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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AIFM3
Full Name:
Apoptosis-inducing factor 3
Alias:
Apoptosis-inducing factor-like protein
Type:
Mass (Da):
66791
Number AA:
605
UniProt ID:
Q96NN9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
E
R
G
K
E
E
L
S
A
S
G
K
G
S
P
Site 2
S32
G
K
E
E
L
S
A
S
G
K
G
S
P
R
A
Site 3
S36
L
S
A
S
G
K
G
S
P
R
A
Y
Q
G
N
Site 4
Y40
G
K
G
S
P
R
A
Y
Q
G
N
G
T
A
R
Site 5
T45
R
A
Y
Q
G
N
G
T
A
R
H
F
H
T
E
Site 6
T51
G
T
A
R
H
F
H
T
E
E
R
L
S
T
P
Site 7
S56
F
H
T
E
E
R
L
S
T
P
H
P
Y
P
S
Site 8
T57
H
T
E
E
R
L
S
T
P
H
P
Y
P
S
P
Site 9
Y61
R
L
S
T
P
H
P
Y
P
S
P
Q
D
C
V
Site 10
S63
S
T
P
H
P
Y
P
S
P
Q
D
C
V
E
A
Site 11
Y112
L
G
H
K
C
P
H
Y
G
A
P
L
V
K
G
Site 12
S150
E
D
F
P
G
L
D
S
L
H
K
F
Q
V
K
Site 13
Y164
K
I
E
K
E
K
V
Y
V
R
A
S
K
Q
A
Site 14
S168
E
K
V
Y
V
R
A
S
K
Q
A
L
Q
L
Q
Site 15
T178
A
L
Q
L
Q
R
R
T
K
V
M
A
K
C
I
Site 16
S186
K
V
M
A
K
C
I
S
P
S
A
G
Y
S
S
Site 17
S188
M
A
K
C
I
S
P
S
A
G
Y
S
S
S
T
Site 18
S219
T
L
R
Q
E
G
F
S
D
R
I
V
L
C
T
Site 19
T226
S
D
R
I
V
L
C
T
L
D
R
H
L
P
Y
Site 20
Y233
T
L
D
R
H
L
P
Y
D
R
P
K
L
S
K
Site 21
S239
P
Y
D
R
P
K
L
S
K
S
L
D
T
Q
P
Site 22
S241
D
R
P
K
L
S
K
S
L
D
T
Q
P
E
Q
Site 23
Y260
P
K
E
F
F
R
A
Y
G
I
E
V
L
T
E
Site 24
T272
L
T
E
A
Q
V
V
T
V
D
V
R
T
K
K
Site 25
S291
D
G
F
K
L
E
Y
S
K
L
L
L
A
P
G
Site 26
S300
L
L
L
A
P
G
S
S
P
K
T
L
S
C
K
Site 27
T303
A
P
G
S
S
P
K
T
L
S
C
K
G
K
E
Site 28
S305
G
S
S
P
K
T
L
S
C
K
G
K
E
V
E
Site 29
T316
K
E
V
E
N
V
F
T
I
R
T
P
E
D
A
Site 30
T319
E
N
V
F
T
I
R
T
P
E
D
A
N
R
V
Site 31
S357
Y
L
T
E
K
A
H
S
V
S
V
V
E
L
E
Site 32
S359
T
E
K
A
H
S
V
S
V
V
E
L
E
E
T
Site 33
T366
S
V
V
E
L
E
E
T
P
F
R
R
F
L
G
Site 34
T395
R
V
K
F
Y
M
Q
T
E
V
S
E
L
R
G
Site 35
S398
F
Y
M
Q
T
E
V
S
E
L
R
G
Q
E
G
Site 36
S414
L
K
E
V
V
L
K
S
S
K
V
V
R
A
D
Site 37
S415
K
E
V
V
L
K
S
S
K
V
V
R
A
D
V
Site 38
S439
A
T
G
F
L
R
Q
S
G
I
G
L
D
S
R
Site 39
S445
Q
S
G
I
G
L
D
S
R
G
F
I
P
V
N
Site 40
S508
L
A
Q
E
A
E
M
S
T
V
P
Y
L
W
T
Site 41
Y524
M
F
G
K
S
L
R
Y
A
G
Y
G
E
G
F
Site 42
Y527
K
S
L
R
Y
A
G
Y
G
E
G
F
D
D
V
Site 43
S576
K
V
A
E
V
L
A
S
G
R
A
I
R
K
R
Site 44
S598
H
S
K
T
G
D
M
S
W
L
T
G
K
G
S
Site 45
S605
S
W
L
T
G
K
G
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation