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Updated November 2019
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Protein Info
Short Name:
ARHGEF17
Full Name:
Rho guanine nucleotide exchange factor 17
Alias:
164 kDa Rho-specific guanine-nucleotide exchange factor; ARHGH; KIAA0337; P164RhoGEF; P164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; TEM4; Tumor endothelial marker 4
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
221673
Number AA:
2063
UniProt ID:
Q96PE2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
G
A
P
R
P
Q
L
Y
R
S
V
S
F
K
L
Site 2
S13
P
R
P
Q
L
Y
R
S
V
S
F
K
L
L
E
Site 3
S15
P
Q
L
Y
R
S
V
S
F
K
L
L
E
R
W
Site 4
S23
F
K
L
L
E
R
W
S
G
G
P
G
L
R
E
Site 5
T33
P
G
L
R
E
E
D
T
D
T
P
G
L
R
R
Site 6
T35
L
R
E
E
D
T
D
T
P
G
L
R
R
R
A
Site 7
S43
P
G
L
R
R
R
A
S
C
R
P
T
T
A
A
Site 8
T47
R
R
A
S
C
R
P
T
T
A
A
R
G
Q
P
Site 9
T48
R
A
S
C
R
P
T
T
A
A
R
G
Q
P
S
Site 10
S55
T
A
A
R
G
Q
P
S
R
R
V
S
K
L
A
Site 11
S59
G
Q
P
S
R
R
V
S
K
L
A
S
G
P
L
Site 12
S63
R
R
V
S
K
L
A
S
G
P
L
A
A
P
A
Site 13
S77
A
Q
P
R
P
L
R
S
L
S
P
S
V
R
Q
Site 14
S79
P
R
P
L
R
S
L
S
P
S
V
R
Q
L
S
Site 15
S81
P
L
R
S
L
S
P
S
V
R
Q
L
S
R
R
Site 16
S86
S
P
S
V
R
Q
L
S
R
R
F
D
A
P
R
Site 17
S98
A
P
R
L
D
D
G
S
A
G
T
R
D
G
G
Site 18
S125
P
A
R
G
A
W
P
S
V
T
E
M
R
K
L
Site 19
T127
R
G
A
W
P
S
V
T
E
M
R
K
L
F
G
Site 20
S138
K
L
F
G
G
P
G
S
R
R
P
S
A
D
S
Site 21
S142
G
P
G
S
R
R
P
S
A
D
S
E
S
P
G
Site 22
S145
S
R
R
P
S
A
D
S
E
S
P
G
T
P
S
Site 23
S147
R
P
S
A
D
S
E
S
P
G
T
P
S
P
D
Site 24
T150
A
D
S
E
S
P
G
T
P
S
P
D
G
A
A
Site 25
S152
S
E
S
P
G
T
P
S
P
D
G
A
A
W
E
Site 26
S165
W
E
P
P
A
R
E
S
R
Q
P
P
T
P
P
Site 27
T170
R
E
S
R
Q
P
P
T
P
P
P
R
T
C
F
Site 28
T175
P
P
T
P
P
P
R
T
C
F
P
L
A
G
L
Site 29
T189
L
R
S
A
R
P
L
T
G
P
E
T
E
G
R
Site 30
T193
R
P
L
T
G
P
E
T
E
G
R
L
R
R
P
Site 31
S216
R
P
A
D
G
L
H
S
W
H
I
F
S
Q
P
Site 32
S221
L
H
S
W
H
I
F
S
Q
P
Q
A
G
A
R
Site 33
S230
P
Q
A
G
A
R
A
S
C
S
S
S
S
I
A
Site 34
S233
G
A
R
A
S
C
S
S
S
S
I
A
A
S
Y
Site 35
S234
A
R
A
S
C
S
S
S
S
I
A
A
S
Y
P
Site 36
S235
R
A
S
C
S
S
S
S
I
A
A
S
Y
P
V
Site 37
S239
S
S
S
S
I
A
A
S
Y
P
V
S
R
S
R
Site 38
Y240
S
S
S
I
A
A
S
Y
P
V
S
R
S
R
A
Site 39
S243
I
A
A
S
Y
P
V
S
R
S
R
A
A
S
S
Site 40
S245
A
S
Y
P
V
S
R
S
R
A
A
S
S
S
E
Site 41
S249
V
S
R
S
R
A
A
S
S
S
E
E
E
E
E
Site 42
S250
S
R
S
R
A
A
S
S
S
E
E
E
E
E
G
Site 43
S251
R
S
R
A
A
S
S
S
E
E
E
E
E
G
P
Site 44
S266
P
Q
L
P
G
A
Q
S
P
A
Y
H
G
G
H
Site 45
Y269
P
G
A
Q
S
P
A
Y
H
G
G
H
S
S
G
Site 46
S275
A
Y
H
G
G
H
S
S
G
S
D
D
D
R
D
Site 47
S277
H
G
G
H
S
S
G
S
D
D
D
R
D
G
E
Site 48
S299
R
P
G
L
R
P
G
S
S
L
L
D
Q
D
C
Site 49
S300
P
G
L
R
P
G
S
S
L
L
D
Q
D
C
R
Site 50
S310
D
Q
D
C
R
P
D
S
D
G
L
N
L
S
S
Site 51
S316
D
S
D
G
L
N
L
S
S
M
N
S
A
G
V
Site 52
S317
S
D
G
L
N
L
S
S
M
N
S
A
G
V
S
Site 53
S320
L
N
L
S
S
M
N
S
A
G
V
S
G
S
P
Site 54
S324
S
M
N
S
A
G
V
S
G
S
P
E
P
P
T
Site 55
S326
N
S
A
G
V
S
G
S
P
E
P
P
T
S
P
Site 56
T331
S
G
S
P
E
P
P
T
S
P
R
A
P
R
E
Site 57
S332
G
S
P
E
P
P
T
S
P
R
A
P
R
E
E
Site 58
S346
E
G
L
R
E
W
G
S
G
S
P
P
C
V
P
Site 59
S348
L
R
E
W
G
S
G
S
P
P
C
V
P
G
P
Site 60
S363
Q
E
G
L
R
P
M
S
D
S
V
G
G
A
F
Site 61
S365
G
L
R
P
M
S
D
S
V
G
G
A
F
R
V
Site 62
S383
S
F
P
S
Y
L
A
S
P
A
G
S
R
G
S
Site 63
S387
Y
L
A
S
P
A
G
S
R
G
S
S
R
Y
S
Site 64
S390
S
P
A
G
S
R
G
S
S
R
Y
S
S
T
E
Site 65
S391
P
A
G
S
R
G
S
S
R
Y
S
S
T
E
T
Site 66
Y393
G
S
R
G
S
S
R
Y
S
S
T
E
T
L
K
Site 67
S394
S
R
G
S
S
R
Y
S
S
T
E
T
L
K
D
Site 68
S395
R
G
S
S
R
Y
S
S
T
E
T
L
K
D
D
Site 69
T396
G
S
S
R
Y
S
S
T
E
T
L
K
D
D
D
Site 70
T398
S
R
Y
S
S
T
E
T
L
K
D
D
D
L
W
Site 71
S406
L
K
D
D
D
L
W
S
S
R
G
S
G
G
W
Site 72
S407
K
D
D
D
L
W
S
S
R
G
S
G
G
W
G
Site 73
S410
D
L
W
S
S
R
G
S
G
G
W
G
V
Y
R
Site 74
Y416
G
S
G
G
W
G
V
Y
R
S
P
S
F
G
A
Site 75
S418
G
G
W
G
V
Y
R
S
P
S
F
G
A
G
E
Site 76
S420
W
G
V
Y
R
S
P
S
F
G
A
G
E
G
L
Site 77
S430
A
G
E
G
L
L
R
S
Q
A
R
T
R
A
K
Site 78
T434
L
L
R
S
Q
A
R
T
R
A
K
G
P
G
G
Site 79
S456
G
G
F
E
P
E
K
S
R
Q
R
K
S
L
S
Site 80
S461
E
K
S
R
Q
R
K
S
L
S
N
P
D
I
A
Site 81
S463
S
R
Q
R
K
S
L
S
N
P
D
I
A
S
E
Site 82
S476
S
E
T
L
T
L
L
S
F
L
R
S
D
L
S
Site 83
S483
S
F
L
R
S
D
L
S
E
L
R
V
R
K
P
Site 84
S493
R
V
R
K
P
G
G
S
S
G
D
R
G
S
N
Site 85
S494
V
R
K
P
G
G
S
S
G
D
R
G
S
N
P
Site 86
S499
G
S
S
G
D
R
G
S
N
P
L
D
G
R
D
Site 87
S507
N
P
L
D
G
R
D
S
P
S
A
G
G
P
V
Site 88
S509
L
D
G
R
D
S
P
S
A
G
G
P
V
G
Q
Site 89
S527
I
P
I
P
A
P
A
S
P
G
T
R
P
T
L
Site 90
T533
A
S
P
G
T
R
P
T
L
K
D
L
T
A
T
Site 91
T538
R
P
T
L
K
D
L
T
A
T
L
R
R
A
K
Site 92
T540
T
L
K
D
L
T
A
T
L
R
R
A
K
S
F
Site 93
S546
A
T
L
R
R
A
K
S
F
T
C
S
E
K
P
Site 94
T548
L
R
R
A
K
S
F
T
C
S
E
K
P
M
A
Site 95
S550
R
A
K
S
F
T
C
S
E
K
P
M
A
R
R
Site 96
T561
M
A
R
R
L
P
R
T
S
A
L
K
S
S
S
Site 97
S562
A
R
R
L
P
R
T
S
A
L
K
S
S
S
S
Site 98
S566
P
R
T
S
A
L
K
S
S
S
S
E
L
L
L
Site 99
S567
R
T
S
A
L
K
S
S
S
S
E
L
L
L
T
Site 100
S568
T
S
A
L
K
S
S
S
S
E
L
L
L
T
G
Site 101
S569
S
A
L
K
S
S
S
S
E
L
L
L
T
G
P
Site 102
T574
S
S
S
E
L
L
L
T
G
P
G
A
E
E
D
Site 103
Y591
P
L
I
V
Q
D
Q
Y
V
Q
E
A
R
Q
V
Site 104
S613
G
A
Q
Q
D
D
G
S
D
A
P
P
G
S
P
Site 105
S619
G
S
D
A
P
P
G
S
P
D
W
A
G
D
V
Site 106
T627
P
D
W
A
G
D
V
T
R
G
Q
R
S
Q
E
Site 107
S632
D
V
T
R
G
Q
R
S
Q
E
E
L
S
G
P
Site 108
S637
Q
R
S
Q
E
E
L
S
G
P
E
S
S
L
T
Site 109
S641
E
E
L
S
G
P
E
S
S
L
T
D
E
G
I
Site 110
S642
E
L
S
G
P
E
S
S
L
T
D
E
G
I
G
Site 111
T644
S
G
P
E
S
S
L
T
D
E
G
I
G
A
D
Site 112
S672
T
G
M
W
R
P
L
S
S
S
S
A
Q
T
N
Site 113
S673
G
M
W
R
P
L
S
S
S
S
A
Q
T
N
H
Site 114
S674
M
W
R
P
L
S
S
S
S
A
Q
T
N
H
H
Site 115
S675
W
R
P
L
S
S
S
S
A
Q
T
N
H
H
G
Site 116
T678
L
S
S
S
S
A
Q
T
N
H
H
G
P
G
T
Site 117
T685
T
N
H
H
G
P
G
T
E
D
S
L
G
G
W
Site 118
S688
H
G
P
G
T
E
D
S
L
G
G
W
A
L
V
Site 119
S696
L
G
G
W
A
L
V
S
P
E
T
P
P
T
P
Site 120
T699
W
A
L
V
S
P
E
T
P
P
T
P
G
A
L
Site 121
T702
V
S
P
E
T
P
P
T
P
G
A
L
R
R
R
Site 122
S715
R
R
R
K
V
P
P
S
G
S
G
G
S
E
L
Site 123
S717
R
K
V
P
P
S
G
S
G
G
S
E
L
S
N
Site 124
S723
G
S
G
G
S
E
L
S
N
G
E
A
G
E
A
Site 125
Y731
N
G
E
A
G
E
A
Y
R
S
L
S
D
P
I
Site 126
S733
E
A
G
E
A
Y
R
S
L
S
D
P
I
P
Q
Site 127
S735
G
E
A
Y
R
S
L
S
D
P
I
P
Q
R
H
Site 128
T746
P
Q
R
H
R
A
A
T
S
E
E
P
T
G
F
Site 129
S747
Q
R
H
R
A
A
T
S
E
E
P
T
G
F
S
Site 130
T751
A
A
T
S
E
E
P
T
G
F
S
V
D
S
N
Site 131
S754
S
E
E
P
T
G
F
S
V
D
S
N
L
L
G
Site 132
S764
S
N
L
L
G
S
L
S
P
K
T
G
L
P
A
Site 133
S781
A
M
D
E
G
L
T
S
G
H
S
D
W
S
V
Site 134
S784
E
G
L
T
S
G
H
S
D
W
S
V
G
S
E
Site 135
S787
T
S
G
H
S
D
W
S
V
G
S
E
E
S
K
Site 136
S790
H
S
D
W
S
V
G
S
E
E
S
K
G
Y
Q
Site 137
Y796
G
S
E
E
S
K
G
Y
Q
E
V
I
Q
S
I
Site 138
S802
G
Y
Q
E
V
I
Q
S
I
V
Q
G
P
G
T
Site 139
S827
G
K
A
P
K
K
K
S
L
S
D
P
S
R
R
Site 140
S829
A
P
K
K
K
S
L
S
D
P
S
R
R
G
E
Site 141
S832
K
K
S
L
S
D
P
S
R
R
G
E
L
A
G
Site 142
S861
E
P
M
L
P
P
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V
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Site 143
S862
P
M
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Q
Site 144
T879
E
P
E
E
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G
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Site 145
S885
A
T
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R
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A
Site 146
T898
E
A
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P
P
A
T
A
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R
N
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Site 147
S914
P
K
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Site 148
S922
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K
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R
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Site 149
S929
S
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K
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E
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R
Site 150
S930
K
K
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E
L
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R
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Site 151
S940
E
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Site 152
T944
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R
Site 153
S946
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Site 154
S948
Q
D
Q
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R
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S
R
Site 155
S953
S
L
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H
A
Site 156
S954
L
S
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R
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S
R
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A
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Site 157
S961
S
R
H
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H
A
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V
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A
T
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M
P
Site 158
T965
R
H
A
S
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A
T
F
M
P
I
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V
P
Site 159
S1002
H
P
T
L
Q
A
P
S
L
E
D
V
T
K
Q
Site 160
T1007
A
P
S
L
E
D
V
T
K
Q
Y
M
L
N
L
Site 161
S1037
L
P
L
A
A
P
P
S
A
E
A
K
P
P
E
Site 162
T1053
A
R
P
A
D
E
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T
P
A
S
K
C
C
S
Site 163
S1056
A
D
E
P
T
P
A
S
K
C
C
S
K
P
Q
Site 164
S1060
T
P
A
S
K
C
C
S
K
P
Q
V
D
M
R
Site 165
S1080
T
L
L
D
T
E
Q
S
Y
V
E
S
L
R
T
Site 166
Y1081
L
L
D
T
E
Q
S
Y
V
E
S
L
R
T
L
Site 167
S1084
T
E
Q
S
Y
V
E
S
L
R
T
L
M
Q
G
Site 168
T1087
S
Y
V
E
S
L
R
T
L
M
Q
G
Y
M
Q
Site 169
Y1092
L
R
T
L
M
Q
G
Y
M
Q
P
L
K
Q
P
Site 170
S1102
P
L
K
Q
P
E
N
S
V
L
C
D
P
S
L
Site 171
S1192
F
L
K
F
L
E
Q
S
M
R
E
N
K
E
K
Site 172
S1203
N
K
E
K
Q
A
L
S
D
L
M
I
K
P
V
Site 173
Y1216
P
V
Q
R
I
P
R
Y
E
L
L
V
K
D
L
Site 174
T1227
V
K
D
L
L
K
H
T
P
E
D
H
P
D
H
Site 175
S1257
R
I
N
K
G
V
R
S
A
E
E
A
E
R
H
Site 176
S1307
I
G
G
K
K
D
R
S
L
F
L
F
T
D
L
Site 177
T1319
T
D
L
I
V
C
T
T
L
K
R
K
S
G
S
Site 178
S1324
C
T
T
L
K
R
K
S
G
S
L
R
R
S
S
Site 179
S1326
T
L
K
R
K
S
G
S
L
R
R
S
S
M
S
Site 180
S1330
K
S
G
S
L
R
R
S
S
M
S
L
Y
T
A
Site 181
S1331
S
G
S
L
R
R
S
S
M
S
L
Y
T
A
A
Site 182
S1333
S
L
R
R
S
S
M
S
L
Y
T
A
A
S
V
Site 183
Y1335
R
R
S
S
M
S
L
Y
T
A
A
S
V
I
D
Site 184
T1336
R
S
S
M
S
L
Y
T
A
A
S
V
I
D
T
Site 185
S1345
A
S
V
I
D
T
A
S
K
Y
K
M
L
W
K
Site 186
T1385
S
R
L
D
E
D
L
T
T
L
G
Q
M
S
K
Site 187
T1386
R
L
D
E
D
L
T
T
L
G
Q
M
S
K
L
Site 188
S1391
L
T
T
L
G
Q
M
S
K
L
S
E
S
L
G
Site 189
S1394
L
G
Q
M
S
K
L
S
E
S
L
G
F
P
H
Site 190
S1403
S
L
G
F
P
H
Q
S
L
D
D
A
L
R
D
Site 191
S1412
D
D
A
L
R
D
L
S
A
A
M
H
R
D
L
Site 192
S1420
A
A
M
H
R
D
L
S
E
K
Q
A
L
C
Y
Site 193
Y1427
S
E
K
Q
A
L
C
Y
A
L
S
F
P
P
T
Site 194
S1430
Q
A
L
C
Y
A
L
S
F
P
P
T
K
L
E
Site 195
T1441
T
K
L
E
L
C
A
T
R
P
E
G
T
D
S
Site 196
S1448
T
R
P
E
G
T
D
S
Y
I
F
E
F
P
H
Site 197
Y1449
R
P
E
G
T
D
S
Y
I
F
E
F
P
H
P
Site 198
S1476
A
K
R
K
L
A
S
S
K
S
C
L
D
P
E
Site 199
S1478
R
K
L
A
S
S
K
S
C
L
D
P
E
F
L
Site 200
S1500
T
R
S
G
M
Q
F
S
C
A
A
P
T
L
N
Site 201
T1505
Q
F
S
C
A
A
P
T
L
N
S
C
P
E
P
Site 202
S1513
L
N
S
C
P
E
P
S
P
E
V
W
V
C
N
Site 203
S1570
C
H
R
E
P
P
P
S
L
R
S
P
P
E
T
Site 204
S1573
E
P
P
P
S
L
R
S
P
P
E
T
A
P
E
Site 205
T1577
S
L
R
S
P
P
E
T
A
P
E
P
A
G
P
Site 206
T1598
A
A
D
E
E
A
A
T
L
A
E
P
G
P
Q
Site 207
T1620
A
G
S
G
L
E
M
T
P
G
L
G
E
G
D
Site 208
S1637
P
E
L
V
P
F
D
S
D
S
D
D
E
S
S
Site 209
S1639
L
V
P
F
D
S
D
S
D
D
E
S
S
P
S
Site 210
S1643
D
S
D
S
D
D
E
S
S
P
S
P
S
G
T
Site 211
S1644
S
D
S
D
D
E
S
S
P
S
P
S
G
T
L
Site 212
S1646
S
D
D
E
S
S
P
S
P
S
G
T
L
Q
S
Site 213
S1648
D
E
S
S
P
S
P
S
G
T
L
Q
S
Q
A
Site 214
T1650
S
S
P
S
P
S
G
T
L
Q
S
Q
A
S
R
Site 215
S1653
S
P
S
G
T
L
Q
S
Q
A
S
R
S
T
I
Site 216
S1656
G
T
L
Q
S
Q
A
S
R
S
T
I
S
S
S
Site 217
S1658
L
Q
S
Q
A
S
R
S
T
I
S
S
S
F
G
Site 218
T1659
Q
S
Q
A
S
R
S
T
I
S
S
S
F
G
N
Site 219
S1662
A
S
R
S
T
I
S
S
S
F
G
N
E
E
T
Site 220
S1663
S
R
S
T
I
S
S
S
F
G
N
E
E
T
P
Site 221
T1669
S
S
F
G
N
E
E
T
P
S
S
K
E
A
T
Site 222
S1671
F
G
N
E
E
T
P
S
S
K
E
A
T
A
E
Site 223
S1672
G
N
E
E
T
P
S
S
K
E
A
T
A
E
T
Site 224
T1676
T
P
S
S
K
E
A
T
A
E
T
T
S
S
E
Site 225
S1682
A
T
A
E
T
T
S
S
E
E
E
Q
E
P
G
Site 226
S1694
E
P
G
F
L
P
L
S
G
S
F
G
P
G
G
Site 227
S1706
P
G
G
P
C
G
T
S
P
M
D
G
R
A
L
Site 228
S1716
D
G
R
A
L
R
R
S
S
H
G
S
F
T
R
Site 229
S1717
G
R
A
L
R
R
S
S
H
G
S
F
T
R
G
Site 230
S1720
L
R
R
S
S
H
G
S
F
T
R
G
S
L
E
Site 231
S1725
H
G
S
F
T
R
G
S
L
E
D
L
L
S
V
Site 232
S1731
G
S
L
E
D
L
L
S
V
D
P
E
A
Y
Q
Site 233
Y1737
L
S
V
D
P
E
A
Y
Q
S
S
V
W
L
G
Site 234
S1739
V
D
P
E
A
Y
Q
S
S
V
W
L
G
T
E
Site 235
S1740
D
P
E
A
Y
Q
S
S
V
W
L
G
T
E
D
Site 236
Y1753
E
D
G
C
V
H
V
Y
Q
S
S
D
S
I
R
Site 237
S1758
H
V
Y
Q
S
S
D
S
I
R
D
R
R
N
S
Site 238
S1765
S
I
R
D
R
R
N
S
M
K
L
Q
H
A
A
Site 239
Y1796
A
N
G
E
L
V
V
Y
Q
R
E
A
G
H
F
Site 240
S1811
W
D
P
Q
N
F
K
S
V
T
L
G
T
Q
G
Site 241
T1813
P
Q
N
F
K
S
V
T
L
G
T
Q
G
S
P
Site 242
T1822
G
T
Q
G
S
P
I
T
K
M
V
S
V
G
G
Site 243
S1843
Q
N
R
V
L
V
L
S
P
D
T
L
Q
L
E
Site 244
Y1854
L
Q
L
E
H
M
F
Y
V
G
Q
D
S
S
R
Site 245
Y1886
G
S
A
H
V
C
L
Y
H
P
D
T
F
E
Q
Site 246
S1910
V
H
R
M
L
A
G
S
D
A
I
I
R
Q
H
Site 247
T1952
T
M
P
T
S
P
G
T
V
S
C
P
R
A
P
Site 248
S1954
P
T
S
P
G
T
V
S
C
P
R
A
P
L
S
Site 249
S1961
S
C
P
R
A
P
L
S
P
T
G
L
G
Q
G
Site 250
T1991
G
F
N
L
L
C
P
T
P
P
P
P
P
D
T
Site 251
T1998
T
P
P
P
P
P
D
T
G
P
E
K
L
P
S
Site 252
S2005
T
G
P
E
K
L
P
S
L
E
H
R
D
S
P
Site 253
S2011
P
S
L
E
H
R
D
S
P
W
H
R
G
P
A
Site 254
Y2033
V
I
S
G
G
D
G
Y
E
D
F
R
L
S
S
Site 255
S2039
G
Y
E
D
F
R
L
S
S
G
G
G
S
S
S
Site 256
S2040
Y
E
D
F
R
L
S
S
G
G
G
S
S
S
E
Site 257
S2044
R
L
S
S
G
G
G
S
S
S
E
T
V
G
R
Site 258
S2046
S
S
G
G
G
S
S
S
E
T
V
G
R
D
D
Site 259
T2048
G
G
G
S
S
S
E
T
V
G
R
D
D
S
T
Site 260
S2054
E
T
V
G
R
D
D
S
T
N
H
L
L
L
W
Site 261
T2055
T
V
G
R
D
D
S
T
N
H
L
L
L
W
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation