M
T
E
K
F
S
S
A
M
Y
M
D
R
G
Site 6
Y63
E
K
F
S
S
A
M
Y
M
D
R
G
A
E
Q
Site 7
Y239
K
C
T
T
F
M
H
Y
Y
P
S
G
E
H
K
Site 8
T254
N
L
L
R
L
A
C
T
L
K
P
D
P
E
L
Site 9
S264
P
D
P
E
L
E
M
S
L
Q
K
Y
V
M
E
Site 10
Y268
L
E
M
S
L
Q
K
Y
V
M
E
S
I
L
K
Site 11
Y285
D
N
K
Q
L
Q
G
Y
L
S
E
L
R
P
V
Site 12
S287
K
Q
L
Q
G
Y
L
S
E
L
R
P
V
T
I
Site 13
Y318
G
P
A
I
Q
D
A
Y
M
H
I
T
S
V
L
Site 14
T360
E
K
V
P
D
E
L
T
H
A
L
E
C
A
M
Site 15
Y404
G
H
T
V
R
H
E
Y
T
V
I
G
Q
K
V
Site 16
T405
H
T
V
R
H
E
Y
T
V
I
G
Q
K
V
N
Site 17
S429
P
G
I
V
T
C
D
S
V
T
Y
N
G
S
N
Site 18
Y440
N
G
S
N
L
P
A
Y
F
F
K
E
L
P
K
Site 19
Y460
V
A
D
S
G
P
L
Y
Q
Y
W
G
R
T
E
Site 20
Y462
D
S
G
P
L
Y
Q
Y
W
G
R
T
E
K
V
Site 21
Y484
I
C
N
R
K
E
D
Y
P
L
L
G
R
N
K
Site 22
Y495
G
R
N
K
E
I
N
Y
F
M
Y
T
M
K
K
Site 23
Y498
K
E
I
N
Y
F
M
Y
T
M
K
K
F
L
I
Site 24
S508
K
K
F
L
I
S
N
S
S
Q
V
L
M
Y
E
Site 25
S509
K
F
L
I
S
N
S
S
Q
V
L
M
Y
E
G
Site 26
Y514
N
S
S
Q
V
L
M
Y
E
G
L
P
G
Y
G
Site 27
Y520
M
Y
E
G
L
P
G
Y
G
K
S
Q
I
L
M
Site 28
S523
G
L
P
G
Y
G
K
S
Q
I
L
M
K
I
E
Site 29
Y531
Q
I
L
M
K
I
E
Y
L
A
Q
G
K
N
H
Site 30
S544
N
H
R
I
I
A
I
S
L
N
K
I
S
F
H
Site 31
Y573
G
L
D
T
C
K
H
Y
K
E
R
Q
T
N
L
Site 32
T578
K
H
Y
K
E
R
Q
T
N
L
R
N
K
V
M
Site 33
T586
N
L
R
N
K
V
M
T
L
L
D
E
K
F
Y
Site 34
S607
F
H
V
Q
F
P
I
S
R
E
I
S
R
M
S
Site 35
S611
F
P
I
S
R
E
I
S
R
M
S
T
L
K
K
Site 36
S614
S
R
E
I
S
R
M
S
T
L
K
K
Q
K
Q
Site 37
T615
R
E
I
S
R
M
S
T
L
K
K
Q
K
Q
L
Site 38
S653
A
Q
F
V
D
S
T
S
W
R
F
M
E
K
L
Site 39
S724
C
I
S
K
E
L
D
S
Y
L
G
E
G
S
C
Site 40
Y725
I
S
K
E
L
D
S
Y
L
G
E
G
S
C
G
Site 41
Y736
G
S
C
G
I
P
F
Y
C
E
E
L
L
K
N
Site 42
T761
Q
T
E
S
E
E
K
T
N
R
T
W
N
N
L
Site 43
Y771
T
W
N
N
L
F
K
Y
S
I
K
L
T
E
K
Site 44
T776
F
K
Y
S
I
K
L
T
E
K
L
N
M
V
T
Site 45
T783
T
E
K
L
N
M
V
T
L
H
S
D
K
E
S
Site 46
S786
L
N
M
V
T
L
H
S
D
K
E
S
E
E
V
Site 47
S790
T
L
H
S
D
K
E
S
E
E
V
C
H
L
T
Site 48
S806
G
V
R
L
K
N
L
S
P
P
T
S
L
K
E
Site 49
T809
L
K
N
L
S
P
P
T
S
L
K
E
I
S
L
Site 50
S810
K
N
L
S
P
P
T
S
L
K
E
I
S
L
I
Site 51
S815
P
T
S
L
K
E
I
S
L
I
Q
L
D
S
M
Site 52
S825
Q
L
D
S
M
R
L
S
H
Q
M
L
V
R
C
Site 53
Y871
L
V
E
S
N
I
F
Y
C
F
R
N
G
K
E
Site 54
S889
A
L
K
Q
N
D
P
S
F
E
V
H
Y
R
S
Site 55
Y894
D
P
S
F
E
V
H
Y
R
S
L
S
L
K
P
Site 56
S896
S
F
E
V
H
Y
R
S
L
S
L
K
P
S
E
Site 57
S898
E
V
H
Y
R
S
L
S
L
K
P
S
E
G
M
Site 58
S902
R
S
L
S
L
K
P
S
E
G
M
D
H
G
E
Site 59
Y975
R
G
R
D
F
I
P
Y
H
H
F
T
V
N
I
Site 60
T1003
A
M
S
H
G
F
K
T
E
E
K
L
I
L
S
Site 61
S1010
T
E
E
K
L
I
L
S
N
S
E
I
P
E
T
Site 62
S1012
E
K
L
I
L
S
N
S
E
I
P
E
T
S
A
Site 63
T1017
S
N
S
E
I
P
E
T
S
A
F
F
P
E
N
Site 64
S1026
A
F
F
P
E
N
R
S
P
E
E
I
R
E
K
Site 65
Y1086
G
E
N
D
K
A
L
Y
Y
F
L
E
I
A
S
Site 66
Y1087
E
N
D
K
A
L
Y
Y
F
L
E
I
A
S
A
Site 67
Y1107
D
N
Y
M
A
Y
M
Y
L
N
E
G
Q
K
L
Site 68
T1117
E
G
Q
K
L
L
K
T
L
K
K
D
K
S
W
Site 69
S1123
K
T
L
K
K
D
K
S
W
S
Q
T
F
E
S
Site 70
S1125
L
K
K
D
K
S
W
S
Q
T
F
E
S
A
T
Site 71
T1127
K
D
K
S
W
S
Q
T
F
E
S
A
T
F
Y
Site 72
S1130
S
W
S
Q
T
F
E
S
A
T
F
Y
S
L
K
Site 73
T1132
S
Q
T
F
E
S
A
T
F
Y
S
L
K
G
E
Site 74
Y1186
E
K
N
R
H
F
H
Y
V
N
R
Q
A
Q
E
Site 75
S1194
V
N
R
Q
A
Q
E
S
P
P
P
G
K
K
R
Site 76
Y1206
K
K
R
L
A
Q
L
Y
R
Q
T
V
C
L
S
Site 77
Y1255
C
F
Q
I
I
K
A
Y
L
D
Y
S
L
Y
H
Site 78
Y1258
I
I
K
A
Y
L
D
Y
S
L
Y
H
H
L
A
Site 79
Y1261
A
Y
L
D
Y
S
L
Y
H
H
L
A
G
Y
K
Site 80
Y1267
L
Y
H
H
L
A
G
Y
K
G
V
W
F
K
Y
Site 81
Y1336
L
Q
N
P
N
R
H
Y
Q
S
L
C
R
L
S
Site 82
S1350
S
R
C
L
L
L
N
S
R
Y
P
Q
L
I
Q
Site 83
T1368
R
L
W
E
L
S
V
T
Q
E
H
I
F
S
K
Site 84
T1395
Y
S
G
F
V
Y
R
T
F
E
E
C
L
E
F
Site 85
Y1406
C
L
E
F
I
H
Q
Y
E
N
N
R
I
L
K
Site 86
Y1430
Y
S
S
V
A
I
W
Y
A
R
L
Q
E
W
D
Site 87
Y1440
L
Q
E
W
D
N
F
Y
K
F
S
N
R
A
K
Site 88
T1454
K
N
L
L
P
R
R
T
M
T
L
T
Y
Y
D
Site 89
T1456
L
L
P
R
R
T
M
T
L
T
Y
Y
D
G
I
Site 90
T1458
P
R
R
T
M
T
L
T
Y
Y
D
G
I
S
R
Site 91
Y1459
R
R
T
M
T
L
T
Y
Y
D
G
I
S
R
Y
Site 92
Y1460
R
T
M
T
L
T
Y
Y
D
G
I
S
R
Y
M
Site 93
Y1466
Y
Y
D
G
I
S
R
Y
M
E
G
Q
V
L
H
Site 94
S1488
Q
S
E
N
A
Q
A
S
G
E
E
L
L
K
N
Site 95
S1541
L
N
T
A
L
R
L
S
E
T
Q
G
N
I
L
Site 96
T1543
T
A
L
R
L
S
E
T
Q
G
N
I
L
E
K
Site 97
S1562
M
N
K
E
S
W
Y
S
T
S
E
L
K
E
D
Site 98
T1574
K
E
D
Q
W
L
Q
T
I
L
S
L
P
S
W
Site 99
S1577
Q
W
L
Q
T
I
L
S
L
P
S
W
E
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation