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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UROC1
Full Name:
Urocanate hydratase
Alias:
FLJ31300; HMFN0320; HUTU; Imidazolonepropionate hydrolase; Urocanase; Urocanase domain containing 1
Type:
Amino Acid Metabolism - histidine; Lyase; EC 4.2.1.49
Mass (Da):
74831
Number AA:
676
UniProt ID:
Q96N76
International Prot ID:
IPI00043499
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0016153
PhosphoSite+
KinaseNET
Biological Process:
GO:0006548
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
V
P
H
A
P
V
R
T
P
S
L
S
P
V
E
Site 2
S35
H
A
P
V
R
T
P
S
L
S
P
V
E
K
Q
Site 3
S37
P
V
R
T
P
S
L
S
P
V
E
K
Q
L
A
Site 4
Y51
A
L
R
N
A
L
R
Y
F
P
P
D
V
Q
E
Site 5
Y71
F
A
Q
E
L
Q
L
Y
G
H
I
Y
M
Y
R
Site 6
Y75
L
Q
L
Y
G
H
I
Y
M
Y
R
F
C
P
D
Site 7
Y88
P
D
I
E
M
R
A
Y
P
I
E
Q
Y
P
C
Site 8
Y93
R
A
Y
P
I
E
Q
Y
P
C
Q
T
K
V
A
Site 9
Y125
F
P
Q
E
L
V
T
Y
G
G
N
G
Q
V
F
Site 10
Y144
Q
F
W
L
T
M
F
Y
L
S
K
M
T
E
E
Site 11
T153
S
K
M
T
E
E
Q
T
L
V
M
Y
S
G
H
Site 12
S167
H
P
L
G
L
F
P
S
S
R
S
A
P
R
L
Site 13
Y185
N
G
M
V
I
P
N
Y
S
S
R
T
E
Y
E
Site 14
S186
G
M
V
I
P
N
Y
S
S
R
T
E
Y
E
K
Site 15
Y191
N
Y
S
S
R
T
E
Y
E
K
L
F
A
L
G
Site 16
Y210
G
Q
M
T
A
G
S
Y
C
Y
I
G
P
Q
G
Site 17
S311
R
K
K
K
E
V
L
S
L
G
Y
H
G
N
V
Site 18
S341
E
C
L
V
D
L
G
S
D
Q
T
S
C
H
N
Site 19
T344
V
D
L
G
S
D
Q
T
S
C
H
N
P
F
N
Site 20
S345
D
L
G
S
D
Q
T
S
C
H
N
P
F
N
G
Site 21
Y354
H
N
P
F
N
G
G
Y
Y
P
V
Q
L
S
F
Site 22
Y355
N
P
F
N
G
G
Y
Y
P
V
Q
L
S
F
T
Site 23
S360
G
Y
Y
P
V
Q
L
S
F
T
E
A
Q
S
L
Site 24
S366
L
S
F
T
E
A
Q
S
L
M
A
S
N
P
A
Site 25
S370
E
A
Q
S
L
M
A
S
N
P
A
V
F
K
D
Site 26
S382
F
K
D
L
V
Q
E
S
L
R
R
Q
V
S
A
Site 27
S388
E
S
L
R
R
Q
V
S
A
I
N
R
L
A
E
Site 28
Y403
E
K
F
F
F
W
D
Y
G
N
A
F
L
L
E
Site 29
T426
E
K
K
G
A
G
R
T
E
F
R
Y
P
S
Y
Site 30
Y430
A
G
R
T
E
F
R
Y
P
S
Y
V
Q
H
I
Site 31
Y433
T
E
F
R
Y
P
S
Y
V
Q
H
I
M
G
D
Site 32
S455
P
F
R
W
V
C
T
S
G
D
P
Q
D
L
A
Site 33
S507
R
H
R
L
V
V
G
S
Q
A
R
I
L
Y
S
Site 34
Y513
G
S
Q
A
R
I
L
Y
S
D
Q
K
G
R
V
Site 35
S549
S
R
D
H
H
D
V
S
G
T
D
S
P
F
R
Site 36
T551
D
H
H
D
V
S
G
T
D
S
P
F
R
E
T
Site 37
S553
H
D
V
S
G
T
D
S
P
F
R
E
T
S
N
Site 38
T558
T
D
S
P
F
R
E
T
S
N
I
Y
D
G
S
Site 39
S559
D
S
P
F
R
E
T
S
N
I
Y
D
G
S
A
Site 40
T585
G
D
A
C
R
G
A
T
W
V
A
L
H
N
G
Site 41
T612
F
G
L
V
L
D
G
T
P
E
A
E
G
R
A
Site 42
S624
G
R
A
R
L
M
L
S
W
D
V
S
N
G
V
Site 43
T655
Q
T
M
Q
E
N
S
T
L
V
V
T
L
P
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation