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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PWWP2A
Full Name:
PWWP domain-containing protein 2A
Alias:
KIAA1935; MST101; PWP2A
Type:
Uncharacterized protein
Mass (Da):
81960
Number AA:
755
UniProt ID:
Q96N64
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
A
A
A
T
A
A
S
P
G
E
G
G
A
G
Site 2
S33
E
M
E
P
I
P
G
S
E
A
G
T
D
P
L
Site 3
T43
G
T
D
P
L
P
V
T
A
T
E
A
S
V
P
Site 4
T45
D
P
L
P
V
T
A
T
E
A
S
V
P
D
G
Site 5
S48
P
V
T
A
T
E
A
S
V
P
D
G
E
T
D
Site 6
S81
P
P
G
E
L
A
R
S
P
E
A
V
G
P
E
Site 7
S96
L
E
A
E
E
K
L
S
V
R
V
A
E
S
A
Site 8
S116
G
G
P
E
L
P
P
S
P
A
S
P
P
E
Q
Site 9
S119
E
L
P
P
S
P
A
S
P
P
E
Q
P
P
A
Site 10
S151
V
P
P
A
G
G
D
S
T
V
S
Q
L
I
P
Site 11
T152
P
P
A
G
G
D
S
T
V
S
Q
L
I
P
G
Site 12
S154
A
G
G
D
S
T
V
S
Q
L
I
P
G
S
E
Site 13
T165
P
G
S
E
V
R
V
T
L
D
H
I
I
E
D
Site 14
S177
I
E
D
A
L
V
V
S
F
R
F
G
E
K
L
Site 15
S193
S
G
V
L
M
D
L
S
K
R
F
G
P
H
G
Site 16
T204
G
P
H
G
I
P
V
T
V
F
P
K
R
E
Y
Site 17
Y211
T
V
F
P
K
R
E
Y
K
D
K
P
E
A
M
Site 18
T224
A
M
P
L
Q
S
N
T
F
Q
E
G
T
E
V
Site 19
T229
S
N
T
F
Q
E
G
T
E
V
K
C
E
A
N
Site 20
S244
G
A
V
P
D
D
P
S
P
V
P
H
P
E
L
Site 21
S252
P
V
P
H
P
E
L
S
L
A
E
S
L
W
T
Site 22
S256
P
E
L
S
L
A
E
S
L
W
T
S
K
P
P
Site 23
T259
S
L
A
E
S
L
W
T
S
K
P
P
P
L
F
Site 24
S260
L
A
E
S
L
W
T
S
K
P
P
P
L
F
H
Site 25
Y272
L
F
H
E
G
A
P
Y
P
P
P
L
F
I
R
Site 26
T281
P
P
L
F
I
R
D
T
Y
N
Q
S
I
P
Q
Site 27
Y282
P
L
F
I
R
D
T
Y
N
Q
S
I
P
Q
P
Site 28
S285
I
R
D
T
Y
N
Q
S
I
P
Q
P
P
P
R
Site 29
Y302
K
R
P
K
R
K
M
Y
R
E
E
P
T
S
I
Site 30
S308
M
Y
R
E
E
P
T
S
I
M
N
A
I
K
L
Site 31
S328
L
C
D
K
C
K
N
S
V
V
A
E
K
K
E
Site 32
S340
K
K
E
I
R
K
G
S
S
A
T
D
S
S
K
Site 33
S341
K
E
I
R
K
G
S
S
A
T
D
S
S
K
Y
Site 34
S345
K
G
S
S
A
T
D
S
S
K
Y
E
D
K
K
Site 35
S346
G
S
S
A
T
D
S
S
K
Y
E
D
K
K
R
Site 36
S357
D
K
K
R
R
N
E
S
V
T
T
V
N
K
K
Site 37
T359
K
R
R
N
E
S
V
T
T
V
N
K
K
L
K
Site 38
T360
R
R
N
E
S
V
T
T
V
N
K
K
L
K
T
Site 39
T367
T
V
N
K
K
L
K
T
D
H
K
V
D
G
K
Site 40
S379
D
G
K
N
Q
N
E
S
Q
K
R
N
A
V
V
Site 41
S389
R
N
A
V
V
K
V
S
N
I
A
H
S
R
G
Site 42
S402
R
G
R
V
V
K
V
S
A
Q
A
N
T
S
K
Site 43
S413
N
T
S
K
A
Q
L
S
T
K
K
V
L
Q
S
Site 44
S420
S
T
K
K
V
L
Q
S
K
N
M
D
H
A
K
Site 45
S447
Q
K
K
Q
N
E
T
S
T
S
K
N
A
H
S
Site 46
S449
K
Q
N
E
T
S
T
S
K
N
A
H
S
K
V
Site 47
Y462
K
V
H
F
T
R
R
Y
Q
N
P
S
S
G
S
Site 48
S466
T
R
R
Y
Q
N
P
S
S
G
S
L
P
P
R
Site 49
S467
R
R
Y
Q
N
P
S
S
G
S
L
P
P
R
V
Site 50
S469
Y
Q
N
P
S
S
G
S
L
P
P
R
V
R
L
Site 51
S488
Y
R
N
E
E
N
D
S
S
L
K
T
G
L
E
Site 52
S489
R
N
E
E
N
D
S
S
L
K
T
G
L
E
K
Site 53
T492
E
N
D
S
S
L
K
T
G
L
E
K
M
R
S
Site 54
S499
T
G
L
E
K
M
R
S
G
K
M
A
P
K
P
Site 55
S508
K
M
A
P
K
P
Q
S
R
C
T
S
T
R
S
Site 56
T511
P
K
P
Q
S
R
C
T
S
T
R
S
A
G
E
Site 57
S512
K
P
Q
S
R
C
T
S
T
R
S
A
G
E
A
Site 58
S515
S
R
C
T
S
T
R
S
A
G
E
A
P
S
E
Site 59
S521
R
S
A
G
E
A
P
S
E
N
Q
S
P
S
K
Site 60
S525
E
A
P
S
E
N
Q
S
P
S
K
G
P
E
E
Site 61
S527
P
S
E
N
Q
S
P
S
K
G
P
E
E
A
S
Site 62
S535
K
G
P
E
E
A
S
S
E
V
Q
D
T
N
E
Site 63
T540
A
S
S
E
V
Q
D
T
N
E
V
H
V
P
G
Site 64
T554
G
D
Q
D
E
P
Q
T
L
G
K
K
G
S
K
Site 65
S560
Q
T
L
G
K
K
G
S
K
N
N
I
S
V
Y
Site 66
S565
K
G
S
K
N
N
I
S
V
Y
M
T
L
N
Q
Site 67
Y567
S
K
N
N
I
S
V
Y
M
T
L
N
Q
K
K
Site 68
T569
N
N
I
S
V
Y
M
T
L
N
Q
K
K
S
D
Site 69
S575
M
T
L
N
Q
K
K
S
D
S
S
S
A
S
V
Site 70
S577
L
N
Q
K
K
S
D
S
S
S
A
S
V
C
S
Site 71
S578
N
Q
K
K
S
D
S
S
S
A
S
V
C
S
I
Site 72
S579
Q
K
K
S
D
S
S
S
A
S
V
C
S
I
D
Site 73
S581
K
S
D
S
S
S
A
S
V
C
S
I
D
S
T
Site 74
S584
S
S
S
A
S
V
C
S
I
D
S
T
D
D
L
Site 75
S587
A
S
V
C
S
I
D
S
T
D
D
L
K
S
S
Site 76
T588
S
V
C
S
I
D
S
T
D
D
L
K
S
S
N
Site 77
S593
D
S
T
D
D
L
K
S
S
N
S
E
C
S
S
Site 78
S594
S
T
D
D
L
K
S
S
N
S
E
C
S
S
S
Site 79
S596
D
D
L
K
S
S
N
S
E
C
S
S
S
E
S
Site 80
S599
K
S
S
N
S
E
C
S
S
S
E
S
F
D
F
Site 81
S600
S
S
N
S
E
C
S
S
S
E
S
F
D
F
P
Site 82
S601
S
N
S
E
C
S
S
S
E
S
F
D
F
P
P
Site 83
S603
S
E
C
S
S
S
E
S
F
D
F
P
P
G
S
Site 84
S610
S
F
D
F
P
P
G
S
M
H
A
P
S
T
S
Site 85
S615
P
G
S
M
H
A
P
S
T
S
S
T
S
S
S
Site 86
T616
G
S
M
H
A
P
S
T
S
S
T
S
S
S
S
Site 87
S617
S
M
H
A
P
S
T
S
S
T
S
S
S
S
K
Site 88
S618
M
H
A
P
S
T
S
S
T
S
S
S
S
K
E
Site 89
T619
H
A
P
S
T
S
S
T
S
S
S
S
K
E
E
Site 90
S620
A
P
S
T
S
S
T
S
S
S
S
K
E
E
K
Site 91
S621
P
S
T
S
S
T
S
S
S
S
K
E
E
K
K
Site 92
S622
S
T
S
S
T
S
S
S
S
K
E
E
K
K
L
Site 93
S630
S
K
E
E
K
K
L
S
N
S
L
K
M
K
V
Site 94
S632
E
E
K
K
L
S
N
S
L
K
M
K
V
F
S
Site 95
S639
S
L
K
M
K
V
F
S
K
N
V
S
K
C
V
Site 96
S643
K
V
F
S
K
N
V
S
K
C
V
T
P
D
G
Site 97
T647
K
N
V
S
K
C
V
T
P
D
G
R
T
I
C
Site 98
T675
W
W
P
A
R
I
L
T
I
T
V
S
R
K
D
Site 99
T677
P
A
R
I
L
T
I
T
V
S
R
K
D
N
G
Site 100
S694
V
R
Q
E
A
R
I
S
W
F
G
S
P
T
T
Site 101
S718
P
F
L
E
N
F
Q
S
R
F
N
K
K
R
K
Site 102
Y728
N
K
K
R
K
G
L
Y
R
K
A
I
T
E
A
Site 103
T733
G
L
Y
R
K
A
I
T
E
A
A
K
A
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation