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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INPP4A
Full Name:
Type I inositol-3,4-bisphosphate 4-phosphatase
Alias:
EC 3.1.3.66; Inositol polyphosphate-4-phosphatase, type I, 107kDa; INP4A; INPP4
Type:
Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.66
Mass (Da):
109956
Number AA:
977
UniProt ID:
Q96PE3
International Prot ID:
IPI00044388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0034597
GO:0016316
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
A
R
E
H
S
P
R
H
G
A
R
A
Site 2
S21
A
R
A
M
Q
R
A
S
T
I
D
V
A
A
D
Site 3
T22
R
A
M
Q
R
A
S
T
I
D
V
A
A
D
M
Site 4
T57
L
A
C
S
E
L
H
T
P
S
L
D
R
K
P
Site 5
S59
C
S
E
L
H
T
P
S
L
D
R
K
P
N
S
Site 6
S66
S
L
D
R
K
P
N
S
F
V
A
V
S
V
T
Site 7
T113
D
S
L
I
N
Q
M
T
Q
V
K
L
S
V
Y
Site 8
S118
Q
M
T
Q
V
K
L
S
V
Y
D
V
K
D
R
Site 9
Y120
T
Q
V
K
L
S
V
Y
D
V
K
D
R
S
Q
Site 10
S126
V
Y
D
V
K
D
R
S
Q
G
T
M
Y
L
L
Site 11
Y131
D
R
S
Q
G
T
M
Y
L
L
G
S
G
T
F
Site 12
T137
M
Y
L
L
G
S
G
T
F
I
V
K
D
L
L
Site 13
T154
R
H
H
R
L
H
L
T
L
R
S
A
E
S
D
Site 14
S160
L
T
L
R
S
A
E
S
D
R
V
G
N
I
T
Site 15
S177
G
W
Q
M
E
E
K
S
D
Q
R
P
P
V
T
Site 16
T184
S
D
Q
R
P
P
V
T
R
S
V
D
T
V
N
Site 17
S186
Q
R
P
P
V
T
R
S
V
D
T
V
N
G
R
Site 18
S210
T
E
A
L
G
I
R
S
K
Y
A
S
L
R
K
Site 19
Y212
A
L
G
I
R
S
K
Y
A
S
L
R
K
D
T
Site 20
S214
G
I
R
S
K
Y
A
S
L
R
K
D
T
L
L
Site 21
T219
Y
A
S
L
R
K
D
T
L
L
K
S
V
F
G
Site 22
Y233
G
G
A
I
C
R
M
Y
R
F
P
T
T
D
G
Site 23
S252
I
L
E
Q
M
A
E
S
V
L
S
L
H
V
P
Site 24
S255
Q
M
A
E
S
V
L
S
L
H
V
P
R
Q
F
Site 25
S284
L
E
E
L
G
E
L
S
P
C
W
E
S
L
R
Site 26
S289
E
L
S
P
C
W
E
S
L
R
R
Q
I
V
T
Site 27
Y298
R
R
Q
I
V
T
Q
Y
Q
T
I
I
L
T
Y
Site 28
Y315
N
L
T
D
L
H
Q
Y
R
G
P
S
F
K
A
Site 29
S319
L
H
Q
Y
R
G
P
S
F
K
A
S
S
L
K
Site 30
S323
R
G
P
S
F
K
A
S
S
L
K
A
D
K
K
Site 31
T336
K
K
L
E
F
V
P
T
N
L
H
I
Q
R
M
Site 32
S351
R
V
Q
D
D
G
G
S
D
Q
N
Y
D
I
V
Site 33
Y355
D
G
G
S
D
Q
N
Y
D
I
V
T
I
G
A
Site 34
S372
A
H
C
Q
G
F
K
S
G
G
L
R
K
K
L
Site 35
T423
A
Q
I
N
T
L
K
T
Q
V
S
Y
Y
A
E
Site 36
S426
N
T
L
K
T
Q
V
S
Y
Y
A
E
R
L
S
Site 37
Y427
T
L
K
T
Q
V
S
Y
Y
A
E
R
L
S
R
Site 38
Y428
L
K
T
Q
V
S
Y
Y
A
E
R
L
S
R
A
Site 39
S433
S
Y
Y
A
E
R
L
S
R
A
A
K
D
R
S
Site 40
T442
A
A
K
D
R
S
A
T
G
L
E
R
T
L
A
Site 41
Y481
L
N
A
A
R
P
D
Y
I
A
S
K
A
S
P
Site 42
S484
A
R
P
D
Y
I
A
S
K
A
S
P
T
S
T
Site 43
S487
D
Y
I
A
S
K
A
S
P
T
S
T
E
E
E
Site 44
S490
A
S
K
A
S
P
T
S
T
E
E
E
Q
V
M
Site 45
T491
S
K
A
S
P
T
S
T
E
E
E
Q
V
M
L
Site 46
T510
D
T
L
M
A
R
W
T
G
R
N
S
R
S
S
Site 47
S514
A
R
W
T
G
R
N
S
R
S
S
L
Q
V
D
Site 48
S517
T
G
R
N
S
R
S
S
L
Q
V
D
W
H
E
Site 49
S568
D
V
F
P
C
A
G
S
C
T
S
K
K
G
N
Site 50
S571
P
C
A
G
S
C
T
S
K
K
G
N
P
D
S
Site 51
S578
S
K
K
G
N
P
D
S
H
A
Y
W
I
R
P
Site 52
S594
D
P
F
C
D
V
P
S
S
P
C
P
S
T
M
Site 53
S595
P
F
C
D
V
P
S
S
P
C
P
S
T
M
P
Site 54
S599
V
P
S
S
P
C
P
S
T
M
P
S
T
A
C
Site 55
T600
P
S
S
P
C
P
S
T
M
P
S
T
A
C
H
Site 56
T612
A
C
H
P
H
L
T
T
H
C
S
P
P
P
E
Site 57
S615
P
H
L
T
T
H
C
S
P
P
P
E
E
S
S
Site 58
S621
C
S
P
P
P
E
E
S
S
P
G
E
W
S
E
Site 59
S622
S
P
P
P
E
E
S
S
P
G
E
W
S
E
A
Site 60
S627
E
S
S
P
G
E
W
S
E
A
L
Y
P
L
L
Site 61
Y667
S
A
P
T
I
A
T
Y
L
S
L
Q
Y
R
R
Site 62
S669
P
T
I
A
T
Y
L
S
L
Q
Y
R
R
D
V
Site 63
S720
A
Q
F
E
S
L
L
S
T
Y
G
E
E
L
A
Site 64
T721
Q
F
E
S
L
L
S
T
Y
G
E
E
L
A
M
Site 65
T747
R
N
V
T
F
K
V
T
Q
A
T
S
S
A
S
Site 66
S751
F
K
V
T
Q
A
T
S
S
A
S
A
D
M
L
Site 67
S754
T
Q
A
T
S
S
A
S
A
D
M
L
P
V
I
Site 68
T762
A
D
M
L
P
V
I
T
G
N
R
D
G
F
N
Site 69
T808
V
G
I
N
E
Q
Q
T
L
A
E
R
F
G
D
Site 70
S817
A
E
R
F
G
D
T
S
L
Q
E
V
I
N
V
Site 71
S826
Q
E
V
I
N
V
E
S
L
V
R
L
N
S
Y
Site 72
S832
E
S
L
V
R
L
N
S
Y
F
E
Q
F
K
E
Site 73
Y833
S
L
V
R
L
N
S
Y
F
E
Q
F
K
E
V
Site 74
S849
P
E
D
C
L
P
R
S
R
S
Q
T
C
L
P
Site 75
S851
D
C
L
P
R
S
R
S
Q
T
C
L
P
E
L
Site 76
T853
L
P
R
S
R
S
Q
T
C
L
P
E
L
L
R
Site 77
T893
R
L
N
G
V
R
F
T
S
C
K
S
A
K
D
Site 78
S894
L
N
G
V
R
F
T
S
C
K
S
A
K
D
R
Site 79
S897
V
R
F
T
S
C
K
S
A
K
D
R
T
A
M
Site 80
S905
A
K
D
R
T
A
M
S
V
T
L
E
Q
C
L
Site 81
S934
Q
A
L
E
C
M
R
S
E
G
C
R
R
E
N
Site 82
T942
E
G
C
R
R
E
N
T
M
K
N
V
G
S
R
Site 83
Y951
K
N
V
G
S
R
K
Y
A
F
N
S
L
Q
L
Site 84
S955
S
R
K
Y
A
F
N
S
L
Q
L
K
A
F
P
Site 85
Y965
L
K
A
F
P
K
H
Y
R
P
P
E
G
T
Y
Site 86
T971
H
Y
R
P
P
E
G
T
Y
G
K
V
E
T
_
Site 87
Y972
Y
R
P
P
E
G
T
Y
G
K
V
E
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation