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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC74B
Full Name:
Coiled-coil domain-containing protein 74B
Alias:
Type:
Mass (Da):
41826
Number AA:
380
UniProt ID:
Q96LY2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
A
G
V
A
A
G
Site 2
T10
G
A
G
V
A
A
G
T
R
P
P
S
S
P
T
Site 3
S14
A
A
G
T
R
P
P
S
S
P
T
P
G
S
R
Site 4
S15
A
G
T
R
P
P
S
S
P
T
P
G
S
R
R
Site 5
T17
T
R
P
P
S
S
P
T
P
G
S
R
R
R
R
Site 6
S20
P
S
S
P
T
P
G
S
R
R
R
R
Q
R
P
Site 7
S28
R
R
R
R
Q
R
P
S
V
G
V
Q
S
L
R
Site 8
S33
R
P
S
V
G
V
Q
S
L
R
P
Q
S
P
Q
Site 9
S38
V
Q
S
L
R
P
Q
S
P
Q
L
R
Q
S
D
Site 10
S44
Q
S
P
Q
L
R
Q
S
D
P
Q
K
R
N
L
Site 11
S56
R
N
L
D
L
E
K
S
L
Q
F
L
Q
Q
Q
Site 12
S65
Q
F
L
Q
Q
Q
H
S
E
M
L
A
K
L
H
Site 13
Y87
R
E
N
K
D
L
R
Y
K
L
I
M
N
Q
T
Site 14
S95
K
L
I
M
N
Q
T
S
Q
K
K
D
G
P
S
Site 15
S102
S
Q
K
K
D
G
P
S
G
N
H
L
S
R
A
Site 16
S107
G
P
S
G
N
H
L
S
R
A
S
A
P
L
G
Site 17
S110
G
N
H
L
S
R
A
S
A
P
L
G
A
R
W
Site 18
S131
W
V
E
P
G
G
P
S
P
A
R
L
K
E
G
Site 19
S139
P
A
R
L
K
E
G
S
S
R
T
H
R
P
G
Site 20
S140
A
R
L
K
E
G
S
S
R
T
H
R
P
G
G
Site 21
T142
L
K
E
G
S
S
R
T
H
R
P
G
G
K
H
Site 22
S156
H
G
R
L
A
G
G
S
A
D
T
V
R
S
P
Site 23
T159
L
A
G
G
S
A
D
T
V
R
S
P
A
D
S
Site 24
S162
G
S
A
D
T
V
R
S
P
A
D
S
L
S
T
Site 25
S166
T
V
R
S
P
A
D
S
L
S
T
S
S
F
Q
Site 26
S168
R
S
P
A
D
S
L
S
T
S
S
F
Q
S
V
Site 27
S170
P
A
D
S
L
S
T
S
S
F
Q
S
V
K
S
Site 28
S171
A
D
S
L
S
T
S
S
F
Q
S
V
K
S
I
Site 29
S174
L
S
T
S
S
F
Q
S
V
K
S
I
S
N
S
Site 30
S177
S
S
F
Q
S
V
K
S
I
S
N
S
G
K
A
Site 31
S181
S
V
K
S
I
S
N
S
G
K
A
R
P
Q
P
Site 32
S190
K
A
R
P
Q
P
G
S
F
N
K
Q
D
S
K
Site 33
S196
G
S
F
N
K
Q
D
S
K
A
D
V
P
Q
K
Site 34
T270
P
L
P
L
R
K
P
T
T
L
R
Q
C
E
V
Site 35
T271
L
P
L
R
K
P
T
T
L
R
Q
C
E
V
L
Site 36
T285
L
I
R
E
L
W
N
T
N
L
L
Q
T
Q
E
Site 37
S298
Q
E
L
Q
H
L
K
S
L
L
E
G
S
Q
R
Site 38
S303
L
K
S
L
L
E
G
S
Q
R
P
Q
A
V
P
Site 39
S314
Q
A
V
P
E
E
A
S
F
P
R
D
Q
E
A
Site 40
T322
F
P
R
D
Q
E
A
T
H
F
P
K
V
S
T
Site 41
S331
F
P
K
V
S
T
K
S
L
S
K
K
C
L
L
Site 42
S333
K
V
S
T
K
S
L
S
K
K
C
L
L
L
S
Site 43
S340
S
K
K
C
L
L
L
S
P
P
V
A
E
R
A
Site 44
T355
I
L
P
A
L
K
Q
T
P
K
N
N
F
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation