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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD6
Full Name:
FERM domain-containing protein 6
Alias:
4.1 ezrin radixin moesin (FERM)-containing protein; C14orf31; FERM domain containing 6; MGC17921; Willin
Type:
Lipid binding protein
Mass (Da):
72044
Number AA:
622
UniProt ID:
Q96NE9
International Prot ID:
IPI00043622
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005739
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y69
I
Q
N
N
E
H
V
Y
M
E
L
S
Q
K
L
Site 2
Y77
M
E
L
S
Q
K
L
Y
K
Y
C
P
K
E
W
Site 3
Y79
L
S
Q
K
L
Y
K
Y
C
P
K
E
W
K
K
Site 4
S89
K
E
W
K
K
E
A
S
K
V
R
Q
Y
E
V
Site 5
Y94
E
A
S
K
V
R
Q
Y
E
V
T
W
G
I
D
Site 6
Y115
I
I
H
F
R
V
Q
Y
Y
V
E
N
G
R
L
Site 7
Y116
I
H
F
R
V
Q
Y
Y
V
E
N
G
R
L
I
Site 8
S124
V
E
N
G
R
L
I
S
D
R
A
A
R
Y
Y
Site 9
Y130
I
S
D
R
A
A
R
Y
Y
Y
Y
W
H
L
R
Site 10
Y131
S
D
R
A
A
R
Y
Y
Y
Y
W
H
L
R
K
Site 11
Y132
D
R
A
A
R
Y
Y
Y
Y
W
H
L
R
K
Q
Site 12
Y133
R
A
A
R
Y
Y
Y
Y
W
H
L
R
K
Q
V
Site 13
S143
L
R
K
Q
V
L
H
S
Q
C
V
L
R
E
E
Site 14
Y176
R
N
K
H
Y
G
K
Y
F
E
P
E
A
Y
F
Site 15
Y182
K
Y
F
E
P
E
A
Y
F
P
S
W
V
V
S
Site 16
S185
E
P
E
A
Y
F
P
S
W
V
V
S
K
R
G
Site 17
Y195
V
S
K
R
G
K
D
Y
I
L
K
H
I
P
N
Site 18
S213
D
Q
F
A
L
T
A
S
E
A
H
L
K
Y
I
Site 19
Y233
L
D
D
V
A
V
H
Y
Y
R
L
Y
K
D
K
Site 20
Y237
A
V
H
Y
Y
R
L
Y
K
D
K
R
E
I
E
Site 21
S246
D
K
R
E
I
E
A
S
L
T
L
G
L
T
M
Site 22
T248
R
E
I
E
A
S
L
T
L
G
L
T
M
R
G
Site 23
Y270
D
E
E
K
Q
L
L
Y
D
F
P
W
T
N
V
Site 24
Y302
P
S
A
R
K
L
I
Y
Y
T
G
C
P
M
R
Site 25
Y303
S
A
R
K
L
I
Y
Y
T
G
C
P
M
R
S
Site 26
T304
A
R
K
L
I
Y
Y
T
G
C
P
M
R
S
R
Site 27
S318
R
H
L
L
Q
L
L
S
N
S
H
R
L
Y
M
Site 28
Y324
L
S
N
S
H
R
L
Y
M
N
L
Q
P
V
L
Site 29
Y346
E
N
E
E
K
K
Q
Y
R
E
S
Y
I
S
D
Site 30
S349
E
K
K
Q
Y
R
E
S
Y
I
S
D
N
L
D
Site 31
Y350
K
K
Q
Y
R
E
S
Y
I
S
D
N
L
D
L
Site 32
S352
Q
Y
R
E
S
Y
I
S
D
N
L
D
L
D
M
Site 33
S366
M
D
Q
L
E
K
R
S
R
A
S
G
S
S
A
Site 34
S369
L
E
K
R
S
R
A
S
G
S
S
A
G
S
M
Site 35
S371
K
R
S
R
A
S
G
S
S
A
G
S
M
K
H
Site 36
S372
R
S
R
A
S
G
S
S
A
G
S
M
K
H
K
Site 37
S375
A
S
G
S
S
A
G
S
M
K
H
K
R
L
S
Site 38
S382
S
M
K
H
K
R
L
S
R
H
S
T
A
S
H
Site 39
S385
H
K
R
L
S
R
H
S
T
A
S
H
S
S
S
Site 40
T386
K
R
L
S
R
H
S
T
A
S
H
S
S
S
H
Site 41
S388
L
S
R
H
S
T
A
S
H
S
S
S
H
T
S
Site 42
S390
R
H
S
T
A
S
H
S
S
S
H
T
S
G
I
Site 43
S391
H
S
T
A
S
H
S
S
S
H
T
S
G
I
E
Site 44
S392
S
T
A
S
H
S
S
S
H
T
S
G
I
E
A
Site 45
S395
S
H
S
S
S
H
T
S
G
I
E
A
D
T
K
Site 46
T401
T
S
G
I
E
A
D
T
K
P
R
D
T
G
P
Site 47
T406
A
D
T
K
P
R
D
T
G
P
E
D
S
Y
S
Site 48
S411
R
D
T
G
P
E
D
S
Y
S
S
S
A
I
H
Site 49
Y412
D
T
G
P
E
D
S
Y
S
S
S
A
I
H
R
Site 50
S413
T
G
P
E
D
S
Y
S
S
S
A
I
H
R
K
Site 51
S415
P
E
D
S
Y
S
S
S
A
I
H
R
K
L
K
Site 52
T423
A
I
H
R
K
L
K
T
C
S
S
M
T
S
H
Site 53
S425
H
R
K
L
K
T
C
S
S
M
T
S
H
G
S
Site 54
S426
R
K
L
K
T
C
S
S
M
T
S
H
G
S
S
Site 55
T428
L
K
T
C
S
S
M
T
S
H
G
S
S
H
T
Site 56
S429
K
T
C
S
S
M
T
S
H
G
S
S
H
T
S
Site 57
S432
S
S
M
T
S
H
G
S
S
H
T
S
G
V
E
Site 58
S433
S
M
T
S
H
G
S
S
H
T
S
G
V
E
S
Site 59
S436
S
H
G
S
S
H
T
S
G
V
E
S
G
G
K
Site 60
S440
S
H
T
S
G
V
E
S
G
G
K
D
R
L
E
Site 61
S472
L
E
Q
M
N
E
E
S
L
E
V
S
P
D
M
Site 62
S476
N
E
E
S
L
E
V
S
P
D
M
C
I
Y
I
Site 63
S490
I
T
E
D
M
L
M
S
R
K
L
N
G
H
S
Site 64
S506
L
I
V
K
E
I
G
S
S
T
S
S
S
S
E
Site 65
S507
I
V
K
E
I
G
S
S
T
S
S
S
S
E
T
Site 66
T508
V
K
E
I
G
S
S
T
S
S
S
S
E
T
V
Site 67
S509
K
E
I
G
S
S
T
S
S
S
S
E
T
V
V
Site 68
S510
E
I
G
S
S
T
S
S
S
S
E
T
V
V
K
Site 69
S511
I
G
S
S
T
S
S
S
S
E
T
V
V
K
L
Site 70
S512
G
S
S
T
S
S
S
S
E
T
V
V
K
L
R
Site 71
T514
S
T
S
S
S
S
E
T
V
V
K
L
R
G
Q
Site 72
S522
V
V
K
L
R
G
Q
S
T
D
S
L
P
Q
T
Site 73
T523
V
K
L
R
G
Q
S
T
D
S
L
P
Q
T
I
Site 74
S525
L
R
G
Q
S
T
D
S
L
P
Q
T
I
C
R
Site 75
T529
S
T
D
S
L
P
Q
T
I
C
R
K
P
K
T
Site 76
T536
T
I
C
R
K
P
K
T
S
T
D
R
H
S
L
Site 77
S537
I
C
R
K
P
K
T
S
T
D
R
H
S
L
S
Site 78
T538
C
R
K
P
K
T
S
T
D
R
H
S
L
S
L
Site 79
S542
K
T
S
T
D
R
H
S
L
S
L
D
D
I
R
Site 80
S544
S
T
D
R
H
S
L
S
L
D
D
I
R
L
Y
Site 81
Y551
S
L
D
D
I
R
L
Y
Q
K
D
F
L
R
I
Site 82
Y569
C
Q
D
T
A
Q
S
Y
T
F
G
C
G
H
E
Site 83
T570
Q
D
T
A
Q
S
Y
T
F
G
C
G
H
E
L
Site 84
Y583
E
L
D
E
E
G
L
Y
C
N
S
C
L
A
Q
Site 85
S605
A
F
P
V
K
R
T
S
K
Y
F
S
L
D
L
Site 86
Y607
P
V
K
R
T
S
K
Y
F
S
L
D
L
T
H
Site 87
S609
K
R
T
S
K
Y
F
S
L
D
L
T
H
D
E
Site 88
T613
K
Y
F
S
L
D
L
T
H
D
E
V
P
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation