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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MACF1
Full Name:
Microtubule-actin cross-linking factor 1, isoform 4
Alias:
620 kDa actin binding protein; ABP620; ACF7; Actin cross-linking factor; Actin cross-linking family protein 7; FLJ45612; FLJ46776; KIAA0465; KIAA1251; MACF; MACF4; Macrophin 1; Microtubule-actin crosslinking 1; Microtubule-actin crosslinking factor 1; Trabeculin-alpha
Type:
Adaptor/scaffold protein
Mass (Da):
670151
Number AA:
5938
UniProt ID:
Q96PK2
International Prot ID:
IPI00432363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0007163
GO:0001707
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
S
G
L
I
A
P
E
T
G
E
N
L
S
L
E
Site 2
S34
P
E
T
G
E
N
L
S
L
E
E
G
I
A
R
Site 3
S73
T
E
S
R
G
P
L
S
V
V
E
A
I
E
K
Site 4
T86
E
K
R
I
I
S
E
T
V
G
L
K
I
L
E
Site 5
S102
H
L
A
T
G
G
F
S
L
S
P
S
E
N
C
Site 6
S104
A
T
G
G
F
S
L
S
P
S
E
N
C
I
N
Site 7
S106
G
G
F
S
L
S
P
S
E
N
C
I
N
L
E
Site 8
S131
W
L
H
S
V
L
E
S
Y
L
R
T
S
K
N
Site 9
Y132
L
H
S
V
L
E
S
Y
L
R
T
S
K
N
L
Site 10
S136
L
E
S
Y
L
R
T
S
K
N
L
I
D
P
N
Site 11
T144
K
N
L
I
D
P
N
T
A
E
K
I
G
L
L
Site 12
S187
L
K
S
G
R
K
V
S
I
F
R
A
V
Q
E
Site 13
T220
G
G
I
V
D
P
R
T
G
H
R
L
T
V
E
Site 14
T225
P
R
T
G
H
R
L
T
V
E
E
A
V
R
H
Site 15
T256
Q
T
G
G
I
I
D
T
V
T
G
Q
R
L
T
Site 16
T263
T
V
T
G
Q
R
L
T
I
D
E
A
V
S
N
Site 17
S321
E
L
A
H
K
I
L
S
N
R
Q
H
I
K
A
Site 18
S339
P
A
T
T
E
I
L
S
W
K
K
A
I
E
S
Site 19
S374
P
H
M
Q
L
A
D
S
A
E
Q
N
I
N
P
Site 20
S389
G
A
A
V
L
P
C
S
K
S
H
P
K
A
T
Site 21
S391
A
V
L
P
C
S
K
S
H
P
K
A
T
A
S
Site 22
T396
S
K
S
H
P
K
A
T
A
S
Q
S
E
N
L
Site 23
S398
S
H
P
K
A
T
A
S
Q
S
E
N
L
L
F
Site 24
S400
P
K
A
T
A
S
Q
S
E
N
L
L
F
Q
L
Site 25
Y412
F
Q
L
M
T
H
S
Y
I
N
V
Q
N
G
Q
Site 26
T431
L
D
K
E
L
M
E
T
L
T
S
R
D
E
Y
Site 27
T433
K
E
L
M
E
T
L
T
S
R
D
E
Y
Q
T
Site 28
S434
E
L
M
E
T
L
T
S
R
D
E
Y
Q
T
S
Site 29
Y438
T
L
T
S
R
D
E
Y
Q
T
S
P
P
K
V
Site 30
T440
T
S
R
D
E
Y
Q
T
S
P
P
K
V
V
E
Site 31
S441
S
R
D
E
Y
Q
T
S
P
P
K
V
V
E
I
Site 32
T455
I
G
H
Q
R
Q
K
T
P
E
G
L
Q
E
S
Site 33
S462
T
P
E
G
L
Q
E
S
A
N
V
K
I
S
G
Site 34
S468
E
S
A
N
V
K
I
S
G
T
F
S
S
G
W
Site 35
S473
K
I
S
G
T
F
S
S
G
W
T
V
R
L
P
Site 36
T476
G
T
F
S
S
G
W
T
V
R
L
P
E
F
Q
Site 37
S485
R
L
P
E
F
Q
F
S
S
Q
N
K
E
Y
P
Site 38
S486
L
P
E
F
Q
F
S
S
Q
N
K
E
Y
P
D
Site 39
Y491
F
S
S
Q
N
K
E
Y
P
D
R
E
D
C
T
Site 40
T498
Y
P
D
R
E
D
C
T
T
E
K
G
K
K
T
Site 41
T499
P
D
R
E
D
C
T
T
E
K
G
K
K
T
T
Site 42
S512
T
T
V
E
T
E
D
S
S
V
E
N
P
E
Q
Site 43
S513
T
V
E
T
E
D
S
S
V
E
N
P
E
Q
D
Site 44
T552
V
Q
R
Q
L
I
G
T
Q
R
E
D
Q
T
A
Site 45
S561
R
E
D
Q
T
A
V
S
V
R
E
N
A
S
R
Site 46
T573
A
S
R
G
H
L
L
T
I
P
P
A
E
A
E
Site 47
S592
V
V
D
K
D
V
F
S
V
E
T
P
K
K
E
Site 48
T595
K
D
V
F
S
V
E
T
P
K
K
E
H
Q
P
Site 49
T606
E
H
Q
P
L
R
N
T
S
F
T
C
Q
N
E
Site 50
S607
H
Q
P
L
R
N
T
S
F
T
C
Q
N
E
Q
Site 51
T609
P
L
R
N
T
S
F
T
C
Q
N
E
Q
A
H
Site 52
T617
C
Q
N
E
Q
A
H
T
L
E
T
E
Y
I
H
Site 53
Y622
A
H
T
L
E
T
E
Y
I
H
D
E
T
G
G
Site 54
S630
I
H
D
E
T
G
G
S
H
I
K
P
Q
S
K
Site 55
S636
G
S
H
I
K
P
Q
S
K
K
L
Q
V
Q
V
Site 56
S655
G
I
K
L
E
L
K
S
E
T
D
G
N
V
H
Site 57
T673
K
K
E
M
L
K
K
T
F
L
A
K
D
D
H
Site 58
S683
A
K
D
D
H
K
E
S
Q
E
A
Q
N
I
A
Site 59
S697
A
G
G
S
M
M
M
S
E
K
T
D
E
E
D
Site 60
T700
S
M
M
M
S
E
K
T
D
E
E
D
S
G
R
Site 61
S705
E
K
T
D
E
E
D
S
G
R
E
I
F
L
S
Site 62
S712
S
G
R
E
I
F
L
S
C
S
H
P
L
E
L
Site 63
T761
R
G
I
V
P
S
H
T
A
V
K
L
M
E
K
Site 64
T780
Q
G
F
F
D
S
Q
T
C
E
S
L
T
T
E
Site 65
S783
F
D
S
Q
T
C
E
S
L
T
T
E
E
V
I
Site 66
T786
Q
T
C
E
S
L
T
T
E
E
V
I
N
E
G
Site 67
T818
S
G
V
L
D
P
R
T
Q
T
L
C
S
V
K
Site 68
T820
V
L
D
P
R
T
Q
T
L
C
S
V
K
D
A
Site 69
S823
P
R
T
Q
T
L
C
S
V
K
D
A
V
T
V
Site 70
T837
V
G
L
L
D
K
E
T
A
T
R
I
L
E
R
Site 71
S861
L
K
R
G
K
K
V
S
V
T
L
A
S
T
L
Site 72
T894
K
G
R
D
A
E
K
T
V
R
E
R
L
I
S
Site 73
S901
T
V
R
E
R
L
I
S
L
Q
M
E
T
T
G
Site 74
T919
P
D
S
K
A
P
L
T
V
V
Q
S
I
D
R
Site 75
T939
E
E
A
V
R
L
L
T
K
Q
V
V
D
G
G
Site 76
S957
H
I
S
G
M
R
L
S
V
D
N
A
F
R
H
Site 77
T991
H
Q
I
F
N
P
E
T
K
E
N
I
S
L
P
Site 78
S1008
I
K
L
D
L
I
T
S
D
L
K
R
E
I
Q
Site 79
T1034
L
I
S
G
Q
R
L
T
L
A
E
A
K
K
E
Site 80
T1045
A
K
K
E
G
L
L
T
N
E
A
V
L
S
P
Site 81
Y1086
D
I
E
S
G
Q
R
Y
L
E
V
I
P
F
S
Site 82
S1100
S
D
I
K
D
G
V
S
D
K
V
L
T
L
S
Site 83
S1107
S
D
K
V
L
T
L
S
Q
A
I
Q
L
G
K
Site 84
T1143
T
A
T
G
K
R
L
T
L
A
S
A
L
E
E
Site 85
S1203
A
N
M
I
Q
I
D
S
S
E
F
S
D
H
R
Site 86
S1204
N
M
I
Q
I
D
S
S
E
F
S
D
H
R
A
Site 87
S1207
Q
I
D
S
S
E
F
S
D
H
R
A
Q
I
E
Site 88
S1251
S
C
N
K
V
E
E
S
E
R
L
F
Q
V
E
Site 89
S1271
E
K
V
K
V
R
V
S
D
G
E
Q
A
K
K
Site 90
S1279
D
G
E
Q
A
K
K
S
R
E
I
S
L
K
E
Site 91
S1283
A
K
K
S
R
E
I
S
L
K
E
F
G
C
K
Site 92
S1298
D
Q
R
K
P
R
M
S
S
D
A
K
E
F
I
Site 93
S1299
Q
R
K
P
R
M
S
S
D
A
K
E
F
I
S
Site 94
S1317
P
H
N
L
K
G
K
S
L
G
Q
V
S
L
T
Site 95
S1322
G
K
S
L
G
Q
V
S
L
T
H
P
Y
S
E
Site 96
T1324
S
L
G
Q
V
S
L
T
H
P
Y
S
E
C
D
Site 97
S1328
V
S
L
T
H
P
Y
S
E
C
D
F
K
L
K
Site 98
T1355
E
E
Q
E
K
A
V
T
K
I
E
I
I
S
H
Site 99
S1366
I
I
S
H
M
K
Q
S
T
S
C
L
D
S
E
Site 100
S1368
S
H
M
K
Q
S
T
S
C
L
D
S
E
E
I
Site 101
S1372
Q
S
T
S
C
L
D
S
E
E
I
R
E
N
Q
Site 102
T1389
V
I
L
E
V
Q
E
T
Y
C
E
T
S
G
K
Site 103
Y1390
I
L
E
V
Q
E
T
Y
C
E
T
S
G
K
L
Site 104
S1413
P
M
N
A
R
V
K
S
K
R
E
K
R
E
V
Site 105
S1425
R
E
V
I
V
E
E
S
I
R
T
C
K
P
A
Site 106
Y1440
F
L
S
E
E
K
L
Y
Q
E
T
A
I
R
D
Site 107
S1451
A
I
R
D
E
H
D
S
H
I
K
S
Q
P
R
Site 108
S1455
E
H
D
S
H
I
K
S
Q
P
R
E
M
T
S
Site 109
T1461
K
S
Q
P
R
E
M
T
S
S
E
K
G
K
E
Site 110
S1463
Q
P
R
E
M
T
S
S
E
K
G
K
E
A
D
Site 111
T1471
E
K
G
K
E
A
D
T
E
M
G
F
S
I
T
Site 112
S1476
A
D
T
E
M
G
F
S
I
T
F
K
I
E
E
Site 113
T1478
T
E
M
G
F
S
I
T
F
K
I
E
E
S
S
Site 114
S1485
T
F
K
I
E
E
S
S
S
Q
V
V
P
Q
G
Site 115
S1486
F
K
I
E
E
S
S
S
Q
V
V
P
Q
G
I
Site 116
T1502
V
K
H
L
D
A
L
T
L
F
S
S
K
Q
A
Site 117
S1506
D
A
L
T
L
F
S
S
K
Q
A
N
E
G
K
Site 118
S1518
E
G
K
V
N
N
L
S
L
C
L
T
L
K
P
Site 119
T1522
N
N
L
S
L
C
L
T
L
K
P
E
E
N
L
Site 120
S1530
L
K
P
E
E
N
L
S
R
E
I
A
C
G
A
Site 121
T1546
S
E
P
F
P
C
M
T
P
R
P
E
G
L
H
Site 122
Y1554
P
R
P
E
G
L
H
Y
Q
E
S
D
G
K
A
Site 123
S1557
E
G
L
H
Y
Q
E
S
D
G
K
A
Q
V
T
Site 124
S1567
K
A
Q
V
T
G
P
S
Q
I
S
K
T
D
K
Site 125
T1572
G
P
S
Q
I
S
K
T
D
K
S
F
Q
G
T
Site 126
S1575
Q
I
S
K
T
D
K
S
F
Q
G
T
T
R
Q
Site 127
T1579
T
D
K
S
F
Q
G
T
T
R
Q
E
T
N
Y
Site 128
T1584
Q
G
T
T
R
Q
E
T
N
Y
Q
D
S
W
V
Site 129
Y1586
T
T
R
Q
E
T
N
Y
Q
D
S
W
V
T
S
Site 130
S1589
Q
E
T
N
Y
Q
D
S
W
V
T
S
K
T
K
Site 131
S1593
Y
Q
D
S
W
V
T
S
K
T
K
E
T
K
H
Site 132
T1595
D
S
W
V
T
S
K
T
K
E
T
K
H
Q
I
Site 133
S1605
T
K
H
Q
I
S
S
S
N
E
C
K
E
K
S
Site 134
S1612
S
N
E
C
K
E
K
S
Y
Q
E
V
S
F
D
Site 135
Y1613
N
E
C
K
E
K
S
Y
Q
E
V
S
F
D
P
Site 136
S1617
E
K
S
Y
Q
E
V
S
F
D
P
A
R
G
L
Site 137
T1630
G
L
K
L
E
E
I
T
V
S
R
P
D
S
K
Site 138
S1632
K
L
E
E
I
T
V
S
R
P
D
S
K
E
V
Site 139
S1636
I
T
V
S
R
P
D
S
K
E
V
R
Y
L
E
Site 140
Y1641
P
D
S
K
E
V
R
Y
L
E
F
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L
S
Site 444
S5511
S
R
S
G
G
R
K
S
L
S
Q
P
T
P
P
Site 445
S5513
S
G
G
R
K
S
L
S
Q
P
T
P
P
P
M
Site 446
T5516
R
K
S
L
S
Q
P
T
P
P
P
M
P
I
L
Site 447
S5524
P
P
P
M
P
I
L
S
Q
S
E
A
K
N
P
Site 448
S5526
P
M
P
I
L
S
Q
S
E
A
K
N
P
R
I
Site 449
T5627
P
T
T
K
L
E
M
T
A
V
A
D
I
F
D
Site 450
Y5640
F
D
R
D
G
D
G
Y
I
D
Y
Y
E
F
V
Site 451
Y5643
D
G
D
G
Y
I
D
Y
Y
E
F
V
A
A
L
Site 452
Y5644
G
D
G
Y
I
D
Y
Y
E
F
V
A
A
L
H
Site 453
Y5657
L
H
P
N
K
D
A
Y
R
P
T
T
D
A
D
Site 454
T5660
N
K
D
A
Y
R
P
T
T
D
A
D
K
I
E
Site 455
T5661
K
D
A
Y
R
P
T
T
D
A
D
K
I
E
D
Site 456
T5671
D
K
I
E
D
E
V
T
R
Q
V
A
Q
C
K
Site 457
Y5693
E
Q
I
G
E
N
K
Y
R
F
F
L
G
N
Q
Site 458
S5704
L
G
N
Q
F
G
D
S
Q
Q
L
R
L
V
R
Site 459
T5744
P
C
R
A
R
G
R
T
N
I
E
L
R
E
K
Site 460
S5759
F
I
L
P
E
G
A
S
Q
G
M
T
P
F
R
Site 461
T5763
E
G
A
S
Q
G
M
T
P
F
R
S
R
G
R
Site 462
S5767
Q
G
M
T
P
F
R
S
R
G
R
R
S
K
P
Site 463
S5772
F
R
S
R
G
R
R
S
K
P
S
S
R
A
A
Site 464
S5775
R
G
R
R
S
K
P
S
S
R
A
A
S
P
T
Site 465
S5776
G
R
R
S
K
P
S
S
R
A
A
S
P
T
R
Site 466
S5780
K
P
S
S
R
A
A
S
P
T
R
S
S
S
S
Site 467
T5782
S
S
R
A
A
S
P
T
R
S
S
S
S
A
S
Site 468
S5784
R
A
A
S
P
T
R
S
S
S
S
A
S
Q
S
Site 469
S5785
A
A
S
P
T
R
S
S
S
S
A
S
Q
S
N
Site 470
S5786
A
S
P
T
R
S
S
S
S
A
S
Q
S
N
H
Site 471
S5787
S
P
T
R
S
S
S
S
A
S
Q
S
N
H
S
Site 472
S5789
T
R
S
S
S
S
A
S
Q
S
N
H
S
C
T
Site 473
S5791
S
S
S
S
A
S
Q
S
N
H
S
C
T
S
M
Site 474
S5794
S
A
S
Q
S
N
H
S
C
T
S
M
P
S
S
Site 475
T5796
S
Q
S
N
H
S
C
T
S
M
P
S
S
P
A
Site 476
S5797
Q
S
N
H
S
C
T
S
M
P
S
S
P
A
T
Site 477
S5800
H
S
C
T
S
M
P
S
S
P
A
T
P
A
S
Site 478
S5801
S
C
T
S
M
P
S
S
P
A
T
P
A
S
G
Site 479
T5804
S
M
P
S
S
P
A
T
P
A
S
G
T
K
V
Site 480
S5807
S
S
P
A
T
P
A
S
G
T
K
V
I
P
S
Site 481
S5814
S
G
T
K
V
I
P
S
S
G
S
K
L
K
R
Site 482
S5815
G
T
K
V
I
P
S
S
G
S
K
L
K
R
P
Site 483
S5817
K
V
I
P
S
S
G
S
K
L
K
R
P
T
P
Site 484
T5823
G
S
K
L
K
R
P
T
P
T
F
H
S
S
R
Site 485
T5825
K
L
K
R
P
T
P
T
F
H
S
S
R
T
S
Site 486
S5828
R
P
T
P
T
F
H
S
S
R
T
S
L
A
G
Site 487
S5829
P
T
P
T
F
H
S
S
R
T
S
L
A
G
D
Site 488
S5832
T
F
H
S
S
R
T
S
L
A
G
D
T
S
N
Site 489
T5837
R
T
S
L
A
G
D
T
S
N
S
S
S
P
A
Site 490
S5838
T
S
L
A
G
D
T
S
N
S
S
S
P
A
S
Site 491
S5840
L
A
G
D
T
S
N
S
S
S
P
A
S
T
G
Site 492
S5841
A
G
D
T
S
N
S
S
S
P
A
S
T
G
A
Site 493
S5842
G
D
T
S
N
S
S
S
P
A
S
T
G
A
K
Site 494
S5845
S
N
S
S
S
P
A
S
T
G
A
K
T
N
R
Site 495
T5846
N
S
S
S
P
A
S
T
G
A
K
T
N
R
A
Site 496
T5850
P
A
S
T
G
A
K
T
N
R
A
D
P
K
K
Site 497
S5858
N
R
A
D
P
K
K
S
A
S
R
P
G
S
R
Site 498
S5860
A
D
P
K
K
S
A
S
R
P
G
S
R
A
G
Site 499
S5864
K
S
A
S
R
P
G
S
R
A
G
S
R
A
G
Site 500
S5868
R
P
G
S
R
A
G
S
R
A
G
S
R
A
S
Site 501
S5872
R
A
G
S
R
A
G
S
R
A
S
S
R
R
G
Site 502
S5875
S
R
A
G
S
R
A
S
S
R
R
G
S
D
A
Site 503
S5876
R
A
G
S
R
A
S
S
R
R
G
S
D
A
S
Site 504
S5880
R
A
S
S
R
R
G
S
D
A
S
D
F
D
L
Site 505
S5883
S
R
R
G
S
D
A
S
D
F
D
L
L
E
T
Site 506
T5890
S
D
F
D
L
L
E
T
Q
S
A
C
S
D
T
Site 507
S5892
F
D
L
L
E
T
Q
S
A
C
S
D
T
S
E
Site 508
S5895
L
E
T
Q
S
A
C
S
D
T
S
E
S
S
A
Site 509
T5897
T
Q
S
A
C
S
D
T
S
E
S
S
A
A
G
Site 510
S5898
Q
S
A
C
S
D
T
S
E
S
S
A
A
G
G
Site 511
S5900
A
C
S
D
T
S
E
S
S
A
A
G
G
Q
G
Site 512
S5909
A
A
G
G
Q
G
N
S
R
R
G
L
N
K
P
Site 513
S5917
R
R
G
L
N
K
P
S
K
I
P
T
M
S
K
Site 514
T5921
N
K
P
S
K
I
P
T
M
S
K
K
T
T
T
Site 515
S5923
P
S
K
I
P
T
M
S
K
K
T
T
T
A
S
Site 516
T5926
I
P
T
M
S
K
K
T
T
T
A
S
P
R
T
Site 517
T5927
P
T
M
S
K
K
T
T
T
A
S
P
R
T
P
Site 518
T5928
T
M
S
K
K
T
T
T
A
S
P
R
T
P
G
Site 519
S5930
S
K
K
T
T
T
A
S
P
R
T
P
G
P
K
Site 520
T5933
T
T
T
A
S
P
R
T
P
G
P
K
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation