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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLIC6
Full Name:
Chloride intracellular channel protein 6
Alias:
Chloride channel A
Type:
Channel, chloride
Mass (Da):
73012
Number AA:
704
UniProt ID:
Q96NY7
International Prot ID:
IPI00165936
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0031404
GO:0005247
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T76
P
E
A
E
A
R
G
T
R
G
A
H
G
E
T
Site 2
S112
A
Q
Q
V
E
G
A
S
P
G
R
G
A
Q
G
Site 3
S132
A
Q
R
E
P
E
D
S
A
A
P
E
R
Q
E
Site 4
S151
R
P
E
V
P
E
G
S
A
S
G
E
A
G
D
Site 5
S153
E
V
P
E
G
S
A
S
G
E
A
G
D
S
V
Site 6
S159
A
S
G
E
A
G
D
S
V
D
A
E
G
P
L
Site 7
S179
A
E
G
P
A
G
D
S
V
E
A
E
G
R
V
Site 8
S189
A
E
G
R
V
G
D
S
V
D
A
E
G
P
A
Site 9
S199
A
E
G
P
A
G
D
S
V
D
A
E
G
P
L
Site 10
S219
A
E
G
P
A
G
D
S
V
D
A
E
G
R
V
Site 11
S249
A
E
G
R
V
G
D
S
V
E
A
G
D
P
A
Site 12
S269
A
G
V
P
A
G
D
S
V
E
A
E
G
P
A
Site 13
S279
A
E
G
P
A
G
D
S
M
D
A
E
G
P
A
Site 14
S293
A
G
R
A
R
R
V
S
G
E
P
Q
Q
S
G
Site 15
S299
V
S
G
E
P
Q
Q
S
G
D
G
S
L
S
P
Site 16
S303
P
Q
Q
S
G
D
G
S
L
S
P
Q
A
E
A
Site 17
S305
Q
S
G
D
G
S
L
S
P
Q
A
E
A
I
E
Site 18
S318
I
E
V
A
A
G
E
S
A
G
R
S
P
G
E
Site 19
S322
A
G
E
S
A
G
R
S
P
G
E
L
A
W
D
Site 20
S342
E
V
P
G
V
K
G
S
E
E
A
A
P
G
D
Site 21
S377
D
E
E
R
R
E
R
S
P
E
G
P
R
E
E
Site 22
S393
A
A
G
G
E
E
E
S
P
D
S
S
P
H
G
Site 23
S396
G
E
E
E
S
P
D
S
S
P
H
G
E
A
S
Site 24
S397
E
E
E
S
P
D
S
S
P
H
G
E
A
S
R
Site 25
S414
A
E
P
E
A
Q
L
S
N
H
L
A
E
E
G
Site 26
S442
R
R
E
D
G
E
A
S
E
P
R
A
L
G
Q
Site 27
Y474
S
R
I
A
I
K
K
Y
L
R
A
G
Y
D
G
Site 28
Y479
K
K
Y
L
R
A
G
Y
D
G
E
S
I
G
N
Site 29
S483
R
A
G
Y
D
G
E
S
I
G
N
C
P
F
S
Site 30
T525
L
Q
N
L
A
P
G
T
N
P
P
F
M
T
F
Site 31
T531
G
T
N
P
P
F
M
T
F
D
G
E
V
K
T
Site 32
Y556
E
K
L
A
P
P
R
Y
P
K
L
G
T
Q
H
Site 33
T561
P
R
Y
P
K
L
G
T
Q
H
P
E
S
N
S
Site 34
S566
L
G
T
Q
H
P
E
S
N
S
A
G
N
D
V
Site 35
Y606
A
L
R
K
L
D
N
Y
L
N
S
P
L
P
D
Site 36
S609
K
L
D
N
Y
L
N
S
P
L
P
D
E
I
D
Site 37
Y618
L
P
D
E
I
D
A
Y
S
T
E
D
V
T
V
Site 38
S619
P
D
E
I
D
A
Y
S
T
E
D
V
T
V
S
Site 39
T624
A
Y
S
T
E
D
V
T
V
S
G
R
K
F
L
Site 40
S626
S
T
E
D
V
T
V
S
G
R
K
F
L
D
G
Site 41
Y672
E
M
T
G
I
W
R
Y
L
N
N
A
Y
A
R
Site 42
Y677
W
R
Y
L
N
N
A
Y
A
R
D
E
F
T
N
Site 43
T685
A
R
D
E
F
T
N
T
C
P
A
D
Q
E
I
Site 44
S697
Q
E
I
E
H
A
Y
S
D
V
A
K
R
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation